scholarly journals Technical Overview and Evaluation of Heartune App: Mapping Music to Heartbeat for Recreational or Medical Purposes (Whitepaper)

2022 ◽  
Vol 13 (01) ◽  
Author(s):  
Dr Nidhi Singh ◽  
Dr Nidhi Singh ◽  
Dr Nidhi Singh ◽  
Dr Nidhi Singh
Keyword(s):  
Music Therapy ◽  
Developmental Delays ◽  
Average Duration ◽  
Complete Recovery ◽  
Current Treatment ◽  
The Novel ◽  
Behavioural Changes ◽  
Meta Analyses ◽  
The Given

This paper aims to verify the feasibility of utilizing the novel application Heartune as a supplemental treatment for Autism, Alzheimers, Depression/anxiety and developmental delays using passive music therapy. The studies and meta-analyses discussed within this whitepaper illustrate the ability of music therapy in general to benefit the wellbeing and behavioural tendencies of those diagnosed with the aforementioned illnesses, and hence the results obtained by this whitepaper justify the utilization of Heartune as a source for the supplemental treatment for over 100 million patients worldwide. Music therapy has been proven to help several children with developmental delays and Autism especially considering the behavioural changes caused by music therapy. Moreover, the therapy has led researchers to conclude that within the average duration of a song ~3 minutes, the user’s heartbeat can change up to 12%, indicating that the application can be utilised to change the heartbeat and hence the user's mood up to a certain extent. The concluding remarks do state that the application is complementary to the current treatment of the patients and does not in any manner propose a complete recovery from the given illness but proposes to reduce the impacts it has on the lives of the patients.

scholarly journals Literatur Review : Terapy Musik Terhadap Hipertensi Kehamilan

2020 ◽  
Vol 5 (1) ◽  
pp. 37-41
Author(s):  
Ahmaniyah Ahmaniyah ◽  
Ratna Indriyani
Keyword(s):  
Music Therapy ◽  
Pregnant Women ◽  
Diastolic Pressure ◽  
Average Duration ◽  
Electronic Database ◽  
Hypertension In Pregnancy ◽  
Electronic Search ◽  
Key Word ◽  
The World ◽  
Significant Effort

                                                                                     Abstract Hypertension in pregnancy is a complication of pregnancy in general, which affects 2% of pregnant women in the world. And is a cause of death of pregnant women in the world, the handling of hypertension is done conventionally, namely hypertension-lowering drugs, but this conventional treatment has many obstacles because it is related to pregnant women who will certainly be related because it is related to pregnant women who will definitely be related to the fetus. Objective: to analyze which music therapy is most effective in reducing blood pressure in pregnant women who have hypertension. Method: This research was reviewed from an electronic database including Science Direct, Pubmed, Google Scholar and other related websites. With the keywords "hypertension, music, pregnancy". A total of 4 of the 5,840 publication ranges from 2015 to December 2019, which discussed music therapy in pregnant women with hypertension and were presented in English, were included in this review. In addition, relevant textbook chapters and guidelines are examined to capture further information or additional reports not identified in the electronic search. Results: from the analysis of many studies showed that music therapy with an average duration of 30 minutes for 1 month showed significant results in reducing hypertension in pregnant women. Conclusion: Music therapy is a significant effort combined with conventional therapy for reducing systolic and diastolic pressure in hypertensive pregnant women. Key word: Pregnancy, Music, Hypertension  

scholarly journals Strategies to Overcome Translation Losses in the Novel “The Grapes of Wrath” by John Steinbeck to Achieve Adequacy in Translation

2020 ◽  
Vol 23 (4) ◽  
pp. 17-32
Author(s):  
Konul Khalilova ◽  
Irina Orujova
Keyword(s):  
John Steinbeck ◽  
Literary Texts ◽  
The Novel ◽  
Source Text ◽  
Grapes Of Wrath ◽  
Thought Patterns ◽  
Translation Techniques ◽  
Current Article ◽  
The Given ◽  
Different Levels

