scholarly journals Pengaruh Pemberian Kedelai terhadap Sistem Reproduksi

2019 ◽  
Vol 1 (1) ◽  
pp. 53-60
Author(s):  
Rizky Aprilia Wikayanti ◽  
Andre Parmonangan Panjaitan
Keyword(s):  
Menstrual Cycle ◽  
Reproductive System ◽  
Experimental Studies ◽  
Review Literature ◽  
Follicular Phase ◽  
Free Concentration ◽  
Human Reproductive ◽  
17Β Estradiol ◽  
Lh Secretion

Kedelai merupakan tanaman Leguminoceae, yang mengandung senyawa isoflavon. Struktur kimianya menyerupai 17β-estradiol yang memiliki kemampuan untuk berikatan dengan reseptor estrogen yang dapat berpengaruh terhadap sistem reproduksi manusia. Tujuan literatur review ini untuk mengetahui efek kedelai terhadap sistem reproduksi manusia. Metode yang digunakan adalah metode literatur review dari 50 artikel PubMed NCBI, Elsevier dan BMJ Journal yang diperoleh hanya 38 artikel yang digumakan dari tahun 2000 sampai dengan tahun 2018. Berbagai penelitian eksperimental yang dilakukan menunjukkan bahwa kedelai memiliki efek terhadap sistem reproduksi manusia. Kedelai dapat menyebabkan sekresi FSH, sekresi LH menurun dan meningkatkan konsentrasi estradiol bebas. Penurunan FSH dan LH dapat menyebabkan gangguan dalam siklus menstruasi terutama pada fase folikular dan  ovulasi, jika fase folikular terganggu maka siklus menstruasi akan menjadi  tidak teratur. Selain itu fitoestrogen yang terkandung dalam kedelai diketahui dapat menghambat 17-β hidroksisteroidoksidoreduktase sehingga mengakibatkan penurunan kadar testosteron.   Kata kunci: kedelai, manusia, reproduksi   THE ROLE OF SOYBEAN FOR REPRODUCTIVE SYSTEM   ABSTRACT Soybean is a Leguminoceae plant, which contains isoflavone compounds. Its chemical structure resembles 17β-estradiol which has ability to bind to estrogen receptors which can affect the human reproductive system. The purpose of this review literature is to determine the effect of soy on the human reproductive system. Using research articles and books related to the effect of soy on the reproductive system from 2000 to 2018. Various experimental studies conducted showed that soy has an effect on the human reproductive system. Soy can cause FSH secretion, decreased LH secretion and increasing the free concentration of estradiol. Decreased FSH and LH can cause disruption in the menstrual cycle, especially in the follicular phase and ovulation, if the follicular phase is disrupted then the menstrual cycle will become irregular. In addition, phytoestrogens contained in soy are known to inhibit 17-β hydroxysteroidoxidoreductase, resulting in a decrease in testosterone levels.   Keywords : human, reproductive, soybean

The effect of oxytocin administration upon the pulsatile secretion of luteinizing hormone in humans

1989 ◽  
Vol 121 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Janet A. Amico ◽  
Donald W. Richardson ◽  
Stephen J. Winters
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Follicular Phase ◽  
The Other ◽  
Healthy Men ◽  
Pulsatile Secretion ◽  
Oxytocin Infusion ◽  
Double Blinded ◽  
Lh Secretion ◽  
Synthetic Oxytocin

Abstract. The effect of iv administration of synthetic oxytocin upon the pulsatile pattern of LH secretion was studied in 5 healthy men and 10 healthy women. Five of the women were studied in the follicular phase of a menstrual cycle and the other 5 were studied in the luteal phase of a cycle. Synthetic oxytocin in 0.9% saline or saline alone was administered via continuous iv infusion for 8 h on 2 consecutive days. Infusions were administered using a double-blinded and radomized schedule. The rate of the oxytocin infusion commenced at 1 mU/min and was increased 1 mU/min every 40 min to a final rate of 12 mU/min. The plasma oxytocin concentration during oxytocin infusion ranged from 2–70 fmol/l. Blood for LH determination was sampled every 20 min in the 5 follicular phase women and every 10 min in the 5 men and 5 luteal phase women. The detect algorithm was used to analyze LH pulsatile secretion. Oxytocin infusion was without significant effect on mean LH, number of LH pulses, or area under the LH curve in men or women studied for the period of observation. Thus it is unlikely that increases in plasma oxytocin regulate the pulsatile secretion of LH in humans.

