On practical application of plasma and laser hardening

2020 ◽  
pp. 266-271
Author(s):  
M.V. Zlokazov ◽  
V.A. Korotkov
Keyword(s):  
Large Scale ◽  
Low Cost ◽  
Cost Effective ◽  
Laser Hardening ◽  
Small Scale ◽  
Scale Production ◽  
Plasma Hardening ◽  
Large Scale Production ◽  
Increase Wear Resistance ◽  
Finishing Machining

Laser and plasma hardening practically do not damage the surface, so the parts after their execution are sent to the assembly without finishing machining, which reduces the complexity and logistics of the process. In conditions of dry friction hardened steel discs 45 and 40Kh increase wear resistance up to 100 times. The service life of parts strengthened by laser and plasma hardening is repeatedly increased. Laser hardening differs from plasma hardening by higher cost of equipment, therefore it is preferable in large-scale production. Plasma installation UDGZ-200, thanks to manual operation, it is possible to temper the surfaces inaccessible or inaccessible to other hardening methods. This, together with the low cost of equipment, makes plasma hardening cost-effective in conditions of single-unit and small-scale productions.

scholarly journals Low-cost Large Scale Vermicompost Unit

2021 ◽  
Vol 2115 (1) ◽  
pp. 012026
Author(s):  
Sonam Solanki ◽  
Gunendra Mahore
Keyword(s):  
Large Scale ◽  
Low Cost ◽  
Small Scale ◽  
Scale Production ◽  
Key Innovation ◽  
Main Challenge ◽  
Long Run ◽  
Large Scale Production ◽  
Term Maintenance

Abstract In the current process of producing vermicompost on a large-scale, the main challenge is to keep the worms alive. This is achieved by maintaining temperature and moisture in their living medium. It is a difficult task to maintain these parameters throughout the process. Currently, this is achieved by building infrastructure but this method requires a large initial investment and long-run maintenance. Also, these methods are limited to small-scale production. For large-scale production, a unit is developed which utilises natural airflow with water and automation. The main aim of this unit is to provide favourable conditions to worms in large-scale production with very low investment and minimum maintenance in long term. The key innovation of this research is that the technology used in the unit should be practical and easy to adopt by small farmers. For long-term maintenance of the technology lesser number of parts are used.

scholarly journals An Exploratory Examination on Small Scale Sugarcane Harvesting Machine

2020 ◽  
Vol 8 (6) ◽  
pp. 5265-5268
Keyword(s):  
Sugar Cane ◽  
Large Scale ◽  
Low Cost ◽  
Small Scale ◽  
Scale Production ◽  
High Demand ◽  
Large Scale Production ◽  
By Products

The work in this paper is focused , about the sugarcane harvesting machine, as India is considered as one of the higher consumers and producers of sugarcane and its by products and to due to huge population, there is a high demand of sugarcane and to meet the demand of population, large scale production has to be adopted, hence for farming and harvesting the sugarcane an automated, low cost harvester is necessary for the farmers to reduce the efforts of sugarcane harvesting and to increase the rate of sugar cane cutting. This machine will be helpful for the farmers having both small and big farms, the work on this paper was carried to identify the major options along with the opportunities and major chances for future enhancement in the field of agriculture industries.

scholarly journals SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
C. Ferreras ◽  
B. Pascual-Miguel ◽  
C. Mestre-Durán ◽  
A. Navarro-Zapata ◽  
L. Clares-Villa ◽  
...  
Keyword(s):  
T Cells ◽  
Large Scale ◽  
Memory T Cells ◽  
Adoptive Cell Therapy ◽  
Cost Effective ◽  
Effector Memory ◽  
Small Scale ◽  
Scale Production ◽  
Specific Memory ◽  
Large Scale Production

Syndrome coronavirus 2 (SARS-CoV-2) pandemic is causing a second outbreak significantly delaying the hope for the virus’ complete eradication. In the absence of effective vaccines, we need effective treatments with low adverse effects that can treat hospitalized patients with COVID-19 disease. In this study, we determined the existence of SARS-CoV-2-specific T cells within CD45RA– memory T cells in the blood of convalescent donors. Memory T cells can respond quickly to infection and provide long-term immune protection to reduce the severity of COVID-19 symptoms. Also, CD45RA– memory T cells confer protection from other pathogens encountered by the donors throughout their life. It is of vital importance to resolve other secondary infections that usually develop in patients hospitalized with COVID-19. We found SARS-CoV-2-specific memory T cells in all of the CD45RA– subsets (CD3+, CD4+, and CD8+) and in the central memory and effector memory subpopulations. The procedure for obtaining these cells is feasible, easy to implement for small-scale manufacture, quick and cost-effective, involves minimal manipulation, and has no GMP requirements. This biobank of specific SARS-CoV-2 memory T cells would be immediately available “off-the-shelf” to treat moderate/severe cases of COVID-19, thereby increasing the therapeutic options available for these patients.

