scholarly journals BACTERIAL BIOFILM IN CHILDREN WITH CHRONIC RHINOSINUSITIS AND CHRONIC ADENOIDITIS

2021 ◽  
Vol 68 (2) ◽  
pp. 256-261
Author(s):  
Radmila Anca Bugari ◽  
◽  
Sorin Bașchir ◽  
Ciprian Mihali ◽  
Luminiţa Turcin ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Bacterial Biofilm ◽  
Public Health Issue ◽  
Bacterial Biofilms ◽  
Symptom Improvement ◽  
Global Public Health ◽  
Paediatric Patients ◽  
Airway Infections ◽  
Chronic Adenoiditis

Chronic rhinosinusitis with chronic adenoiditis in children represents a global public health issue, seriously affecting the quality of parents and children life, because of its irritating symptoms like intermittent snoring, mouth breathing, dry mouth, nasal obstruction, headaches increased irritability and focus disorders on children. Bacterial biofilms are highly associated with the chronic infectious processes in children. Correct therapeutical management of this diagnostic combination is mandatory to improve the quality of one’s life. Objectives. The aim of the study is: to observe the ratio of adenoid mucosa covered with bacterial biofilm extracted from the nasopharynx of 50 paediatric patients suffering of chronic rhinosinusitis (RSC) and chronic adenoiditis (CA); and to point the fact that the adenoids contaminated with bacterial biofilm are a generator for chronic upper airway infections in children. Material and methods. We have measured using an image analysis program the bacterial biofilm covering the entire surface of the extracted adenoids mases, from 28 girls and 22 boys aged between 5 and 12 years diagnosed with CRS and CA. Control visits were performed to verify symptom improvement at 1, 3 and 6 months. Outcomes. Adenoids extracted from paediatric patients diagnosed with CRS and CA presented bacterial biofilms coverage on almost the entire mucosa (86.75%). Conclusions. Adenoid mases removed from paediatric patients with CSR and CA have most of their mucosal covered with bacterial biofilm. In the nasopharynx of paediatric patients with CSR and CA, bacterial biofilm can play the role of a constant fountain of infection. Adenoid mass removal explains the symptomatic improvement observed post operatory in the CRS with CA paediatric patients that do not respond to antibiotic therapy.

Medication-related harm: a geriatric syndrome

2019 ◽  
Vol 49 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Jennifer M Stevenson ◽  
J Graham Davies ◽  
Finbarr C Martin
Keyword(s):  
Older Adults ◽  
Public Health Issue ◽  
Geriatric Syndrome ◽  
Global Public Health ◽  
New Approach ◽  
Proactive Approach ◽  
Health And Social Care ◽  
Tailored Approach ◽  
Related Harm

Abstract The WHO Global Patient Safety Challenge: Medication Without Harm recognises medication-related harm (MRH) as a global public health issue. Increased life-expectancy coupled with multimorbidity and polypharmacy leads to an increased incidence of MRH, especially in older adults: at a cost of approximately £400 million to the National Health Service (NHS) in England. Harm from medicines has long been recognised by geriatricians, and strategies have been developed to mitigate harm. In general, these have focused on the challenges of polypharmacy and appropriateness of medicines, but impact on the quality of life, clinical and economic outcomes has been variable and often disappointing. The problem of MRH in older adults will continue to grow unless a new approach is adopted. Emerging evidence suggests that we need to take a broader approach as described in our conceptual model, where well-recognised physiological changes are incorporated, as well as other rarely considered psychosocial issues that influences MRH. Parallels may be drawn between this approach and the management of geriatric syndromes. We propose there must be a greater emphasis on MRH, and it, of itself, should be considered as a geriatric syndrome, to bring the spotlight onto the problem and to send a clear signal from geriatric experts that this is an important issue that needs to be addressed using a co-ordinated and tailored approach across health and social care boundaries. This requires a more proactive approach to monitor and review the medicines of older adults in response to their changing need.

scholarly journals Data Mining Techniques for Pandemic Outbreak in Healthcare

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Nur Izyan Suraya Abdul Satar ◽  
Azlinah Mohamed ◽  
Azliza Mohd Ali
Keyword(s):  
Public Health ◽  
Data Mining ◽  
Past Research ◽  
Large Datasets ◽  
Public Health Issue ◽  
Mining Method ◽  
Global Public Health ◽  
Data Mining Technique ◽  
Mining Technique

