scholarly journals ADRB2 gene polymorphism and preterm labor

2022 ◽  
pp. 9-17
Author(s):  
R. E. Kazakov ◽  
R. A. Chilova ◽  
K. O. Akopov ◽  
E. A. Sokova
Keyword(s):  
Preterm Labor ◽  
Gene Polymorphisms ◽  
Gene Encoding ◽  
Physiological Processes ◽  
History Of ◽  
Β2 Adrenergic Receptor ◽  
Adrb2 Gene ◽  
Scientific Facts ◽  
Relationship Of

This article discusses issues related to the role of polymorphism of the ADRB2 gene encoding β2-adrenergic receptor in preterm labor and tocolysis. Information is provided on scientific studies related to the search for associations of the carriage of alleles and genotypes of ADRB2 with the preterm labor, as well as with the pharmacological response to tocolytic therapy using β2-adrenergic agonists. The history of the discovery of the relationship of ADRB2 gene polymorphisms with preterm labor is presented in chronological order. As scientific facts emerge, researchers are faced with the question: how can ADRB2 gene polymorphisms affect physiological processes? That is, whether they affect by changing the primary structure of the receptor or by changing the level of expression. Depending on the answer to this question, pharmacogenetics are faced with a further task: what to study - individual polymorphisms or haplotypes?

scholarly journals Structure of the human TIMP-3 gene and its cell cycle-regulated promoter

1995 ◽  
Vol 311 (2) ◽  
pp. 549-554 ◽  
Author(s):  
M Wick ◽  
R Härönen ◽  
D Mumberg ◽  
C Bürger ◽  
B R Olsen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Alternative Polyadenylation ◽  
Regulatory Elements ◽  
Detailed Knowledge ◽  
Gene Encoding ◽  
Cycle Progression ◽  
Physiological Processes ◽  
Cycle Regulation

The gene encoding tissue inhibitor of metalloproteinases-3 (TIMP-3) is regulated during development, mitogenic stimulation and normal cell cycle progression. The TIMP-3 gene is structurally altered or deregulated in certain diseases of the eye and in tumour cells. A detailed knowledge of the TIMP-3 gene and its regulatory elements is therefore of paramount importance to understand its role in development, cell cycle progression and disease. In this study, we present the complete structure of the human TIMP-3 gene. We show that TIMP-3 is a TATA-less gene, which initiates transcription at one major site, is composed of five exons and four introns spanning a region of approximately 30 kb, and gives rise to three distinct mRNAs, presumably due to the usage of alternative polyadenylation signals. Using somatic cell hybrids the TIMP-3 locus was mapped to chromosomal location 22q13.1 We also show that the TIMP-3 5′ flanking region is sufficient to confer both high basal level expression in growing cells and cell cycle regulation in serum-stimulated cells. While the first 112 bases of the promoter, which harbour multiple Sp1 sites, were found to suffice for high basal level activity, the adjacent region spanning positions -463 and -112 was found to be a major determinant of serum inducibility. These results provide an important basis for further investigations addressing the role of TIMP-3 in physiological processes and pathological conditions.

Ethics Committees and Consultation in Mental Health

2018 ◽  
Author(s):  
Don C. Postema
Keyword(s):  
Ethics Education ◽  
Ethics Committees ◽  
The United States ◽  
Biomedical Ethics ◽  
Spiritual Beliefs ◽  
The Social ◽  
History Of ◽  
Relationship Of ◽  
The Relationship

Understanding the role of ethics committees in providing ethics consultations, ethics education, and ethics-related policies is the context for exploring the relationship of ethics, psychiatry, and religious and spiritual beliefs. After a brief history of biomedical ethics in the United States since the mid-20th century, this chapter presents several case studies that exemplify frequently encountered tensions in these relationships. The central contention is that respecting these beliefs is not equivalent to acquiescing to ethical claims based on them. Rigorous critical reflection and psychiatric insight, coupled with the values embedded in the social practices of healthcare, provide the grounds for evaluating the weight and bearing of religious and spiritual beliefs in ethically complex cases. This is one contribution that ethics committees can make at the intersection of psychiatry and religion.