scholarly journals Synthesis, Characterization, and Applications of Silver Nano Fibers in Humidity, Ammonia, and Temperature Sensing

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 682
Author(s):  
Haroon-Ur Rashid ◽  
Muhammad Ali ◽  
Mahidur R. Sarker ◽  
Sawal Hamid Md Ali ◽  
Naseem Akhtar ◽  
...  
Keyword(s):  
Relative Humidity ◽  
Large Scale ◽  
Cost Effective ◽  
Device Fabrication ◽  
Temperature Sensing ◽  
Small Scale ◽  
Scale Production ◽  
Sensing Applications ◽  
Large Scale Production ◽  
Response And Recovery

The promising chemical, mechanical, and electrical properties of silver from nano scale to bulk level make it useful to be used in a variety of applications in the biomedical and electronic fields. Recently, several methods have been proposed and applied for the small-scale and mass production of silver in the form of nanoparticles, nanowires, and nanofibers. In this research, we have proposed a novel method for the fabrication of silver nano fibers (AgNFs) that is environmentally friendly and can be easily deployed for large-scale production. Moreover, the proposed technique is easy for device fabrication in different applications. To validate the properties, the synthesized silver nanofibers have been examined through Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-Ray diffraction (XRD). Further, the synthesized silver nanofibers have been deposited over sensors for Relative humidity (RH), Ammonia (NH3), and temperature sensing applications. The sensor was of a resistive type, and found 4.3 kΩ for relative humidity (RH %) 30–90%, 400 kΩ for NH3 (40000 ppm), and 5 MΩ for temperature sensing (69 °C). The durability and speed of the sensor verified through repetitive, response, and recovery tests of the sensor in a humidity and gas chamber. It was observed that the sensor took 13 s to respond, 27 s to measure the maximum value, and took 33 s to regain its minimum value. Furthermore, it was observed that at lower frequencies and higher concentration of NH3, the response of the device was excellent. Furthermore, the device has linear and repetitive responses, is cost-effective, and is easy to fabricate.

SARS-CoV-2 specific memory T lymphocytes from COVID-19 convalescent donors: identification, biobanking and large-scale production for Adoptive Cell Therapy

2020 ◽  
Author(s):  
C Ferreras ◽  
B Pascual-Miguel ◽  
C Mestre-Durán ◽  
A Navarro-Zapata ◽  
L Clares-Villa ◽  
...  
Keyword(s):  
T Cells ◽  
Large Scale ◽  
Memory T Cells ◽  
Adoptive Cell Therapy ◽  
Cost Effective ◽  
Effector Memory ◽  
Small Scale ◽  
Scale Production ◽  
Specific Memory ◽  
Large Scale Production

ABSTRACTSARS-CoV-2 is causing a second outbreak so the hope for its complete eradication is far from happening. In the absence of effective vaccines, it is mandatory to find effective treatments with low adverse effects able to treat hospitalized patients with COVID-19 disease. In this work, we determined the existence of SARS-CoV-2 specific T cells within the CD45RA− T memory cells from the blood of convalescent donors. Memory T cells can respond quickly to the infection and provide long-term immune protection to reduce the severity of the COVID-19 symptoms. Also, CD45RA− memory T cells confer protection from other pathogens the donors encountered in their life. This is vital to clear other secondary infections usually developed in hospitalized COVID-19 patients. SARS-CoV-2 specific memory T cells were found within all the CD45RA− subsets CD3+, CD4+, CD8+, and in the central memory and effector memory subpopulations. The procedure to obtain the cells is feasible, easy to implement for small scale manufacture, quick and cost-effective involving minimal manipulation, and without GMP condition requirements. This biobank of specific SARS-CoV-2 memory T cells would be immediately available ‘off-the-shelf’ to treat moderate/severe cases of COVID-19 increasing the therapeutic options available for these patients.

