scholarly journals Rationale for a New Outpatient Drug Therapy Algorithm in COVID-19 Patients Based on the Principle of «Multi-hit» Approach

2021 ◽  
Vol 66 (3-4) ◽  
pp. 49-61
Author(s):  
K. A. Zykov ◽  
E. A. Sinitsyn ◽  
A. V. Rvacheva ◽  
A. O. Bogatyreva ◽  
A. A. Zykova ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Practical Experience ◽  
Mechanisms Of Action ◽  
Multiple Exposure ◽  
Therapy Algorithm ◽  
Medical Institutions ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Complex Algorithm ◽  
Outpatient Drug

The aim of the work was to justify the algorithm of outpatient drug therapy in patients with COVID-19, based on the principle of «Multi-hit» Approach. The algorithm is based on the published results of clinical studies and observations, authors’ own practical experience in the use and management of more than 4 thousand patients diagnosed with COVID-19 of varying severity during the 2020 pandemic. The article substantiates a complex algorithm for the treatment of outpatients with COVID-19, which includes etiotropic, pathogenetic, and symptomatic components of therapy with different mechanisms of action. The described approach is the 1st stage (outpatient) of a complex algorithm for managing patients with COVID-19. It has been successfully implemented in the system of outpatient care for patients with novel coronavirus infections in several leading medical institutions in Russia. The authors believe that the developed algorithm for providing outpatient drug therapy for COVID-19, based on the principle of multiple exposure, may be useful in real clinical practice of managing patients with coronavirus infection.

Possible benefits of reformulating antiviral drugs with nanoemulsion system in the treatment of novel coronavirus infection

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Manish Kumar ◽  
Chandra Prakash Jain
Keyword(s):  
Drug Delivery ◽  
Drug Therapy ◽  
Pulmonary Surfactant ◽  
Antiviral Drug ◽  
Treatment Strategies ◽  
Drug Dosage ◽  
Antiviral Drugs ◽  
Antiviral Action ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Background: An outbreak of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection or COVID 19, causing serious threats to all around the world. Until an effective and safe vaccine for novel coronavirus is developed by scientists, current drug therapy should by optimize for the control and treatment of COVID 19. Objective: In this manuscript, we are presenting a perspective on possible benefits of reformulating antiviral drug dosage form with nanoemulsion system against novel coronavirus infection. Methods: Literature review has been done on COVID 19, treatment strategies, novel drug delivery systems and role of pulmonary surfactant on lungs protection. Results: Nanoemulsion system and its components have certain biophysical properties which could increase the efficacy of drug therapy. Antiviral drugs, delivered through a nanoemulsion system containing P-gp inhibitor (surfactant and cosolvent), can inhibit the cellular resistance to drugs and would potentiate the antiviral action of drugs. Pulmonary surfactant (PS) assisted antiviral drug delivery by nanoemulsion system could be another effective approach for the treatment of COVID 19. Use of functional excipients like pulmonary surfactant (PS) and surfactant proteins (SPs), in the formulation of the antiviral drug-loaded nanoemulsion system can improve the treatment of coronavirus infection. Conclusion: In our opinion for synergizing antiviral action, lipid and protein portion of PS and their commercial analogs should be explored by pharmaceutical scientists to use them as a functional excipient in the formulation of antiviral drugloaded nanoemulsion system.

Current state and trends of occupational incidence in the Samara region

2021 ◽  
pp. 58-64
Author(s):  
Sergey Anatolievich Babanov
Keyword(s):  
Occupational Diseases ◽  
Biological Factor ◽  
Working Population ◽  
Permanent Disability ◽  
Current State ◽  
Medical Institutions ◽  
Working Age ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Medical Examinations

At present, the preservation and strengthening of the health of the working population is one of the priority tasks of health care in the Russian Federation, including in the Samara region. Up to 39.7 % of the country's working-age population work in conditions that do not meet sanitary and hygienic requirements. Unsatisfactory working conditions are the main reason for the development of occupational diseases among the working population in the Samara region. 42 acute occupational diseases with permanent disability, including 13 acute occupational diseases with fatal outcomes from the biological factor «novel coronavirus infection caused by the COVID-19 virus», are registered in the workers of medical institutions. In the Samara region, there is a low detection rate of occupational diseases revealed in the course of preventive medical examinations — 43.08 %, this figure remains below the national average — 59.31 %.

scholarly journals Opportunities of the therapist in prevention and at the rehabilitation stage after new coronaviral infection (COVID-19) in comorbid patients with arterial hypertension

