scholarly journals Potensi Kandungan Biji Anggur dalam Mempercepat Penyembuhan Luka

2020 ◽  
Vol 2 (2) ◽  
pp. 139-146
Author(s):  
Nadia Zulfa Firdaus ◽  
Asisther Avivo Alda ◽  
Ika Sari Gunawan
Keyword(s):  
Wound Healing ◽  
Vitis Vinifera ◽  
Subcutaneous Tissue ◽  
Grape Seed ◽  
The Body ◽  
Google Scholar ◽  
Vitis Vinifera L ◽  
Grape Seeds ◽  
Inflammatory Phase ◽  
Healing Wound

Luka adalah kondisi diskontinuitas skruktur anatomi jaringan tubuh mulai dari lapisan epitel kulit sampai lapisan jaringan subkutis, lemak, otot, tulang, serta struktur lain di sekitarnya seperti pembuluh darah, saraf, dan tendon akibat adanya trauma. Penyembuhan luka adalah proses dinamis yang meliputi unsur-unsur tubuh, pembuluh darah, fibroblast, dan sel epitel yang dirangkum dalam tiga fase utama yaitu fase inflamasi, fase proliferasi, dan fase maturasi. Biji anggur (Vitis vinifera L.) mengandung berbagai vitamin, karotenoid, senyawa polifenol, dan sterol yang menunjukkan efek menguntungkan pada penyembuhan luka. Tujuan dari tinjauan pustaka ini adalah untuk melaporkan temuan ilmiah terbaru tentang peran kandungan biji anggur dalam penyembuhan luka dengan sintesis kolagen, mencegah efek merusak dari radikal bebas, memastikan stabilitas dan integritas membran biologis, serta memproduksi kolagen yang mempercepat penyembuhan luka. Metode yang digunakan adalah metode literature searching melalui database NCBI dan Google Scholar. Tahun penerbitan sumber pustaka adalah dari tahun 2000 sampai tahun 2019 dengan 22 sumber pustaka. Tema yang dikumpulkan terkait dengan kandungan biji anggur terhadap penyembuhan luka. Hasil dari sintesis artikel yang telah ditemukan yaitu biji anggur bermanfaat dalam mempercepat penyembuhan luka. Kata kunci: biji anggur, penyembuhan luka, polifenol THE POTENTION OF GRAPE SEED TOWARD ACCELERATE HEALING WOUND ABSTRACT Wound is condition of discontinue anatomical structure of the body's tissue from the epithelial layer of the skin to the subcutaneous tissue layer, fat, muscle, bone, and other surrounding structures such as blood vessels, nerves, and tendons due to trauma. Wound healing is a dynamic process involving the body, fibroblasts, and epithelial cells which are summarized in three main phases, namely the inflammatory phase, the proliferation phase, and the maturation phase. Grape seeds (Vitis vinifera L.) contain various vitamins, carotenoids, polyphenol compositions, and sterols which have beneficial effects on wound healing. The purpose of this literature evaluation is to report the latest scientific findings on the role of grape seeds in wound recovery by collagen synthesis, prevent damage to free radicals, ensure and integrate biological membranes, and produce collagen that can repair wounds. The method used in this article is literature seacrhing through the NCBI database and Google Scholar. The year of reaching the library source is from 2000 to 2019 with 22 library sources. The theme collected is related to grape seeds on wound healing. The results of the synthesis of articles that have been found are grape seeds that are beneficial in improving wound healing.  Keywords: grape seed, healing wound, pholiphenol  

scholarly journals Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Foods ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 1360
Author(s):  
Maria E Martin ◽  
Elena Grao-Cruces ◽  
Maria C Millan-Linares ◽  
Sergio Montserrat-de la Paz
Keyword(s):  
Vitis Vinifera ◽  
Seed Oil ◽  
Grape Seed ◽  
Vitis Vinifera L ◽  
Grape Seeds ◽  
Wine Production ◽  
Food Industries ◽  
Grape Seed Oil ◽  
Antioxidant Effects