scholarly journals Tecnologia, ciência e o papel da educação: a ponderação da crítica de Theodor W. Adorno

2012 ◽  
Vol 1 (2) ◽  
Author(s):  
Priscila Monteiro Chaves ◽  
Gomercindo Ghiggi
Keyword(s):  
Human Action ◽  
Special Importance ◽  
Contemporary World ◽  
Theodor Adorno ◽  
History Of ◽  
The Subject ◽  
Relationship Of ◽  
The Relationship ◽  
Critical Consideration

Resumo: Considerando o avanço das tecnologias bem como o binômio indissociável formado por ela e pela ciência – e consequentemente atrelados à educação –, configurando práticas enraizadas culturalmente na sociedade atual, o presente artigo traz como objetivo central discutir a relação da técnica (tékhné) com a concepção de homem que se quer formar, à luz das críticas adornianas. Ponderando o imperativo de subverter a ideologia utilitarista da educação, tal reflexão se justifica pela necessidade de compreensão do papel do educador, bem como da instituição escolar, mediante tal avanço nos últimos tempos. Concluindo que esta relação não pode suceder de maneira alienada, acrítica e indiferente, pois uma educação após Auschwitz deve certamente estar receptiva à relevância essencial da tecnologia em um mundo contemporâneo. No entanto, não é o sujeito que está a serviço dela e sim a relação contrária, em que o educando possa valer-se dos recursos tecnológicos como mais uma dimensão do agir humano. Como potente braço prolongado do operari humano, pensada como acontecimento paradigmático na história do ser. Palavras-chave: Theodor Adorno; tecnologia; educação; professor. TECHNOLOGY, SCIENCE AND THE ROLE OF EDUCATION: A CRITICAL CONSIDERATION OF THEODOR W. ADORNO Abstract: Considering the advancement of technologies as well as the inseparable duo formed by her and science - and thus tied to education - setting culturally rooted practices in today's society, this paper aims at discussing the relationship of technique (tékhné) with the concept of man constructed in the light of adornian criticism. Given the imperative to subvert the utilitarian ideology of education. Such reflection is justified by the necessity of understanding the role of the educator as well as the school, by this advance in recent times. Concluding that this relationship can not succeed in an alienated, uncritical and indifferent way, since an education after Auschwitz should certainly be receptive to the special importance of technology in a contemporary world. However, it is not the subject who is in her service, but the opposite relationship, in which the student can make use of technological resources as another dimension of human action. A powerful extended arm of human operari, thought as paradigmatic event in the history of being. Keywords: Theodor Adorno; technology; education; teacher.  

scholarly journals Medieval encyclopedia as a form of of religious worldview universalization (on the example of "Speculum Maius " by Vincent of Beauvais)

2021 ◽  
pp. 42-63
Author(s):  
Alla Aristova
Keyword(s):  
Middle Ages ◽  
Secular Culture ◽  
Religious Doctrine ◽  
Religious Worldview ◽  
Medieval Europe ◽  
Christian Worldview ◽  
European Science ◽  
History Of ◽  
Relationship Of

The article actualizes the significance of scholastic encyclopedias for the religious and secular culture of medieval Europe. Their role as a compendium of accumulated knowledge and at the same time ideological synthesis of Christian religious doctrine and scientific achievements, ancient and scholastic traditions, university, and church-monastery intellectual culture is shown. The main attention is paid to the multi-volume Vincent of Beauvais’ work «Speculum Maius» («The Great Mirror») as the most significant work among medieval encyclopedias and its conceptual completion. The extraordinary role of the encyclopedia as a documentary evidence of knowledge, ideas, worldview, mentality of the Western European Middle Ages is proved. The author outlines the principles of codification of «The Great Mirror»; highlights the influence of the Christian-theological context on the content, structure and methods of organizing its material; the relationship of encyclopedic work with the processes of development and rationalization of the religious worldview. The focus is on the universalizing potential of the Christianity concepts, the extraordinary expression of which was the work by Vincent of Beauvais. The aspiration for universality was manifested both in the desire to understand the world as a Whole, created by God-completed omnipresence, and in attempts to base all the accumulated human experience, all kinds of knowledge and life on the principles of the Christian worldview. The encyclopedia is valued as a real «mirror» of an entire era, the medieval reception of Christianity, the history of European science and knowledge.

