scholarly journals PECULIARITIES OF PRENATAL VAGINA MORPHOGENESIS

2019 ◽  
Vol 72 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Tetiana V. Khmara ◽  
Іhor І. Zamorskii ◽  
Mariana O. Ryznychuk ◽  
Mariana I. Kryvchanska ◽  
Oleh M. Boichuk ◽  
...  
Keyword(s):  
Rapid Development ◽  
Age Groups ◽  
Posterior Wall ◽  
Reproductive Organs ◽  
Urogenital Sinus ◽  
Human Fetuses ◽  
Crown Rump Length ◽  
Human Ontogenesis ◽  
Upper Third ◽  
Female Reproductive Organs

Introduction: The rapid development of perinatal gynecology requires from the anatomists comprehensive studies of the patterns of prenatal morphogenesis and the development of topographic and anatomical relationships of female reproductive organs in the human fetuses of different age groups. The aim: To study the development and formation of the vaginal topography in the prenatal period of human ontogenesis. Materials and methods: The study has been conducted based on 23 series of histological and topographic-anatomical sections of human prefetuses aged 9-12 weeks with 31.0-80.0 mm of crown-rump length (CRL) and 83 specimens of female human fetuses aged 4-9 months with 81.0-345.0 mm of CRL by means of a complex of adequate morphological methods of investigation. Results and conclusions: Vaginal formation occurs during the 9th week of embryogenesis (prefetuses of 31.0-41.0 mm of CRL) due to the fusion of two different embryonic structures: mesodermal paramesonephral ducts and endodermal urogenital sinus. In this case, the caudal regions of the paramesonephral ducts are transformed into the uterus and the superior two thirds of the vagina, and the inferior third of the vagina develops from the urogenital sinus. Common uterovaginal canal, divided into right and left cavities by mesenchymal septum, is formed in the female prefetuses of 38.0-43.0 mm of CRL due to the fusion of the caudal regions of the paramesonephral ducts in the area of the posterior wall of the urogenital sinus. Complete dissolving of the septum of the uterovaginal canal occurs in prefetuses of 55.0-58.0 mm of CRL. The anterior and posterior vaginal vaults of the same depth are formed in 5-month-old fetuses. Canalization of vagina in the caudo-cranial direction is observed in the fetuses of 170.0-185.0 mm of CRL, with no clear boundary between the uterovaginal canal and the urogenital sinus. The vaginal epithelium in the upper third part originates from the uterovaginal canal, and in the lower two thirds of the vagina – from the urogenital sinus. In the 6-month-old fetuses there was detected the variability of the shape of the superior, middle and inferior third of the vagina, namely: oval (5 cases), elongated-oval (2 cases), stellate (1 case); in the lower third, the H-shaped form was predominantly found (6 fetuses). The proliferation of the hymen membrane occurs in fetuses of 220.0-245.0 mm of CRL. The absence of timely proliferation of the hymen membrane can lead to its atresia, and its premature proliferation causes the appearance of transverse vaginal septa.

scholarly journals FETAL ANATOMY OF PARATHYROID GLANDS

2020 ◽  
Vol 73 (1) ◽  
pp. 52-57 ◽  
Author(s):  
Lesia Ya. Lopushniak ◽  
Тatiana V. Khmara ◽  
Оleh М. Boichuk ◽  
Mariana A. Ryznychuk ◽  
Leonid V. Shvyhar ◽  
...  
Keyword(s):  
Jugular Vein ◽  
Age Groups ◽  
Parathyroid Glands ◽  
Brachiocephalic Vein ◽  
Human Fetuses ◽  
Crown Rump Length ◽  
Fetal Period ◽  
External Structure ◽  
Human Ontogenesis ◽  
The Right