Brand equity, online reviews, and message trust: the moderating role of persuasion knowledge

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Fayez Ahmad ◽  
Francisco Guzmán
Keyword(s):  
Brand Equity ◽  
Experimental Studies ◽  
Online Reviews ◽  
Review Literature ◽  
Online Review ◽  
Persuasion Knowledge ◽  
Content Type ◽  
Mediating Role ◽  
The Relationship

Purpose This paper aims to investigate whether a message from a brand with stronger brand equity generates more trust than a message from a brand with lower brand equity, and thus is more likely to encourage consumers to write online reviews. This paper also explores what happens when consumers become aware that brands are trying to persuade them to write a review. Design/methodology/approach Through three experimental studies, where participants were randomly assigned to a brand that has either a stronger or weaker brand equity, participants’ intention to write reviews was measured. Trust in the message was measured to study its mediating role, and persuasion knowledge of the participants was manipulated to investigate its moderating effect. Findings The findings confirm that consumers are more likely to write online reviews when a message comes from a brand that has stronger brand equity, trust in the message mediates the relationship between brand equity and consumer intention to write an online review, and persuasion knowledge has a differential effect on consumer intention to write reviews. Originality/value The study adds to the brand equity and online review literature by providing evidence that a higher level of consumer trust on brands that have stronger brand equity leads to an increased intention to write a review for the brand. It also shows that consumers’ awareness of the motive of the brand is more beneficial for brands with strong brand equity, contributing to persuasion knowledge literature.

Differential effects of progesterone on secretion of gonadotropic hormones in the rhesus monkey

1981 ◽  
Vol 240 (5) ◽  
pp. E489-E492
Author(s):  
J. A. Resko ◽  
W. E. Ellinwood ◽  
E. Knobil
Keyword(s):  
Menstrual Cycle ◽  
Macaca Mulatta ◽  
Luteal Phase ◽  
Rhesus Macaques ◽  
Follicular Phase ◽  
Base Line ◽  
Inhibitory Effects ◽  
New Information ◽  
Lh Secretion ◽  
Gonadotropic Hormones

To obtain new information on the site of the inhibiting actions of progesterone (P) during the follicular phase of the cycle, we administered P continuously to 13 rhesus macaques (Macaca mulatta) from days 5 through 12 of the menstrual cycle. This treatment produced luteal-phase levels (approximately 6 ng/ml of serum) within 4 h. (FSH) concentrations dropped significantly from pretreatment amounts (P less than 0.01). During this time, both immunoreactive luteinizing hormone (LH) (n = 8 animals) and bioactive LH (n = 5) remained stable. The 17 beta-estradiol (E2) concentrations dropped significantly below base line 24 h after treatment (P less than 0.05). The decline in E2 occurred after the decline in FSH. Inhibition of FSH continued for 40 h, after which both FSH and LH rose steadily in a way that resembled a preovulatory surge on days 8 or 9 of the menstrual cycle, and then returned to base line by day 10. When gonadotropins were at their zenith, the ovary did not respond by secreting E2. None of the effects mentioned above were found in control animals treated with blank implants. These data demonstrate that P administered during the follicular phase inhibits FSH but not LH secretion. This initial inhibition probably occurs at a hypothalamic-pituitary site, but after 40 h direct inhibitory effects on the ovary cannot be ruled out. P stimulates the release of gonadotropin in female monkeys despite reduced production of E2 by the ovary.

scholarly journals Kisspeptins in physiology and pathology of sex development - new diagnostic and therapeutic approaches

2014 ◽  
Vol 12 (4) ◽  
pp. 3-12
Author(s):  
Irina Leorovna Nikitina ◽  
Alekber Azizovich Bayramov ◽  
Yuliya Nikolaevna Khoduleva ◽  
Petr Dmitriyevich Shabanov
Keyword(s):  
Reproductive System ◽  
Sexual Differentiation ◽  
System Development ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Sex Development ◽  
Human Reproductive ◽  
Modern Knowledge ◽  
The Brain

The article is dedicated to mechanisms of the human reproductive system development mechanisms. The evolution of the opinions on that processes was analysed. The review of modern knowledge of molecular and genetic causes of sex development, new mechanisms of gonadal axis regulation and role of kisspeptins in pubertat start and sexual differentiation of the brain are presented. The new actual directions of scientific research as well as the applications of kisspeptin drugs for new therapeutic approaches, treatment of hormone-dependent diseases and abnormalities of sex developmentare are observed.

scholarly journals Menstrual phase-dependent differences in neurobehavioral performance: the role of temperature and the progesterone/estradiol ratio