Pandemic outbreaks such as SARS-CoV, MERS-CoV and Covid-19 have attracted worldwide attention since these viruses have affected many countries and become a global public health issue. In 2019, Covid-19 was announced as a pandemic disease and categorized as a public health emergency globally. It is ranked as the sixth most serious pandemic internationally. This pandemic tracking and analysis require an appropriate method that gives better performance in terms of accuracy, precision and recall that defines its pattern since it involves huge and complicated datasets from the pandemic. Pattern identification is currently applied in many instances due to the rapid growth of data besides having the   potential to generate a knowledge-rich environment which can help to significantly improve the quality of clinical decisions and identify the relationships between data items. Therefore, there is a need to review the techniques in data mining on the pandemic outbreak that focuses on healthcare. The goal of this study was to analyze the algorithms from the data mining method that had been implemented for pandemic outbreaks in past research such as SARS-CoV, MERS-CoV and Covid-19. The result shows that 2 main algorithms, namely Naïve Bayes and Decision Tree, from the classification method, are appropriate algorithms and give more than 90% accuracy in both the pandemic and healthcare. This will be further considered and investigated for future analysis on large datasets of Covid-19 which can help researchers and healthcare practitioners in controlling the infection of the coronavirus using the data mining technique discussed.

scholarly journals Evidence of bacterial biofilms in chronic rhinosinusitis: factors affecting and the impact on prognosis

2018 ◽  
Vol 4 (6) ◽  
pp. 1405
Author(s):  
Vivek Gogia ◽  
Lakshmi Vaid ◽  
P. P. Singh ◽  
Rumpa Saha
Keyword(s):  
Chronic Rhinosinusitis ◽  
Potential Role ◽  
Sinus Surgery ◽  
Bacterial Biofilms ◽  
Postoperative Evaluation ◽  
Factors Affecting ◽  
Disease Prognosis ◽  
Osteomeatal Complex ◽  
The Impact

<p class="abstract"><strong>Background:</strong> The aim of the study was to study the evidence of bacterial biofilms in chronic rhinosinusitis (CRS) and its effect on disease prognosis by correlating between symptom score, computed tomography (CT) score and endoscopy score.</p><p class="abstract"><strong>Methods:</strong> 40 samples of bacteriologically positive CRS patients were studied and data analyzed using SNOT-20 questionnaire, nasal endoscopy scores and CT grading. Functional endoscopic sinus surgery was done in all CRS patients to clear blockage and ensures patency of osteomeatal complex. Postoperative evaluation continued at 2 weeks, 1 month and 3 months. A comparison made between preoperative and postoperative SNOT-20 and endoscopy scores of patients with and without biofilms.  </p><p class="abstract"><strong>Results:</strong> Patients with biofilm forming bacteria have significantly poor preoperative and postoperative SNOT-20 score and endoscopy score as compared to bio-film negative patients; however the quality of life improved in both the groups.</p><p class="abstract"><strong>Conclusions:</strong> Biofilms play a potential role in postoperative prognosis of patients undergoing FESS. Further studies and research is required for assigning them as a definite proprietor for CRS.</p>

scholarly journals FIGHTING AGAINST GLOBAL HIV EPIDEMIC: AVAILABLE OPTIONS TO FOCUS ON

2019 ◽  
Vol 7 (7) ◽  
pp. 102-105
Author(s):  
Homa Nath Sharma ‘Raju’ ◽  
Sagar Baral ◽  
Yadav Baral
Keyword(s):  
Vaccine Development ◽  
Treatment Strategies ◽  
Cost Effective ◽  
Public Health Issue ◽  
Effective Vaccine ◽  
Global Public Health ◽  
Immunodeficiency Virus ◽  
Great Progress ◽  
Made In

