CLINICAL AND LABORATORY ASPECTS OF ACUTE OBSTRUCTIVE BRONCHITIS IN CHILDREN INFECTED WITH MYCOPLASMA PNEUMONIAE

The aim of the work is to improve the prognosis of acute bronchitis on the basis of the study of etiology, clinical anamnestic and laboratory-instrumental features of acute bronchitis in children infected with Mycoplasma pneumoniae. Materials and methods: Medical records of inpatients, data from laboratory and clinical examinations, orders from the Ministry of Health of Ukraine. Statistical processing of the obtained results was carried out with the calculation of parametric and non-parametric criteria. The study included 72 patients with acute obstructive bronchitis, infected with Mycoplasma pneumoniae and patients not infected with intracellular pathogens who were hospitalized under the conditions of pediatric ward of children of younger and older children of the National Children’s Clinical Hospital №24. Results: Found that infected with mycoplasma compared with uninfected intracellular infection, more characteristic course of acute obstructive bronchitis on the background of febrile temperature with its duration of more than 4 days, the presence of midbubble and single dry or wet rales, as well as. In general, in patients infected with mycoplasma, compared with patients infected with chlamydia, there is a higher functional stress of immunity with the phenomena of exhaustion. Conclusions: Attention is drawn to the fact that clinical, laboratory data and immunological examinations with the use of systematic analysis make it possible to predict the consequences in the history of children with intracellular infections of various somatic pathologies. In doing so, multivariate and correlation analyzes make it possible to develop new diagnostic criteria.

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The importance of histopathology in the diagnosis of isolated renal sarcoidosis: a case report

Brazilian Journal of Nephrology ◽

10.1590/2175-8239-jbn-2018-0069 ◽

2018 ◽

Vol 40 (3) ◽

pp. 291-295

Author(s):

João Onofre Trindade Filho ◽

Kaline Daniele de Souza Amaro ◽

Allana Desirée Teixeira de Oliveira ◽

Cecília Neta Alves Pegado Gomes ◽

Hermann Ferreira Costa ◽

...

Keyword(s):

Case Report ◽

Medical Records ◽

Clinical Laboratory ◽

Histopathological Examination ◽

Laboratory Data ◽

Rare Condition ◽

Unknown Etiology ◽

Renal Manifestation ◽

Systemic Inflammatory Disease ◽

Rule Out

ABSTRACT Introduction: Sarcoidosis is a systemic inflammatory disease of unknown etiology, characterized by the presence of non-caseating granulomas in several organs; renal impairment alone is a rare condition. When it affects the kidneys, the most prevalent manifestations are hypercalcemia and hypercalciuria. This paper aims to address the topic of renal sarcoidosis, by means of a case report, and reinstate the importance of histopathology in its diagnosis. Methods: The data came from an observational clinical study with a qualitative approach, through an interview with the renal sarcoidosis patient and data from her medical records. Case report: Patient D.M.S., 50 years old, Caucasian, presented with reddish eyes and body pains lasting for fifteen days as first manifestations of the disease. Upon kidney ultrasound scan, we found renal parenchymal nephropathy. Serial renal function and metabolic tests reported anemia and progressive urea and creatinine changes, as well as hypercalcemia and hypercalciuria, confirming acute kidney failure (AKF). A histopathological examination suggested the diagnosis, which was confirmed by clinical, laboratory and histopathological data. There was therapeutic resolution after steroid therapy. Discussion: The symptomatology of sarcoidosis is diverse and often non-specific. Renal manifestation, which usually occurs after organ involvement, is present in less than 5% of patients, and about 1% to 2% of these patients may develop AKF. Conclusions: The use of histopathology together with clinical and laboratory data to diagnose isolated renal sarcoidosis, rule out other etiologies and introduce early treatment is of paramount importance.