The aim: To study the forms of anatomical variability of the external structure of the upper and lower parathyroid glands in the fetal period of human ontogenesis. Materials and methods: The study involved 48 specimens of human fetuses with 81,0-375,0 mm of crown-rump length (CRL). The study was conducted by means of macromicroscopic preparation, morphometry and variation statistics method. Results: The age and individual anatomical variability, complex way of development and formation of synotopic embryotropographic correlations of the upper and lower parathyroid glands in the prenatal period of human ontogenesis create numerous prerequisites for the emergence of variants of their external structure and topography in the fetuses of both different and the same age groups. Conclusions: There is a significant anatomical variability of the upper and lower parathyroid glands in 4-10-month-old fetuses, which is manifested by varieties of their shape and topical location. Aplasia of the upper parathyroid glands, which was found in two human fetuses aged 7 months, was due to the fetures of their organogenesis and the formation of syntopy in the embryonic and prefetal periods of their development. Parathyroid glands are mainly supplied with blood by the branches of the inferior thyroid artery. The branches of the upper thyroid artery and the arteries of adjacent organs: larynx, trachea and esophagus are involved in the blood supply. The right and left inferior thyroid veins are tributaries of the corresponding brachiocephalic vein, paired (right and left) superior and middle thyroid veins are those for the internal jugular vein.

scholarly journals PROFIL KANDIDIASIS VULVOVAGINALIS DI POLIKLINIK KULIT DAN KELAMIN RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JANUARI – DESEMBER 2013

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Novita Limbu Tasik ◽  
Grace M. Kapantow ◽  
Renate T. Kandou
Keyword(s):  
Candida Albicans ◽  
Combination Therapy ◽  
Medical Record ◽  
Vaginal Discharge ◽  
Age Groups ◽  
Descriptive Study ◽  
Reproductive Organs ◽  
Frequent Type ◽  
First Time ◽  
Female Reproductive Organs

Abstract: Vulvovaginalis candidiasis (VVC) is a disease of female reproductive organs with the site of infection at the vulva and vagina mucosa characterized by vaginal discharge and itching due to the uncontrolled growth of the fungus Candida albicans. This study aimed to obtain the profile of vulvovaginalis candidiasis cases at Prof. Dr. R. D. Kandou Hospiptal Manado from January to December 2013. This was a retrospective descriptive study using the medical record. The results showed that of 29 VVC cases (0.70%), the largest age groups were 15-24 and 25-44 years (41.4%). Housewives and students were the most found jobs (20.7%). The discharge accompanied by itching was found in 34.5% of cases. The use of douching and pregnancy were predisposing factors (13.8%). Gram examinations resulted in spores, budding cell, and pseudohyphae were found in 62.1% of cases. Patients who was infected by VVC for the first time were 82.8%. The most frequent type of therapy was combination therapy (48.3%). Keywords: vulvovaginalis candidiasis   Abstrak: Kandidiasis vulvovaginalis (KVV) merupakan suatu penyakit organ reproduksi pada wanita dimana terjadi infeksi pada mukosa vulva dan vagina ditandai dengan adanya keputihan dan gatal dikarenakan pertumbuhan tidak terkendali dari jamur Candida albicans. Penelitian ini bertujuan untuk mengetahui profil pasien kandidiasis vulvovaginalis di RSUP Prof. Dr. R. D. Kandou Manado periode Januari – Desember 2013. Penelitian ini bersifat deskriptif retrospektif dengan mengevaluasi catatan rekam medik pasien. Hasil penelitian menunjukkan terdapat 29 kasus KVV. Kelompok umur terbanyak 15-24 dan 25-44 tahun (41,4%); pekerjaan terbanyak ialah ibu rumah tangga dan pelajar (20,7%); keputihan disertai gatal (34,5%); faktor predisposisi terbanyak yaitu penggunaan douching dan kehamilan (13.8%). Pemeriksaan Gram ditemukan spora, buddingcell dan pseudohifa ditemukan pada 62,1% kasus. Pasien yang baru pertama kali terinfeksi KVV  sebanyak 82,8%. Jenis terapi terbanyak yang diberikan yaitu terapi kombinasi sebanyak 48,3%). Kata kunci: kandidiasis vulvovaginalis

scholarly journals Anatomic variability of the nerves of the triceps surae in early human fetuses

Morphologia ◽  
2021 ◽  
Vol 15 (3) ◽  
pp. 101-108
Author(s):  
T.V Komar
Keyword(s):  
Functional Organization ◽  
Tibial Nerve ◽  
Age Groups ◽  
Triceps Surae ◽  
Human Fetuses ◽  
Crown Rump Length ◽  
Intramuscular Nerves ◽  
The Right ◽  
Early Human ◽  
Fibular Nerve