scholarly journals The Portuguese Maritime Voyages of Discovery: the exploration of the history of a city with an App as an educational resource

2019 ◽  
pp. 85-99 ◽  
Author(s):  
Cláudia Faria ◽  
Elsa Guilherme ◽  
Joaquim Pintassilgo ◽  
Maria João Mogarro ◽  
Ana Sofia Pinho ◽  
...  
Keyword(s):  
Teaching And Learning ◽  
Participant Observation ◽  
Collaborative Work ◽  
Mobile Technologies ◽  
School Students ◽  
History Of ◽  
Relationship Of ◽  
The Relationship ◽  
The City

In this paper we present an evaluation of an App for mobile devices, ‘Roteiro dos Descobrimentos’, as an educational digital resource for primary school students. The study involved the participation of 131 students and eight teachers. Data were collected from participant observation, students’ questionnaires and interviews to students and teachers. According to students, they learned new things, related with the topics explored, in an easy and funny way. Students also emphasized as positive aspects the fact that they had to face different challenges and the need to mobilize their knowledge to solve them. Teachers referred that students showed great interest and enthusiasm during the activities. As main gains, teachers stressed that the application fosters the relationship of students with the city, facilitates collaboration, and promotes students’ autonomy. In resume, it seems that the playful and interactive dimension of the App promoted the development of important skills such as the ability to interact with the environment, collaborative work, autonomy, and reading and interpretation skills. As a conclusion, there is a great receptivity to integrate mobile technologies in the teaching and learning process, but the role of the teacher can’t be dismissed, as a mediator and educator.

Early Modern Oels and the Singularities of Local History*

2019 ◽  
Vol 38 (2) ◽  
pp. 211-239
Author(s):  
Maria Piasecka
Keyword(s):  
Early Modern ◽  
Local History ◽  
Local Context ◽  
Historical Event ◽  
Cultural Aspects ◽  
The People ◽  
History Of ◽  
Print Shop ◽  
Relationship Of

Abstract The article explores the local history of the Silesian city of Oels as presented in selected early modern books and pamphlets published primarily in the local print shop, but also in other cities. A prominent example of such a historical event is the 1535 tempest, descriptions of which were published in its immediate aftermath. The much-later Beschreibung of 1657 is presented as an example of creating local identity through emphasizing two cultural aspects linked to the event: the alleged nefarious role of the Jewish community and the special relationship of the local citizens with the dukes of, at first, the Podebrad, and later the Württemberg families. Although natural disasters are repetitive occurrences, the 1535 tempest was understood by the people of Oels in a singular manner, which was characteristic for the local context. The thesis about the singularity of the local history is further corroborated through a number of examples from Oels. Different aspects of singularity dominate in different publications depicting local events: the singularity of situations, people and places.

Isfahan during the Turko-Mongol Period (11th-15th Centuries)

2018 ◽  
Vol 16 (1-2) ◽  
pp. 253-312
Author(s):  
David Durand-Guédy
Keyword(s):  
Local Communities ◽  
General Context ◽  
Urban Decline ◽  
Local Elites ◽  
History Of ◽  
Special Circumstances ◽  
Relationship Of ◽  
The Relationship ◽  
Synthesis View

AbstractThis article deals with the history of Isfahan during the five centuries between the arrival of the Turks and the beginning of the Safavid period. It attempts to identify the continuities and ruptures from three different perspectives: To what extent can we speak of an urban decline? What was the relationship of the Isfahanis with the imperial rulers? How did the general context impact the makeup and the organisation of the society? It appears that Isfahan demonstrated remarkable resilience over the period, and that it is only beginning with the Timurid period that we can speak of a decline. Likewise, there is remarkable continuity in the ways in which the local elites collaborated with or resisted the imperial players. The role of the Ṣāʿid family, which held the cadial function over four centuries, is emblematic in this respect. Conversely, under special circumstances, the imperial players were able to exert great substantial influence on the local communities, and it is this political backing which explains the strengthening of the Hanafis in the sixth/twelfth century, and that of the Shiis in the following. One of the main accomplishments of this synthesis view of Isfahan history is that it assesses the effects of the Mongol domination relative to that of other periods.

