scholarly journals Elevated C-Reactive Protein (CRP) during First-Trimester For Gestational Diabetes Screening

2021 ◽  
Keyword(s):  
Gestational Diabetes ◽  
First Trimester ◽  
Diabetes Screening ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals C-reactive protein as a screening test for gestational diabetes mellitus in first-trimester of pregnancy: a prospective cohort study

2018 ◽  
Vol 7 (12) ◽  
pp. 4798 ◽  
Author(s):  
Tarek A. Farghaly ◽  
Neveen A. Helmy ◽  
Ahmed M. Abbas ◽  
Abdel Ghaffar M. Ahmed
Keyword(s):  
Diabetes Mellitus ◽  
Cohort Study ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
First Trimester ◽  
Oral Glucose ◽  
C Reactive Protein ◽  
Reactive Protein

Background: The current study aims to determine if increased inflammation identified by increased C-reactive protein (CRP) level is associated with the subsequent development of gestational diabetes mellitus (GDM).Methods: A prospective cohort study conducted at a tertiary University Hospital included 496 booking for their antenatal care visit between 10-12 weeks of gestation. They were tested for presence of CRP in blood. All women without a history of antenatal type 1 or type 2 diabetes undergo routine GDM screening with the 50-g oral glucose-loading test (GLT) between 24 and 28 weeks 'gestation. Women whose 1-h post-loading plasma glucose level >7.8 mmol/l (>140 mg/dl) undergo a diagnostic, fasting, 100-g, 3-h oral glucose tolerance test (OGTT) within 1-2 weeks following the GLT.Results: Among these 496 women, a total of 27 women (5.4%) were diagnosed as GDM and 10 women (2.0%) were diagnosed as IGT at week 24-28. The CRP was positive and higher in the GDM diagnosed group (p=0.000) compared to those who did not develop GDM. CRP was positively correlated with diagnosis of GDM (r=0.438, p=0.012).Conclusions: There is an association between first-trimester inflammation, marked by increased CRP levels and subsequent risk of GDM.

scholarly journals Elevated first trimester C-reactive protein as a predictor of gestational diabetes

2019 ◽  
Vol 6 (5) ◽  
pp. 1482
Author(s):  
Sanjay Parihar ◽  
Rajesh Singh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
First Trimester ◽  
Antenatal Visit ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
First Trimester Of Pregnancy

Background: The incidence of type 2 diabetes is increasing at an alarming rate, particularly among young women. GDM is a unique prediabetes state that shares common risk factors with type 2 diabetes, and similar alterations in carbohydrate metabolism. Objectives of this study the elevation of C-reactive protein in the first trimester of pregnancy as a predictor of gestational diabetes.Methods: This hospital-based study comprised of patients (Primigravida) visiting the obstetric OPD or admitted in Obstetric wards. Detailed history and clinical examination of the patient was recorded on a Proforma. Blood samples of patients were taken for: (i) C-reactive protein in first trimester of pregnancy; and (ii) Blood sugar (fasting & post-prandial) during their first antenatal visit and patients were followed up in subsequent visits in second and third trimester for development of gestational diabetes.Results: There were seven women who developed gestational diabetes and had elevated first trimester C- reactive protein levels as compared to other group in which only two women developed gestational diabetes mellitus but did not have elevated C-reactive protein in their first trimester. However, there were two women, who had elevated C-reactive protein, but did not subsequently develop gestational diabetes mellitus and women with C-reactive protein in normal range who did not develop gestational diabetes mellitus were 56.Conclusion: An association between first trimester inflammation marked by increased CRP levels, and subsequent risk of development of GDM has been identified.

scholarly journals First-Trimester C-Reactive Protein and Subsequent Gestational Diabetes

Diabetes Care ◽  
2003 ◽  
Vol 26 (3) ◽  
pp. 819-824 ◽  
Author(s):  
M. Wolf ◽  
L. Sandler ◽  
K. Hsu ◽  
K. Vossen-Smirnakis ◽  
J. L. Ecker ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
First Trimester ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era: Implications of Il-6 In Diabesity

2021 ◽  
Vol 22 (3) ◽  
pp. 1213
Author(s):  
Anna Lucia Fedullo ◽  
Antonio Schiattarella ◽  
Maddalena Morlando ◽  
Anna Raguzzini ◽  
Elisabetta Toti ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Mediterranean Diet ◽  
Viral Infections ◽  
High Body Mass Index ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Gestational Weight ◽  
Poor Outcomes

The aim of this review is to highlight the influence of the Mediterranean Diet (MedDiet) on Gestational Diabetes Mellitus (GDM) and Gestational Weight Gain (GWG) during the COVID-19 pandemic era and the specific role of interleukin (IL)-6 in diabesity. It is known that diabetes, high body mass index, high glycated hemoglobin and raised serum IL-6 levels are predictive of poor outcomes in coronavirus disease 2019 (COVID-19). The immunopathological mechanisms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection include rising levels of several cytokines and in particular IL-6. The latter is associated with hyperglycemia and insulin resistance and could be useful for predicting the development of GDM. Rich in omega-3 polyunsaturated fatty acids, vitamins, and minerals, MedDiet improves the immune system and could modulate IL-6, C reactive protein and Nuclear Factor (NF)-κB. Moreover, polyphenols could modulate microbiota composition, inhibit the NF-κB pathway, lower IL-6, and upregulate antioxidant enzymes. Finally, adhering to the MedDiet prior to and during pregnancy could have a protective effect, reducing GWG and the risk of GDM, as well as improving the immune response to viral infections such as COVID-19.

scholarly journals A STUDY TO ASSESS PREDICTIVE ROLE OF C-REACTIVE PROTEIN IN EARLY PREGNANCY AMONG WOMEN

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Neeti Mahla ◽  
Mukesh Choudhary
Keyword(s):  
Early Pregnancy ◽  
Quantitative Estimation ◽  
First Trimester ◽  
Normal Pregnancy ◽  
P Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Predictive Role ◽  
The Difference

Background: To Assess Predictive Role of C-Reactive Protein In Early Pregnancy among Women Methods: Hospital based comparative analysis was conducted on Women with early pregnancy upto 14 weeks with either abdominal pain or vaginal bleeding or suspected extrauterine pregnancy. C-reactive protein (CRP) quantitative estimation is done by turbi-diametric method. Collected samples were sent to a designated lab of our hospital. Results: The mean c-reactive protein level in cases 2.31 with min-max value ranging from 0.80-3.91mg/dl while in controls mean c-reactive protein value came to be 9.12 with min-max range from 3.21-24.16 mg/dl. The difference between the two groups is significant as p value is less than 0.001. Conclusion: Our results of significantly increased CRP levels in normal pregnancy and a clear association between CRP and normal pregnancy, support the clinical application of this diagnostic tool in early pregnancy, especially as a predictor of abnormal first trimester pregnancies. Keywords: CRP, Pregnancy, Women

Sign in / Sign up

Export Citation Format

Share Document