Clinical and Biochemical Considerations Regarding Stress and Arrhythmic Risk in Patients with Chronic Viral Liver Diseases

The prevalance of depression and anxiety is higher at the patients diagnosticated with viral liver disease. The corelation between stress and chronic liver disease is a natural, implicit one, but still insufficiently studied. The study has the objective of finding out the clinical and also biochemical correlations between stress and chronic viral diseases. Our research was realised on a group of 78 patients with chronic viral liver disease, who underwent an evaluation of the stress level, both from a subjective point of view and based on concrete methods like questionnaires. The patients were asked to espress their state more or less affected by stress, and, subsequently, they were subjected to a questionnaire that was analyzed, followed by establishing the necessary correlations. Our patients were also evaluated by cardiologicaly, psychologicaly and psyhiatricaly examinations. After the first evaluation we had these results :38 patients (49.19%) consider that they have an average stress level, 18 patients (22.58%) have a high stress level. Only 22 patients (28.22%) declared stress was at a low level. We divided the pacients in two groups, function of Qt (questionare total score) results and we observed that a number of 38 patients ( 49.19%) registered �Qt 20 and 40 patients (50.81%) had Qt � 20, 63 patients (50.81%).We found a strong correlation between the patients� subjective evaluation of the stress level and the objective evaluation of stress level according to the used questionnaire, which confirms the objectivity of our study. We found a direct corelation, with a morphological, biochemical and functional support between stress and the arrhythmia risk in the evolution of chronic liver disease. We consider very important a complex examination psychiatricaly, psychologicaly and cardiological of the pacients diagnosticated with viral liver disease in order to help them and to prevent arrhythmic events, depression, anxiety and other mood disorders.

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Quality of life in patients with chronic liver disease

Vojnosanitetski pregled ◽

10.2298/vsp160616339p ◽

2018 ◽

Vol 75 (5) ◽

pp. 453-460

Author(s):

Dusan Popovic ◽

Darija Kisic-Tepavcevic ◽

Nada Kovacevic ◽

Tamara Milovanovic ◽

Miodrag Krstic ◽

...

Keyword(s):

Quality Of Life ◽

Liver Disease ◽

Chronic Liver Disease ◽

Short Form ◽

Chronic Liver ◽

Depression And Anxiety ◽

Behavioral Factors ◽

Sf 36 ◽

Composite Scores

Background/Aim. Quality of life is impaired in patients with the chronic liver disease (CLD). Patients with this disease have numerous disabling problems which lead to a reduced health related quality of life (HRQoL). The aim of our study was to evaluate the predictive value of selected socio-demographic and clinical characteristics on HRQoL in Serbian cohort of patients with the CLD. Methods. Over a period of one year, we performed a study which included patients with the CLD. We used Short Form Health Survay-36 (SF-36) for assessment of HRQoL. The assessment of depression and anxiety was made by using Hamilton scale of depression and anxiety, while the assessment of fatigue was performed by Fatigue severity scale. Results. The study included 103 patients with the CLD. The average values of the overall SF-36 scores were 52.6 ? 20.4, while the mean score of the composite scores were 53.5 ? 19.6 for the Mental component summary and 49.8 ? 21.3 for the Physical component summary. Some domains of HRQoL were significantly affected by following factors: gender, age, employment status, alcohol consumption, depression, anxiety and fatigue. Predictors of physical components of HRQoL were employment, depression and fatigue, and predictors of mental components were depression and fatigue. Conclusion. The tested socio-demographic, clinical and behavioral factors have an impact on the HRQoL in patients with the CLD. The most important predictors of HRQoL are behavioral factors suggesting the need for an adequate therapeutic action in order to improve the HRQoL in these patients.

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Immunological Impact of Whey Protein on Peripheral Blood Mononuclear Cells of Patients with Chronic Liver Disease

Current Nutrition & Food Science ◽

10.2174/1573401317666210216113801 ◽

2021 ◽

Vol 17 ◽

Author(s):

Yani Gláucia Gomide Mizubuti ◽

Maria Isabel Toulson Davisson Correia ◽

Thales Antônio da Silva ◽

Simone de Vasconcelos Generoso ◽

Antônio Lúcio Teixeira ◽

...

Keyword(s):

Liver Disease ◽

Chronic Liver Disease ◽

Whey Protein ◽

Peripheral Blood ◽

Mononuclear Cells ◽

High Stress ◽

Chronic Liver ◽

Similar Response ◽

Peripheral Blood Mononuclear ◽

Cytokine Levels

Background: Recent in vitro studies point to the immune properties of milk proteins. Objective: To investigate the immunomodulating properties of whey protein isolate (WHEY) compared to those of casein (CAS) on peripheral blood mononuclear cell (PBMC) death and supernatant cytokine levels in chronic liver disease (CLD) patients and healthy individuals. Method: The role of WHEY on the immune cells was evaluated under stimulated and non-stimulated conditions to determine cellular death and cytokine production, post-exposure with 40, 400 or 4.000 μg mL-1 of WHEY or CAS. Flow cytometry was used to identify the monocyte and lymphocyte population. Cytokines were measured from the supernatants of 24 hour-old PBMC cultures. Results: Compared to CAS, WHEY significantly decreased lymphocyte death at 4.000 μg mL-1 in both groups of individuals with no effects on the monocyte population regardless of the group. At the same concentration (4.000 μg mL-1), WHEY increased TNF and IL-10 cytokine levels in the stimulated PBMC supernatant from CLD patients. Conclusion: Compared to CAS, WHEY exerted immunomodulating effects in CLD patients. Similar response may be anticipated for other pathological conditions in which high stress and immune dysfunction are present.

