scholarly journals Emotional sphere disorders in patients with cognitive impairments in depressive disorders

2020 ◽  
pp. 51-54
Author(s):  
Serhii Yaroslavtsev
Keyword(s):  
Cognitive Impairment ◽  
Depressive Disorder ◽  
Affective Disorders ◽  
Depressive Disorders ◽  
Cognitive Impairments ◽  
Bipolar Affective Disorder ◽  
Emotional Lability ◽  
Low Mood ◽  
Different Types ◽  
Depressive Reaction

362 patients with cognitive impairment in depressive disorders were examined: 123 patients with recurrent depressive disorder (RDD), 141 patients with bipolar affective disorder (BAD) and 98 patients with prolonged depressive reaction (PDR). A set of research methods was used: clinical-psychopathological and statistical. As a result of the study, the clinical and psychopathological features of affective disorders in different types of depressive disorders were identified: a predominance of apathy, emotional lability, hypothymia, anxiety, feelings of dissatisfaction, despair and anhedonia were identified in patients with RDD; a low mood, apathy, emotional coldness, hypothymia, ambivalence of emotions, dysphoria, dissatisfaction, feelings of sadness and annoyance were identified in patients with BAD; a feelings of despair, anxiety, dissatisfaction, hypothymia, fear, sadness, feelings of horror and fear, emotional lability, feelings of anger, hostility and shame and sensitivity were dominated in patients with PDR.

CHARACTERISTICS OF COGNITIVE IMPAIRMENT IN PATIENTS WITH DEPRESSIVE DISORDERS

2020 ◽  
Vol 86 (1) ◽  
pp. 41-49
Author(s):  
S. A. Yaroslavtsev
Keyword(s):  
Differential Diagnosis ◽  
Cognitive Impairment ◽  
Depressive Disorder ◽  
Affective Disorder ◽  
Depressive Disorders ◽  
Bipolar Affective Disorder ◽  
Cognitive Dysfunctions ◽  
Visual Spatial ◽  
Linguistic Functions ◽  
Depressive Reaction

362 patients with cognitive impairment in depressive disorders were examined: 123 patients with recurrent depressive disorder (RDD), 141 patients with bipolar affective disorder (BAD) and 98 people with prolonged depressive reaction (PDR). It was found that cognitive dysfunctions were less pronounced in patients with PDR, than in patients with RDD and BAR (p<0,035). Cognitive dysfunctions in depressive disorders was underlined by the presence of disorders in the mental sphere, in the sphere of attention, executive, visual-spatial and linguistic functions. The differential features of cognitive impairment in patients with RDD, BAR and PDR are highlighted and it should be taken during conducting differential diagnosis of cognitive impairment in depressive disorders. Keywords: patients with cognitive impairment, depressive disorders, cognitive dysfunctions, recurrent depressive disorder, bipolar depressive disorder, prolonged depressive reaction.

scholarly journals Peculiarities of the perception process in patients with cognitive impairments in depressive disorders

2020 ◽  
pp. 58-62
Author(s):  
Serhii Yaroslavtsev
Keyword(s):  
Cognitive Impairment ◽  
Depressive Disorder ◽  
Depressive Disorders ◽  
High Selectivity ◽  
Bipolar Affective Disorder ◽  
Negative Stimulus ◽  
Neutral Stimulus ◽  
Positive Stimulus ◽  
Perception Process ◽  
Depressive Reaction

362 patients with cognitive impairment in depressive disorders were examined: 123 patients with recurrent depressive disorder (RDD), 141 patients with bipolar affective disorder (BAD) and 98 patients with prolonged depressive reaction (PDR). A set of research methods was used: clinical-psychopathological, psychodiagnostic (Munsterberg test) and statistical. The features of the perception process were established for various types of depressive disorders: in patients with RDD, there was a predominance of average, increased and decreased selectivity of attention to neutral stimulus (30.89 %, 21.95 % and 21.95 %, respectively), high selectivity of attention to negative stimulus (33.33 %) and decreased and low selectivity of attention to positive stimulus (54.47 % and 20.33 %, respectively); in patients with BAD, a predominance of average and reduced selectivity of attention to neutral stimulus (45.39 % and 36.17 %, respectively) and average selectivity of attention to negative and positive stimulus (38.30 % and 38.30 %, respectively) were recorded; in patients with PDR, the prevalence of average and reduced selectivity of attention to neutral stimulus (42.86 % and 34.69 %, respectively), increased and decreased selectivity of attention to negative stimulus (29.59 % and 16.33 %, respectively), increased selectivity of attention to positive stimulus (43.88 %). Key words: patients with cognitive impairment, depressive disorders, perception process, recurrent depressive disorder, bipolar depressive disorder, prolonged depressive reaction