SLEEP ◽  
2019 ◽  
Vol 43 (2) ◽  
Author(s):  
Leilah K Grant ◽  
Joshua J Gooley ◽  
Melissa A St Hilaire ◽  
Shantha M W Rajaratnam ◽  
George C Brainard ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Cognitive Performance ◽  
Sex Hormones ◽  
Luteal Phase ◽  
Light Exposure ◽  
Sleep Loss ◽  
Follicular Phase ◽  
Menstrual Phase ◽  
Nighttime Light

Abstract Study objectives Women in the luteal phase of the menstrual cycle exhibit better cognitive performance overnight than women in the follicular phase, although the mechanism is unknown. Given the link between core body temperature (CBT) and performance, one potential mechanism is the thermoregulatory role of progesterone (P4), estradiol (E2), and their ratio (P4/E2), which change across the menstrual cycle. We examined the role of P4/E2 in modulating performance during extended wake in premenopausal women. Additionally, we compared the acute effects of nighttime light exposure on performance, CBT, and hormones between the menstrual phases. Methods Participants were studied during a 50 h constant routine and a 6.5 h monochromatic nighttime light exposure. Participants were 16 healthy, naturally cycling women (eight follicular; eight luteal). Outcome measures included reaction time, attentional failures, self-reported sleepiness, CBT, melatonin, P4, and E2. Results As compared to women in the luteal phase, women in the follicular phase exhibited worse performance overnight. CBT was significantly associated with performance, P4, and P4/E2 but not with other sex hormones. Sex hormones were not directly related to performance. Light exposure that suppressed melatonin improved performance in the follicular phase (n = 4 per group) to levels observed during the luteal phase and increased CBT but without concomitant changes in P4/E2. Conclusions Our results underscore the importance of considering menstrual phase when assessing cognitive performance during sleep loss in women and indicate that these changes are driven predominantly by CBT. Furthermore, this study shows that vulnerability to sleep loss during the follicular phase may be resolved by exposure to light.

scholarly journals The Effects of Menstrual Cycle Phase on Exercise Performance in Eumenorrheic Women: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 50 (10) ◽  
pp. 1813-1827 ◽  
Author(s):  
Kelly Lee McNulty ◽  
Kirsty Jayne Elliott-Sale ◽  
Eimear Dolan ◽  
Paul Alan Swinton ◽  
Paul Ansdell ◽  
...  
Keyword(s):  
Systematic Review ◽  
Menstrual Cycle ◽  
Effect Size ◽  
Exercise Performance ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Follicular Phase ◽  
Effect Sizes ◽  
Cycle Phase ◽  
Early Follicular Phase

Abstract Background Concentrations of endogenous sex hormones fluctuate across the menstrual cycle (MC), which could have implications for exercise performance in women. At present, data are conflicting, with no consensus on whether exercise performance is affected by MC phase. Objective To determine the effects of the MC on exercise performance and provide evidence-based, practical, performance recommendations to eumenorrheic women. Methods This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Four databases were searched for published experimental studies that investigated the effects of the MC on exercise performance, which included at least one outcome measure taken in two or more defined MC phases. All data were meta-analysed using multilevel models grounded in Bayesian principles. The initial meta-analysis pooled pairwise effect sizes comparing exercise performance during the early follicular phase with all other phases (late follicular, ovulation, early luteal, mid-luteal and late luteal) amalgamated. A more comprehensive analysis was then conducted, comparing exercise performance between all phases with direct and indirect pairwise effect sizes through a network meta-analysis. Results from the network meta-analysis were summarised by calculating the Surface Under the Cumulative Ranking curve (SUCRA). Study quality was assessed using a modified Downs and Black checklist and a strategy based on the recommendations of the Grading of Recommendations Assessment Development and Evaluation (GRADE) working group. Results Of the 78 included studies, data from 51 studies were eligible for inclusion in the initial pairwise meta-analysis. The three-level hierarchical model indicated a trivial effect for both endurance- and strength-based outcomes, with reduced exercise performance observed in the early follicular phase of the MC, based on the median pooled effect size (ES0.5 = − 0.06 [95% credible interval (CrI): − 0.16 to 0.04]). Seventy-three studies had enough data to be included in the network meta-analysis. The largest effect was identified between the early follicular and the late follicular phases of the MC (ES0.5 = − 0.14 [95% CrI: − 0.26 to − 0.03]). The lowest SUCRA value, which represents the likelihood that exercise performance is poor, or among the poorest, relative to other MC phases, was obtained for the early follicular phase (30%), with values for all other phases ranging between 53 and 55%. The quality of evidence for this review was classified as “low” (42%). Conclusion The results from this systematic review and meta-analysis indicate that exercise performance might be trivially reduced during the early follicular phase of the MC, compared to all other phases. Due to the trivial effect size, the large between-study variation and the number of poor-quality studies included in this review, general guidelines on exercise performance across the MC cannot be formed; rather, it is recommended that a personalised approach should be taken based on each individual's response to exercise performance across the MC.