Wine production is an ancient human activity that generates several by-products, which include some constituents known for their potential in health care and for their role in the food or cosmetic industries. Any variety of grape (Vitis vinifera L.) contains nutrients and bioactive compounds available from their juice or solid parts. Grape seed extract has demonstrated many activities in disease prevention, such as antioxidant effects, which make it a potential source of nutraceuticals. Grape seed is a remarkable winery industry by-product due to the bioactivity of its constituents. Methods for recovery of oil from grape seeds have evolved to improve both the quantity and quality of the yield. Both the lipophilic and hydrophilic chemicals present in the oil of V. vinifera L. make this wine by-product a source of natural nutraceuticals. Food and non-food industries are becoming novel targets of oil obtained from grape seeds given its various properties. This review focuses on the advantages of grape seed oil intake in our diet regarding its chemical composition in industries not related to wine production and the economic and environmental impact of oil production.

scholarly journals Management of Chronic Non-Healing Wound using Ayurvedic drugs - A Case Study

2020 ◽  
Vol 11 (2) ◽  
pp. 337-341
Author(s):  
Hemanta Kumar Panigrahi
Keyword(s):  
Wound Healing ◽  
Subcutaneous Tissue ◽  
Oral Intake ◽  
Central Research Institute ◽  
Central Research ◽  
Ayurvedic Drugs ◽  
Superficial Wound ◽  
Healing Wound ◽  
Skin Loss ◽  
External Wound

Sushruta in 1st part of his compendium described about wound healing its types etc. as Vranitopasaniya adhyaya. Ayurveda described so many compound medicines and oil for oral administration and topical application to accelerate the wound healing. But this is not scientifically validated. So there is always a search for finding a newer and better medicine for wound healing. I am presenting a case of 42 year old married male with complain of superficial external wound with mild pain,  mal odour  and not healing  since 45 days in spite of taking allopathic conventional treatment in his lower limb. The study was done in my outpatient department of Central Research institute for cardiovascular disease, Punjabi Bagh, New Delhi. On examination it was found that surface area of superficial wound is 22.5 sq. cm. having full thickness, skin loss involving necrosis of subcutaneous tissue extended down to underlying fascia. Necessary laboratory investigations were done prior to initiate the treatment. The wound was irrigated with Panchvalkala kasaya and dressing with Jatyadi Tail was done daily followed by oral intake of Triphala guggulu 500mg twice in a day and Amalaki churna 6gm twice in a day was administered orally for 28th days. Periodic follow up was done on 0, 7, 14, and in 28 days. This regimen was found to be effective in faster wound epithelialization, and reducing wound exudates. There was no evidence of any allergic reaction as well as no evidence showing any adverse event on the wound.

scholarly journals Flavanol Glycoside Content of Grape Seeds and Skins of Vitis vinifera Varieties Grown in Castilla-La Mancha, Spain

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 4001 ◽  
Author(s):  
José Pérez-Navarro ◽  
Guillaume Cazals ◽  
Christine Enjalbal ◽  
Pedro Miguel Izquierdo-Cañas ◽  
Sergio Gómez-Alonso ◽  
...  
Keyword(s):  
Vitis Vinifera ◽  
High Performance ◽  
Grape Seed ◽  
Grape Seeds ◽  
Grape Berries ◽  
La Mancha ◽  
Liquid Chromatography Tandem Mass ◽  
Grape Varieties ◽  
Grape Seed Extracts ◽  
Seed Extracts

Glycosylated flavanols (monoglycosides and diglycosides) in skin and seed extracts of Vitis vinifera grapes grown in Castilla-La Mancha (Spain) were investigated using ultra-high-performance liquid chromatography—tandem mass spectrometry (UHPLC-ESI-QQQ-MS/MS). Six grape varieties (Airén, Tempranillo, the recently identified Albillo Dorado, Montonera del Casar, Moribel, and Tinto Fragoso) were studied over two consecutive years (2016 and 2017). A total of twenty monomeric flavanol monoglycosides, four diglycosylated monomers, and three dimeric flavanol monoglycosides were detected in all grape samples. The diversity observed in the composition of glycosylated flavanol in the grape berries suggests a strong influence of variety and grape tissue (skin or seed). Monomeric flavanol glycosides were more abundant in grape seed extracts, in contrast with monoglycosylated dimeric forms. In addition, the glycosylated flavanol content was related to berry color in grape skins, with higher concentrations measured in black grape varieties.

