ELECTROCARDIOGRAPHIC CHANGES IN NEWBORNS FROM MOTHERS WITH METABOLIC SYNDROME

2021 ◽  
Vol 74 (6) ◽  
pp. 1349-1354
Author(s):  
Valeriy I. Pokhylko ◽  
Olena M. Kovalova ◽  
Svitlana M. Tsvirenko ◽  
Yuliia I. Cherniavska ◽  
Halyna O. Soloiova ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular System ◽  
Electrolyte Disorders ◽  
Aim Analysis ◽  
Electrocardiographic Changes ◽  
Prolonged Qt Interval ◽  
Electrocardiographic Parameters ◽  
Gestational Age At Birth ◽  
Disorders Of Lipid Metabolism ◽  
Integrated Indicators

The aim: Analysis of electrocardiographic parameters in newborns from mothers with metabolic syndrome. Materials and methods: We conducted a prospective cohort trial of 125 newborns, which included the study of their anthropometric, clinical and laboratory indicators and, in particular, ECG parameters. The main group consisted of 40 children, born from mothers with diagnosed metabolic syndrome, the comparison group included 2 subgroups: 28 term newborn and 57 preterm, from mothers without metabolic syndrome. Results: In newborns from mothers with metabolic syndrome on a fragmentary ECG we revealed abnormal depolarization, manifested by changes in the ventricular complex –QRS expansion (p<0.001), impaired conduction (p = 0.004), changes of T wave (p<0.001) and prolonged QT interval (p<0.001). There are such risk factors for QT prolongation in neonates: disease cardiovascular system and disorders of lipid metabolism in mother, asphyxia at birth and electrolyte disorders (hypernatremia OR 0.97), weight too high to gestational age at birth in newborn (OR 2.97), increased blood pressure in the neonatal period (OR 1.07), artificial feeding (OR 3.01). Conclusions: Metabolic syndrome in women during pregnancy has a pronounced effect on the cardiovascular system of the newborn. The detected signs of cardiac dysfunction on the ECG can serve as early integrated indicators of metabolic syndrome and cardiovascular disease in children.

scholarly journals Influence of Physical Therapy Means on Indicators of Cardiovascular System Activity, Metabolism and Psychoemotional Status of Elderly Individuals with Metabolic Syndrome and Frailty

2021 ◽  
Vol 6 (1) ◽  
pp. 271-279
Author(s):  
N. P. Koval ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Heart Rate ◽  
Physical Therapy ◽  
Therapeutic Alliance ◽  
Cardiovascular System ◽  
Elderly People ◽  
Physical Performance ◽  
Biochemical Parameters ◽  
Adaptive Potential ◽  
Low Level

An increase in the prevalence of insulin resistance in the elderly, associated with physiological changes in carbohydrate metabolism during the aging process, is associated with a high risk of cardiovascular accidents and endocrine diseases. This problem requires a solution by healthcare professionals with medication and non-medication. The purpose of the study was to determine the effectiveness of the program of physical therapy by the dynamics of indicators of the cardiovascular system, carbohydrate and lipid metabolism, psychoemotional status of elderly people with frailty and metabolic syndrome. Material and methods. 96 elderly people were examined. The control group consisted of persons without metabolic syndrome and without frailty. The main group 1 consisted of patients with metabolic syndrome and frailty with a low level of therapeutic alliance who did not want to cooperate with a physical therapist and / or actively improve their health on their own. The main group 2 included patients who agreed to undergo a developed program of physical therapy (a high level of therapeutic alliance) using kinesitherapy, massage, nutritional correction, education of the patient and his family, elements of cognitive training and occupational therapy for 1 year. The effectiveness of the program was assessed by the dynamics of systolic and diastolic blood pressure, heart rate, Kvass endurance coefficient, Baevsky's adaptive potential, Robinson's index, physical performance (based on the results of a 6-minute test), carbohydrate parameters (fasting blood glucose and after glucose load) and lipid (concentration of cholesterol, triglycerides, high density lipoproteins) metabolism, the level of depression according to the GDS-15 questionnaire. Results and discussion. In elderly people with frailty and metabolic syndrome, a statistically significant (p <0.05) deterioration in the parameters of the functioning of the cardiovascular system (according to the levels of DBP, heart rate at rest, Kvass endurance coefficient, Baevsky's adaptive potential, Robinson's index), physical performance (according to the results of a 6-minute test - distance, severity of fatigue, shortness of breath, cardialgia), biochemical parameters (fasting hyperglycemia, impaired glucose tolerance, atherogenic dyslipidemia), psycho-emotional state (depression) from their peers. The use of physical therapy tools led to a statistically significant improvement (p <0.05) of all the studied parameters of the functioning of the cardiovascular system, biochemical parameters in elderly people with metabolic syndrome and frailty, an increase in their physical performance, and an improvement in psycho-emotional status. A low level of therapeutic / rehabilitative alliance led to unsatisfactory fulfillment or non-fulfillment of the recommendations provided by patients and is associated with a lack of improvement in the state of the cardiovascular system, physical performance, age-associated depression. Conclusion. It is advisable to include physical therapy means in the rehabilitation programs for elderly patients with comorbid pathology like frailty and metabolic syndrome for the prevention of cardiovascular accidents

