Inflammatory myofibroblastic tumor of the lung: presentations of an uncommon finding

2018 ◽  
pp. 1-4
Keyword(s):  
Surgical Resection ◽  
Inflammatory Myofibroblastic Tumor ◽  
Clinical Symptoms ◽  
Pediatric Population ◽  
Lower Lobe ◽  
Malignant Potential ◽  
The Body ◽  
Low Grade ◽  
Diagnostic Challenge ◽  
Anaplastic Lymphoma

Inflammatory myofibroblastic tumor (IMT) is a rare occurrence most commonly affecting the pediatric population. It is considered a diagnostic challenge because of nonspecific clinical symptoms and radiologic presentations. IMT is a soft-tissue tumor that can occur throughout the body but is most commonly found in the lung. This article discusses the case of a 10-year-old girl who presented to our hospital with abnormal chest radiograph. Imaging revealed a heterogenous mass in the superior aspect of the left lower lobe. It was found incidentally when the patient presented to the emergency department. Surgical resection proved a diagnostic and therapeutic measure confirming diagnosis of IMT. The tumor has potential to cause illness either by its rare malignant potential or by mass effect. Because lesions are often asymptomatic with a predilection for pediatric patients, cases describing appropriate management are essential. IMT is a rare tumor of borderline malignant potential. IMT of the lung may invade hilar structures, the mediastinum, and the pleura. Lesions range in diameter from 1.5 to 14 cm. Etiology of the tumor is unclear but may include immune response to infection, trauma, or surgery. Affected patients may present with cough and shortness of breath but are often asymptomatic. Histology is unique but not specific. Immunohistochemistry can differentiate the tumor, by staining for overexpression of the anaplastic lymphoma kinase oncogene. In conclusion, surgical resection is the preferred diagnostic and therapeutic regimen for IMT. The majority of IMTs follow a benign course, but exceptions qualify as low-grade malignancies. As a result, it is important to identify, treat, and maintain vigilance. This case encompasses presentation, diagnosis, and treatment of pulmonary IMT and highlights best practices in addressing IMT for adolescent patients.

Inflammatory myofibroblastic tumor in children

2021 ◽  
Vol 25 (4) ◽  
pp. 284-289
Author(s):  
V. N. Stalmakhovich ◽  
I. N. Kaygorodova ◽  
I. B. Li ◽  
A. P. Dmitrienko ◽  
A. S. Strashinski
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Mediastinal Tumor ◽  
Clinical Symptoms ◽  
Lung Tumor ◽  
Superior Vena ◽  
Vena Cava ◽  
Lower Lobe ◽  
Middle Lobe ◽  
Brachiocephalic Vein ◽  
Biological Potential

Introduction. Inflammatory myofibroblastic tumor (IMT) is a rare volumetric neoplasm in the childhood which originates from the mesodermal tissue , and by the classification of soft tissue tumors refers to the tumors with intermediate biological potential.Purpose. To present a case of rare volumetric formation in the lungs and mediastinum in children.Material and methods. The publication presents three clinical observations of children with IMT. In all three boys (aged 6, 8 and 15), tumors were localized in the right hemithorax: lower lobe of the lung (two children), upper anterior mediastinum (one) without a reliable organ accessory.Results. There were no specific clinical symptoms of the disease. In two children, the volumetric formation was found accidentally: in one child, a rounded tumor above the liver was found during an ultrasound examination of the abdomen; in the other one, during chest X-ray prophylactic examination. Only in one case, the lung tumor caused respiratory failure during exercise due to the complete atelectasis of the lower lobe and emphysema of the middle lobe which was caused by the growth of the tumor from the parenchyma of the lower lobe into the lumen of the lower lobe and intermediate bronchi. There were no significant shifts in clinical and biochemical blood tests. Cancer markers were negative. Surgery was indicated because of the volume formation topography which was confirmed by the multispiral computed tomography with vascular contrast and fibrobronchoscopy. Surgical volume – thoracotomy, lobtumorectomy (1 child); thoracotomy, pulmonotomy, tumorectomy (1 child); thoracoscopy, removal of the mediastinal tumor (1 child). The most technically difficult was mobilization and removal of the mediastinal tumor when it was separated from the superior vena cava and in the chest aperture where it was intimately fused with the brachiocephalic vein. The postoperative period was without complications. All children recovered.Conclusion. IMT of the thoracic organs is not a rare case. It is not possible to reliably verify the nature of the tumor process in the preoperative period. Surgical treatment is radical and, in some cases, endovideotechnologies may be applied.