Value heterochromatin and polymorphic varian gene folat cycle in women with miscarried and losses of pregnancy

2016 ◽  
pp. 148-151
Author(s):  
Jafar Aliyev Taran Kyzy ◽  
Keyword(s):  
Genetic Counseling ◽  
Gene Polymorphisms ◽  
Chromosomal Polymorphism ◽  
Benign Tumors ◽  
Clinical Effects ◽  
Causal Connection ◽  
Medical Genetic ◽  
History Of ◽  
Polymorphic Variants

The article presents data from surveys of women of losses of pregnancy (LP) in history, conducted within the medical genetic counseling, given the urgency of specifying genetic factors that actually are in causal connection with the LP specification clinical effects of epigenetic variability. The objective: to clarify the meaning of the changes in women heterochromatin (chromosomal polymorphism) and polymorphic variants of genes folat cycle enzymes as potential risk factors and pathogenic primordial LP. Patients and methods. The study involved two groups of women: I - 154 observations with complicated obstetric history in LP and II - 32 healthy women with uncomplicated reproductive history, held preconception planning to prevent pregnancy. Studied genealogical history, especially of internal organs, genitalia. Special studies included cytogenetic analysis, identification of gene polymorphisms system folat cycle methylentetrahydrofolate reductase [MTHFR] (C677T, A1298C, G1793A); methionine synthase reductase [MTRR] (A66G). Results. Women with a history of LP in 36.4% identified chromosome polymorphisms (SNPs extreme variants of chromosome polymorphism) on the background of various risk alleles of polymorphic variants of genes folat cycle; 7.1% of them is a polymorphism of the 21st chromosome. These genetic features are interpreted as a significant risk factor for LP as grounds for targeted in-depth medical and genetic examination. Prevalence among women with a history of PL undifferentiated forms cjnnective tissue and mesoderm dysplasia, benign tumors and «precancerous» states, as well as the prevalence of cardiovascular and psycho-neurological disease in pedigree suggests pathogenetic link these phenomena, the role of chromosomal polymorphism and polymorphic variants of genes of pathogenic folat cycle as primordial. Conclusion. The data on the place and role of heterochromatin and gene polymorphisms folat cycle in the origin LP should be mandatory option when examining women within the medical genetic counseling. Key words: pregnancy, reproductive losses, chromosomal instability, folat cycle genes, ancestry.

Mathematical and Elemental Coordinates: The Role of Imagination

2014 ◽  
Vol 44 (2) ◽  
pp. 161-169
Author(s):  
Bernard Freydberg
Keyword(s):  
Practical Reason ◽  
Fractal Geometry ◽  
History Of Philosophy ◽  
Creative Evolution ◽  
Logic Of Imagination ◽  
History Of ◽  
Dance Companies ◽  
Relationship Of ◽  
The Relationship

Both in Force of Imagination: The Sense of the Elemental (2000) and in his very recent Logic of Imagination: The Expanse of the Elemental (2012), John Sallis enacts a reconfiguration of the relationship of geometry to elementology, which might be regarded more generally as a rethinking of the relation of mathematics to philosophy. The paper will trace this reconfiguration in two ways: (1) as it lies present but concealed in the history of philosophy, for example, in Descartes’ so-called “dualism” and in Kant’s pure productive imagination, and (2) in its present creative evolution in fractal geometry, as Sallis interprets it. Sallis draws together the mathematical affinity with a fundamental aesthetic drive, likening mathematical patterns to choreographic ones. I conclude by following this strain as it points to specific dance companies, and to my own sense of aesthetic homecoming as presented in my Imagination in Kant’s Critique of Practical Reason.

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