scholarly journals Basic Disease Of The Muscle And Numbness And Weakness - A Test For Physiotherapists In The Serious Consideration Units

2020 ◽  
Vol 2 (09) ◽  
pp. 5-8
Author(s):  
Valentina Maratkyzy ◽  
Lyudmila Kosybayeva
Keyword(s):  
Blood Flow ◽  
Peripheral Neuropathy ◽  
Muscle Quality ◽  
Improve Quality ◽  
Early Activation ◽  
Length Of Hospitalization ◽  
Improve Blood Flow ◽  
Back To Work

The advancement of basic patient related summed up neuromuscular shortcoming, alluded to as basic sickness peripheral neuropathy and basic ailment myopathy , is a significant entanglement in patients admitted to escalated care units. Both BSP and BAM cause muscle shortcoming and paresis in fundamentally sick patients during their ICU remain. Early activation or kinesiotherapy have demonstrated muscle shortcoming inversion in fundamentally sick patients giving quicker come back to work, diminishing weaning time, and length of hospitalization. Activities as inactive, dynamic, and opposed structures have demonstrated to improve quality and mental prosperity. Clinical preliminaries utilizing neuromuscular electrical incitement to build bulk, muscle quality and improve blood flow to the encompassing tissue have demonstrated helpful. The job of electrical incitement is problematic up 'til now. Late proof demonstrates no distinction among rewarded and untreated muscles. Future exploration is prescribed to direct clinical preliminaries utilizing neuromuscular electrical incitement, works out, and early activation as a treatment convention in bigger populaces of patients in ICU.  

scholarly journals Hemorrhoids in pregnant and postpartum women: principles of therapy

2016 ◽  
pp. 22-25
Author(s):  
N. A. Lomova ◽  
N. V. Dubrovina ◽  
I. E. Dragun ◽  
E. S. Tolstopyatova
Keyword(s):  
Blood Flow ◽  
Chronic Disease ◽  
Conservative Treatment ◽  
Postpartum Period ◽  
Blood Circulation ◽  
Postpartum Women ◽  
Drug Of Choice ◽  
Common Diseases ◽  
Hemostatic Effects ◽  
Improve Blood Flow

Hemorrhoids is one of the most common diseases during pregnancy and in the postpartum period. It can be acute and chronic, and manifests itself in the form of thrombosis, inflammation or bleeding. The course of the disease can be either chronic or acute. Acute hemorrhoids is a complication of the chronic process and is further subdivided into forms according to the severity of inflammation and thrombosis. The classification reflects the pathogenesis of hemorrhoids; it is convenient and practical allowing for an unbiased approach in outlining indications and selecting the desired method of treatment depending on the stage of the disease and its severity. Conservative treatment of acute and chronic hemorrhoids is aimed at relief of symptoms of acute hemorrhoids, preventing complications as well as exacerbations of the chronic disease. Medications used in the treatment have anti-inflammatory, analgesic, hemostatic effects, improve blood flow and blood circulation in cavernous formations. The article tells about the drug of choice in the treatment of hemorrhoids in pregnant and postpartum women.

scholarly journals Gentiopicroside Ameliorates Diabetic Peripheral Neuropathy by Modulating PPAR- Γ/AMPK/ACC Signaling Pathway

2018 ◽  
Vol 50 (2) ◽  
pp. 585-596 ◽  
Author(s):  
Yi Lu ◽  
Jiayin Yao ◽  
Chulian Gong ◽  
Bao Wang ◽  
Piao Zhou ◽  
...  
Keyword(s):  
Blood Flow ◽  
Peripheral Neuropathy ◽  
Signaling Pathway ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Diabetic Peripheral Neuropathy ◽  
Nerve Conduction Velocity ◽  
Nerve Blood Flow ◽  
Ppar Γ ◽  
Compound C