scholarly journals Variety of radiological findings in a family with COVID-19: a case report

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Farideh Gharekhanloo ◽  
Iraj Sedighi ◽  
Salman Khazaei
Keyword(s):  
Ct Scan ◽  
Clinical Symptoms ◽  
Close Contact ◽  
Pediatric Population ◽  
Case Series ◽  
Lower Lobe ◽  
Ground Glass Opacity ◽  
Imaging Features ◽  
Standard Regimen ◽  
Asymptomatic Children

Abstract Introduction In December 2019, a case series of pneumonia associated with seafood and wet animal market was reported as coronavirus disease 2019 (COVID-19) in Wuhan, Hubei, China. The COVID-19 less frequently affects the pediatric group, and asymptomatic children are commonly reported. This feature is important due to the potential transmissibility of COVID-19 through these cases. There is a variety of atypical clinical symptoms and imaging manifestations among children infected with COVID-19. Case presentation We report two sisters with COVID-19 pneumonia who had close contact with their 77-year-old grandmother. Their grandmother expired with a confirmed diagnosis of COVID-19. The older sister (15 years old) firstly presented with severe cough, fever, dyspnea, diarrhea, and lymphopenia. A chest computed tomography (CT) scan showed atypical lobar pneumonic infiltration only in the left lower lobe. The younger sister (6 years old) was affected the following day with milder symptoms (i.e., fever and cough). Her chest CT scan demonstrated typical mild generalized patchy ground-glass opacity with interlobular septal thickening scattered in both lungs. The CT presentation of their grandmother showed typical bilateral white lungs with crazy paving appearance. The standard regimen for both sisters was administrated, and the patients’ respiratory conditions improved after 5 days of treatment. Both cases were discharged with good general conditions. Conclusion Children are considered potentially important causes of COVID-19 transmission. The symptoms in children are milder, and clinicians should be aware of taking a definite history of infected family members. Atypical clinical symptoms and imaging features are more common in children than adults; therefore, it is necessary to identify the typical and atypical imaging patterns of COVID-19 pneumonia in the pediatric population.

scholarly journals Unusual dissemination patterns of low-grade astrocytomas in childhood

2008 ◽  
Vol 66 (1) ◽  
pp. 45-49 ◽  
Author(s):  
Patricia Imperatriz Porto Rondinelli ◽  
Carlos Alberto Martinez Osório ◽  
Marcela Pécora Cohen ◽  
Paulo Eduardo Ribeiro Santos Novaes
Keyword(s):  
Spinal Cord ◽  
Surgical Resection ◽  
High Frequency ◽  
Pediatric Population ◽  
Low Grade ◽  
Medical Experience ◽  
Complete Surgical Resection ◽  
Medical Reports

CONTEXT: Low-grade astrocytomas are intracerebral lesions of relatively high frequency in the under-18 pediatric population. They often present indolent behaviour, and complete surgical resection is the choice treatment. In cases where the surgery is not possible, chemotherapy and radiotherapy may be used. Medical reports do not recommend examination of the spinal cord at diagnosis or during treatment, since the risk of dissemination of the lesion to the spine is minimal according to medical experience. We describe here four cases of children with low-grade astrocytoma with aggressive dissemination to the neuroaxis.

scholarly journals Metastatic Chordoma: A Diagnostic Challenge on Fine Needle Aspiration

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Ghassan Tranesh ◽  
Aziza Nassar
Keyword(s):  
Fine Needle Aspiration ◽  
Malignant Tumors ◽  
Lung Nodule ◽  
Lower Lobe ◽  
Axial Skeleton ◽  
Needle Aspiration ◽  
Low Grade ◽  
Diagnostic Challenge ◽  
Fine Needle ◽  
Tumors Of Bone

Chordomas are primary low grade malignant tumors of bone that usually arise within both ends of axial skeleton. The Notochord is a midline, ectoderm-derived structure that defines the phylum of chordates. Chordomas may pose difficult diagnostic challenges when encountered in secondary locations, such as lungs or other parenchymatous organs. We report the cytologic findings of a metastatic chordoma sampled through CT-scan guided fine needle aspiration (FNA) of lower lobe lung nodule in a 54-year-old man diagnosed with recurrent chordoma involving the lumber spine and paraspinal region.

scholarly journals Rare Nasal Mass: Inflammatory Myofibroblastic Tumor of Nose and Paranasal Sinuses

