scholarly journals Breast Cancer Diagnosis and Treatment Wait Times in Specialized Diagnostic Units Compared with Usual Care: A Population-Based Study

2020 ◽  
Vol 27 (4) ◽  
pp. 377-385
Author(s):  
C. Webber ◽  
M. Whitehead ◽  
A. Eisen ◽  
C.M.B. Holloway ◽  
P.A. Groome
Keyword(s):  
Breast Cancer ◽  
Usual Care ◽  
Early Stage ◽  
Breast Cancer Diagnosis ◽  
Population Based ◽  
Cross Sectional Study ◽  
Coordinated Care ◽  
Cross Sectional ◽  
Treatment Interval ◽  
Diagnostic Interval

Background：Breast assessment sites (bass) were developed to provide expedited and coordinated care for patients being evaluated for breast cancer (bca) in Ontario. We compared the diagnostic and treatment intervals for patients diagnosed at a bas and for those diagnosed through a usual care (uc) route. Methods: This population-based, cross-sectional study of patients diagnosed with bca in Ontario during 2007–2015 used linked administrative data. “Diagnostic interval” was the time from the earliest cancer-related health care encounter before diagnosis to diagnosis; “treatment interval” was the time from diagnosis to treatment. Diagnosis at a (bas was determined from the patient’s biopsy and mammography institutions. Interval lengths for the (bas and uc groups were compared using multivariable quantile regression, stratified by detection method. Results: The diagnostic interval was shorter for patients who were (bas-diagnosed than for those who were uc-diagnosed, with adjusted median differences of −4.0 days [95% confidence interval (ci): −3.2 days to −4.9 days] for symptomatic patients and −5.4 days (95% ci: −4.7 days to −6.1 days) for screen-detected patients. That association was modified by stage at diagnosis, with larger differences in patients with early-stage cancers. In contrast, the treatment interval was longer in patients who were (bas-diagnosed than in those who were uc-diagnosed, with adjusted median differences of 4.2 days (95% ci: 3.8 days to 4.7 days) for symptomatic patients and 4.2 days (95% ci: 3.7 days to 4.8 days) for screen-detected patients. Conclusions: Diagnosis of bca through a (bas was associated with a shorter diagnostic interval, but a longer treatment interval. Although efficiencies in the diagnostic interval might help to reduce distress experienced by patients, the longer treatment intervals for patients who are (bas-diagnosed remain a cause for concern.

Evaluation of ER, PR, HER2 / neu Receptor Status in Breast Cancer - A Cross Sectional Study from Manipur

2021 ◽  
Vol 8 (29) ◽  
pp. 2595-2600
Author(s):  
Themthingla Zimik ◽  
Angelica Laiphrakpam ◽  
Deepa Longjam ◽  
Sushila Devi L
Keyword(s):  
Breast Cancer ◽  
Early Stage ◽  
Public Awareness ◽  
Progesterone Receptors ◽  
Cross Sectional Study ◽  
Correct Treatment ◽  
Cross Sectional ◽  
Duct Carcinoma ◽  
Treatment Protocols ◽  
Screening Programs

BACKGROUND Breast cancer is the most common cancer in women worldwide and has surpassed cervical cancer in India. As a result of regular mammography screening programs and public awareness, early-stage breast cancer with better prognosis has occurred. Immunohistochemistry (IHC) is now a common practice in tumour evaluation which are of importance in diagnosis as well as for deciding the treatment and of prediction of prognosis in breast cancer. The present study was undertaken in view of correlating the histopathology of the tumour and IHC profile with respect to oestrogen receptor (ER), progesterone receptor (PR) and HER2 / neu. METHODS The study is a cross-sectional prospective analysis of patients with primary carcinoma of breast who are undergoing surgery over a period of 2 years from September 2017 to August 2019. All specimens were processed and stained with haematoxylin and eosin and immunohistochemistry was done for oestrogen and progesterone receptors and HER 2neu. RESULTS A total of 20 cases of breast carcinoma specimens were studied, whose age ranged from 24 - 72 years of age. All the 20 cases occurred in females. Infiltrating duct carcinoma was the most histological subtype noted in this study comprising 85 % (17 / 20) of cases. In the study 50 % (10/20) of the cases showed ER / PR positivity with negative HER2 / neu while 15 % (3/15) of cases were negative for ER / PR and HER2 / neu and only one case showed positivity for all three markers. 10 cases (50 %) had lymph node metastases in this study. CONCLUSIONS Breast cancer is the most commonly diagnosed malignancy in Indian women and is also the leading cause of cancer death in women worldwide. Assessment of receptor (ER, PR and HER – 2 / neu) status along with histopathological grading and staging will guide the clinicians to impart a correct treatment protocols to the patients. It will also be of great help in assessing the prognosis. KEYWORDS Breast Cancer, Histopathology, Immunohistochemistry

scholarly journals Relationship of fatigue with depressive symptoms and level of physical activity in women with breast cancer diagnosis

