PENGARUH VARIASI KONSENTRASI HPMC DAN GLISERIN TERHADAP SIFAT FISIK GEL HAND SANITIZER EKSTRAK ETANOL  DAUN PALA (Myristica fragrans Houtt.)

Daun pala (Myristica fragrans Houtt.) memiliki senyawa metabolit sekunder seperti flavonoid, saponin dan tanin. Oleh karena itu, daun pala dikembangkan ke dalam bentuk sediaan gel hand sanitizer yang berpotensi sebagai antibakteri. Dalam formulasi gel, penggunaan gelling agent dan humektan merupakan faktor penting yang dapat menghasilkan sediaan gel yang stabil. Tujuan dari penelitian ini yaitu untuk mengetahui stabilitas sediaan gel hand sanitizer ekstrak etanol daun pala dengan variasi konsentrasi HPMC dan gliserin. Gel hand sanitizer ini dibuat 3 formulasi dengan variasi HPMC dan gliserin, yaitu formula 1 (HPMC 1% : gliserin 5%), formula 2 (HPMC 1.5% : gliserin 7.5%), formula 3 (HPMC 2%, gliserin 10%). Uji stabilitas yang dilakukan terhadap sediaan menggunakan metode cycling test sebanyak 6 siklus. Berdasarkan hasil analisis cycling test 6 siklus dihasilkan bahwa formula yang memiliki stabilitas paling baik adalah formula 1 dengan variasi konsentrasi HPMC 1% dan gliserin 5%.

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Formulation and physical stability test of hand sanitizer based on nutmeg oil (Myristica fragrans Houtt)

IOP Conference Series Earth and Environmental Science ◽

10.1088/1755-1315/800/1/012032 ◽

2021 ◽

Vol 800 (1) ◽

pp. 012032

Author(s):

R D Agustin ◽

Y M J Taihuttu

Keyword(s):

Physical Stability ◽

Stability Test ◽

Hand Sanitizer ◽

Myristica Fragrans ◽

Myristica Fragrans Houtt

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Uji Aktivitas Minyak Atsiri Daun Pala (Myristica fragrans Houtt.) terhadap Malassezia furfur secara In Vitro

Jurnal Cerebellum ◽

10.26418/jc.v5i4b.44819 ◽

2021 ◽

Vol 5 (4B) ◽

pp. 1549

Author(s):

Qurratul Aini ◽

Muhamad Agus Wibowo ◽

Mahyarudin Mahyarudin

Keyword(s):

Pityriasis Versicolor ◽

Tween 20 ◽

Malassezia Furfur ◽

Myristica Fragrans ◽

Myristica Fragrans Houtt ◽

Post Hoc ◽

One Way Anova

Latar Belakang. Pityriasis versicolor atau panu merupakan infeksi jamur superfisial pada kulit yangdisebabkan oleh Malassezia furfur. Minyak atsiri daun pala diketahui mengandung senyawa metabolit sekunder yang berpotensi sebagai antijamur. Metode. Penelitian ini merupakan eksperimental murni menggunakan Rancangan Acak Lengkap (RAL). Uji aktivitas antijamur menggunakan metode difusi cakram Kirby-Bauer dengan variasi konsentrasi 10%, 25%, 50%, 75% dan 100%. Kontrol positif yang digunakan adalah ketokonazol 30 µg/disk sedangkan kontrol negatif yang digunakan adalah Tween 20. Analisis data menggunakan uji statistic One Way ANOVA dan dilanjutkan dengan uji Post Hoc Least Significant Different (LSD). Hasil. Hasil uji aktivitas antijamur minyak atsiri daun pala pada konsentrasi 25%, 50%, 75% dan 100% membentuk zona hambat dengan rata-rata diameter sebesar 8,875mm, 9,625mm, 10mm, dan 15mm. Uji statistik menunjukkan nilai signifikansi (p < 0,05) yang mengindikasikan terdapat perbedaan bermakna antar kelompok perlakuan. Kesimpulan. Minyak atsiri daun pala memiliki aktivitas antijamur terhadap Malassezia furfur.