scholarly journals SYNDROMAL CHARACTERISTICS OF DEPRESSIVE MANIFESTATIONS AMONG PATIENTS COGNITIVE IMPAIRMENTS IN DEPRESSIVE DISORDERS

2020 ◽  
Vol 7 (3) ◽  
pp. 152-156
Author(s):  
Galyna Kalenska ◽  
Sergey Yatoslavtsev
Keyword(s):  
Cognitive Impairment ◽  
Depressive Disorders ◽  
Cognitive Impairments ◽  
Bipolar Affective Disorder ◽  
Major Depressive ◽  
Suicidal Thoughts ◽  
Loss Of Appetite ◽  
Major Depressive Episodes ◽  
Depressive Episodes ◽  
Depressive Reaction

362 patients with cognitive impairment at depressive disorders were examined, of them 123 patients with recurrent depressive disorder (RDD), 141 patients with bipolar affective disorder (BAD) and 98 patients with prolonged depressive reaction (PDR). Differentiated clinical and psychopathological features of patients with cognitive impairment at depressive disorders were established: 1) combination of apathetic-adynamic, astheno-energetic and anxious symptom complexes;  predominance of moderate and major depressive episodes;  severity of apathy, subjective and objective signs of depression,  decrease in concentration and ability to feel were determined in patients with RDD; 2) combination of astheno-energetic, apathetic-adynamic, and melancholic symptom complexes;  predominance of moderate and major depressive episodes; the severity of apathy, subjective signs of depression, suicidal thoughts, insomnia and  decrease in concentration  in patients with BAD; 3) combination of anxious and apathetic-adynamic symptom complexes; the predominance of moderate and minor depressive episodes; the severity of internal stress, apathy, suicidal thoughts and loss of appetite  in patients with PDR.

scholarly journals Predictors of suicidal behavior in patients with cognitive impairments in depressive disorders

2020 ◽  
Vol 24 (4 (96)) ◽  
pp. 58-64
Author(s):  
N. Maruta ◽  
S. Yaroslavtsev
Keyword(s):  
Cognitive Impairment ◽  
Depressive Disorder ◽  
Interpersonal Relationships ◽  
Suicidal Behavior ◽  
Cognitive Functions ◽  
Affective Disorders ◽  
Suicide Risk ◽  
Depressive Disorders ◽  
Bipolar Affective Disorder ◽  
Autonomic Disorders

The aim of the study was to determine predictors of suicide risk in patients with cognitive impairment in depressive disorders.Material and methods. 362 patients with cognitive impairment in depressive disorders were examined: 123 patients with recurrent depressive disorder, 141 patients with bipolar affective disorder and 98 patients with prolonged depressive reaction. A set of research methods was used to study the factors of suicidal behavior in patients with cognitive impairment in depressive disorders: clinical-psychopathological, psychodiagnostic (questionnaire "Self-assessment of the severity of autoaggressive predictors") and mathematical-statistical. Results of the research. Predictors of suicide risk in patients with cognitive impairment in depressive disorders were identified. The moderate level of autoaggression and aggression, low level of impulsivity, high and severe narrowing of cognitive functions, severe narrowing of interpersonal relationships, severity of affective disorders, moderate and severe autonomic disorders were identified in patients with recurrent depressive disorder. Pronounced and moderate level of autoaggression, aggression and impulsivity, high and pronounced level of narrowing of cognitive functions, pronounced narrowing of interpersonal relationships, severity of affective disorders, moderate and severe level of autonomic disorders were identified in patients with bipolar affective disorder. Moderate levels of autoaggression and narrowing of cognitive functions, low levels of aggression, severe impulsivity, affective disorders and narrowing of interpersonal relationships, and high levels of autonomic disorders were identified in patients with prolonged depressive reaction.Conclusions. As a result of the study, the features of suicidal behavior in patients with cognitive impairment in depressive disorders were identified. It can act as diagnostic criteria and predictors of suicidal behavior in differential diagnostics and could take into account when creating psychocorrectional programs aimed at reducing suicidal risk in patients with cognitive dysfunctions in depressive disorders.