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Clinical Predictors of Wheezing Among Children Infected With Mycoplasma Pneumoniae

Frontiers in Pediatrics ◽

10.3389/fped.2021.693658 ◽

2021 ◽

Vol 9 ◽

Author(s):

Kaimeng Kong ◽

Ying Ding ◽

Beirong Wu ◽

Min Lu ◽

Haoxiang Gu

Keyword(s):

Mycoplasma Pneumoniae ◽

Laboratory Data ◽

Area Under The Curve ◽

Electronic Medical Record System ◽

Clinical Predictors ◽

Record System ◽

Medical Record System ◽

History Of ◽

Radiological Patterns ◽

Tract Infections

Background:Mycoplasma pneumoniae (MP) not only was a common pathogen of respiratory tract infections, but also could trigger the exacerbation of asthmatic symptoms in children with or without asthma.Objective: This study aimed to identify possible risk factors associated with wheezing among children diagnosed with MP infection.Methods: A retrospective analysis of medical records of children aged 28 days to 18 years old who visited the Shanghai Children's Hospital between January 2019 and January 2020 was carried out, and all children were then classified into three groups: two wheezing groups (with or without MP infection) and a non-wheezing group with MP infection. Information including patient's demographics, clinical features, laboratory data, and radiography findings was extracted from the electronic medical record system. Chest radiographs were reviewed independently by two board-certified, blinded pediatric radiologists.Results: A total of 1,512 patients were included in our study, and 21.9% of them belonged to the wheezing group without MP infection. Among 1,181 patients with MP infection, 295 people (25.0%) suffered from wheezing, and males accounted for 61%. Through the multivariable logistic regression analyses, we found that six variables were positively associated with wheezing attacks in children with MP infection: male gender (likelihood ratio [LR] = 2.124, 95% confidence interval [CI]: 1.478–3.053), history of allergy (LR= 3.301, 95% CI: 2.206–4.941), history of wheezing (LR = 7.808, 95% CI: 5.276–11.557), autumn in reference to summer (LR = 2.414, 95% CI: 1.500–3.885), non-end-point infiltration in reference to consolidation or pleural effusion (LR = 1.982, 95% CI: 1.348–2.914), and infiltration scope (LR = 1.773, 95% CI: 1.293–2.432). However, the model showed that the probability of wheezing after MP infection decreased as age increased (LR = 0.257, 95% CI: 0.196–0.337). Moreover, the area under the curve (AUC) of the regression model was as high as 0.901 (0.847–0.955).Conclusion: The model integrated with factors including gender, age, season, radiological patterns, infiltration scope, and history of allergy performed well in predicting wheezing attack after MP infection in children.

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Clinical Characteristics, Dynamic Profile of Radiology and Laboratory Findings in Coronavirus Disease 2019

10.21203/rs.3.rs-25659/v1 ◽

2020 ◽

Author(s):

ailing liu ◽

Jing Zhang ◽

Wei Qiao ◽

Wei Zang ◽

Yingying Zhang ◽

...

Keyword(s):

Clinical Laboratory ◽

Laboratory Data ◽

Oxygenation Index ◽

Laboratory Findings ◽

Single Centre Study ◽

History Of ◽

Group A ◽

The Mean ◽

Group B ◽

Dynamic Profile

Abstract Background Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, more and more data from different area and different stages of disease have been needed.Methods In this retrospective, single-centre study, we included all 38 confirmed cases of Covid-19 in Weihai from Jan 24 to Feb 24, 2020. Patients were divided into group A by normal Oxygenation Index (OI), group B by abnormal OI (less than 400 mmHg).The dynamic changes in clinical laboratory parameters were tracked from day 1 to day 32 after the onset of the disease at 4-day intervals. Cases were analyzed for clinical, radiological features and laboratory data. Outcomes were followed up until Feb 24, 2020.Results 38 patients with Covid-19 were included in this study, 68.42% patients were family clustered, and 97.37% patients had a history of exposure. The mean days between exposure and onset were about 5 days. Most patients were men, mean age was 43 years, 52.6% patients had chronic diseases. Most patients had fever or cough, about a third of patients had expectoration or fatigue, and 5 (13.16%) patients had shortness of breath.

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Differential diagnosis of thyroid diseases by the x-ray fluorescent method

Problems of Endocrinology ◽

10.14341/probl10394 ◽

2019 ◽

Vol 43 (3) ◽

pp. 38-42

Author(s):

I. О. Tomashevsky

Keyword(s):