Background. Establishing fetal anatomical variability of intramuscular nerves and their connections plays an important role in the search for and development of new methods for the diagnostic and treatment posterior region of the leg. Objective – to find out the topographic and anatomical features of the innervation of the triceps surae in human fetuses 4-6 months. Methods. The study was performed on 46 human fetuses 81.0-230.0 mm crown-rump length (CRL) length using macromicroscopic preparation, vascular injection, and morphometry. Results. In early human fetuses, the anatomical variability of the distribution of intramuscular nerves in the thickness of the triceps surae was established, which is due to the variability of the structure and topography of the tibial nerve, structural and functional organization of triceps surae, arterial branching and interneural connections in the thickness of the heads of the gastrocnemius and soleus in fetuses of different and the same age groups, and sometimes in the same fetus. Conclusion. The main source of innervation of the triceps surae is the tibial nerve, which can be presented by a single trunk, main and additional trunks, or several independent trunks. The nerves in the thickness of the triceps are unevenly distributed. The highest concentration of muscular branches of the tibial nerve is determined in the medial head of the gastrocnemius and the medial part of the soleus. Information on fetal topography of intramuscular nerves in the thickness of the right and left triceps surae, as well as forms of their anatomical variability, both in fetuses of different and the same age and sometimes in the same fetus, due to structural-functional organization of the components of the triceps surae, the type of branching of arteries and nerves in the thickness of the heads of the gastrocnemius and soleus. Atypical variants of the topography of the tibial nerve and common fibular nerve in early fetuses, as well as interneural connections in the thickness of the components of the triceps surae, are more common on the right lower leg.

scholarly journals MORPHOMETRICAL PARAMETRS OF PARAMESONEPHRIC DUCTS AND THEIR DE-RIVATIVES AT THE BEGINNING OF THE FETAL PERIOD OF HUMAN ONTOGENESIS

2018 ◽  
Vol 17 (3) ◽  
pp. 58-63
Author(s):  
B. Yu. Banul ◽  
D. V. Pronyayev
Keyword(s):  
Reproductive Organs ◽  
Morphometric Parameters ◽  
Urinary System ◽  
Fallopian Tubes ◽  
Important Condition ◽  
Fetal Period ◽  
Wide Range ◽  
Gynecological Diseases ◽  
Human Ontogenesis ◽  
Female Reproductive Organs

An important condition to understand etiopathogenesis of gynecological diseases is improvement of examination of fetal morphogenesis concerning the urinary system and other organs. For example, chronic pelvic ache can result from a wide range of disorders: endometriosis, myoma, commissures, cystitis, colitis, pathology of the femoral joint and diseases of the pelvic bones. Meanwhile the majority of these diseases can be diagnosed, prevented or treated during antenatal period. 50 specimens of human fetuses were examined by means of a complex of morphological methods in order to study morphogenesis of the internal female reproductive organs at the beginning of the uterine period. The article deals with the features of the development of paramesonephric ducts and their derivatives at the beginning of the fetal period of human ontogenesis. At the beginning of the fetal period the position and shape of the fallopian tubes are found to be caused by close correlations with the adjacent organs and structures. From three to six narrow portions are formed along the uterine tube. The morphometric parameters of the ampulla of the fallopian tubes vary depending on the age of the fetus.

scholarly journals RECONSTRUCTION OF THE FEMALE UROGENITAL COMPLEX IN THE PRENATAL PERIOD OF ONTOGENESIS

2021 ◽  
Vol 20 (1) ◽  
pp. 18-24
Author(s):  
Oleh Marchuk ◽  
Olga Antonyuk ◽  
Yuliya Marchuk ◽  
Denis Andriychuk ◽  
Volodymyr Marchuk
Keyword(s):  
Age Groups ◽  
Vertical Direction ◽  
Reproductive Organs ◽  
Urogenital Sinus ◽  
Histological Changes ◽  
Outer Border ◽  
Vaginal Canal ◽  
Vertical Sections ◽  
Further Development ◽  
Loose Layer