Acupuncture and Neurostimulation Therapy for Erectile Dysfunction in the Patients with the Metabolic Syndrome

10.12737/9074 ◽  
2015 ◽  
Vol 22 (1) ◽  
pp. 38-46
Author(s):  
Долаев ◽  
R. Dolaev
Keyword(s):  
Metabolic Syndrome ◽  
Electrical Stimulation ◽  
Erectile Dysfunction ◽  
Endothelial Dysfunction ◽  
Therapeutic Effect ◽  
Biochemical Markers ◽  
The Metabolic Syndrome ◽  
Treat Ment ◽  
Integrated Indicators ◽  
Stimulation Of

There were 40 patients with a metabolic syndrome with erectile dysfunction under observation. All patients received physiotherapy exercises, psychotherapeutic correction of a sex disadaptation, epicutaneous electrical stimulation of cavernous bodies of a penis and muscles of a pelvic bottom, and acupuncture according to specially developed scheme. It is proved that the combination of medical methods provides duration of therapeutic effect after course of treat-ment. Normalization of integrated indicators of the International index of erectile function came at 72,5% of patients. Vegetative indicators reached values of norm at 72,5% of patients, normalization of volume of a prostate came at 72,5% of patients, a prostate hemodynamic – at 70% of patients. The penil hemodynamic was normalized at 72,5% of patients. Normalization of functional activity hypothalamic – adrenal and testicular system came at 70% of patients. Components of a copulative cycle reached values of norm at 70% of patients. Carbohydrate metabolism was normalized at 75%, lipide – at 72,5%, biochemical markers of endothelial dysfunction – at 72,5% of patients, the index of exacerbations of a metabolic syndrome decreased by 1,9 times. The remote results of therapeutic effect in 1 year after treatment showed that appreciable improvement was observed at 55%, improvement – at 25%, without improvement – at 20% of patients.

scholarly journals Changes of morphofunctional state of cardiovascular system in adolescents with metabolic syndrome manifestations

2021 ◽  
Vol 12 (1) ◽  
pp. 21-30
Author(s):  
Natalya V. Gonchar ◽  
Аnzhela А. Аvakyan ◽  
Svetlana N. Chuprova ◽  
Nikolay V. Slizovskiy
Keyword(s):  
Metabolic Syndrome ◽  
Arterial Hypertension ◽  
Cardiovascular System ◽  
Autonomic Dysfunction ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Holter Monitoring ◽  
Left Ventricular ◽  
Diagnostic Methods ◽  
Group 2

The results of investigation of features of morphofunctional state of cardiovascular system in adolescents with manifestations of metabolic syndrome depending on presence of hyperuricemia are presented. In the cardiorheumatology department of the hospital, 34 adolescent patients were observed. Criteria for inclusion in the study: the presence of increased blood pressure levels, increased body mass index values. Depending on serum uric acid levels, patients were divided into two groups: group 1 patients without hyperuricemia (n = 18) and group 2 patients with hyperuricemia (n = 16). Functional diagnostic methods were used: standard 12-channel electrocardiography, transtoral echocardiography, daily Holter monitoring. The main attention was paid to the study of the parameters of the left ventricle. Students t-test was used to determine the significance of the differences, the results at p 0.05 were considered reliable. It was established that adolescents with hyperuricemia were more often diagnosed with primary and secondary arterial hypertension, less often with labile arterial hypertension and autonomic dysfunction syndrome by hypertensive type, and adolescents without hyperuricemia were equally often diagnosed with primary arterial hypertension and labile arterial hypertension, autonomic dysfunction syndrome by hypertensive type. Signs of left ventricular remodeling according to echocardiography were more often noted in boys without hyperuricemia (62.5% of cases) than in girls without hyperuricemia (10%; p 0.01) and in boys with hyperuricemia (26.7%; p 0,05). The findings indicated more significant changes in the morphofunctional state of the cardiovascular system in adolescents with hypertensive conditions and manifestations of metabolic syndrome without hyperuricemia, which requires further study.

scholarly journals Serum electrolytes disorder and its associated factors among adults admitted with metabolic syndrome in Jimma Medical Center, South West Ethiopia: Facility based crossectional study