Autoimmune Thyroiditis ◽

Clinical Laboratory ◽

Laboratory Data ◽

Thyroid Diseases ◽

Benign Tumors ◽

Commercial Sample ◽

X Ray ◽

Thyroid Adenomas ◽

The Usa ◽

History Of

Intrathyroid stable iodine (ISI) was measured in 249 women aged 36 to 55 living in Moscow. 179 of these suffered from thyroid tumors and autoimmune thyroiditis and 70 without history of thyroid diseases with normal thyroid status confirmed by clinical laboratory data and ISI values of at least 200 pg/g, considered as the critical, were controls. ISI concentrations were measured using a Russian commercial sample for noninvasive x-ray fluorescent analysis. Using the same device, ISI was measured in thyroid samples with cancer and benign tumors, embedded in paraffin blocks, sent from the USA (n - 47) and Russia (n = 126); in addition, these samples were examined histologically. ISI concentrations were lower in cancer, thyroid adenomas, and autoimmune thyroiditis than in control. An ISI concentration lower than 200 pg/g indicates autoimmune thyroiditis with a probability of 96%. Use of L- thyroxin test increases the probability of the disease recognition to 98%.

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Spectrum of acute, recurrent and chronic pancreatitis in children

Journal of the Pakistan Medical Association ◽

10.47391/jpma.540 ◽

2020 ◽

pp. 1-11

Author(s):

Muhammad Imran ◽

Sabeen Abid Khan ◽

Munir Iqbal Malik

Keyword(s):

Acute Pancreatitis ◽

Chronic Pancreatitis ◽

Retrospective Study ◽

Medical Records ◽

Clinical Presentation ◽

Clinical Laboratory ◽

Epigastric Pain ◽

Paediatric Population ◽

Older Children ◽

Successful Recovery

Abstract Objective: To determine the clinical presentation, aetiology and outcome of pancreatitis in paediatric population. Method: The retrospective study was conducted at Shifa International Hospital, Islamabad, Pakistan, and comprised data of children with pancreatitis presenting between 2013 and 2018. Medical records were reviewed and findings of clinical, laboratory workup and management were noted on a specifically developed proforma. Data was analysed using SPSS 23. Results: Of the 51 subjects, 28(54.9%) were boys. The overall mean age was 10.6+4.9 years. The most frequent clinical symptom was epigastric pain 39(76.5%). The most common aetiology was gallstones/pancreatic stones 19(37.25%). Mean hospital stay was 5.1± 1.8 days, and it was longer in children aged up to 5 years compared to older children (p<0.05). Acute pancreatitis was seen in 23(45.09%) patients, followed by recurrent 19(37.25%) and chronic 9(17.64%). There was no mortality. Conclusion: Timely diagnosis and prompt management of hemodynamic status could lead to successful recovery without any serious complications in paediatric pancreatitis. Continuous...

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Postelimination Status of Childhood Leprosy: Report from a Tertiary-Care Hospital in South India

BioMed Research International ◽

10.1155/2013/328673 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 15

Author(s):

P. Chaitra ◽

Ramesh Marne Bhat

Keyword(s):

Medical Records ◽

South India ◽

Tertiary Care Hospital ◽

Pediatric Population ◽

Tertiary Care ◽

Care Hospital ◽

Older Children ◽

History Of ◽

Clinicopathological Pattern ◽

Different Parts

Introduction. Leprosy, a statistically “eliminated” disease from the globe, continues to linger around in its endemic countries including India.Objective. This study describes the epidemiological and clinicopathological pattern of the disease seen in children over a period of 8 years following its elimination in India.Materials and Methods. Medical records of all leprosy cases up to 14 years of age registered between April 2005 and March 2013 were retrospectively analyzed. Data were retrieved using a predesigned proforma and entered into the database system for analysis.Results. Child proportion of newly registered leprosy cases did not show a significant decline in the years following its elimination. The disease seemed to manifest frequently in older children with an insignificant gender predilection. More than half of child cases had a history of household contact. Paucibacillary leprosy dominated in them with a solitary skin lesion as the most frequent presentation. Although nerve thickening was seen in nearly half of these children, neuritis and lepra reactions were less common. Deformity at the time of diagnosis was noted in 13.89% of cases. Although smear positivity was not a common feature in children affected with leprosy, a good clinicohistopathological correlation was observed in those who underwent biopsy.Conclusion. Our study and reports from different parts of the country depict the unturned curves in the epidemiology of childhood leprosy which mirrors active transmission in the community, lacunae in diagnosis, and the need to strengthen contact screening activities in the pediatric population to sustain elimination.