scholarly journals Peculiarities of the attention process at depressive disorders

2020 ◽  
pp. 55-59
Author(s):  
Serhii Yaroslavtsev
Keyword(s):  
Differential Diagnosis ◽  
Cognitive Impairment ◽  
Depressive Disorder ◽  
Key Words ◽  
Depressive Disorders ◽  
Bipolar Affective Disorder ◽  
Work Efficiency ◽  
Working Capacity ◽  
Attention Process ◽  
Depressive Reaction

362 patients with cognitive impairment in depressive disorders were examined: 123 patients with recurrent depressive disorder, 141 patients with bipolar affective disorder and 98 people with prolonged depressive reaction. Peculiarities of the process of attention of patients with depressive disorders were the presence of a decrease in concentration, stability and switching of attention, decrease in work efficiency and working capacity. The peculiarities of the functioning of attention indicators were determined for various types of depressive disorders, which can use as diagnostic criteria in the differential diagnosis of cognitive impairment in depressive disorders. Key words: cognitive impairment, depressive disorders, persistence, concentration and switching of attention, recurrent depressive disorder, bipolar depressive disorder, prolonged depressive reaction

scholarly journals Some Predictors of Depressive Disorders in the Context of Clinical Patomorphosis

2021 ◽  
Vol 6 (4) ◽  
pp. 77-82
Author(s):  
O. O. Belov ◽  
Keyword(s):  
Cognitive Impairment ◽  
Clinical Picture ◽  
Depressive Disorders ◽  
Clinical Symptoms ◽  
Emotional Lability ◽  
Obsessive Compulsive ◽  
Diagnostic Strategies ◽  
Low Mood ◽  
Self Blame ◽  
Initial Stage

The purpose of the study was to study the clinical and psychopathological phenomenology of the initial stage of depressive disorders in the context of clinical pathomorphosis. Materials and methods. Features of clinical symptoms of the initial stage of depressive disorders in the comparative aspect in the context of clinical pathomorphosis based on the analysis of medical records of 236 patients who were treated for depressive disorders in 1971-1995 (ICD-9 codes 296.1, 296.3) and clinical examination of 245 patients with depressive disorders in 2015-2019 (ICD-10 codes F 31.3, F 31.4, F 32.0, F 32.1, F 32.2, F 33.0, F 33.1, F 33.2) are considered. Results and discussion. It was established that there is a predominance in the clinical picture of modern depressive disorders of low mood (in general in 91.4% of patients, 91.6% of men and 91.3% of women, p>0.05), dyssomnia (93.1%, 92.5% and 93.5%, respectively, p>0.05), anxiety, fear (84.5%, 78.5%, 89.1%, respectively, p<0.01), asthenia (82.4%, 77.6% and 86.2%, respectively, p>0.05), somatic vegetative symptoms (82.9%, 77.6% and 87.0%, respectively, p<0.01), apathy (78.8%, 69.2% and 86.2%, respectively, p<0.01) and ideas of self-humiliation and self-blame (69.8%, 72.9% and 67.4%, respectively, p<0.01), and the relatively low prevalence of obsessive symptoms (55.1%, 54.2% and 55.8%, respectively, p<0.05), emotional lability (51.0%, 54.2% and 48.6%, respectively, p<0.01) and cognitive impairment (45.3%, 43.9% and 46.4%, respectively, p<0.05) with a predominance of emotional lability and ideas of self-humiliation and self-blame in men, and manifestations of anxiety, fear, apathy, cognitive impairment, obsessive and somatic vegetative symptoms in women, which gives grounds to consider that the main predictors of depressive disorder at the initial stage of low mood are dyssomnia, anxiety fear, asthenia and somatic vegetative symptoms. The revealed features suggest the presence of a clinical pathomorphosis of depressive disorders. The clinical pathomorphosis of the initial stage of depressive disorders is in a significant reduction in the clinical picture of low mood, ideas of self-abasement and self-blame, emotional lability and cognitive impairment, and an increase in anxiety, fear, asthenia, apathy, obsessive symptoms and obsessive-compulsive symptoms, with significantly greater gender differentiation of clinical symptoms of depression. Conclusion. The identified patterns are embedded in the general trend towards polymorphism and clinical undifferentiation of modern depressive disorders, significant involvement of patients with sleep disorders, asthenic, apathetic and somatic vegetative symptoms, which requires revision of diagnostic strategies and individualization of diagnosis. The identified patterns can be used for early diagnosis of depressive disorders and prevention of depression

