RELATIONSHIP BETWEEN METABOLIC AND IMMUNOLOGICAL INDICATORS AFTER CORRECTION BY ALLOGENIC HEPATOCYTES IN ACUTE TOXIC, ISCHEMIC AND ALCOHOL LIVER INJURY

2021 ◽  
Vol 1 (1) ◽  
pp. 27-37
Author(s):  
Е. S. Litvinova ◽  
A. I. Konoplya ◽  
I. M. Kholimenko ◽  
A. G. Kotsar’
Keyword(s):  
Immune System ◽  
Liver Diseases ◽  
Metabolic Disorders ◽  
Functional Organization ◽  
Metabolic Changes ◽  
The Body ◽  
Immune Disorders ◽  
Number Of Patients ◽  
Relationship Of ◽  
The Relationship

Immune disorders arising from liver damage of various origins and the mechanisms of their development are still poorly understood. The functions of the immune system are carried out against the background of metabolic processes and their shifts caused by the action of various agents on the body, as well as liver cells - hepatocytes. Typical metabolic changes that occur when the liver is affected by various toxic factors are combined with certain features of metabolic disorders in certain organs and tissues, due to the specifics of their structural and functional organization, the nature of the inducing agent and the primary link of its effect on cells and the body as a whole. The relationship of numerous metabolic changes, violations of the functional activity of hepatocytes arising in such a pathology with the dysfunction of the immune system has not yet been sufficiently studied, as well as the most effective methods of correction have not been established. Currently, the issues of pathogenesis, diagnosis and treatment of acute liver diseases remain among the most relevant in medicine, both due to the complexity of diagnosis and the choice of optimal treatment methods, and the tendency towards an increase in the number of patients with these diseases. The emergence and development of cellular technologies have created serious scientific prerequisites in this area.

scholarly journals Lipometabolism and Glycometabolism in Liver Diseases

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Hao-ran Ding ◽  
Jing-lin Wang ◽  
Hao-zhen Ren ◽  
Xiao-lei Shi
Keyword(s):  
Liver Disease ◽  
Liver Diseases ◽  
Metabolic Disorders ◽  
Liver Metabolism ◽  
Metabolic Changes ◽  
The Body ◽  
Pathological State ◽  
Metabolic Imbalance ◽  
Life Threatening ◽  
The Relationship

The liver is the main metabolic organ in the body especially in lipometabolism and glycometabolism. Carbohydrates and fats disorders can result in insulin resistance in the liver. Metabolic imbalance can even lead to life-threatening conditions. Therefore, it is essential to maintain the normal metabolic function of the liver. When the liver is in a pathological state, liver metabolism homeostasis is damaged, and metabolic disorders will further aggravate liver disease. Consequently, it is essential to determine the relationship between liver diseases and metabolic disorders. Here we review a lot of evidence that liver diseases are closely related to lipometabolism and glycometabolism. Although the disorder of the liver metabolism is caused by different liver diseases, the break of metabolic balance is determined by changes in the state of the liver. We discuss the relationship between liver disease and metabolic changes, outline the process of how metabolic changes are regulated by liver diseases, and describe the role which metabolic changes play in the process and prognosis of liver disease.

Subclinical hypothyroidism: treat or watch?

2021 ◽  
pp. 98-108
Author(s):  
I. A. Tsanava ◽  
S. V. Bulgakova ◽  
A. V. Melikova
Keyword(s):  
Thyroid Hormones ◽  
Subclinical Hypothyroidism ◽  
Metabolic Disorders ◽  
Reference Range ◽  
Cognitive Disorders ◽  
The Body ◽  
Relationship Of ◽  
The Relationship ◽  
Serum Tsh ◽  
Tsh Levels

Manifest hypothyroidism occurs in more than 5 % of the population, while prevalence of subclinical hypothyroidism is much higher and reaches 15 %. In the practice of an endocrinologist, in most cases, the diagnosis and treatment of manifest hypothyroidism does not raise questions, while subclinical changes in thyroid hormones quite often generate a lot of discussions. The generally accepted reference range for TSH up to 4.50 μIU / ml is in conflict with data showing that more than 95 % of healthy people with euthyroidism have serum TSH levels up to 2.5 μIU / ml. At the same time, a lot of data has been accumulated on the effect of even slightly altered levels of thyroid hormones and TSH on various tissues, organs and systems of the body, especially on the cardiovascular, nervous and reproductive systems. This review analyzes the results of studies aimed at studying the relationship of subclinical hypothyroidism with cardiovascular and metabolic disorders, cognitive disorders, pathology of pregnant women.

scholarly journals Clinical significance and features of laboratory determination of vitamin D