The current article involves the issues of losses, gains, or survivals contributing to literature in the process of translation. It represents a thorough study based on the novel “The Grapes of Wrath” by John Steinbeck from English and, respectively, its translation into Azerbaijani by Ulfet Kurchayli. It investigates the problematic areas or challenges emerging from the source-text discrepancies. Furthermore, this article also concentrates on the issue of cultural non-equivalence or the losses occurring in translating English literary texts into Azerbaijani. The paper identifies the translation techniques adopted by the translator of John Steinbeck’s The Grapes of Wrath. Adopting certain techniques rather than others has led to many losses on different levels. The translator’s important role as a cultural insider is also emphasized. The wide gap, distance, or the differences between the cultures, languages, and thought patterns of the English and Azerbaijani language speakers are the main factors resulting in various losses in the process of translation. Coping with these extra-linguistic constraints is harder than the linguistic ones as the translator has no choice in the given situations, deleting these elements from the TT or replacing them with elements that do not fit the context. This article aims at determining translation losses and gains, defining ways that the translator employs for compensating losses, through the analysis of John Steinbeck’s style in The Grapes of Wrath. The article concludes that there are some situations where the translation of a certain text from the SL into the TL embraces alteration in the whole informational content of the text, in the form of expressions or words.

Music therapy effectiveness by duration in patients with cancer: a meta-regression

2021 ◽  
pp. bmjspcare-2021-003163
Author(s):  
Ronald Chow ◽  
Robert Bergner ◽  
Elizabeth Prsic
Keyword(s):  
Quality Of Life ◽  
Music Therapy ◽  
Positive Association ◽  
Well Being ◽  
Patients With Cancer ◽  
Therapy Effectiveness ◽  
Meta Regression ◽  
Meta Analyses ◽  
The Impact

ObjectivesSeveral reviews and meta-analyses have reported on music therapy for physical and emotional well-being among patients with cancer. However, the duration of music therapy offered may range from less than 1 hour to several hours. The aim of this study is to assess whether longer duration of music therapy is associated with different levels of improvement in physical and mental well-being.MethodsTen studies were included in this paper, reporting on the endpoints of quality of life and pain. A meta-regression, using an inverse-variance model, was performed to assess the impact of total music therapy time. A sensitivity analysis was conducted for the outcome of pain, among low risk of bias trials.ResultsOur meta-regression found a trend for positive association between greater total music therapy time and improved better pain control, but it was not statistically significant.ConclusionThere is a need for more high-quality studies examining music therapy for patients with cancer, with a focus on total music therapy time and patient-related outcomes including quality of life and pain.

Music and Developmental Disabilities

2016 ◽  
pp. 2374-2391
Author(s):  
Michelle Renee Blumstein
Keyword(s):  
Developmental Disabilities ◽  
Music Therapy ◽  
Developmental Delays ◽  
Music Therapists ◽  
Building Environment ◽  
The Individual ◽  
First Time

The following chapter presents a compilation of research about various types of technology that are employed by music therapists to benefit children with developmental delays. Music therapy can be an effective way to meet the goals of the individual. Music can also be a very powerful motivator. Previous musical skill or experience is not required for music therapy to be effective for clients with developmental disabilities or for clients more generally. Many music-based technologies are designed to create a positive, successful, and enjoyable experience for all users. Music therapy can provide a safe and confidence building environment where children are able to feel in control of a situation, possibly for the first time in their lives.

Encorafenib, binimetinib and cetuximab combined therapy for patients with BRAFV600E mutant metastatic colorectal cancer

2020 ◽  
Vol 16 (6) ◽  
pp. 161-173 ◽  
Author(s):  
Sanne CFA Huijberts ◽  
Robin MJM van Geel ◽  
Rene Bernards ◽  
Jos H Beijnen ◽  
Neeltje Steeghs
Keyword(s):  
Growth Promotion ◽  
Combined Therapy ◽  
Braf Inhibitor ◽  
Mek Inhibitor ◽  
Current Treatment ◽  
The Novel ◽  
Efficacy And Safety ◽  
First Line ◽  
Metastatic Setting ◽  
Mitogen Activated Protein

Approximately 10–15% of colorectal cancers (CRCs) harbor an activating BRAF mutation, leading to tumor growth promotion by activation of the mitogen-activated protein kinases pathway. BRAFV600E mutations are prognostic for treatment failure after first-line systemic therapy in the metastatic setting. In contrast to the efficacy of combined BRAF and MEK inhibition in melanoma, BRAFV600E mutant CRC is intrinsically unresponsive due to upregulation of HER/EGFR. However, combining the EGFR inhibitor cetuximab, the BRAF inhibitor encorafenib and the MEK inhibitor binimetinib improves overall survival. This review discusses the current treatment field for patients with BRAFV600E mutant metastatic CRC and summarizes the pharmacology, efficacy and safety of the novel doublet and triplet therapies consisting of encorafenib and cetuximab with or without binimetinib.