In 9-weeks prefetuses, urogenital complexes are located lower than in prefetuses of previous age groups. In the vertical sections of the urogenital cords, the paramesonephric ducts diff erentiate into the uterine tubes. Above the entrance to the pelvis, the urogenital cords pass obliquely in the vertical direction, at the level of which the paramesonephric ducts are connected, on both sides of which the mesonephric ducts are located. The primary kidneys are completely reduced in their upper two-thirds, the reduction of mesonephric cells in the lateral areas of the lower third of the kidneys begins. The caudal divisions of the paramesonephric ducts touch dorsally to the wall of the urogenital sinus, while the lower ends of the mesonephric ducts are in the thickness of the wall. The urogenital cords (mesonephric and paramesonephric ducts) protrude above the upper ends of the primary kidneys and below the permanent kidneys. The mesonephric and paramesonephric ducts are clearly demarcated by a layer of loosely spaced mesenchymal cells.In 10-weeks prefetuses, due to the connection of the lower vertical parts of the paramesonephric ducts, a common uterine- vaginal canal is formed, lined with pseudolayered epithelium. Mesonephric ducts retain their lumen in fragments.In 11-weeks prefetuses, the upper vertical sections of the urogenital cords, in connection with the reduction of the mesonephric ducts, contain mainly paramesonephric ducts, which are separated from each other by a loose layer of the mesenchyme. From these sections of paramesonephric ducts uterine tubes are formed. Oblique (middle) sections of the paramesonephric ducts with further development are transformed into intrauterine parts of the uterine tubes. The lower caudal sections of the paramesonephric ducts are transformed into the uterus and the upper two-thirds of the vagina.In 12-weeks prefetuses, the primary kidneys are almost completely reduced. Only single mesonephric tubules within their caudal area are determined. In parallel, there are intense processes of formation of internal female reproductive organs. The cranial ends of the uterine tubes expand, acquiring a funnel- shaped shape. The outer border of the infundibulum of the tube reminds a zigzag line, which is evidence of the beginning of the formation of the fi mbria of the uterine tube. The lumens of the mesonephric ducts are reduced to 6±0.1 μm, and in some parts of their walls are in contact with each other. Transformation of paramesonephric ducts into their derivatives (uterine tubes, uterus, upper part of the vagina) is accompanied by corresponding histological changes of their walls.

Ultrastructural aspects of gymnosperms reproductive organs tissues due to their functional condition

1978 ◽  
Vol 36 (2) ◽  
pp. 440-441
Author(s):  
G. M. Kozubov
Keyword(s):  
Metabolic Activity ◽  
Functional Condition ◽  
Reproductive Organs ◽  
Considerable Change ◽  
Complicated Structure ◽  
Tetrad Stage ◽  
Ubisch Bodies ◽  
Similar Organization ◽  
Female Reproductive Organs ◽  
High Metabolic Activity

The ultrastructure of reproductive organs of pine, spruce, larch and ginkgo was investigated. It was found that the male reproductive organs possess similar organization. The most considerable change in the ultrastructure of the microsporocytes occur in meiosis. Sporoderm is being laid at the late tetrad stage. The cells of the male gameto-phyte are distinguished according to the metabolic activity of the or- ganells. They are most weakly developed in the spermiogenic cell. Ta-petum of the gymnosperms is of the periplasmodic - secretorial type. The Ubisch bodies which possess similar structure in the types investigated but are specific in details in different species are produced in tapetum.Parietal and subepidermal layers are distinguished for their high metabolic activity and are capable of the autonomous photosynthesis. Female reproductive organs differ more greatly in their struture and have the most complicated structure in primitive groups. On the first stages of their formation the inner cells of nucellus are transformed into the nucellar tapetum in which the structures similar to the Ubisch bodies taking part in the formation of the sporoderm of female gametophyte have been found.

Efficacy of one-dose intramuscular rabies vaccine as pre-exposure prophylaxis in travellers

2021 ◽  
Author(s):  
Deborah J Mills ◽  
Colleen L Lau ◽  
Christine Mills ◽  
Luis Furuya-Kanamori
Keyword(s):  
Immune System ◽  
Rapid Development ◽  
Age Groups ◽  
Rabies Vaccine ◽  
Post Exposure Prophylaxis ◽  
Post Intervention ◽  
Quasi Experimental ◽  
Alternative Schedule ◽  
Insufficient Time ◽  
Exposure Prophylaxis