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Effect of Nutmeg Flesh (Myristica fragrans Houtt) against Streptococcus mutans growth

Journal of Syiah Kuala Dentistry Society ◽

10.24815/jds.v5i1.19682 ◽

2021 ◽

Vol 5 (1) ◽

pp. 42-46

Author(s):

Putri Rahmi Noviyandri ◽

NURHADISAH , ◽

Santi Chismirina

Keyword(s):

Streptococcus Mutans ◽

Native Plants ◽

Antibacterial Properties ◽

Inhibition Zone ◽

Anova Analysis ◽

Myristica Fragrans ◽

Significant Difference ◽

Myristica Fragrans Houtt ◽

The One ◽

One Way Anova

Streptococcus mutans is an oral commensal. Its bacteria are involved in the dental caries pathogenesis. Nutmeg flesh (Myristica fragrans Houtt) is one of the native plants of Indonesia. Nutmeg flesh (Myristica fragrans Houtt) contains antibacterial properties such as alkaloids, flavonoids, tannins, terpenoids, saponins, and essential oil. The purpose of this study is to determine the effect of nutmeg flesh (Myristica fragrans Houtt) extract in the inhibition of Streptococcus mutans growth. The extract of nutmeg flesh (Myristica fragrans Houtt) was made using the maceration method with ethanol 96% as the solvent. The Diffusion methods to identify the inhibition of Streptococcus mutans growth. The concentration of nutmeg flesh (Myristica fragrans Houtt) extract used in this study were 25%, 50%, 75%, and 100. The one-way ANOVA analysis showed that there was the effect of nutmeg flesh (Myristica fragrans Houtt) extract on Streptococcus mutans growth with value p0.05, and then data was tested by Least Significant Difference (LSD). This study's conclusion showed an effect of nutmeg flesh (Myristica fragrans Houtt) extract in inhibiting Streptococcus mutans growth. The concentration of nutmeg flesh (Myristica fragrans Houtt) extract, which has the greatest inhibition zone on the growth of Streptococcus mutans, is at a concentration of 100% is 33,53 mm. KEYWORDS: Nutmeg flesh (Myristica fragrans Houtt), Streptococcus mutans

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Effect of Nutmeg Flesh (Myristica fragrans Houtt) against Streptococcus mutans growth

Journal of Syiah Kuala Dentistry Society ◽

10.24815/jds.v5i1.20010 ◽

2020 ◽

Vol 5 (1) ◽

pp. 42-46

Author(s):

Putri Rahmi Noviyandri ◽

Nurhadisah Nurhadisah ◽

Santi Chismirina

Keyword(s):

Streptococcus Mutans ◽

Native Plants ◽

Antibacterial Properties ◽

Inhibition Zone ◽

Anova Analysis ◽

Myristica Fragrans ◽

Significant Difference ◽

Myristica Fragrans Houtt ◽

The One ◽

One Way Anova

Streptococcus mutans is an oral commensal. Its bacteria are involved in the dental caries pathogenesis. Nutmeg flesh (Myristica fragrans Houtt) is one of the native plants of Indonesia. Nutmeg flesh (Myristica fragrans Houtt) contains antibacterial properties such as alkaloids, flavonoids, tannins, terpenoids, saponins, and essential oil. The purpose of this study is to determine the effect of nutmeg flesh (Myristica fragrans Houtt) extract in the inhibition of Streptococcus mutans growth. The extract of nutmeg flesh (Myristica fragrans Houtt) was made using the maceration method with ethanol 96% as the solvent. The Diffusion methods to identify the inhibition of Streptococcus mutans growth. The concentration of nutmeg flesh (Myristica fragrans Houtt) extract used in this study were 25%, 50%, 75%, and 100. The one-way ANOVA analysis showed that there was the effect of nutmeg flesh (Myristica fragrans Houtt) extract on Streptococcus mutans growth with value p0.05, and then data was tested by Least Significant Difference (LSD). This study's conclusion showed an effect of nutmeg flesh (Myristica fragrans Houtt) extract in inhibiting Streptococcus mutans growth. The concentration of nutmeg flesh (Myristica fragrans Houtt) extract, which has the greatest inhibition zone on the growth of Streptococcus mutans, is at a concentration of 100% is 33,53 mm

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Phytochemical and Pharmacological Activity of Myristica fragrans Houtt (Myristicaceae)

INTERNATIONAL JOURNAL OF TOXICOLOGICAL AND PHARMACOLOGICAL RESEARCH ◽

10.25258/ijtpr.v9i01.9038 ◽

2017 ◽

Vol 9 (01) ◽

Author(s):

Md Arifur Rahman Chowdhury ◽

Manirujjaman . ◽

Md Mazedul Haq

Keyword(s):