scholarly journals Analysis of family anxiety in women with depressive disorders of different genesis and macrosocial, mesosocial and microsocial maladaptation of different expression

2019 ◽  
Vol 84 (3) ◽  
pp. 61-69
Author(s):  
R.I. Isakov
Keyword(s):  
Bipolar Disorder ◽  
Depressive Disorder ◽  
Depressive Episode ◽  
Affective Disorders ◽  
Depressive Disorders ◽  
Psychosocial Rehabilitation ◽  
Adjustment Disorder ◽  
General Tendency ◽  
Rehabilitation Measures ◽  
Depressive Reaction

252 women with depressive disorders were examined: 94 people were with psychogenic (prolonged depressive reaction caused by adjustment disorder), 83 women were with endogenous (depressive episode; recurrent depressive disorder; bipolar disorder, current episode of depression) and 75 patients were with organic depression (organic affective disorders). 48 women had no signs of psychosocial maladaptation, the remaining 204 had manifestations of macrosocial, mesosocial and microsocial maladaptation of varying severity. The features of family anxiety in women with depression of various origins and different severity of macrosocial, mesosocial and microsocial maladaptation were investigated in order to determine the target targets of differentiated psychosocial rehabilitation of patients in this contingent. Clinical-psychopathological and psychodiagnostic methods were used. There was revealed a general tendency towards an increase in the indicators of family guilt, family anxiety and family tension as the degree of macrosocial, mesosocial and microsocial maladaptation increased. At the same time, the greatest differences in indicators were observed between the groups with moderate and severe maladaptation, and the smallest differences were observed between the groups without signs of disadaptation and with signs of mild maladaptation. The data obtained should be taken into account when developing treatment and rehabilitation measures for patients of this contingent.

scholarly journals Aerobic or strength training and flexibility activities and mild cognitive impairment: CETI cohort

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
C Dupré ◽  
B Bongue ◽  
L Fruteau de Laclos ◽  
J Blais ◽  
M-J Sirois
Keyword(s):  
Physical Activity ◽  
Cognitive Impairment ◽  
Neurodegenerative Diseases ◽  
Cognitive Impairments ◽  
Cognitive Status ◽  
Physical Activities ◽  
Community Dwelling ◽  
Different Types ◽  
Initiative Program ◽  
The Impact

Abstract Background Previous studies have been notably criticized for not studying the different types of physical activity. The objective of this work was to examine the association between types of physical activity and cognitive decline in older people. Methods This is a sub-group analysis from the CETI cohort, a multicenter prospective study conducted by the Canadian Emergency Team Initiative Program (CETIE), between 2011 and 2016. Participants were community-dwelling seniors aged ≥ 65 years, consult emergency services for minor injuries with follow-up at 3 and 6 months. Physical activity was assessed by the RAPA (Rapid assessment of Physical activity), which describes the level of aerobic activities and the overall level of muscle strength and flexibility activities. The cognitive status was assessed with the Montreal Cognitive Assessment (MoCA) and the Telephone Interview for Cognitive Status (TICS), using their current cut-offs (MoCA &lt;26/30 and TICS &lt; = 35/50) for mild cognitive impairments (MCI). Logistic regression, COX models and splines were used to examine the association between the type of physical activities and the onset of cognitive impairment. Results At inclusion, 281 individuals were free of MCI, or 43.8% of the total sample, with an average age of 73 years. During follow-ups, MCI appeared in 31.7% of participants initially free of it. The risk of MCI was lower with higher muscular strength & flexibility physical activities (HR = 0.84 [0.70-0.99]), while the relationship with aerobic physical activities was not significant. Conclusions These results showed a potential link between strength & flexibility activities and cognitive impairments, but not with aerobic physical activities. Further analyses are needed to examine whether these relationships persist as a function of the adjustment variables, or statistical methods. This study contributes to the debate on the evaluation of physical activity in the elderly, and its link with neurodegenerative diseases. Key messages This study analyzed the link between types of physical activity and mild cognitive disorders. The aim is to put in place preventive policies of aging, specially in neurodegenerative diseases. The work allowed us to see the effect of the different types of physical activity and the impact of the statistical method on the results.