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Etiology of Pertussis Syndrome

PEDIATRICS ◽

10.1542/peds.68.1.148 ◽

1981 ◽

Vol 68 (1) ◽

pp. 148-149

Author(s):

Ben Zion Garty ◽

Moshe M. Drucker ◽

Menachem Nitzan

Keyword(s):

Chlamydia Trachomatis ◽

Laboratory Investigation ◽

Mycoplasma Pneumoniae ◽

Bordetella Pertussis ◽

Age Distribution ◽

Previous History ◽

Older Children ◽

Chlamydia Trachomatis Infection ◽

Young Infants ◽

History Of

Keller et al1 reported the interesting finding that 91 of 100 patients with pertussis syndrome were infected with Bordetella pertussis or had been exposed to this agent. Their article, however, did not mention the precise age distribution of the patients who "ranged from six weeks to adulthood." It is possible that the etiologic factors of pertussis syndrome in young infants is somewhat different from the etiology of pertussis syndrome in older children. We believe that the laboratory investigation of pertussis syndrome during the first months of life should include examinations for Chlamydia trachomatis infection in addition to the search for Bordetella, Mycoplasma pneumoniae, and viruses, as demonstrated by the following case: A 4-week-old boy with previous history of conjunctivitis was admitted because of paroxysms of staccato cough followed by occasional vomiting or cyanosis.

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Conflicts over Control and Use of Medical Records at the New York Hospital before the Standardization Movement

The Journal of Law Medicine & Ethics ◽

10.1111/j.1748-720x.2011.00631.x ◽

2011 ◽

Vol 39 (4) ◽

pp. 640-648 ◽

Cited By ~ 1

Author(s):

Eugenia L. Siegler ◽

Andrew B. Cohen

Keyword(s):

New York ◽

Medical Records ◽

Laboratory Data ◽

Vital Signs ◽

Medical Interventions ◽

Hospital Medical ◽

Utilization Data ◽

History Of ◽

Research And Education ◽

The Many

Medical records contain important clues about the history of medicine. These documents, which ostensibly describe the course of a patient's illness, are “unique constructions that allow us to observe the social and technical structure of contemporary healing.” As such, the 21st-century hospital medical record reflects the many components of inpatient care: medical interventions, billing, legal documentation, research, and education. It is comprised of a wide array of elements: professionals' notes; vital signs and other descriptive information; laboratory data and test results; demographic information; orders, charges, diagnostic and treatment codes; and other utilization data. It is well understood that many people share and need this information. Current controversies over records involve not control, but computerization, security, and accessibility. Although health professionals offer input, decisions about hospital medical records have been considered largely an administrative responsibility.

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FRI0350 FACTORS ASSOCIATED WITH PERIPHERAL EROSIVE RADIOGRAPHIC DISEASE IN A CONSECUTIVE SERIES OF 794 PSA PATIENTS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.6088 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 770-771

Author(s):

M. G. Catanoso ◽

P. Macchioni ◽

A. Marchesoni ◽

S. D’angelo ◽

R. Ramonda ◽

...

Keyword(s):