scholarly journals Thermoelectric Performance of Mechanically Mixed BixSb2-xTe3—ABS Composites

Materials ◽  
2021 ◽  
Vol 14 (7) ◽  
pp. 1706
Author(s):  
Zacharias Viskadourakis ◽  
Argiri Drymiskianaki ◽  
Vassilis M. Papadakis ◽  
Ioanna Ioannou ◽  
Theodora Kyratsi ◽  
...  
Keyword(s):  
Polymer Composites ◽  
Large Scale ◽  
Low Cost ◽  
Acrylonitrile Butadiene Styrene ◽  
Thermoelectric Performance ◽  
Scale Production ◽  
Bismuth Antimony Telluride ◽  
Mechanical Mixing ◽  
Large Scale Production ◽  
Bi Doping

In the current study, polymer-based composites, consisting of Acrylonitrile Butadiene Styrene (ABS) and Bismuth Antimony Telluride (BixSb2−xTe3), were produced using mechanical mixing and hot pressing. These composites were investigated regarding their electrical resistivity and Seebeck coefficient, with respect to Bi doping and BixSb2-xTe3 loading into the composite. Experimental results showed that their thermoelectric performance is comparable—or even superior, in some cases—to reported thermoelectric polymer composites that have been produced using other complex techniques. Consequently, mechanically mixed polymer-based thermoelectric materials could be an efficient method for low-cost and large-scale production of polymer composites for potential thermoelectric applications.

scholarly journals Extensive Screening of Green Solvents for Safe and Sustainable UiO-66 Synthesis

2020 ◽  
Author(s):  
Diletta Morelli Venturi ◽  
Filippo Campana ◽  
Fabio Marmottini ◽  
Ferdinando Costantino ◽  
Luigi Vaccaro
Keyword(s):  
Large Scale ◽  
Low Cost ◽  
Metal Organic Framework ◽  
Dimethyl Formamide ◽  
Scale Production ◽  
Green Solvents ◽  
High Quality ◽  
Color Code ◽  
Large Scale Production ◽  
Metal Organic

<p>Zirconium based Metal-Organic Framework UiO-66 is to date considered one of the benchmark compound among stable MOFs and it has attracted a huge attention for its employment in many strategic applications. Large scale production of UiO-66 for industrial purposes requires the use of safe and green solvents, fulfilling the green chemistry principles and able to replace the use of <i>N,N</i>-Dimethyl-Formamide (DMF), which, despite its toxicity, is still considered the most efficient solvent for obtaining UiO-66 of high quality. Herein we report on a survey of about 40 different solvents with different polarity, boiling point and acidity, used for the laboratory scale synthesis of high quality UiO-66 crystals. The solvents were chosen according the European REACH Regulation 1907/2006 among those having low cost, low toxicity and fully biodegradable. Concerning MOF synthesis, the relevant parameters chosen for establishing the quality of the results obtained are the degree are the crystallinity, microporosity and specific surface area, yield and solvent recyclability. Taking into account also the chemical physical properties of all the solvents, a color code was assigned in order to give a final green assessment for the UiO-66 synthesis. Defectivity of the obtained products, the use of acidic modulators and the use of alternative Zr-salts have been also taken into consideration. Preliminary results lead to conclude that GVL (γ-valerolactone) is among the most promising solvents for replacing DMF in UiO-66 MOF synthesis. </p>

scholarly journals Transgenic goats producing an improved version of cetuximab in milk

2020 ◽  
Author(s):  
Götz Laible ◽  
Sally Cole ◽  
Brigid Brophy ◽  
Paul Maclean ◽  
Li How Chen ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Large Scale ◽  
Growth Factor Receptor ◽  
Cost Effective ◽  
Scale Production ◽  
Cancer Treatments ◽  
Large Scale Production ◽  
Immunogenic Epitope ◽  
Dependent Cell ◽  
Transgenic Goats