2020 ◽  
Vol 22 ◽  
Author(s):  
Luciana Beatriz Bosi Mendonça de Moura Matoso ◽  
Leonessa Boing ◽  
Thainá Korpalski ◽  
Mirella Dias ◽  
Jéssica Moratelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Depressive Symptoms ◽  
Clinical Information ◽  
Breast Cancer Diagnosis ◽  
Cross Sectional Study ◽  
Short Version ◽  
Cross Sectional ◽  
Oncology Research ◽  
Severe Fatigue

Abstract Breast cancer is the most frequent in women, resulting in fatigue and depressive symptoms as consequence of treatment, but physical activity can help in this process. The aim of this study was to investigate the relationship between fatigue, depressive symptoms and practice of physical activity of women with breast cancer during treatment or after cancer treatment. This is a cross-sectional study with 179 women (56.89 ± 9.4 years) from the Oncology Research Center - CEPON, using questionnaire on general and clinical information, fatigue (Piper Fatigue Scale) depressive symptoms (Beck Depression Inventory) and physical activity (IPAQ - short version). Women with moderate to severe fatigue underwent physiotherapy (p = 0.001) and women with no fatigue had minimum depressive symptoms (p ?0.001). Level of physical activity was not associated with fatigue, with most women being insufficiently active and women with mild fatigue had longer walking time than those without fatigue (p = 0.049). Women with depressive symptoms were almost three times more likely of having mild to severe fatigue and those who underwent physiotherapy were twice as likely of having mild to severe fatigue. Women with fatigue had greater presence of depressive symptoms. Professionals working in the field of oncology should recommend the practice of physical activity in order to minimize the side effects of treatment and observe depressive symptoms and fatigue in these women.

scholarly journals Prevalence of Cervical Intra Epithelial Neoplasia (CIN) among the sexually active married Women at Rajshahi Division

2019 ◽  
Vol 33 (1) ◽  
pp. 17-20
Author(s):  
Jesmin Shahela ◽  
Najnin Monira ◽  
Ashrafunnesa ◽  
Afroz Romana ◽  
Sarkar Mousumi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Early Stage ◽  
Population Based ◽  
Cross Sectional Study ◽  
Married Women ◽  
Sexually Active ◽  
Cross Sectional ◽  
Socioeconomic Condition ◽  
Normal Cervix ◽  
Good Number

Background: Cervical cancer is 4th most common cancer in women in the world and the most common form of cancer in women in developing countries. Population based cervical cancer screening and treatment of intraepitheial neoplasia in early stage can reduce morbidity and mortality associated with cervical cancer. To determine the prevalence of cervical intra epithelial neoplasia (CIN) among sexually active and married women in Rajshahi Division of Bangladesh. Place and Duration: This population based cross sectional study was carried out in 4 selected Upazilla from 4 different districts of Rajshahi Division from 1st December 2014 to 31st May 2015. Study on 1050 sexually active women between 25 to 55 years of age who fulfilled the inclusion criteria enrolled in the study after taking the consent. Result: Among 1050 enrolled women 90 (8.5%) were VIA positive and 91 were colposcopically abnormal and among them 33 were CIN positive & 58 had chronic cervictis with or without squamorus metaplasia. Mean age of CIN positive women was 36.75 years, 92.2% were housewife & 7.8% were service holder and in 64.6% women education level was up to XII class. In fifty five percent of their husband was day labouer from poor socioeconomic condition. Conclusion: VIA and Colopscopy can differentiate a normal cervix from a precancerous cervix with reasonable accuracy. Till now a good number of studies had been carried out in different countries of world and it is now well established that sensitivity of the test is very good. From the present study we can conclude that it will give a very good information about the prevalence of CIN in our country and by proper management of the CIN cases the incidence of carcinoma cervix can be reduced. Bangladesh J Obstet Gynaecol, 2018; Vol. 33(1) : 17-20

scholarly journals Breast Cancer in Men: Clinical and Pathological Analysis of 817 Cases