2015 ◽  
Vol 8 (1) ◽  
pp. 38-40
Author(s):  
Jafferhusein Sura ◽  
Praveen Kumar Rathore ◽  
Divya Sharma ◽  
Eishaan Bhargava
Keyword(s):  
Paranasal Sinuses ◽  
Inflammatory Myofibroblastic Tumor ◽  
Neck Region ◽  
The Body ◽  
Unknown Etiology ◽  
Diagnostic Challenge ◽  
Head And Neck Region ◽  
Nasal Mass ◽  
Neoplastic Process ◽  
Nose And Paranasal Sinuses

ABSTRACT Inflammatory myofibroblastic tumor (IMFT) also known as pseudotumor is a condition of unknown etiology, that mimmicks a neoplastic process clinically and radiologically. They occur all over the body with few exceptions. In the head and neck region, they are rare. The orbit, maxilla, nasopharynx and skull base are sites where they have been reported. We present a case of a 32-year-old male having a mass in the cheek, which presented a diagnostic challenge. How to cite this article Sura J, Raj A, Rathore PK, Sharma D, Khurana N, Wadhwa V, Bhargava E. Rare Nasal Mass: Inflammatory Myofibroblastic Tumor of Nose and Paranasal Sinuses. Clin Rhinol An Int J 2015;8(1):38-40.

scholarly journals Rare cause of lung atelectasis in a young woman

2019 ◽  
Vol 12 (1) ◽  
pp. e227969
Author(s):  
Paula Inês Pedro ◽  
Dolores Canário ◽  
Miguel Lopes ◽  
Despina Argyropoulou
Keyword(s):  
Surgical Resection ◽  
Fdg Pet ◽  
Mucoepidermoid Carcinoma ◽  
Lower Lobe ◽  
Pathological Examination ◽  
Low Grade ◽  
High Grade ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Pulmonary mucoepidermoid carcinoma is an extremely rare intrathoracic malignancy, comprising less than 1% of all lung tumours. These are very slow growing and are classified into low grade and high grade based on histological features. Surgical resection is the primary treatment with excellent outcomes, while chemotherapy or radiotherapy effectiveness is not known. Preoperative fluorine-18 fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) is useful for predicting tumour grade and postsurgical prognosis.A clinical case of a 31-year-old woman who presented with dyspnoea on exertion, cough and wheezing is reported. Imaging studies revealed a mass involving the left lower lobe bronchus and atelectasis. 18F-FDG PET/CT showed uptake in the described mass with a maximum standardised uptake value of 9.7. Complete surgical resection was performed, and pathological examination revealed a high-grade mucoepidermoid carcinoma with tumour-free margins. Adjuvant chemotherapy was given and there is no evidence of tumour recurrence.

Lhermitte-Duclos Disease in Pediatric Population: Report of 2 Cases

2021 ◽  
pp. 1-7
Author(s):  
Ivethe Pregúntegui-Loayza ◽  
Alejandro Apaza-Tintaya ◽  
Alberto Ramírez-Espinoza ◽  
Nancy Mayo-Simón ◽  
Mauro Toledo-Aguirre
Keyword(s):  
Posterior Fossa ◽  
Clinical Symptoms ◽  
Pediatric Population ◽  
Clinical Manifestations ◽  
Granular Cell ◽  
Cowden Syndrome ◽  
Low Grade ◽  
Nccn Guidelines ◽  
Asymptomatic Children ◽  
Slow Growing

<b><i>Introduction:</i></b> Lhermitte-Duclos disease (LDD), also known as dysplastic cerebellar gangliocytoma, is an uncommon disorder in children, characterized by being a slow-growing lesion of the posterior fossa, which mainly affects the granular cell layer of the cerebellar parenchyma and may be associated with other multiple hereditary hamartomas and neoplasms. <b><i>Case Presentation:</i></b> We report 2 cases of LDD in pediatric patients and describe clinical symptoms and radiological and histopathological characteristics. In addition, we analyzed the relation to Cowden Syndrome based on the International Cowden Syndrome Consortium Operational Criteria and the most updated guidelines by the National Comprehensive Cancer Network (NCCN Guidelines Version 1.2020). <b><i>Conclusion:</i></b> LDD is a very rare disease in childhood but should be considered in the differential diagnosis of posterior fossa lesions. LDD can mimic low-grade glial tumors or infectious diseases. Patients develop late clinical manifestations due to the slow-growing pattern, and conservative treatment with outpatient follow-up may be an option in asymptomatic children.