ABSTRACTTherapeutic monoclonal antibodies (mAbs) represent one of the most important classes of pharmaceutical proteins to treat human diseases. Most are produced in cultured mammalian cells which is expensive, limiting their availability. Goats, striking a good balance between a relatively short generation time and copious milk yield, present an alternative platform for the cost-effective, flexible, large-scale production of therapeutic mAbs. Here, we focused on cetuximab, a mAb against epidermal growth factor receptor, that is commercially produced under the brand name Erbitux and approved for anti-cancer treatments. We generated several transgenic goat lines that produce cetuximab in their milk. Two lines were selected for detailed characterization. Both showed stable genotypes and cetuximab production levels of up to 10g/L. The mAb could be readily purified and showed improved characteristics compared to Erbitux. The goat-produced cetuximab (gCetuximab) lacked a highly immunogenic epitope that is part of Erbitux. Moreover, it showed enhanced binding to CD16 and increased antibody-dependent cell-dependent cytotoxicity compared to Erbitux. This indicates that these goats produce an improved cetuximab version with the potential for enhanced effectiveness and better safety profile compared to treatments with Erbitux. In addition, our study validates transgenic goats as an excellent platform for large-scale production of therapeutic mAbs.

scholarly journals Extensive Screening of Green Solvents for Safe and Sustainable UiO-66 Synthesis

2020 ◽  
Author(s):  
Diletta Morelli Venturi ◽  
Filippo Campana ◽  
Fabio Marmottini ◽  
Ferdinando Costantino ◽  
Luigi Vaccaro
Keyword(s):  
Large Scale ◽  
Low Cost ◽  
Metal Organic Framework ◽  
Dimethyl Formamide ◽  
Scale Production ◽  
Green Solvents ◽  
High Quality ◽  
Color Code ◽  
Large Scale Production ◽  
Metal Organic

<p>Zirconium based Metal-Organic Framework UiO-66 is to date considered one of the benchmark compound among stable MOFs and it has attracted a huge attention for its employment in many strategic applications. Large scale production of UiO-66 for industrial purposes requires the use of safe and green solvents, fulfilling the green chemistry principles and able to replace the use of <i>N,N</i>-Dimethyl-Formamide (DMF), which, despite its toxicity, is still considered the most efficient solvent for obtaining UiO-66 of high quality. Herein we report on a survey of about 40 different solvents with different polarity, boiling point and acidity, used for the laboratory scale synthesis of high quality UiO-66 crystals. The solvents were chosen according the European REACH Regulation 1907/2006 among those having low cost, low toxicity and fully biodegradable. Concerning MOF synthesis, the relevant parameters chosen for establishing the quality of the results obtained are the degree are the crystallinity, microporosity and specific surface area, yield and solvent recyclability. Taking into account also the chemical physical properties of all the solvents, a color code was assigned in order to give a final green assessment for the UiO-66 synthesis. Defectivity of the obtained products, the use of acidic modulators and the use of alternative Zr-salts have been also taken into consideration. Preliminary results lead to conclude that GVL (γ-valerolactone) is among the most promising solvents for replacing DMF in UiO-66 MOF synthesis. </p>

ChipsetT: Embedded Die Substrate Applications

2013 ◽  
Vol 2013 (DPC) ◽  
pp. 000377-000397
Author(s):  
Jon G. Aday ◽  
Ted Tessier ◽  
Kazuhisa Itoi ◽  
Satoshi Okude
Keyword(s):  
Large Scale ◽  
Cost Effective ◽  
Scale Production ◽  
Robust Solution ◽  
Sintered Metal ◽  
Design Flexibility ◽  
Fine Pitch ◽  
Large Scale Production ◽  
Bottom Side ◽  
Board Level

Embedded die substrate technologies are being developed in an assortment of configurations and for different market segments. The technology being discussed in this paper will be focused on both a fan out technology – ChipsetT Fan-Out and a system in package approach (ChipsetT SiP) in which a multiple component bill of materials (BOM) is used. The Chipset process is based on the WABE (Wafer and Board Level Embedding) technology. WABE technology is based on co-lamination of multilayer polyimide flex wiring and conductive z-axis sintered metal interconnections. This ChipsetT Fan Out technology allows for large scale production of fan out type solutions which can allow for very thin packages in addition to unique pin out solutions such as pin compatibility for a competitor part. The ChipsetT SiP also allows embedding of single or multiple silicon die and/or components. Additional components can also be placed using conventional SMT on the top or bottom side of the package. There is a great deal of design flexibility with this technology which makes it a great solution for applications trying to reduce their x-y size or z-height. When utilizing RDL technology on the embedded die we are able to do the fine pitch routing in order to allow the substrate to route at larger pitches ensuring an overall cost effective solution. This paper will focus on the different classes of applications that have benefited from this technology and will discuss the benefits and tradeoffs of the different solutions that have been engineered. Assembly and reliability data will be presented on several of the applications showing a robust solution set.

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