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241486
Author(s):  
Abebe Timerga ◽  
Endryas Kelta ◽  
Chala Kenenisa ◽  
Belay Zawdie ◽  
Aklilu Habte ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Odds Ratio ◽  
Associated Factors ◽  
Medical Center ◽  
Electrolyte Disorders ◽  
Serum Electrolytes ◽  
Electrolyte Disorder ◽  
Factors Associated ◽  
South West ◽  
South West Ethiopia

Background Electrolytes play an important role in controlling acid base balance, blood clotting, and body fluid and muscle contractions. Serum electrolytes concentrations are most commonly used tests for assessment of a patient’s clinical conditions, and are associated with morbidity and mortality. Any derangements from the normal range of electrolyte levels in the body is described as electrolyte disorders. The Current study was aimed to determine serum electrolytes disorder and its associated factors among adults admitted with metabolic syndrome at Jimma medical center, South West Ethiopia. Methods A Facility based cross sectional study was conducted on 256 patients admitted medical center with metabolic syndrome during the study period. The World Health Organization stepwise assessment tools and patients’ medical records were used to collect information on factors associated with electrolyte disorders. Bivariable and Multivariable logistic regression analyses were performed to identify factors associated with electrolyte disorder at the level of significance of p value <0.25 with 95% confidence interval of crude odds ratio and <0.05 with 95% confidence interval of adjusted odds ratio respectively. Results The overall prevalence of electrolyte disorders was 44.1% (95%CI:40.99–47.20) with hyponatremia 42.9% (95%CI:39.81–45.99) as the leading electrolyte disorder followed by hypokalemia 20.7% (95%CI:18.17–23.23), hypochloremia 17.6% (95%CI:15.22–19.98) and hypocalcemia 9.4% (95%CI:7.57–11.22). Non-formal education [AOR: 6.81; 95%CI:(3.48,17.01)] alcohol consumption [AOR: 4.28; 95%CI:(1.71,10.70)], diuretics, diuretics [AOR: 4.39; 95%CI:(2.10,9.15)], antidiabetics [AOR: 5.18; 95%CI:(2.44,11.00)], and body mass index [AOR: 11.51; 95%CI:(3.50,18.81)] were identified as independent factors for electrolyte disturbance in multivariable logistic regression. Conclusion The finding of the study revealed that nearly half the study participants with metabolic syndromes had electrolyte disorder. Educational status, habit of alcohol consumption, diuretics, antidiabetics, and having higher body mass index were the independent factors associated with electrolyte disorders. Determination of Serum electrolytes, proper administration of diuretic and health education on behavioral factors were the necessary measures that should be done by concerned bodies to reduce electrolytes disorder.

THE IMPACT OF COMPLEX DRUG KRATAL ON THE FUNCTIONAL STATE OF CARDIOVASCULAR SYSTEM IN RATS WITH METABOLIC SYNDROME

2015 ◽  
pp. 94-100
Author(s):  
O. V. Ivanova ◽  
◽  
T. S. Zvyagina ◽  
N. I. Gorbenko ◽  
A. S. Shalamay ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular System ◽  
Functional State ◽  
The Impact ◽  
Complex Drug

scholarly journals Electrocardiographic Changes Associated With Ibrutinib Exposure

2020 ◽  
Vol 27 (1) ◽  
pp. 107327482093180
Author(s):  
Michael G. Fradley ◽  
Allan Welter-Frost ◽  
Matthew Gliksman ◽  
Josephine Emole ◽  
Federico Viganego ◽  
...  
Keyword(s):  
Qt Interval ◽  
Ventricular Arrhythmias ◽  
Qt Dispersion ◽  
Corrected Qt Interval ◽  
Qt Intervals ◽  
Electrocardiographic Changes ◽  
The Absolute ◽  
Significant Change ◽  
Electrocardiographic Parameters ◽  
Electrocardiogram Ecg

Although ibrutinib-associated atrial and ventricular arrhythmias have been well described, there is little information about ibrutinib’s effects on other electrocardiographic parameters, particularly the QT interval. Using our database of 137 patients treated with ibrutinib, we retrospectively identified 21 patients in whom an electrocardiogram (ECG) was obtained both prior to and after ibrutinib exposure. All traditional ECG parameters as well as QT dispersion were manually measured by an electrophysiologist. Compared to baseline ECGs, post ibrutinib ECGs demonstrated QT interval shortening from 386 ms to 356 ms ( P = .007), corrected QT interval shortening using Bazett’s formula from 446 ms to 437 ms ( P = .04), and corrected QT interval shortening using Fridericia’s formula from 425 ms to 407 ms ( P = .003). QT dispersion also increased post ibrutinib exposure compared to baseline (39.8 ms vs 57.3 ms, P = .002). There was no significant change in other ECG parameters. In conclusion, both the absolute and corrected QT intervals significantly shortened after ibrutinib exposure, while there was a significant increase in QT dispersion. These findings may point to a common underlying electrophysiologic mechanism of ibrutinib-associated arrhythmias.

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