Determination of gluten immunogenic peptides for the management of the treatment adherence of celiac disease: A systematic review

Background. Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. Our aim is to establish a risk gradient for celiac disease based on HLA-DQ profile in a brazilian representative population and the relevance of DQ2.2 in celiac disease development. Materials and Methods. 237 celiac patients and 237 controls (both groups with 164 females and 73 males) were included. All samples were tested for the presence of predisposing HLA-DQ alleles using the PCR-SSP method. Results were considered significant when p<0.05. Disease risk was expressed as 1 : N for each HLA-DQ category described at this study. Results. DQ2.5 and/or DQ8 were detected in 224 celiac patients (94.5%) and 84 controls (35.4%). Eight celiac patients (3.4%) and 38 controls (16%) disclosed only DQ2.2. Even though DQ2.2 (β2/β2 or β2/x) showed a low CD risk of 1 : 251 and 1 : 550, respectively, the genotype DQ2.5/DQ2.2 (β2/β2) showed high CD risk of 1 : 10 (p<0.0001). The disease risk gradient ranged from 1 : 3014 to 1 : 7. Conclusion. Our study allowed the determination of a risk gradient for celiac disease development in at-risk population, showing that DQ2.2 variant was relevant when associated with DQ2.5.

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Dynamics and Considerations in the Determination of the Excretion of Gluten Immunogenic Peptides in Urine: Individual Variability at Low Gluten Intake

Nutrients ◽

10.3390/nu13082624 ◽

2021 ◽

Vol 13 (8) ◽

pp. 2624

Author(s):

Laura Coto ◽

Carolina Sousa ◽

Angel Cebolla

Keyword(s):

Celiac Disease ◽

False Negative ◽

Individual Variability ◽

Lateral Flow Immunoassay ◽

Gluten Free ◽

Negative Results ◽

Immunogenic Peptides ◽

False Negative Results ◽

Healthy Participants

Background: A lifelong strict gluten-free diet is the only available treatment for celiac disease, but total exclusion of gluten is difficult to achieve. The aim of this study was to determine the range of time and the amount of gluten immunogenic peptides (GIP) excreted in urine after specific gluten ingestions. Methods: 20 healthy participants followed the same diet for 12 days in which 50 mg and 2 g of gluten were ingested and all the urinations were collected. GIP were analyzed by lateral flow immunoassay (LFIA) tests and quantified using an LFIA reader. Results: GIP were detected in 15% and 95% of participants after 50 mg and 2 g gluten intakes, respectively. The higher frequency and concentration of GIP was found between 6 and 9 h after both gluten ingestions. The ranges of detection were 3–12 h (50 mg) and 0–15 h (2 g). Conclusions: An increase in the frequency of urine tests may be a suitable approach to avoid false negative results. The use of the LFIA test in three urine samples collected at different times may show a sensitivity of 19.6% for a gluten ingestion like 50 mg, increasing to 93% after 2 g consumption.

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Diagnostic Accuracy of IgA Anti-Transglutaminase and IgG Anti-Deamidated Gliadin for Diagnosis of Celiac Disease in Children under Two Years of Age: A Systematic Review and Meta-Analysis

Nutrients ◽

10.3390/nu14010007 ◽

2021 ◽

Vol 14 (1) ◽

pp. 7

Author(s):

Giulia N. Catassi ◽

Alfredo Pulvirenti ◽

Chiara Monachesi ◽

Carlo Catassi ◽

Elena Lionetti

Keyword(s):

