scholarly journals Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites

2016 ◽  
Vol 12 ◽  
pp. 969-984 ◽  
Author(s):  
Antonio Dávila-Céspedes ◽  
Peter Hufendiek ◽  
Max Crüsemann ◽  
Till F Schäberle ◽  
Gabriele M König
Keyword(s):  
Secondary Metabolites ◽  
In Silico ◽  
Structural Type ◽  
Biologically Active ◽  
Active Metabolites ◽  
Genome Sequences ◽  
Structural Types ◽  
Biologically Active Metabolites ◽  
In Silico Analyses

Myxobacteria are famous for their ability to produce most intriguing secondary metabolites. Till recently, only terrestrial myxobacteria were in the focus of research. In this review, however, we discuss marine-derived myxobacteria, which are particularly interesting due to their relatively recent discovery and due to the fact that their very existence was called into question. The to-date-explored members of these halophilic or halotolerant myxobacteria are all grouped into the suborder Nannocystineae. Few of them were chemically investigated revealing around 11 structural types belonging to the polyketide, non-ribosomal peptide, hybrids thereof or terpenoid class of secondary metabolites. A most unusual structural type is represented by salimabromide fromEnhygromyxa salina. In silico analyses were carried out on the available genome sequences of four bacterial members of the Nannocystineae, revealing the biosynthetic potential of these bacteria.

scholarly journals Secondary Metabolites of Purpureocilliumlilacinum

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 18
Author(s):  
Wei Chen ◽  
Qiongbo Hu
Keyword(s):  
Secondary Metabolites ◽  
Biological Activities ◽  
Chemical Diversity ◽  
Biologically Active ◽  
Parasitic Nematodes ◽  
Active Metabolites ◽  
Comprehensive Overview ◽  
Lead Compounds ◽  
Purpureocillium Lilacinum ◽  
Biologically Active Metabolites

Fungi can synthesize a wealth of secondary metabolites, which are widely used in the exploration of lead compounds of pharmaceutical or agricultural importance. Beauveria, Metarhizium, and Cordyceps are the most extensively studied fungi in which a large number of biologically active metabolites have been identified. However, relatively little attention has been paid to Purpureocillium lilacinum. P. lilacinum are soil-habituated fungi that are widely distributed in nature and are very important biocontrol fungi in agriculture, providing good biological control of plant parasitic nematodes and having a significant effect on Aphidoidea, Tetranychus cinnbarinus, and Aleyrodidae. At the same time, it produces secondary metabolites with various biological activities such as anticancer, antimicrobial, and insecticidal. This review attempts to provide a comprehensive overview of the secondary metabolites of P. lilacinum, with emphasis on the chemical diversity and biological activity of these secondary metabolites and the biosynthetic pathways, and gives new insight into the secondary metabolites of medical and entomogenous fungi, which is expected to provide a reference for the development of medicine and agrochemicals in the future.

scholarly journals STUDY OF THE COMPOSITION AND PROPERTIES OF SECONDARY METABOLITES OF THE LICHEN USNEA BARBATA

2017 ◽  
pp. 121-127
Author(s):  
Надежда (Nadezhda) Сергеевна (Sergeevna) Лыскова (Lyskova) ◽  
Юлия (Iuliia) Генриховна (Genrikhovna) Базарнова (Bazarnova) ◽  
Игорь (Igor') Вадимович (Vadimovic) Кручина-Богданов (Kruchina-Bogdanov )
Keyword(s):  
Secondary Metabolites ◽  
Visible Region ◽  
Antimicrobial Properties ◽  
Usnic Acid ◽  
Modern Society ◽  
Biologically Active ◽  
Active Metabolites ◽  
Dry Extract ◽  
Lichen Metabolites ◽  
Biologically Active Metabolites

In the modern society value of many biological resources remains underestimated. Lichens are one of the unique poorly studied bioresources. These are amazing organisms, formed by symbiosis of algae and fungus. Due to this combination, lichens have a number of unique properties.In this article the results of study the composition of biologically active secondary lichen metabolites of the Usnea barbata lichen. Antioxidant activity and antimicrobial properties of dry lichen extract against bacteria Bac. Subtilis. The conditions for extraction of biologically active metabolites using solvent systems such as water, water-ethanol mixtures with ethanol content of 40 and 70%, 1,4-dioxane and a mixture of 1,4-dioxane and water (1: 1) were selected. With use of the modern analytical methods, the composition of secondary metabolites in the extracts was studied. By the method of spectroscopy in the UV and visible region of the spectrum to determine the content usnic acid, which is 16,2 (solvent - water) to 60,0 (1,4-dioxane) mg/100 ml of extract.It is shown that the dioxane extract has pronounced atioxidant properties. The active substances (in terms of usnic acid) of the dry extract of lichen Usnea barbata are able to inhibit the growth of bacteria Bac. Subtilis.