Clinical Laboratory ◽

Tertiary Care ◽

Laboratory Data ◽

Diagnostic Delay ◽

Disease Diagnosis ◽

Biological Agents ◽

Consecutive Series ◽

Imaging Data ◽

Erosive Disease ◽

History Of

Background:Few studies have examined the correlation between clinical demographic and laboratory parameters with peripherical radiological erosive disease in PsA pts.Objectives:To examine the association between clinical, demographical and laboratory data and the presence of radiographic erosions (RE) in the peripheral joints of psoriatic arthritis (PsA) pts.Methods:A cross-sectional study was conducted in consecutive patients with PsA afferring 7 rheumatological italian tertiary care centers. Demographical, clinical, laboratory and imaging data were collected according to a standardized protocol. A patient was considered as affected by erosive disease (ED) if at least one joint presented radiographic erosions at hand and/or feet rx examination. Patients with ED at early rx examination (before 5 y from disease diagnosis) were considered as early ED (EED) pts and pts without ED at 6 y or more rx examination from disease diagnosis were considered as not EED (NEED).The association between the presence of joint erosions and demographical, clinical and laboratory data was assessed using logistic regression analysis. The results were expressed in terms odds ratios (OR), and 95% confidence intervals (CI).Results:Rx hand and feet examination were available for analysis in 492/794 (39.9 % females, mean age 53.3 ± 13.2 y, mean PsA duration 16.9 ± 16.8 y, ED 171 pts). 48 pts had EED and 133 pts had NEED. At univariate analyses factors significantly associated with EED (p < 0.20) were PsA duration (OR=0.979,95%CI 0.953-1.006, p = 0.119), diagnostic delay (OR=1.077, 95%CI 1.018-1.138, p = 0.009), history of peripheral enthesitis (OR=2.308,95%CI 0.904-5.888, p= 0.080), hypertrigliceridemia (OR=2.756,95%CI 0.997-7.618, p = 0.0.051), hypercholesterolemia (OR=1.687, 95%CI 0.777-3.661, p = 0.186), hyperuricemia (OR=0.450, 95%CI 0.174-1.166, p = 0.10), use of biological agents (OR=1.712, 95%CI 0.873-3.355, p=0.118). Factors significantly associated with EED at multivariate regression analyses were diagnostic delay (OR = 1.11, 95% CI: 1.01, 1.22), history of enthesitis (OR = 3.15, 95% CI: 1.23, 8.22), use of therapy with biological agents (OR = 3.60, 95% CI: 1.31, 9.85) with protective effect of hyperuricemia (OR = 0.25, 95% CI: 0.07, 0.90).Conclusion:The presence of EED in a group of consecutive PsA patients is correlated to diagnostic delay and history of enthesitis. Longitudinal study may confirm these associations.Disclosure of Interests:Maria Grazia Catanoso: None declared, Pierluigi Macchioni: None declared, Antonio Marchesoni Speakers bureau: Abbvie, Pfizer, UCB, Novartis, Celgene, Eli Lilly, Salvatore D’Angelo Speakers bureau: AbbVie, Biogen, BMS, Celgene, Janssen, Lilly, MSD, Novartis, Pfizer, Sanofi, and UCB, Roberta Ramonda Speakers bureau: Novartis, Celgene, Janssen, Pfizer, Abbvie, Lilly, Alberto Cauli: None declared, fabio perrotta: None declared, Roberto Bortolotti: None declared, mariana lofrano: None declared, laura rotunno: None declared, maria grazia lorenzin: None declared, Guido Valesini: None declared, giovanni mathieu: None declared, Giuseppe Paolazzi: None declared, Carlo Salvarani Grant/research support from: consulting and investigator fees from Abbvie, Pfizer, MSD, Roche, Celgene, Novartis, Consultant of: consulting and investigator fees from Abbvie, Pfizer, MSD, Roche, Celgene, Novartis

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Prevalence and clinical characteristics of patients with biologically false-positive reactions with serological syphilis testing in contemporary practice: 10-year experience at a tertiary academic hospital

Sexually Transmitted Infections ◽

10.1136/sextrans-2020-054628 ◽

2020 ◽

pp. sextrans-2020-054628

Author(s):

Yuri Ishihara ◽

Koh Okamoto ◽

Hironori Shimosaka ◽

Yoshikazu Ono ◽

Yoshiaki Kanno ◽

...

Keyword(s):

False Positive ◽

Clinical Characteristics ◽

Clinical Laboratory ◽

Serological Test ◽

Laboratory Data ◽

Test Results ◽

Academic Hospital ◽

History Of ◽

Low Incidence ◽

Contemporary Practice

ObjectivesBiologically false positive (BFP) reactions are well described in early literature. However, only a few recent reports described the incidence and clinical characteristics of patients with BFP reactions. We reviewed the serological test results of patients tested for syphilis in our hospital in the past decade and described the clinical characteristics of patients with BFP reactions.MethodsThis is a retrospective study of patients tested for syphilis in a tertiary academic hospital. All serological results were retrieved from the clinical laboratory database. We calculated the incidence of BFP reactions. Clinical characteristics and laboratory data of patients with BFP reactions were reviewed manually.ResultsAmong 94 462 subjects, 588 patients had BFP reactions (0.62%). Most BFP reactions were observed in patients aged over 60 years, with a history of malignancy and autoimmune diseases. Eighty-five per cent of patients had low rapid plasma reagin (RPR) titre (≤1:4), but two patients had extremely high RPR titre (≥1:256). BFP reactions were more likely to persist beyond 6 months among patients with RPR titre of ≥1:8. There was no statistically significant correlation between RPR titre and total protein albumin gap, surrogate of immunoglobulin levels among patients with BFP reactions.ConclusionThere was a low incidence of BFP reactions in the last decade. A minority of BFP reactions had high non-treponemal antibody titre and persisted longer than 6 months. In the era of re-emergence of syphilis, this information could help clinicians interpret the results of well-established diagnostic tests for syphilis.

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