Systematic Review ◽

Celiac Disease ◽

Diagnostic Accuracy ◽

Sensitivity And Specificity ◽

Meta Analysis ◽

Statistical Significance ◽

Intestinal Biopsy ◽

Igg Antibodies ◽

Gliadin Peptide

The need of adding the determination of anti-deamidated gliadin peptide (DGP) IgG to anti-transglutaminase (TTG) IgA antibodies for diagnosis of celiac disease (CD) in children <2 years of age is controversial. We performed a systematic review and meta-analysis to evaluate, by head-to-head comparison, the diagnostic accuracy of TTG IgA and DGP IgG antibodies. We searched PubMed, MEDLINE, and Embase databases up to January 2021. The diagnostic reference was intestinal biopsy. We calculated the sensitivity and specificity of these tests and the odds ratio (OR) between the tests. Fifteen articles were eligible for the systematic review and ten were eligible for the meta-analysis. Sensitivity and specificity were 0.96 (95% confidence interval (CI), 0.91–0.98) and 0.96 (95% CI, 0.85–0.99) for DGP IgG and 0.93 (95% CI, 0.88–0.97) and 0.98 (95% CI, 0.96–0.99) for TTG IgA, respectively. TTG IgA specificity was significantly higher (OR 9.3 (95% CI, 2.3–37.49); p < 0.001) while the sensitivity of DGP IgG was higher without reaching statistical significance (OR: 0.6 (95% CI, 0.24–1.51); p = 0.28). Both the meta-analysis and the systematic review showed that some children with early CD are missed without the DGP IgG test. In children <2 years of age, TTG IgA is the best CD screening test; however, the addition of DGP IgG may increase the diagnostic sensitivity.

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The association between ectopic pregnancy and inflammatory bowel disease, irritable bowel syndrome, and celiac disease: A systematic review

Journal of Obstetrics and Gynaecology Research ◽

10.1111/jog.14705 ◽

2021 ◽

Author(s):

Jonah I. R. Talavera ◽

Allison M. Parrill ◽

Chris Elsayad ◽

Joshua Fogel ◽

John C. Riggs ◽

...

Keyword(s):

Systematic Review ◽

Inflammatory Bowel Disease ◽

Irritable Bowel Syndrome ◽

Celiac Disease ◽

Ectopic Pregnancy ◽

Bowel Disease ◽

Inflammatory Bowel ◽

Irritable Bowel

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A Systematic Review of Replicative Self-Determination Intervention Studies

The Journal of Special Education ◽

10.1177/0022466919850188 ◽

2019 ◽

Vol 54 (1) ◽

pp. 29-39

Author(s):

John L. Luckner ◽

Rashida Banerjee ◽

Sara Movahedazarhouligh ◽

Kaitlyn Millen

Keyword(s):

Systematic Review ◽

Intervention Studies ◽

Self Determination ◽

Future Research ◽

Replication Studies ◽

Research Designs ◽

Replication Research ◽

Quality Of Research

Current federal legislation emphasizes the use of programs, interventions, strategies, and activities that have been demonstrated through research to be effective. One way to increase the quantity and quality of research that guides practice is to conduct replication research. The purpose of this study was to undertake a systematic review of the replication research focused on self-determination conducted between 2007 and 2017. Using methods used by Cook and colleagues, we identified 80 intervention studies on topics related to self-determination, of which 31 were coded as replications. Intervention study trends, rate of replication studies, percentage of agreements between findings of original and replication studies, amount of author overlap, and types of research designs used are reported along with recommendations for future research.

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Safety of Adding Oats to a Gluten-Free Diet for Patients With Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies

Gastroenterology ◽

10.1053/j.gastro.2017.04.009 ◽

2017 ◽

Vol 153 (2) ◽

pp. 395-409.e3 ◽

Cited By ~ 37

Author(s):

María Inés Pinto-Sánchez ◽

Natalia Causada-Calo ◽

Premysl Bercik ◽

Alexander C. Ford ◽

Joseph A. Murray ◽

...

Keyword(s):

Systematic Review ◽

Celiac Disease ◽

Observational Studies ◽

Meta Analysis ◽

Gluten Free Diet ◽

Gluten Free

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Descriptive Study of the Different Tools Used to Evaluate the Adherence to a Gluten-Free Diet in Celiac Disease Patients

Nutrients ◽

10.3390/nu10111777 ◽

2018 ◽

Vol 10 (11) ◽

pp. 1777 ◽

Cited By ~ 5

Author(s):

Luis Rodrigo ◽

Isabel Pérez-Martinez ◽

Eugenia Lauret-Braña ◽

Adolfo Suárez-González

Keyword(s):

Celiac Disease ◽

Multidisciplinary Approach ◽

Descriptive Study ◽

Duodenal Mucosa ◽

Gluten Free Diet ◽

Gluten Free ◽

Autoimmune Process ◽

Duodenal Biopsies

Celiac disease (CD) is a genetically conditioned autoimmune process that appears in susceptible people. It can affect people of any age, and slightly predominates in females. It has a fairly homogenous global distribution, with an average prevalence of 1–2%, the frequency having increased in recent decades. The only effective treatment is a strict and permanent gluten-free diet (GFD), although the level of compliance is poor, at about 50% of cases. To monitor the effectiveness of the GFD, several procedures involving various approaches are employed: (a) Periodic visits by expert Nutritionists; (b) Clinical follow-up; (c) Serological time controls of specific antibodies; (d) Serial endoscopies with collection of duodenal biopsies; (e) Use of structured questionnaires; and (f) Determination of gluten peptides derived from gluten in faeces and/or urine. All of these procedures are useful when applied, alone or in combination, depending on the cases. Some patients will only need to consult to their doctors, while others will require a multidisciplinary approach to assess their compliance with the GFD. In children, normalization of duodenal mucosa was achieved in 95% of cases within two years, while it is more delayed in adults, whose mucosa take longer time (3–5 years) to heal completely.