Abstract Background Current guidelines for rabies pre-exposure prophylaxis (PrEP) recommend multiple vaccine doses. Travellers sometimes present for pre-travel consultation with insufficient time to complete standard PrEP schedules. We investigated the efficacy of one-dose intramuscular (IM) vaccine in priming the immune system (as PrEP) by measuring antibody response to simulated post-exposure prophylaxis (PEP). Methods A quasi-experimental pre–post intervention clinical trial was conducted at a specialist travel clinic in Australia. Adults (≥18 years) without a history of rabies vaccination were included. At Visit 1, seronegative status was confirmed and one dose of 0.5 ml IM rabies vaccine (Verorab®) administered. At Visit 2 (≥60 days after Visit 1), serology was repeated and a simulated PEP dose (0.5 ml IM) given on this day and again 3 days later (Visit 3). Serology was repeated at Visit 4 (7 days after Visit 2). Results A total of 94 antibody-negative participants were included (<50 years [n = 50]; ≥50 years [n = 44]). At Visit 2, 38.0 and 31.8% of participants aged <50 and ≥50 years were antibody-positive (≥0.5 EU/ml). At Visit 4, all participants were antibody-positive; 82.0 and 47.7% of participants aged <50 and ≥50 years had antibody levels >4 EU/ml, respectively. Conclusions One-dose IM vaccine was effective as PrEP for priming the immune system in both age groups, resulting in rapid development of antibodies 7 days after commencing simulated PEP. If there is insufficient time to complete a standard PrEP schedule, one-dose IM could be considered as an alternative schedule for short trips, rather than not offering travellers any doses at all. Clinical trials registration: ACTRN12619000946112.

Medical Metaphors of Women's Bodies: Menstruation and Menopause

1988 ◽  
Vol 18 (2) ◽  
pp. 237-254 ◽  
Author(s):  
Emily Martin
Keyword(s):  
19Th Century ◽  
Reproductive Organs ◽  
Central Control ◽  
Centralized Control ◽  
Medical Texts ◽  
Women's Bodies ◽  
Waste Products ◽  
Bureaucratic Organization ◽  
Medical Metaphors ◽  
Female Reproductive Organs

Implicit, underlying imagery in medical descriptions of menstruation and menopause is exposed, beginning with 19th century views. Contemporary medical texts and teaching reveal two fundamental assumptions about women's bodies. First, they assume that female reproductive organs are organized as if they form a hierarchical, bureaucratic organization under centralized control. Given this assumption, menopause comes to be described negatively, as a process involving breakdown of central control. Second, they assume that women's bodies are predominantly for the purpose of production of desirable substances, primarily babies. Given this assumption, menstruation comes to be seen negatively, as a process involving failed production, waste products, and debris. Alternative imagery that works from our current understanding of physiology, but avoids denigration of women's bodies, is suggested.

Effects of Growth Hormone on Female Reproductive Organs

2001 ◽  
Vol 30 (5) ◽  
pp. 265-271 ◽  
Author(s):  
G. G. Kaiser ◽  
F. Sinowatz ◽  
G. A. Palma
Keyword(s):  
Growth Hormone ◽  
Reproductive Organs ◽  
Female Reproductive Organs

Ultrastructure of the female reproductive organs (ovary, vitellaria, and Mehlis' gland) of Halipegus eccentricus (Trematoda: Derogenidae)

1986 ◽  
Vol 64 (10) ◽  
pp. 2203-2212 ◽  
Author(s):  
Jon M. Holy ◽  
Darwin D. Wittrock
Keyword(s):  
Cell Types ◽  
Reproductive Organs ◽  
Golgi Body ◽  
Digenetic Trematode ◽  
Secretory Cells ◽  
Cortical Granules ◽  
Golgi Bodies ◽  
Transmission Electron ◽  
Vitelline Cells ◽  
Female Reproductive Organs

The female reproductive organs (ovary, vitellaria, and Mehlis' gland) of the digenetic trematode Halipegus eccentricus were studied by transmission electron microscopy. Oocytes entered diplotene while in the ovary and produced cortical granules and lipid bodies. Vitelline cells produced large amounts of eggshell protein but no yolk bodies. Two types of Mehlis' gland secretory cells were present, distinguishable by the morphology of their rough endoplasmic reticulum, Golgi bodies, and secretory bodies, and by the persistence of recognizable secretory material within the ootype lumen after exocytosis. In an attempt to standardize the nomenclature regarding the cell types of the Mehlis' gland, a classification that takes into account these four criteria is proposed. Two basic types of Golgi body organization were noted for the cells of the female reproductive system: a stack of flattened cisternae (Mehlis' gland alpha cells) and spherical Golgi bodies with vesicular cisternae (oocytes, vitelline cells, and Mehlis' gland beta cells).

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