scholarly journals Cognitive impairments in patients with treatment resistant epilepsy and complex rehabilitation

2021 ◽  
Vol 8 (2) ◽  
pp. 123-129
Author(s):  
Volodymyr Korostiy ◽  
Iryna Blazhina
Keyword(s):  
Quality Of Life ◽  
Cognitive Decline ◽  
Cognitive Training ◽  
Affective Disorders ◽  
Depressive Disorders ◽  
Cognitive Impairments ◽  
Control Group ◽  
Quality Of Life Scale ◽  
Patients With Epilepsy

Background. The study of features of comorbid pathology in patients with epilepsy is of particular interest due to the high prevalence of this pathology and a significant impact on the quality of life of patients and their social adaptation. Aim. The aim of the research was to detect versatile cognitive impairments and affective disorders in epilepsy, and to study the results of cognitive training and psychoeducation. Materials and methods. The theoretical analysis of modern scientific researches in the field of cognitive and affective impairments during epilepsy was carried out. We studied the features of clinical and psychopathological manifestations in patients, suffering from epilepsy. The study covered 146patients (85 men and 61 women) who were in inpatient care. The following psychodiagnostic techniques were used: the MOCA test, the Toronto Cognitive Assessment (TorCA), the MiniMult test, the Münsterberg test, the quality of life scale, the Hamilton scale of depression and anxiety. Results. This publication offers the results of a study of cognitive and affective disorders the quality of life in patients who suffer from epilepsy and the results of online cognitive training and psychoeducation. We found cognitive decline in 88% of patients with epilepsy and improvement of cognitive functions by methods of non-pharmacological correction. Conclusions. Affective and cognitive disorders significantly affects the quality of life of patients, their ability to work and socialization. The conducted research showed that compared to the control group of healthy persons, patients with epilepsy showed improvement in their cognitive decline, anxiety and depressive disorders. Cognitive online training appeared to be effective for the patients with epilepsy.

Basic mechanisms of, and treatment targets for, depressive disorders

2020 ◽  
pp. 779-788
Author(s):  
Marcela Pereira ◽  
Roberto Andreatini ◽  
Per Svenningsson
Keyword(s):  
Major Depressive Disorder ◽  
Immune System ◽  
Depressive Disorder ◽  
Affective Disorders ◽  
Sleep Disturbances ◽  
Depressive Disorders ◽  
Signs And Symptoms ◽  
Molecular Pathways ◽  
Therapy Targets ◽  
Gene Environment

The diagnosis of major depressive disorder (MDD) relies on the presence of a certain number of signs and symptoms, including feelings of guilt, hopelessness, dysphoria, cognitive dysfunction, persistent sleep, and appetite abnormalities. These signs and symptoms overlap with other conditions such as anxiety, bipolar, and seasonal affective disorders. This chapter provides an overview of the basic neurobiological mechanisms underlying MDD and its treatment. There are several alterations in the molecular pathways and neuronal networks associated with MDD. The chapter focuses here on: gene × environment interactions, dysfunctional brain circuitries, neurotransmitter alterations, maladaptation in neurotrophins and neuroplasticity, hypothalamus–pituitary–adrenal (HPA) axis dysfunction, abnormal immune system responses, circadian arrhythmicity, and sleep disturbances. The chapter briefly describes the mechanisms of actions for approved antidepressant therapies and also discusses recent insights into the pathophysiology of MDD and future possible therapy targets.

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