HIV continues to be a major global public health issue, having claimed more than 32 million lives so far. While great progress has been made in preventing and treating HIV, there is still much to do. A safe and cost-effective vaccine that prevents HIV infection is considered the best strategy for containing the epidemic. However; historically, the vaccine development for HIV prevention has been extremely difficult. Anti-Retroviral Therapy (ART) has improved the quality of life of Human immunodeficiency virus (HIV) patients worldwide. This reality suggests that continuing on HIV vaccine research, now we should also consider applying other short-term available prevention and treatment strategies to mitigate the effect of the epidemic.

scholarly journals Peran biofilm bakteri terhadap derajat keparahan rinosinusitis kronis berdasarkan skor Lund-Mackay

2018 ◽  
Vol 47 (2) ◽  
pp. 113
Author(s):  
Y Yolazenia ◽  
Bestari Jaka Budiman ◽  
Effy Huriyati ◽  
Aziz Djamal ◽  
Rizanda Machmud ◽  
...  
Keyword(s):  
Ct Scan ◽  
Chronic Rhinosinusitis ◽  
Paranasal Sinuses ◽  
Cross Sectional Study ◽  
Bacterial Biofilm ◽  
Bacterial Biofilms ◽  
Cross Sectional ◽  
Exact Test ◽  
Significant Difference ◽  
Scan Data

Latar belakang: Rinosinusitis kronis (RSK) adalah penyakit inflamasi mukosa hidung dan sinus paranasal yang berlangsung lebih dari 12 minggu. Berbagai kondisi telah dikaitkan dengan patogenesis penyakit ini, seperti infeksi bakteri, jamur, superantigen, dan biofilm. Banyak penelitian telah menunjukkan terdapatnya biofilm bakteri pada pasien dengan RSK. Biofilm bakteri dapat memfasilitasi terjadinya resistensi pada antibiotik. CT Scan sinus paranasal (SPN) merupakan pemeriksaan penunjang pilihan untuk diagnosis radiologik RSK. Lund dan Mackay telah mengembangkan suatu sistem berdasarkan skor dari CT Scan SPN untuk menilai kuantifikasi proses peradangan pada sinus paranasal. Beberapa penelitian menunjukkan bahwa pasien dengan biofilm bakteri memiliki skor Lund-Mackay CT Scan SPN yang lebih tinggi pada saat pra operatif. Tujuan: Penelitian ini bertujuan untuk mengetahui peran biofilm bakteri terhadap derajat keparahan RSK berdasarkan skor Lund-Mackay. Metode: Penelitian ini adalah penelitian cross-sectional dengan jumlah total sampel adalah 48 orang pasien RSK. Sekret hidung diambil menggunakan kapas lidi steril dengan swab pada meatus medius lalu dilakukan identifikasi bakteri dan pemeriksaan biofilm dengan tube method. Skor Lund-Mackay dihitung dari CT Scan SPN potongan koronal. Data dianalisis dengan uji Fisher. Hasil: Proporsi pasien RSK dengan skor Lund-Mackay yang tinggi lebih banyak pada pasien dengan biofilm (46,2%), dibandingkan tanpa biofilm (44,4%). Secara statistik tidak terdapat perbedaan bermakna pada skor Lund-Mackay antara pasien dengan biofilm dan tanpa biofilm (p=1,000). Kesimpulan: Tidak terdapat hubungan antara biofilm bakteri dengan derajat keparahan RSK berdasarkan skor Lund-Mackay. Kata Kunci: Rinosinusitis kronis, biofilm bakteri, tube method, skor Lund-Mackay ABSTRACT Background: Chronic rhinosinusitis (CRS) is inflammation of the nose and paranasal sinuses with the symptoms duration more than 12 weeks. Many conditions have been linked to its pathogenesis such as bacterial and fungal infection, superantigens and biofilm. Many studies showed the presence of bacterial biofilms in patients with CRS. Bacterial biofilms can facilitate the resistance to antibiotics. Paranasal sinuses (PNS) CT scan is the method of choice for radiological diagnosis of CRS. Lund and Mackay has developed a scoring system based on the CT finding to assess the quantification of inflammatory process in PNS. Some research suggested that patients with bacterial biofilms have higher Lund-Mackay score pre-operatively. Purpose: To determine the role of bacterial biofilms to the severity of CRS according to Lund-Mackay score. Methods: This was a cross-sectional study with 48 CRS patient’s sample. Nasal discharges were taken by swab in middle meatal using sterile cotton buds, followed by identification of bacteria and detection of bacterial biofilms using tube method. Lund-Mackay score was counted from coronal section of PNS CT Scan. Data was analyzed by Fisher’s exact test. Results: Proportion of patients CRS with high Lund-Mackay score was more common in patient with biofilm (46.2%) compared to patients without biofilm (44.4%). Statistically, there was no significant difference of Lund-Mackay score between patient with biofilm and without biofilm (p=1.00). Conclusion: There was no relationship between the bacterial biofilm with the severity of CRS according to Lund-Mackay score. Keywords: Chronic rhinosinusitis, bacterial biofilm, tube method, Lund-Mackay scores