2021 ◽  
Vol 2 (5) ◽  
pp. 6-15
Author(s):  
Dmitry I. Trukhan ◽  
◽  
Evgeny L. Davydov ◽  
Natalia A. Chusova ◽  
Innokenty S. Chusov ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Integrated Approach ◽  
Adverse Outcomes ◽  
The Novel ◽  
Comorbid Conditions ◽  
Vulnerable Group ◽  
Medical Institutions ◽  
Rehabilitation Period ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Comorbid patients are the most vulnerable group for the novel coronavirus infection (COVID-19), spread by the SARS-CoV-2 virus, which has a particularly high risk of adverse outcomes. The problem of managing comorbid patients in a pandemic requires an integrated approach aimed both at optimal management of comorbid conditions in patients who are in self-isolation and forced limitation of visits to medical institutions, and at the management of comorbid conditions in patients with COVID-19. Acquired since March 2020, when WHO announced the COVID-19 pandemic, global clinical experience in managing patients with a new coronavirus infection highlights a number of other pressing issues, especially for comorbid patients. These include issues of specific and nonspecific prophylaxis, as well as the supervision of comorbid patients in the rehabilitation period, especially in the framework of the post-COVID syndrome. This review addresses the issues of specific and non-specific prophylaxis of COVID-19, and also discusses the possibilities of indapamide and nitrendipine for the treatment of comorbid patients with arterial hypertension during a pandemic, and in patients with postcoid syndrome at the re-abiding stage.

scholarly journals Seasonal flu shot and the COVID-19 pandemic: don’t miss the last chance

2020 ◽  
Vol 4 (11) ◽  
pp. 687-690
Author(s):  
A.L. Zaplatnikov ◽  
◽  
A.A. Girina ◽  
E.I. Burtseva ◽  
V.I. Svintsitskaya ◽  
...  
Keyword(s):  
Key Factors ◽  
Positive Effects ◽  
Flu Vaccination ◽  
Medical Institutions ◽  
Seasonal Flu ◽  
Coronavirus Infection ◽  
Flu Shot ◽  
Novel Coronavirus ◽  
Low Coverage ◽  
Russian Medical

This article addresses the data on flu vaccination in the coronavirus disease 2019 (COVID-19) pandemic. It was demonstrated that flu vaccination decreases the incidence and rate of severe influenza. The result is the significant reduction in the rate of the referral to medical care and less workload of all divisions of medical institutions (i.e., outpatient and inpatient departments, first aid and emergency, laboratories etc.). This decreases the burden on health care system and preserves forces to fight the COVID-19 pandemic. The positive effects of flu vaccination on the morbidity, severity, and outcomes from COVID-19 are highlighted. The authors also focus on the low coverage of flu vaccination as one of the key factors of the inadequate preventive efficacy of immunization. The authors provide their own findings on the low coverage of flu vaccination (6.9%) among the children with laboratory verified influenza who were admitted to hospital. Considering an unfavorable situation with the spread of coronavirus infection, the activities aimed at the increase in the coverage of flu vaccination should be promptly accelerated. KEYWORDS: vaccination, flu, novel coronavirus infection, pandemic, COVID-19, seasonal flu shot. FOR CITATION: Zaplatnikov A.L., Girina A.A., Burtseva E.I., Svintsitskaya V.I. Seasonal flu shot and the COVID-19 pandemic: don’t miss the last chance. Russian Medical Inquiry. 2020;4(11):687–690. DOI: 10.32364/2587-6821-2020-4-11-687-690.

scholarly journals Trauma rates in children in the period of restrictive measures related to the spread of the new coronavirus infection (COVID-19)

2021 ◽  
Vol 9 (1) ◽  
pp. 5-16
Author(s):  
Olga A. Kuptsova ◽  
Anna V. Zaletina ◽  
Sergey V. Vissarionov ◽  
Alexey G. Baindurashvili ◽  
Avtandil G. Mikava ◽  
...  
Keyword(s):  
Outpatient Surgery ◽  
City Hospital ◽  
Mary Magdalene ◽  
Sports Events ◽  
Health Authorities ◽  
Medical Institutions ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Limb Fractures ◽  
Restrictive Measures