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A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease

PLoS ONE ◽

10.1371/journal.pone.0241156 ◽

2021 ◽

Vol 16 (3) ◽

pp. e0241156

Author(s):

Fazel Isapanah Amlashi ◽

Zahra Norouzi ◽

Ahmad Sohrabi ◽

Hesamaddin Shirzad-Aski ◽

Alireza Norouzi ◽

...

Keyword(s):

Systematic Review ◽

Helicobacter Pylori ◽

Celiac Disease ◽

Publication Bias ◽

Meta Analysis ◽

Protective Role ◽

Negative Association ◽

Risk Of Bias ◽

Control Group ◽

Synthesis Methods

Background and objectives Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CeD and human H. pylori colonization. Data sources Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated. Synthesis methods Meta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed. Results Twenty-six studies were included in this systematic review, with a total of 6001 cases and 135512 control people. The results of meta-analysis on 26 studies showed a significant and negative association between H. pylori colonization and CeD (pooled OR = 0.56; 95% CI = 0.45–0.70; P < 0.001), with no publication bias (P = 0.825). The L’Abbé plots also showed a trend of having more H. pylori colonization in the control group. Among subgroups, ORs were notably different only when the data were stratified by continents or risk of bias; however, subgroup analysis could not determine the source of heterogeneity. Conclusions According to the meta-analysis, this negative association might imply a mild protective role of H. pylori against celiac disease. Although this negative association is not strong, it is statistically significant and should be further considered. Further investigations in both molecular and clinic fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of H. pylori colonization in CeD patients. Systematic review registration number (PROSPERO) CRD42020167730 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=167730.

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Accuracy of recommended sampling and assay methods for the determination of plasma-free and urinary fractionated metanephrines in the diagnosis of pheochromocytoma and paraganglioma: a systematic review

Endocrine ◽

10.1007/s12020-017-1300-y ◽

2017 ◽

Vol 56 (3) ◽

pp. 495-503 ◽

Cited By ~ 34

Author(s):

Roland Därr ◽

Matthias Kuhn ◽

Christoph Bode ◽

Stefan R. Bornstein ◽

Karel Pacak ◽

...

Keyword(s):

Systematic Review ◽

Assay Methods

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Psychosocial interventions to improve HIV treatment adherence: A systematic review

10.31234/osf.io/a5pcj ◽

2021 ◽

Author(s):

Stefanella Costa-Cordella ◽

Alejandra Rossi ◽

Aitana Grasso-Cladera ◽

Javiera Duarte ◽

Claudia P. Cortes

Keyword(s):

Systematic Review ◽

Treatment Adherence ◽

Peer Support ◽

Psychosocial Interventions ◽

Hiv Treatment ◽

People Living With Hiv ◽

Individual Counselling ◽

Suboptimal Adherence ◽

Study Designs

Introduction: The problem of suboptimal adherence to antiretroviral treatment (ART) can be overcome through multidisciplinary management that includes evidence-based psychosocial interventions. Existing reviews focus only on randomized controlled trials, overlooking valuable interventions whose evidence comes from different study designs. This review aimed to synthesize the current state of the art in psychological interventions for ART adherence, integrating studies with a variety of research designs.Methods: We conducted a systematic review following PRISMA guidelines. We searched five databases for articles reporting a psychosocial intervention to improve treatment adherence for people living with HIV. The quality of each study was analyzed, and the data summarized using a narrative synthesis method.Results and discussion: Twenty-six articles were identified for inclusion. Individual counselling was the most common intervention, followed by peer-support based interventions delivered virtually or in person. Most interventions mixed different strategies, combining technology with individual counselling and peer support. It is important to note that the quality of evidence was not dependent on the study design.Conclusion: While the evidence requires further advancement, the review provides insight into which psychosocial interventions are helpful in improving ART treatment adherence.

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