2020 ◽  
Vol 14 (4) ◽  
pp. 155798832090810
Author(s):  
Fernanda Servidoni Spreafico ◽  
Cassio Cardoso-Filho ◽  
Cesar Cabello ◽  
Luis Otávio Sarian ◽  
Luiz Carlos Zeferino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Prevalence Ratio ◽  
Breast Cancer Diagnosis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Histological Types ◽  
The Mean ◽  
Breast Cancer In Men

The objective of the current study was to describe breast cancer cases in men according to age, stage, and histology, calculating risks compared to women. It is a retrospective cross-sectional study of all breast cancer cases of the Hospital Cancer Registry of São Paulo state, Brazil, 2000–2015. Variables were age, sex, stage, and histology. Absolute numbers and proportions, Mann–Whitney test and prevalence ratio with 95% confidence interval were used. The study included 93,737 cases, of which 817 were males. The mean age at diagnosis was 60.3 years in men and 56.2 years in women ( p < .001). Stage II was the most common in both sexes (33.9% in men and 36.5% in women). Men had a higher frequency of stage III than women (PR 1.18, 95% CI 1.01–1.37). Stage 0 was significantly more common in women (PR 0.69, 95% CI 0.51–0.94). Ductal carcinoma and its variants were the most common histological types in both sexes (88.7% in men and 89.0% in women). Men had a higher frequency of rarer histological types such as papillary (PR 2.17, 95% CI 1.36–3.44) and sarcomas (PR 4.10, 95% CI 1.86–9.01). In conclusion, in men, breast cancer diagnosis occurred in more advanced ages and stages. Invasive ductal carcinoma was the primary histological type observed, although rarer types were more frequent.

Long-term outcome of cardiac function in a population-based cohort of breast cancer survivors: A cross-sectional study

2017 ◽  
Vol 81 ◽  
pp. 56-65 ◽  
Author(s):  
Liselotte M. Boerman ◽  
Saskia W.M.C. Maass ◽  
Peter van der Meer ◽  
Jourik A. Gietema ◽  
John H. Maduro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiac Function ◽  
Breast Cancer Survivors ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Term Outcome ◽  
Cross Sectional ◽  
Long Term Outcome

Mindfulness and concerns about adjuvant endocrine therapy (AET).

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e23170-e23170
Author(s):  
Norah Lynn Henry ◽  
Eli Iacob ◽  
Kathi Mooney ◽  
Eric Garland
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Treatment Satisfaction ◽  
Early Stage ◽  
Cross Sectional Study ◽  
Present Moment ◽  
Five Facet Mindfulness Questionnaire ◽  
Dispositional Mindfulness ◽  
Cross Sectional ◽  
Improve Compliance

e23170 Background: Poor adherence to AET for early stage breast cancer is associated with increased recurrence and mortality. Interventions to improve adherence have been minimally effective. Mindfulness is paying attention on purpose in the present moment with an attitude of openness and acceptance. In this cross-sectional study, we examined clinicopathologic, and psychosocial factors, including dispositional mindfulness, associated with increased concerns about medication. Methods: Women with stage 1-3 breast cancer who had taken at least one dose of AET within 2 years of enrollment completed questionnaires to examine medication beliefs (Beliefs about Medication Questionnaire), symptoms (FACT-ES), treatment satisfaction (Treatment Satisfaction Questionnaire for Medication II), and mindfulness (Five Facet Mindfulness Questionnaire-15). Descriptive statistics were used for demographic and clinical variables. Linear regression was used to examine the associations between medication concerns and both treatment satisfaction and mindfulness measures. Results: Of the 101 enrolled patients, 43 were taking tamoxifen, 46 an aromatase inhibitor (AI), and 12 had discontinued AET; average time on AET was 11 months (SD 6.3). 32% had stage 2 disease and 22% had stage 3. Concerns about medications was moderately negatively correlated with mindfulness (ρ = -0.349, p < 0.001). In the baseline model, medication concerns were associated with increased side effects but not with age at diagnosis, stage, or current AET status. When controlling for age, stage, current AET status, and side effects, there was a trend towards increased mindfulness and decreased medication concerns. Conclusions: Dispositional mindfulness may be associated with fewer concerns about medication. If mindfulness is shown to influence medication adherence, interventions such as mindfulness training to improve compliance with AET could be investigated.

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