BACKGROUND: Due to the spread of the novel coronavirus infection (COVID-19) and the introduction of restrictive measures to prevent its spread, there has been a change in the organization and work of medical institutions. New rules for admitting patients with injuries, limiting hospitalization of planned patients, examining patients for coronavirus infection, examining parents of children with injuries, conducting remote consultations, and identifying areas without COVID-19 for repeated outpatient care have been introduced in trauma centers and hospitals. New conditions for the organization and functioning of outpatient and inpatient departments have had an impact on the picture of child trauma. AIM: This study aims to conduct a comparative analysis of the level and nature of musculoskeletal injuries in children who sought medical care during the COVID-19 pandemic and injuries that occurred during the same period of the previous year. MATERIALS AND METHODS: The analysis of the medical history data of 3820 patients aged 0 to 17 years, who were admitted to the City Center for Outpatient Surgery and Trauma of St. Petersburg St. Mary Magdalene Childrens City Hospital No. 2 during the period from March 16, 2020, to May 31, 2020, and for the same period in 2019. RESULTS: The number of initial visits with trauma in 2019 was 2851 patients, whereas during the same period in 2020, 969 patients came with trauma. In general, during the study period in 2020, the trauma rate decreased by 66% compared with the same period in 2019. Despite the general decrease in the level of injuries in the study period in 2020, in the injured structures of the musculoskeletal system, the proportion of limb fractures was 35% and exceeded the same indicator in 2019 (p = 0.004, 2 criterion). In 2020, the level of street injuries (p 0.0001) decreased by 83%, while there was a 61% increase in domestic injuries (p 0.0001) and a 47% increase in traffic injuries (p 0.0001). CONCLUSION: The relationship between the outbreak of a pandemic and a decrease in the number of visits to the trauma center of Childrens Hospital No. 2 was revealed and a change in the structure of injuries depending on their cause. This change may be associated with restrictive measures, the transfer to distance learning, the ban on organized sports events, and the reduced usage of playgrounds. This information can be useful for planning the work of health authorities and distributing resources during future pandemic situations.

Experience in Applying Hyperbaric Oxygen Therapy Using Portable Pressure Chambers for the Treatment of Patients with the Novel Coronavirus Infection COVID-19

Biomeditsina ◽  
2020 ◽  
pp. 39-46
Author(s):  
A. S. Samoilov ◽  
Yu. D. Udalov ◽  
M. V. Sheyanov ◽  
A. V. Gholinsky ◽  
A. B. Litvinenko
Keyword(s):  
Oxygen Saturation ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Capillary Blood ◽  
Blood Hemoglobin ◽  
Patient Groups ◽  
Radiological Changes ◽  
Coronavirus Infection ◽  
Novel Coronavirus

This communication presents the experience of using mobile pressure chambers in patients with the confi rmed novel coronavirus infection in hospital settings. The obtained preliminary results indicate positive antihypoxic effects of hyperbaric oxygen therapy (HBO) applied in the form of increased saturation. After a session of HBO, patients demonstrated an increase in the oxygen saturation of capillary blood hemoglobin at the average level of 3.71 points. Differences between SatO2 levels prior to and following HBO treatment were signifi cant in the CT2, CT3 and CT4 groups (p0.05). As expected, the effi cacy of HBO in terms of the oxygen saturation of capillary blood hemoglobin was the greatest in the patient groups showing pronounced clinical and radiological changes in the lungs.

Review on Efficacy of Herbal Antiviral Drugs against COVID-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1116-1121
Author(s):  
Pooja P. Thakre ◽  
Vinod Ade ◽  
Shweta Parwe
Keyword(s):  
Physical Contact ◽  
Research Articles ◽  
Herbal Drugs ◽  
Plant Origin ◽  
Respiratory Pathway ◽  
Traditional Medicines ◽  
The Past ◽  
Primary Health ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Coronavirus disease (CoViD-19) is an infection of the respiratory system caused due to various viruses affects the respiratory pathway, and it can spread from one person to another by coughing, sneezing or physical contact. Commonly include cough, cold, fever are the symptoms. Viral diseases increase worldwide concern, including emerging and chronic viruses. The invention of new anti-viral drugs from plants has implicit in the past. The Coronavirus disease 19 (COVID-19) caused due to severe acute respiratory syndrome, which is a transmittable and pathogenic viral infection. Several traditional medicines of plant origin having antimicrobial and anti-inflammatory properties some have been studied for their anti-viral properties and immune-modulating effects. Herbal drugs are now in massive requirement in the developing countries for primary health care not because of their economical but also for better civilising adequacy, improved compatibility with the human body and significantly fewer side effects. This review gives an overview of some critical traditionally used medicinal herbs with anti-viral properties—the literature regarding the drugs of this group, collected from Ayurveda classics. Research articles are collected from published material and discussed per therapeutic actions. Most of the Herbs are with Katu Rasa (pungent) and Ushna Virya (hot potency). They are indicated in diseases, viz. Kasa (cough), Shwas (asthma), Krumi (worm/ infection). Krumihara property drugs which are correlated with anti-viral action helps to prevent against Novel coronavirus infection.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

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