scholarly journals Inflammatory Myofibroblastic Tumor of Common Bile Duct in a Girl

2016 ◽  
Vol 7 (4) ◽  
pp. 28 ◽  
Author(s):  
Aureen Ruby DCunha ◽  
Susan Jehangir Homi ◽  
Reju Joseph Thomas
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Inflammatory Myofibroblastic Tumor ◽  
Soft Tissues ◽  
Tumor Resection ◽  
Malignant Lesion ◽  
The Body ◽  
Low Grade ◽  
Diagnostic Dilemma ◽  
Oral Steroids

Inflammatory myofibroblastic tumor (IMT) is a rare, low grade malignant lesion which can occur anywhere in the body. It children it is usually found in the visceral soft tissues with a potential for local invasion and recurrence, and rarely distant metastasis. We report the diagnostic dilemma faced in the management of a 12-year old girl who presented with obstructive jaundice with a mass lesion at the distal end of the common bile duct. She underwent a tumor resection with a bilio-enteric bypass followed by a course of oral steroids and celecoxib.

scholarly journals Orbital myxoma: A case report

2020 ◽  
Vol 11 ◽  
pp. 43
Author(s):  
Luke Weisbrod ◽  
Kyle Smith ◽  
Paul Camarata ◽  
Anthony Alvarado ◽  
Brian Andrews
Keyword(s):  
The Body ◽  
High Rate ◽  
Gross Total Resection ◽  
Low Grade ◽  
Benign Neoplasms ◽  
Diagnostic Challenge ◽  
Total Resection ◽  
Radiographic Findings ◽  
Orbital Wall ◽  
Orbitozygomatic Approach

Background: Myxomas are rare, locally infiltrative, benign neoplasms of mesenchymal origin. Although benign, these tumors are locally aggressive with a high rate of recurrence following conservative resection. Their relative infrequency, variable location, and insidious growth present a diagnostic challenge to clinicians. Cases of myxomas have been described throughout the body, but intraosseous myxomas of the orbit are exceedingly rare. Case Description: We report a case of a 53-year-old male with a history of chronic sinusitis and symptoms of hyposmia and bifrontal headaches refractory medical management who presented for neurosurgical evaluation after radiographic findings of an orbital lesion. Physical examination was unremarkable with intact extraocular movements. Prior radiographic workup demonstrated a 2.4 × 2.7 × 2.2 cm expansile lesion involving the bony left superior and lateral orbit. A prior open biopsy was performed which demonstrated a low-grade spindle cell neoplasm consistent with intraosseous myxoma. Definitive resection was recommended through the left orbitozygomatic craniotomy. The patient tolerated the procedure well without complications. Gross total resection was achieved. Reconstruction of the orbital roof and lateral orbital wall was performed with a frontal bone autograft and titanium plating. Postoperative course was uneventful, and the patient was discharged home postoperative day 2. At 1-month follow-up visit, the patient remained neurologically intact. Surveillance imaging at 6 months and 1 year remained stable without signs of recurrence. Conclusion: Intraosseous orbital myxomas are exceedingly rare entities. Although they are considered benign neoplasms, myxomas demonstrate high recurrence rates. The authors report a unique case of an orbital myxoma that was successfully treated through an orbitozygomatic approach achieving gross total resection.

scholarly journals A Case of Papillary Urothelial Neoplasm of Low Malignant Potential (PUNLMP) in Childhood

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Reza Abbasion ◽  
Amir Jafarpisheh ◽  
Paria Dehghanian ◽  
Mahdi Mottaghi
Keyword(s):  
Urinary Tract Infection ◽  
Pediatric Population ◽  
Malignant Potential ◽  
Low Grade ◽  
Age Group ◽  
Delay In Diagnosis ◽  
Low Malignant Potential ◽  
One Year ◽  
Urothelial Neoplasm

Urothelial carcinoma (UC) of the bladder is exceedingly rare in the pediatric population. It commonly presents as isolated hematuria. Considering the age group, the physician’s low index of suspicion causes a delay in diagnosis. We present a seven-year-old girl complaining of dysuria and painless, intermittent hematuria. She was misdiagnosed with urinary tract infection several times. Although the initial ultrasound showed no abnormality, the second ultrasound after one year detected the tumor. The confirmation and resection are simultaneously achieved by cystoscopy. We concluded that chemotherapy is unnecessary due to the tumor’s low-grade nature and the absence of detrusor involvement. One-year follow-up showed no relapse.

Sign in / Sign up

Export Citation Format

Share Document