2020 ◽  
pp. 40-45
Author(s):  
L. B. Drygina
Keyword(s):  
Vitamin D ◽  
Liver Diseases ◽  
Calcium Metabolism ◽  
Active Form ◽  
The Body ◽  
Biological Factors ◽  
Relationship Of ◽  
The Relationship ◽  
Convincing Data

The classic function of vitamin D is to regulate calcium metabolism. Currently, however, convincing data have been obtained on the relationship of vitamin D deficiency with the development of a number of diseases. The article analyzes the results of recent studies that present the effects of vitamin D on the immune system, cardiovascular system and liver diseases. Discusses the mechanisms of admission of vitamin D in the body, presents new data on the regulation of levels of active form of vitamin D phosphatonins (FGF23, MEPE, sFRP-4) and protein Klotho. The characteristic of methods of determination of vitamin D in blood serum is presented. Biological factors that influence the results of quantitative determination of vitamin D with different methods are considered separately.

THE RELATIONSHIP OF MASS OF THE BODY, FISHERY LENGTH AND THE FISH – PRODUCTIVITY OF ONE-YEARS OF PIKEPERCH BY THE BREEDING THEM IN PONDS FOR CARPS

2017 ◽  
Vol 59 (2) ◽  
pp. 014-021
Author(s):  
Saya K. Koyshibaeva ◽  
◽  
Shokhan A. Alpeyisov ◽  
Evgeniy V. Fedorov ◽  
Nina S. Badryzlova ◽  
...  
Keyword(s):  
The Body ◽  
Relationship Of ◽  
The Relationship ◽  
Fish Productivity

Epilogue

2017 ◽  
Author(s):  
Joshua S. Walden
Keyword(s):  
The Body ◽  
The Self ◽  
The Individual ◽  
Relationship Of ◽  
The Relationship

The book’s epilogue explores the place of musical portraiture in the context of posthumous depictions of the deceased, and in relation to the so-called posthuman condition, which describes contemporary changes in the relationship of the individual with such aspects of life as technology and the body. It first examines Alfred Hitchcock’s Vertigo to view how Bernard Herrmann’s score relates to issues of portraiture and the depiction of the identity of the deceased. It then considers the work of cyborg composer-artist Neil Harbisson, who has aimed, through the use of new capabilities of hybridity between the body and technology, to convey something akin to visual likeness in his series of Sound Portraits. The epilogue shows how an examination of contemporary views of posthumous and posthuman identities helps to illuminate the ways music represents the self throughout the genre of musical portraiture.

The Psychology of Memory in Spenser's Faerie Queene

PMLA ◽  
1932 ◽  
Vol 47 (1) ◽  
pp. 89-96
Author(s):  
Daniel C. Boughner
Keyword(s):  
The Body ◽  
World City ◽  
Faerie Queene ◽  
Extended Treatment ◽  
Relationship Of ◽  
The Relationship ◽  
The Faerie Queene

From Plato and Aristotle, Hippocrates and Galen, through the medieval commentators, the Elizabethans inherited a body of complex psychological principles. An examination of these principles and their bearing on The Faerie Queene has so far been only casual and incidental. Since in Book ii, Canto ix, the poet combines one of the most widely used of medieval motifs—the conception of the body as a world, city, or castle—with certain current doctrines of psychology, such an inquiry is especially apposite. Spenser's use of the abundant contemporaneous literature of psychology affords material for an extended treatment such as that which Miss Anderson has made of Shakespeare's plays. The present study purposes to set forth one aspect of his system of psychology—his psychology of memory in the allegory of the Castle of Alma, to make clear the relationship of his system to the current Elizabethan doctrines, and to establish the purpose of certain departures from those doctrines.

The Materiality of the Text and Manuscript Culture

2021 ◽  
pp. 48-62
Author(s):  
Martin Eisner
Keyword(s):  
Human Person ◽  
Essential Element ◽  
The Body ◽  
Manuscript Culture ◽  
Christian Anthropology ◽  
Body And Soul ◽  
Christian Thought ◽  
Relationship Of ◽  
Materiality Of The Text ◽  
The Relationship

This article investigates the significance of the manuscripts of Virgil and other classical poets that Dante might have read. Calling attention to the presence of musical notation (neumes) in copies that share the particular Virgilian readings Dante quotes, this essay explores the resonance of one of those passages (Aeneas’ dream of Hector) in Dante’s poem. It shows how Dante uses this Virgilian episode to craft his encounter with Manfred where he considers the relationship of body and soul that constitutes one of the major differences between classical and Christian thought, as Augustine frequently noted. Just as Christian anthropology maintains that the body constitutes an essential element of the human person, this essay argues that the materiality of the texts Dante read constitutes a crucial source for understanding how Dante interpreted these texts.