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The Interstitial Lymphatic Peritoneal Mesothelium Axis in Portal Hypertensive Ascites: When in Danger, Go Back to the Sea

International Journal of Inflammation ◽

10.4061/2010/148689 ◽

2010 ◽

Vol 2010 ◽

pp. 1-18 ◽

Cited By ~ 11

Author(s):

M. A. Aller ◽

I. Prieto ◽

S. Argudo ◽

F. de Vicente ◽

L. Santamaría ◽

...

Keyword(s):

Portal Hypertension ◽

Liver Disease ◽

Chronic Liver Disease ◽

Ischemia Reperfusion ◽

Lymph Flow ◽

Point Of View ◽

Chronic Liver ◽

Low Grade ◽

Extrahepatic Cholestasis ◽

Peritoneal Mesothelium

Portal hypertension induces a splanchnic and systemic low-grade inflammatory response that could induce the expression of three phenotypes, named ischemia-reperfusion, leukocytic, and angiogenic phenotypes.During the splanchnic expression of these phenotypes, interstitial edema, increased lymph flow, and lymphangiogenesis are produced in the gastrointestinal tract. Associated liver disease increases intestinal bacterial translocation, splanchnic lymph flow, and induces ascites and hepatorenal syndrome. Extrahepatic cholestasis in the rat allows to study the worsening of the portal hypertensive syndrome when associated with chronic liver disease. The splanchnic interstitium, the mesenteric lymphatics, and the peritoneal mesothelium seem to create an inflammatory pathway that could have a key pathophysiological relevance in the production of the portal hypertension syndrome complications. The hypothetical comparison between the ascitic and the amniotic fluids allows for translational investigation. From a phylogenetic point of view, the ancestral mechanisms for amniotic fluid production were essential for animal survival out of the aquatic environment. However, their hypothetical appearance in the cirrhotic patient is considered pathological since ultimately they lead to ascites development. But, the adult human being would take advantage of the potential beneficial effects of this “amniotic-like fluid” to manage the interstitial fluids without adverse effects when chronic liver disease aggravates.

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Impairment of health-related quality of life in functional dyspepsia and chronic liver disease: the influence of depression and anxiety

Alimentary Pharmacology & Therapeutics ◽

10.1111/j.1365-2036.2008.03619.x ◽

2008 ◽

Vol 27 (7) ◽

pp. 561-571 ◽

Cited By ~ 26

Author(s):

S. HAAG ◽

W. SENF ◽

W. HÄUSER ◽

S. TAGAY ◽

D. GRANDT ◽

...

Keyword(s):

Quality Of Life ◽

Liver Disease ◽

Chronic Liver Disease ◽

Functional Dyspepsia ◽

Chronic Liver ◽

Depression And Anxiety ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Assessment of depression and anxiety in patients with chronic liver disease

Vojnosanitetski pregled ◽

10.2298/vsp130904007p ◽

2015 ◽

Vol 72 (5) ◽

pp. 414-420 ◽

Cited By ~ 5

Author(s):

Dusan Popovic ◽

Djordje Culafic ◽

Darija Kisic-Tepavcevic ◽

Nada Kovacevic ◽

Milan Spuran ◽

...

Keyword(s):

Liver Disease ◽

Gastrointestinal Bleeding ◽

Chronic Liver Disease ◽

Serum Potassium ◽

Mean Corpuscular Volume ◽

Rating Scale ◽

Chronic Liver ◽

Corpuscular Volume ◽

Depression And Anxiety ◽

The Mean

Background/Aim. In recent years mental health of patients including those with chronic liver disease (CLD), has become interesting because its disturbance leads to reduced quality of life, that is associated with worsening of clinical outcome, reduced compliance and increased mortality. The aim of the study was to determinate the frequency and severity of depression and frequency of anxiety in patients with CLD and to assess the contribution of selected socio-demographic, clinical and laboratory risk factors for depression and anxiety. Methods. In this cross-sectional study, we used the Hamilton depression rating scale (HDRS) and Hamilton anxiety rating scale (HARS) in patients with CLD. Results. The study included 54 male and 43 female patients. Depression was present in 62.9%, and anxiety in 13.4% of the patients. A higher HDRS was noted in the patients older than 50 years (p = 0.022) and unemployed patients (p = 0.043). The patients with at least one episode of gastrointestinal bleeding had a significantly higher frequency of anxiety than those without bleeding (p = 0.018). A higher HARS score was present in the women (p = 0.011), unemployed patients (p = 0.008) and those with non-alcoholic liver disease (p = 0.007). There was a significant correlation between the mean corpuscular volume (MCV) and the value of the HDRS score, and between serum potassium and sodium levels and HDRS score. Conclusion. Age and the mean corpuscular volume have significant influence on the HDRS score while unemployment, gastrointestinal bleeding, serum potassium and serum sodium have predictive value for HARS score.

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