scholarly journals Resveratrol-enriched grape seed oil (Vitis vinifera L.) protects from white fat dysfunction in obese mice

2019 ◽  
Vol 62 ◽  
pp. 103546
Author(s):  
Mohammed Mahanna ◽  
Maria C. Millan-Linares ◽  
Elena Grao-Cruces ◽  
Carmen Claro ◽  
Rocío Toscano ◽  
...  
Keyword(s):  
Vitis Vinifera ◽  
Seed Oil ◽  
Grape Seed ◽  
Vitis Vinifera L ◽  
Obese Mice ◽  
Grape Seed Oil ◽  
White Fat

Phenolic composition and physicochemical parameters of Carménère, Cabernet Sauvignon, Merlot and Cabernet Franc grape seeds (Vitis vinifera L.) during ripening

LWT ◽  
2012 ◽  
Vol 48 (1) ◽  
pp. 134-141 ◽  
Author(s):  
Elías Obreque-Slier ◽  
Remigio López-Solís ◽  
Lorena Castro-Ulloa ◽  
Cristian Romero-Díaz ◽  
Álvaro Peña-Neira
Keyword(s):  
Vitis Vinifera ◽  
Physicochemical Parameters ◽  
Vitis Vinifera L ◽  
Cabernet Sauvignon ◽  
Phenolic Composition ◽  
Grape Seeds ◽  
Cabernet Franc

Inhibitory effect of phenolic compounds from grape seeds (Vitis vinifera L.) on the activity of angiotensin I converting enzyme

LWT ◽  
2013 ◽  
Vol 54 (1) ◽  
pp. 265-270 ◽  
Author(s):  
Joana Afonso ◽  
Cláudia P. Passos ◽  
Manuel A. Coimbra ◽  
Carlos M. Silva ◽  
Patrício Soares-da-Silva
Keyword(s):  
Phenolic Compounds ◽  
Vitis Vinifera ◽  
Inhibitory Effect ◽  
Vitis Vinifera L ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Grape Seeds ◽  
Angiotensin I Converting Enzyme

scholarly journals Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome

2008 ◽  
Vol 34 (2) ◽  
pp. 162-184 ◽  
Author(s):  
Sashwati Roy ◽  
Savita Khanna ◽  
Cameron Rink ◽  
Sabyasachi Biswas ◽  
Chandan K. Sen
Keyword(s):  
Wound Healing ◽  
Receptor Interaction ◽  
Cutaneous Wound Healing ◽  
Wound Edge ◽  
Cutaneous Wound ◽  
Rapid Induction ◽  
Inflammatory Phase ◽  
Genes Encoding ◽  
Oxidative Phosphorylation Pathway ◽  
Healing Wound

This work represents a maiden effort to systematically screen the transcriptome of the healing wound-edge tissue temporally using high-density GeneChips. Changes during the acute inflammatory phase of murine excisional wounds were characterized histologically. Sets of genes that significantly changed in expression during healing could be segregated into the following five sets: up-early (6–24 h; cytokine-cytokine receptor interaction pathway), up-intermediary (12–96 h; leukocyte-endothelial interaction pathway), up-late (48–96 h; cell-cycle pathway), down-early (6–12 h; purine metabolism) and down-intermediary (12–96 h; oxidative phosphorylation pathway). Results from microarray and real-time PCR analyses were consistent. Results listing all genes that were significantly changed at any specific time point were further mined for cell-type (neutrophils, macrophages, endothelial, fibroblasts, and pluripotent stem cells) specificity. Candidate genes were also clustered on the basis of their functional annotation, linking them to inflammation, angiogenesis, reactive oxygen species (ROS), or extracellular matrix (ECM) categories. Rapid induction of genes encoding NADPH oxidase subunits and downregulation of catalase in response to wounding is consistent with the fact that low levels of endogenous H2O2is required for wound healing. Angiogenic genes, previously not connected to cutaneous wound healing, that were induced in the healing wound-edge included adiponectin, epiregulin, angiomotin, Nogo, and VEGF-B. This study provides a digested database that may serve as a valuable reference tool to develop novel hypotheses aiming to elucidate the biology of cutaneous wound healing comprehensively.

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