Eculizumab Modifies Outcomes in Adults with Atypical Hemolytic Uremic Syndrome with Acute Kidney Injury

2018 ◽  
Vol 48 (3) ◽  
pp. 225-233 ◽  
Author(s):  
Mercedes Cao ◽  
Bruna N. Leite ◽  
Tamara Ferreiro ◽  
María Calvo ◽  
Constantino Fernández ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Hemolytic Uremic Syndrome ◽  
Kidney Function ◽  
Case Reports ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Kidney Injury ◽  
Complete Recovery ◽  
Genetic Abnormalities ◽  
Uremic Syndrome ◽  
Meta Analyses

Background: Atypical hemolytic uremic syndrome (aHUS) is a rare disease associated with congenital or acquired genetic abnormalities that result in uncontrolled complement activation, leading to thrombotic microangiopathy and kidney failure. Until recently, the only treatment was plasma exchange or plasma infusion (PE/PI), but 60% of patients died or had permanent kidney damage despite treatment. Eculizumab, a complement inhibitor, has shown promising results in aHUS. However, data are mainly extracted from case reports or studies of heterogeneous cohorts, and no direct comparison with PE/PI is available. Methods: An observational retrospective study of adult, dialysis-dependent aHUS patients with acute kidney injury (AKI) who were treated with either PE/PI alone or with second-line eculizumab in our center. We compared the effect of PE/PI and eculizumab on kidney function, hypertension, proteinuria, hematologic values, relapse, and death. Results: Thirty-one patients were included (females, 18; sporadic aHUS, 29; mean age, 46 ± 20 years). Twenty-six patients were treated with PE/PI alone, and 5 were deemed to be plasma-resistant and received eculizumab after stopping PE/PI. Among patients receiving eculizumab, 80% attained complete recovery of kidney function, 100% stopped dialysis, 20% had decreased proteinuria, and no patient relapsed (vs. 38.5, 50, 15.4, and 11.5%, respectively, of patients receiving only PE/PI). At 1-year of follow-up, no deaths had occurred in either group. Conclusion: Eculizumab shows greater efficacy than PE/PI alone for the treatment of adult aHUS patients with AKI. Prospective studies and meta-analyses are warranted to confirm our findings and set guidelines for treatment, monitoring, and maintenance.

scholarly journals How to read and interpret the results of a Bayesian network meta-analysis: a short tutorial

2019 ◽  
Vol 20 (2) ◽  
pp. 106-115 ◽  
Author(s):  
D. Hu ◽  
A. M. O'Connor ◽  
C. B. Winder ◽  
J. M. Sargeant ◽  
C. Wang
Keyword(s):  
Bayesian Network ◽  
Bayesian Approach ◽  
Probability Distributions ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Forest Plot ◽  
The Novel ◽  
Meta Analyses ◽  
Realistic Data

AbstractIn this manuscript we use realistic data to conduct a network meta-analysis using a Bayesian approach to analysis. The purpose of this manuscript is to explain, in lay terms, how to interpret the output of such an analysis. Many readers are familiar with the forest plot as an approach to presenting the results of a pairwise meta-analysis. However when presented with the results of network meta-analysis, which often does not include the forest plot, the output and results can be difficult to understand. Further, one of the advantages of Bayesian network meta-analyses is in the novel outputs such as treatment rankings and the probability distributions are more commonly presented for network meta-analysis. Our goal here is to provide a tutorial for how to read the outcome of network meta-analysis rather than how to conduct or assess the risk of bias in a network meta-analysis.

scholarly journals The philosophical problems in modern fiction: The concept of being in E. Schmitt’s "Noah’s child"

2019 ◽  
Vol 72 ◽  
pp. 03012
Author(s):  
Elena Ivanova ◽  
Ekaterina Ivanova
Keyword(s):  
Human Perception ◽  
Literary Text ◽  
The Novel ◽  
Moral Choice ◽  
Historical Material ◽  
The World ◽  
Modern Fiction ◽  
The Given