The development of the lamb with particular reference to the alimentary tract

1964 ◽  
Vol 6 (2) ◽  
pp. 169-178 ◽  
Author(s):  
R. V. Large
Keyword(s):  
Body Weight ◽  
Alimentary Tract ◽  
Live Weight ◽  
The Body ◽  
Root Transformation ◽  
Feeding Regimes ◽  
Gut Fill ◽  
Relationship Of ◽  
The Relationship

1. Thirty Suffolk × Half bred lambs were slaughtered at the following ages: two twin lambs at birth and two singles and two twins at 1, 2, 3, 4, 6, 8 and 16 weeks of age.2. The following weights were recorded: live-weight immediately before slaughter; and carcass, head, skin, feet, alimentary tract, heart, liver, kidneys, lungs and trachea, and blood immediately afterwards.3. The alimentary tract was emptied and weighed in four separate parts; reticulo-rumen, omasum-abomasum, small intestine, large intestine.4. The volumes of the reticulo-rumen and the omasum-abomasum were measured by immersing in water and filling the organs with water to 2 cm. pressure.5. The in vitro digestive efficiency of rumen liquor from lambs of 1, 2, 3 and 4 weeks of age was assessed.6. Empty body weight was considered to be valuable in comparing animals of different ages or from different feeding regimes or at different times of the year because variations in gut ‘fill’ were eliminated.7. There were no differences between singles and twins in the relationship of the fresh weights of the parts of the body to empty body weight, except that development of the liver and the blood was rather slower for singles.8. Little evidence was found of a difference in rate of development of the alimentary tract between singles an d twins, although the log an d square root transformation suggested a possible difference in reticulo-rumen size in favour of twins, significant at the 5% level.

scholarly journals Frequency of non-motor symptoms in Peruvian patients with Parkinson's disease

2013 ◽  
Vol 71 (4) ◽  
pp. 216-219 ◽  
Author(s):  
Carlos Cosentino ◽  
Yesenia Nuñez ◽  
Luis Torres
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Progressive Increase ◽  
Motor Symptoms ◽  
Number Of Patients ◽  
Progression Of Disease ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship ◽  
Non Motor Symptoms

Introduction: Non-motor symptoms in Parkinson's disease are often not well recognized in clinical practice. Non-motor symptoms questionnaire (NMSQuest) is a simple instrument that allows patients or caregivers to report non-motor symptoms in a practical manner. Objective: We attempted to determine the prevalence of non-motor symptoms in three hundred Parkinson's disease outpatients. Results: The mean total non-motor symptoms was 12.41, ranging from 0 to 27 of a maximum of 30. At least one was present in 99.3% of patients. A progressive increase in mean total score was observed across each 5-year interval. Depression domain scored the most “positive” answers while urinary and anxiety /memory were secondly and thirdly most prevalent respectively. Conclusion: The large number of patients included in this study allowed evaluation of the occurrence of non-motor symptoms in early and advanced disease in addition to the relationship of these kinds of symptoms with progression of disease.

scholarly journals Relationship of Depression, Aging and Immune System During Covid-19 Pandemic: A Review

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Farah Iylia Binti Fauzi ◽  
Siti Fatimah Binti Salleh ◽  
Mohammad Shahadat Hossen
Keyword(s):  
Mental Health ◽  
Immune System ◽  
Elderly People ◽  
Social Isolation ◽  
Mental Health Problems ◽  
Preventive Measures ◽  
Coping Mechanisms ◽  
Depression And Anxiety ◽  
Relationship Of ◽  
The Relationship

COVID-19 is a highly contagious virus that first appeared in China in December 2019. It has affected over 157 million people and killed over 3.2 million. The paper reviews the function of the immune system for COVID-19 prevention, depression, and anxiety due to COVID-19 and their effects on the immune system and the relationship of aging with the immune system and depression and anxiety. It has been found that several elderly people lack the coping mechanisms required to deal with the stress caused by COVID-19. Hence, identifying the factors and mechanisms that lead to this resilience will aid in the development of preventive measures for certain elderly people and groups with more severe mental health problems. Additionally, it would be beneficial to understand how technology could be leveraged to accomplish this goal. During the pandemic, various steps such as social isolation, quarantine, and self-isolation are needed to be implemented properly to slow the spread of the virus. Meanwhile, to help halt the pandemic, everybody must be vaccinated as soon as possible until any bans on social gatherings and social isolation can be removed, allowing other sectors such as schooling, social activities, and life to resume normalcy.

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