New Method for Simultaneous Determination of Ascorbic and Acetylsalicylic Acids in Effervescent Tablets

2017 ◽  
Vol 68 (11) ◽  
pp. 2495-2598 ◽  
Author(s):  
Simona Bungau ◽  
Delia Mirela Tit ◽  
Ciprian Iovan ◽  
Lucian Copolovici ◽  
Rica Boscencu ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Acetylsalicylic Acid ◽  
Type Systems ◽  
Pharmaceutical Drugs ◽  
Important Goal ◽  
Mixture Ratio ◽  
Real Concentration ◽  
Preliminary Separation ◽  
Set Up

The determination of the real concentration in different pharmaceutical drugs represents a very important goal of the pharmaceutical industry. The main aim of the study was to set up a simple, cheap and rapid method in order to determine both ascorbic and acetylsalicylic acid content of effervescent tablets that could be found on the pharmaceutical market, without preliminary separation or extraction. For this purpose, a very simple and reliable clock method based on two Landolt-type systems of reactions, based on potentiometric techniques, has been developed. The method has been tested on different effervescent tablets which contain ascorbic acid and acetylsalicylic acid in different mixture ratio.

SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN, ACETYLSALICYLIC ACID AND ASCORBIC ACID IN TABLET FORM USING HPLC

1999 ◽  
Vol 15 (2-3) ◽  
Author(s):  
Cemal Akay ◽  
Bülent Gümüsel ◽  
Tuncer Degim ◽  
Senol Tartılmıs ◽  
S. Cevheroglu
Keyword(s):  
Ascorbic Acid ◽  
Acetylsalicylic Acid ◽  
Simultaneous Determination ◽  
Tablet Form

scholarly journals A Simple and Cost-Effective TLC-Densitometric Method for the Quantitative Determination of Acetylsalicylic Acid and Ascorbic Acid in Combined Effervescent Tablets

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3115 ◽  
Author(s):  
Alina Pyka-Pająk ◽  
Małgorzata Dołowy ◽  
Wioletta Parys ◽  
Katarzyna Bober ◽  
Grażyna Janikowska
Keyword(s):  
Ascorbic Acid ◽  
Quantitative Determination ◽  
Acetylsalicylic Acid ◽  
High Performance ◽  
Limit Of Detection ◽  
Volume Ratio ◽  
Cost Effective ◽  
Pharmaceutical Formulations ◽  
Limit Of Quantification

A new, simple, and cost-effective TLC-densitometric method has been established for the simultaneous quantitative determination of acetylsalicylic acid and ascorbic acid in combined effervescent tablets. Separation was performed on aluminum silica gel 60F254 plates using chloroform-ethanol-glacial acid at a volume ratio of 5:4:0.03 as the mobile phase. UV densitometry was performed in absorbance mode at 200 nm and 268 nm for acetylsalicylic acid and ascorbic acid, respectively. The presented method was validated as per ICH guidelines by specificity, linearity, accuracy, precision, limit of detection, limit of quantification, and robustness. Method validations indicate a good sensitivity with a low value of LOD and LOQ of both examined active substances. The linearity range was found to be 1.50–9.00 μg/spot and 1.50–13.50 μg/spot for acetylsalicylic and ascorbic acid, respectively. A coefficient of variation that was less than 3% confirms the satisfactory accuracy and precision of the proposed method. The results of the assay of combined tablet formulation equal 97.1% and 101.6% in relation to the label claim that acetylsalicylic acid and ascorbic acid fulfill pharmacopoeial requirements. The developed TLC-densitometric method can be suitable for the routine simultaneous analysis of acetylsalicylic acid and ascorbic acid in combined pharmaceutical formulations. The proposed TLC-densitometry may be an alternative method to the modern high-performance liquid chromatography in the quality control of above-mentioned substances, and it can be applied when HPLC or GC is not affordable in the laboratory.

Using AuCo alloy nanoparticles/HS-graphene modified electrode for the selective determination of dopamine, ascorbic acid and uric acid

2014 ◽  
Vol 6 (22) ◽  
pp. 9059-9065 ◽  
Author(s):  
Zhe Liu ◽  
Xueliang Wang ◽  
Li Sun ◽  
Zhangyu Yu
Keyword(s):  
Ascorbic Acid ◽  
Uric Acid ◽  
Modified Electrode ◽  
Electrochemical Method ◽  
Alloy Nanoparticles ◽  
Selective Determination ◽  
Set Up

An electrochemical method for the selective determination of dopamine (DA), ascorbic acid (AA) and uric acid (UA) was set up using an AuCo alloy nanoparticle/HS-graphene modified electrode.

scholarly journals Simultaneous Determination of Ascorbic Acid and Acetylsalicylic Acid in Pharmaceutical Formulations

2001 ◽  
Vol 84 (1) ◽  
pp. 37-42 ◽  
Author(s):  
M Ines Toral ◽  
Nelson Lara ◽  
Pablo Richter ◽  
Andres Tassara ◽  
A E Tapia ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Standard Deviation ◽  
Acetylsalicylic Acid ◽  
Simultaneous Determination ◽  
Analytical Signal ◽  
Pharmaceutical Formulations ◽  
Zero Crossing ◽  
First Derivative ◽  
Methanolic Hydrochloric Acid

Abstract A direct, simple, and practical first-derivative spectrophotometric method is described for simultaneous determination of ascorbic acid and acetylsalicylic acid. The effects of the solvent, excipients, and spectral variables on the analytical signal were investigated. The drugs were determined simultaneously with a 0.01M methanolic hydrochloric acid solution as the solvent, and the signals were evaluated directly by using the zero-crossing method at 245.0 and 256.0 nm for acetylsalicylic acid and ascorbic acid, respectively. The method allows the simultaneous determinations of acetylsalicylic acid and ascorbic acid in the ranges of 6.6 × 10−6 to 1.5 × 10−4M and 3.4 × 10−6 to 2.0 × 10−4M, respectively, with standard deviation of <2.0%. The proposed method was applied to determinations of these drugs in tablets.

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