The article is devoted to the analysis of the novel by a contemporary writer, E.E. Schmitt “Noah‟s child” in terms of the realization of the important philosophical problems, updated with the time. The novelty of the given material is due primarily to the choice of the author, whose work is still to be reflected. This article examines the philosophical issues of existence implemented at various levels of the literary text: from the title to its symbolism. Drawing on biblical and historical material, in a novelistic genre E. Schmitt managed to present his vision of the problems of faith and disbelief, identity of the nation, the moral choice, etc. While not denying the value of the God in human perception of the world, the writer asserts the idea that the man himself is responsible for all what is happening on the ground and in the society, so the novel “Noah‟s child” can be seen as a passionate appeal to contemporaries to strive for the harmony of coexistence.

scholarly journals Treatment of subacute thoracic spine fracture-dislocation by total vertebrectomy and spine shortening

2013 ◽  
Vol 18 (2) ◽  
pp. 194-200 ◽  
Author(s):  
Alecio C. E. S. Barcelos ◽  
Ricardo V. Botelho
Keyword(s):  
Posterior Approach ◽  
Posterior Instrumentation ◽  
Complete Recovery ◽  
Current Treatment ◽  
Fracture Dislocation ◽  
Fracture Dislocations ◽  
Thoracic Spine Fracture ◽  
Surgical Teams ◽  
Anterior Support ◽  
Vertebral Resection

Vertebral resection with spine shortening has been primarily reported for the treatment of demanding cases of nontraumatic disorders. Recently, this technique has been applied to the treatment of traumatic disorders. The current treatment of vertebral fracture-dislocation when there is partial or total telescoping of the involved vertebrae is a combined anterior-posterior approach with corpectomy, anterior support implant, and further posterior instrumentation. These procedures usually require 2 surgical teams, involve longer operating times and greater risk of surgical complications related to the anterior approach, and commonly entail longer postoperative care before discharge. The authors report on 2 patients with high thoracic fracture-dislocations with telescoping (T-2 and T-4) who were treated in the subacute phase with total spondylectomy (T-3 and T-5, respectively) and spine shortening by using only a posterior approach. Complete recovery of the sagittal balance was achieved with this technique and the postoperative periods were clinically uneventful. One patient presented with asymptomatic hemothorax that did not require drainage. In paraplegic patients with anterior thoracic dislocation fractures in which one vertebral body blocks the reduction of the other, total spondylectomy and spine shortening seem to be a reasonably safe and effective technique.

scholarly journals FANNY BURNEY’S EPISTOLARY ROMANTICISM AND BLOGGING

2019 ◽  
Vol 1 (1) ◽  
pp. 35-44
Author(s):  
Oksana Anossova
Keyword(s):  
The Novel ◽  
Fanny Burney ◽  
Modern Life ◽  
Epistolary Novel ◽  
Romantic Era ◽  
David Garrick ◽  
Written Form ◽  
The One ◽  
The Given ◽  
George Iii

Fanny Burney at 15 wrote in her diary addressing her thoughts to ‘Nobody’, to her silent ‘self’ and interlocutor. Nobody learnt about this fact until her diaries were published. She became famous with her first epistolary novel about a young lady entering the world, though in the Preface to the novel the author pretended to be an editor of the letters. Her writing could be compared to contemporary blogs. Novelty and variety of subjects, personally coloured irony and wit, acute eyesight, ability to entertain a reader with an unusual insight of the ordinary event or situation (e.g., ‘Directions for Coughing, Sneezing, or Moving Before the King and Queen’), a dramatist talent to create dialogues and remember speaker’s intonation and other speech parameters, a lot of short fragments imprinting emotions and restoring the epoch in diaries and letters, - everything features her style and specifies her as a Romanticism writer. Some of the subjects could be accepted as obsolete though regarding different situations, circumstances and the performance the given descriptions of the royal household politely discussed by the Keeper of the Robe to Queen Charlotte, wife of George III, and a close acquaintance of British famous actor David Garrick (1717-1779) and even world-known painter Joshua Reynolds (1723-1792) some of the episodes described in diaries could be praised for their author’s dramatic playwright talent. Blogging in its well-written form, the one possessing style and distinguishing good literature characteristics, could be compared to diaries reflecting every instant of modern life and becoming immediately public. Freedom of female voice in Romantic era and freedom of mass-media writer and reader on the verge of Millennium are manifested in both epochs

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