Spices with Breast Cancer Chemopreventive and Therapeutic Potentials: A Functional Foods Based-Review

2018 ◽  
Vol 18 (2) ◽  
pp. 182-194 ◽  
Author(s):  
Aliyu Muhammad ◽  
Mohammed Auwal Ibrahim ◽  
Ochuko Lucky Erukainure ◽  
Ibrahim Malami ◽  
Auwal Adamu
Keyword(s):  
Breast Cancer ◽  
Urban Areas ◽  
Cancer Chemoprevention ◽  
Biologically Active ◽  
Active Metabolites ◽  
Rural And Urban Areas ◽  
Anticancer Properties ◽  
Rural And Urban ◽  
Breast Cancer Chemoprevention ◽  
Biologically Active Metabolites

Background: Cancer is a multifaceted metabolic disease that affects sizeable dwellers of rural and urban areas. Among the various types of cancer, mammary cancer is one of the most frequently diagnosed cancers in women. Its menace can be curbed with locally consumed spices due to their multiple bioactive phytochemicals. Aims: This review focuses on the breast cancer chemopreventive and therapeutic potentials of locally consumed spices. Methods/Results: The most commonly consumed spices with breast cancer chemopreventive and chemotherapeutic phytochemical include pepper, onions, ginger, garlic, curry and thyme containing many biologically active metabolites ranging from vitamins, fatty acids esters, polyphenols/phenolics, sulfurcontaining compounds and anthraquinones with proven antioxidant, anti-inflammatory, immuno-modulatory, antitumor and anticancer properties against breast cancer/carcinogenesis. Therefore, extracts and active principles of these spices could be explored in breast cancer chemoprevention and possibly therapeutically which may provide an avenue for reducing the risk and prevalence of breast cancer.

ChemInform Abstract: Biologically Active Metabolites of the Actinobacterium Streptomyces sp. GW 33/1593.

ChemInform ◽  
2009 ◽  
Vol 40 (30) ◽  
Author(s):  
M. P. Sobolevskaya ◽  
V. A. Denisenko ◽  
S. Fotso ◽  
H. Laach ◽  
N. I. Menzorova ◽  
...  
Keyword(s):  
Biologically Active ◽  
Active Metabolites ◽  
Streptomyces Sp ◽  
Biologically Active Metabolites

Biologically Active Metabolites from Marine Organisms

1995 ◽  
Vol 42 (4) ◽  
pp. 735-738 ◽  
Author(s):  
Jingyu Su ◽  
Longmei Zeng ◽  
Yongli Zhong ◽  
Xiong Fu
Keyword(s):  
Marine Organisms ◽  
Biologically Active ◽  
Active Metabolites ◽  
Biologically Active Metabolites

The chemistry of fungal antagonism and defense

1995 ◽  
Vol 73 (S1) ◽  
pp. 1265-1274 ◽  
Author(s):  
James B. Gloer
Keyword(s):  
Interdisciplinary Studies ◽  
Biologically Active ◽  
Model Systems ◽  
Fungal Metabolites ◽  
Ecological Studies ◽  
Active Metabolites ◽  
Broad Array ◽  
Fungal Antagonism ◽  
Antifungal Chemotherapy ◽  
Biologically Active Metabolites

Mechanisms of fungal antagonism and defense often include the production of biologically active metabolites by one species that exert effects on potential competitors and (or) predators. Studies carried out in our laboratory and others clearly indicate that such ecological phenomena can serve as valuable leads to the discovery of novel and potentially useful bioactive fungal metabolites. There is evidence that some of these compounds may render advantages to the producing organism, although careful and definitive ecological studies are required to determine this. Nevertheless, the results summarized here demonstrate the broad array of possible benefits that can arise from interdisciplinary studies in this area. This paper focuses primarily on our own investigations of the chemistry involved in fungal antagonism and defense using coprophilous and sclerotial fungi as model systems. These results have potential implications in many areas of study, including fungal ecology, secondary metabolism, chemotaxonomy, organic chemistry, structure determination, antifungal chemotherapy, and insect control. Key words: fungi, antifungal, insecticide, antagonism, chemical defense, secondary metabolites.

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