Acetic Acid ◽

Phenolic Content ◽

Methanolic Extract ◽

Radical Scavenging ◽

Antioxidant Property ◽

Free Radical Scavenging ◽

Total Phenolic ◽

Writhing Test ◽

Myristica Fragrans ◽

Myristica Fragrans Houtt

Objective: Myristica fragrans Houtt commonly used as traditional medicine for alleviating of various disorders. The purpose of our study was to map out the in vitro antioxidant property and in vivo anti-hyperglycemic and analgesic effect of the methanolic extract of Myristica fragrans Houtt. (Seed and mace) (Myristicaceae) on Swiss albino mice. Methods: The processed powder of Myristica fragrans Houtt (seed and mace) were subjected to methanolic extraction by soxhlet filtration methods, and the desiccated extract was used for screening of antioxidant by DPPH free radical scavenging assessment as well as total phenolic content by using folin-ciocalteu reagent.Anti-hyperglycemic effect and analgesic action tested through alloxan induced antidiabetics test and acetic acid-tempted writhing test on mice. Results: In DPPH free radical scavenging assessment, free radicals neutralization expressed as % of inhibition 49.69±0.06% also by IC50 values as 68.43 µg/ml surmise middle level of antioxidant property. The total phenolic content expressed as 186.25 mg/g equivalent of gallic acid indicates, active phenolic content. Oral administration of 200 and 400 mg/kg of extract dose and reference drug vildagliptin (50 mg/kg) for the duration of the 4-day study period, and initiated % of inhibition the blood glucose level measured as 22.48%, 44.78% and 62.02% regard as the significant anti-hyperglycemic properties. The analgesic activity was investigated by using the acetic acid-induced writhing test in mice, at the dose of 200 mg/kg body and 400mg/kg weight, and resulting 50.4% and 68.10% correspondingly, which was considerably significant with a standard drug. Conclusion: The present study suggests that methanolic extract of seed and mace of Myristica fragrans Houtt can manage moderate oxidative stress as well as perform the painkilling action. Besides, prolong medication may enhance the new dimension of anti-hyperglycemic activity.

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Karekteristik Mikrokapsul Oleoresin Fuli Pala (Myristica Fragrans Houtt) Yang Dienkapsulasi Dengan Gum Arab

Jurnal Teknologi Pangan dan Hasil Pertanian ◽

10.26623/jtphp.v14i2.1281 ◽

2020 ◽

Vol 14 (2) ◽

pp. 1

Author(s):

Alston Millan

Keyword(s):

Scavenging Activity ◽

Myristica Fragrans ◽

Myristica Fragrans Houtt

ABSTRAK Tujuan penelitian ini adalah untuk mengetahui pengaruh formulasi berbagai total padatan yang terdiri dari gum Arab sebagai enkapsulan dan oleoresin fuli pala sebagai core terhadap karakteristik mikrokapsul yang dihasilkan. Variasi formulasi oleoresin fuli pala dan gum arab yang dicobakan adalah A1 (5%), A2 (10%), A3 (15%), A4 (20%) dan A5 (20%). Pembentukan emulsi dilakukan dengan Turrax homogenizer dengan kecepatan 4000 rpm selama 5 menit. Pembentukan mikrokapsul dilakukan dengan menggunakan pengering semprot (spray dryer) dengan suhu inlet dan outlet masing-masing 1100C dan 620C. Mikrokapsul yang dihasilkan dianalisis karakteristiknya yang meliputi rendemen mikrokapsul, kadar oleoresin terkapsulkan, kadar oleoresin tak terkapsulkan, kadar air, engel of repose, wettability dan rehidrasi, aktivitas antioksidan dengan metode RSA (radikal scavenging activity) DPPH (2-2Dhpypenil-2 Picrylhydrazil) dan kromatografi gas-spektrometri massa (GC-MS). Mikrokapsul yang terbaik diperoleh dengan variasi formulasi oleoresin fuli pala dan gum arab adalah A1 (5%). Sifat mikrokapsul yang diperoleh menpunyai rendemen mikrokapsul 24,68%, oleoresin terkapsulkan 92,68%, oleoresin tak terkapsulkan 7,607%, kadar air 8,444%, angel of repose 19,083 (0), wettability 5,9 (menit), aktivitas antioksidan (IC50) 1032 ppm dan kromatografi gas-spektrometri massa (GC-MS) dengan komponen terbesar penyusun mikrokapsul oleoresin fuli pala yaitu sabinene hexane, 4-methylene-1-, myristycin, phenol 2,6 dimetoksi-4-2 (2-peopenil), phenol, 2-metoksi-4-(propennyl).

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