Background/Aims: Gentiopicroside is promising as an important secoiridoid compound against pain. The present study aimed to investigate the analgesic effect and the probable mechanism of Gentiopicroside on Diabetic Peripheral Neuropathy (DPN), and to figure out the association among Gentiopicroside, dyslipidemia and PPAR- γ/AMPK/ACC signaling pathway. Methods: DPN rat models were established by streptozotocin and RSC96 cells were cultured. Hot, cold and mechanical tactile allodynia were conducted. Blood lipids, nerve blood flow, Motor Nerve Conduction Velocity (MNCV) and Sensory Nerve Conduction Velocity (SNCV) were detected. Gene and protein expression of PPAR- γ/AMPK/ACC pathway was analyzed by reverse transcription-quan titative polymerase chain reaction (RT-qPCR) and Westernblot. Besides, PPAR-γ antagonist GW9662 and agonist rosiglitazone, AMPK antagonist compound C and activator AICAR as well as ACC inhibitor TOFA were used to further confirm the relationship between PPAR-γ and AMPK. Results: The results demonstrated that Gentiopicroside markedly ameliorated hyperalgesia with prolonged paw withdrawal latency to heat and cold stimuli and fewer responses to mechanical allodynia compared with DPN model group. Gentiopicroside regulated dyslipidemia, enhanced nerve blood flow and improved MNCV as well as SNCV. Gentiopicroside suppressed ACC expression through the activation of AMPK and PPAR-γ mediated the activation of AMPK and subsequent inhibition of ACC expression. Conclusion: In conclusion, the present study demon strated that Gentiopicroside exerted nerve-protective effect and attenuated experimental DPN by restoring dyslipidmia and improved nerve blood flow through regulating PPAR-γ/AMPK/ACC signal pathway. These results provided a promising potential treatment of DPN.

Vasodilator drugs and peripheral vascular disorders

1964 ◽  
Vol 2 (6) ◽  
pp. 22-24
Keyword(s):  
Blood Flow ◽  
Smooth Muscle ◽  
Nicotinic Acid ◽  
Cerebrovascular Disease ◽  
Blood Vessels ◽  
Ethyl Alcohol ◽  
Peripheral Vascular ◽  
Future Issue ◽  
Vascular Disorders ◽  
Improve Blood Flow

Many drugs are claimed to be effective vasodilators which can improve blood flow in peripheral vascular disorders. Among them are noradrenaline antagonists such as tolazoline (Priscol - Ciba), azapetine (Ilidar - Roche) and phenoxybenzamine (Dibenyline - SKF), and drugs which act directly on the smooth muscle of blood vessels, such as isoxsuprine (Duvadilan - Crookes; Dilavase - Organon), nicotinyl alcohol (Ronicol - Roche), and cyclandelate (Cyclospasmol - Camden). Nicotinic acid, papaverine and ethyl alcohol are also used as vasodilators. Claims that cyclandelate and certain other drugs are indicated in the treatment of cerebrovascular disease will be discussed in a future issue.

scholarly journals Vasomodulation of peripheral blood flow by focused ultrasound potentiates improvement of diabetic neuropathy

2020 ◽  
Vol 8 (1) ◽  
pp. e001004 ◽  
Author(s):  
Joo-Shin Tan ◽  
Chou-Ching Lin ◽  
Gin-Shin Chen
Keyword(s):  
Blood Flow ◽  
Peripheral Neuropathy ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Diabetic Peripheral Neuropathy ◽  
Nerve Conduction Velocity ◽  
Focused Ultrasound ◽  
Blood Perfusion ◽  
The Third ◽  
Neural Fiber

ObjectiveEffective treatment methods for diabetic peripheral neuropathy are still lacking. Here, a focused ultrasound (FUS) technique was developed to improve blood flow in diabetic peripheral vessels and potentially treat diabetic peripheral neuropathy.Research design and methodsMale adult Sprague-Dawley rats at 4 weeks poststreptozotocin injections were adopted as models for diabetic neuropathic rats. For single FUS treatment, blood perfusion in the skin of the pad of the middle toe was measured before, during, and after the medial and lateral plantar arteries were treated by FUS. For multiple FUS treatments, blood perfusion measurements, von Frey and hot plate testing and nerve conduction velocity measurements were performed before ultrasonic treatment on the first day of each week, and the microvascular and neural fiber densities in the pad of the toe were measured on the first day of the last week.ResultsThe blood perfusion rate significantly increased for 7–10 min in the control and neuropathic rats after a single ultrasound exposure. Multiple ultrasound treatments compared with no treatments significantly increased blood perfusion at the second week and further enhanced perfusion at the third week in the neuropathic rats. Additionally, the paw withdrawal force and latency significantly increased from 34.33±4.55 g and 3.96±0.25 s at the first week to 39.10±5.02 g and 4.77±0.71 s at the second week and to 41.13±2.57 g and 5.24±0.86 s at the third week, respectively. The low nerve conduction velocity in the diabetic rats also improved after the ultrasound treatments. Additionally, ultrasound treatments halted the decrease in microvessel and neural fiber densities in the skin of the diabetic toes. Histologic analysis indicated no damage to the treated arteries or neighboring tissue.ConclusionsFUS treatment can increase upstream arterial blood flow in diabetic feet, ameliorate the decrease in downstream microvessel perfusion and halt neuropathic progression.

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