scholarly journals Role of the novel cytokine IL-37 in inflammations and tumors of human reproductive system

2018 ◽  
Vol 2 (3) ◽  
Author(s):  
Zhao J ◽  
Qiu L ◽  
Xu Y ◽  
Guo Y ◽  
Li P ◽  
...  
Keyword(s):  
Reproductive System ◽  
The Novel ◽  
Human Reproductive

The menstrual cycle

2020 ◽  
pp. 500-510
Author(s):  
Lucy H.R. Whitaker ◽  
Karolina Skorupskaite ◽  
Jacqueline A. Maybin ◽  
Hilary O.D. Critchley
Keyword(s):  
Side Effects ◽  
Menstrual Cycle ◽  
Targeted Therapies ◽  
Reproductive System ◽  
Reproductive Tract ◽  
External World ◽  
Heavy Menstrual Bleeding ◽  
Female Reproductive System ◽  
Human Reproductive ◽  
Personalized Approach

The female human reproductive system comprises the hypothalamic–pituitary–ovarian axis and the reproductive tract (fallopian tubes, uterus, cervix, and vagina). The principal functions of this system are to produce an ovum, enable its fertilization and implantation, and allow growth and safe expulsion of the fetus into the external world. The menstrual cycle is critical for facilitation of the initial steps of this raison d’etre of the female reproductive system. As a greater understanding of the menstrual cycle biology is garnered, therapies that directly target pathways underpinning the regulation of normal and heavy menstrual bleeding are likely to emerge. Such future targeted therapies have the potential to offer a more personalized approach to management with minimization of undesirable side effects.

scholarly journals Estrogen receptor (ESR) 2 partially offsets the absence of ESR1 in gonadotropes of pituitary-specific Esr1 knockout female mice

Reproduction ◽  
2012 ◽  
Vol 143 (4) ◽  
pp. 549-558 ◽  
Author(s):  
José E Sánchez-Criado ◽  
Kourtney Trudgen ◽  
Yolanda Millán ◽  
Alfonso Blanco ◽  
José Monterde ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Pituitary Cells ◽  
Immunohistochemical Expression ◽  
Female Mice ◽  
Serum Lh ◽  
Pituitary Glands ◽  
17Β Estradiol ◽  
Lh Secretion ◽  
Estrogen Receptor 1

Estrogen receptor 1 and 2 (ESR1 and 2) mediate estrogen (E) action on gonadotrope function. While much is known about the effects of ESR1 on the gonadotrope, there is still some controversy regarding the effects of ESR2. To investigate the role of ESR2 in the gonadotrope, 45-day-old female mice of two different genotypes were used: wild type (WT) and pituitary (gonadotropes and thyrotropes)-specific Esr1 knockout (KO). All mice were ovariectomized (OVX) and 15 days later injected over 3 days with 2.5 μg 17β-estradiol (E2), 0.2 mg of the selective ESR1 or 2 agonists, propylpyrazole triol and diarylpropionitrile, respectively, or 0.1 ml oil. The day after treatment, anterior pituitary glands were dissected out for evaluation of gonadotrope ultrastructural morphology and pituitary immunohistochemical expression of progesterone receptor (Pgr (Pr)). Blood was collected and serum LH levels were assessed. Activation of ESR1 in WT mice resulted in the following: i) uterine ballooning and vaginal cornification, ii) negative feedback on LH secretion, iii) increased number of homogeneous (functional) gonadotropes, and iv) pituitary Pgr expression (35.9±2.0% of pituitary cells). Activation of ESR1 in KO mice induced normal uterine, vaginal, and LH secretion responses, but failed to increase the number of functional gonadotropes, and induced significantly lower Pgr expression (21.0±3.0% of pituitary cells) than in WT mice. Whilst activation of ESR2 had no significant effects in WT mice, it doubled the number of functional gonadotropes exhibited by KO mice injected with oil. It is concluded that E2 exerted its action in KO mouse gonadotropes via ESR2.

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