scholarly journals Health-Related Quality of Life Impairment Among Patients With Severe Chronic Rhinosinusitis With Nasal Polyps in the SINUS-24 Trial

2021 ◽  
Vol 147 (2) ◽  
pp. AB133
Author(s):  
Jorge Maspero ◽  
Carl Philpott ◽  
Peter Hellings ◽  
Claire Hopkins ◽  
Martin Wagenmann ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Mucosal Eosinophilia and Neutrophilia Are Not Associated With QOL or Olfactory Function in Chronic Rhinosinusitis

2021 ◽  
pp. 194589242098743
Author(s):  
Nyssa F. Farrell ◽  
Jess C. Mace ◽  
David A. Sauer ◽  
Andrew J. Thomas ◽  
Mathew Geltzeiler ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyposis ◽  
Cross Sectional Study ◽  
Olfactory Function ◽  
Sinus Surgery ◽  
Small Subset ◽  
Cross Sectional ◽  
Snot 22

Background Chronic rhinosinusitis (CRS) is often differentiated by histopathologic phenotypes (eosinophilic versus neutrophilic), which may impact disease severity measures and outcomes. As such, it has been suggested that counts of cellular elements be included as part of a standard pathological report following endoscopic sinus surgery (ESS). Objectives This cross-sectional study evaluated associations of mucosal eosinophilia and neutrophilia with measures of quality-of-life (QoL) and olfactory function. Methods Patients with medically refractory CRS completed the SNOT-22 survey and Brief Smell Identification Test (BSIT) at enrollment. In addition, baseline Lund-Mackay computed tomography (CT) and Lund-Kennedy endoscopy scores were collected. Ethmoid mucosa was biopsied during ESS and reviewed using microscopy to quantify densest infiltrate of eosinophils or neutrophils per high-powered-field (HPF). Eosinophilic CRS (eCRS) and neutrophilic CRS (nCRS), both with and without nasal polyposis (NP), were compared across SNOT-22 and BSIT scores. Results 77/168 patients demonstrated mucosal eosinophilia (eCRS) while a total of 42/168 patients demonstrated mucosal neutrophilia (nCRS). After adjusting for polyp status, 35/168 had eCRSsNP, 42/168 eCRSwNP, 75/168 non-eCRSsNP, 16/168 non-eCRSwNP. Additionally, 22/161 were noted to have nCRSsNP, 20/161 nCRSwNP, 84/161 non-nCRSwNP, and 35/161 non-nCRSsNP. A small subset of patients demonstrated both eosinophilia and neutrophilia: 14 CRSwNP and 7 CRSsNP. When evaluating average Lund-Mackay Scores (LMS), significant differences existed between non-eCRSsNP and eCRSsNP (p = 0.006). However, after controlling for nasal polyps, eosinophilia did not significantly associate with differences in the Lund-Kennedy Score. Neutrophilia did not significantly associate with any changes in LMS or LKS after controlling for NP. Eosinophilic and neutrophilic histopathologic subtypes did not significantly associate with differences in baseline SNOT-22 or BSIT measures after controlling for NP. Conclusion Neither the presence of mucosal eosinophilia nor mucosal neutrophilia demonstrated significant associations with SNOT-22 quality-of-life or BSIT olfactory function scores when controlling for comorbid nasal polyposis.

scholarly journals To hydrate or not to hydrate? The effect of hydration on survival, symptoms and quality of dying among terminally ill cancer patients

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Chien-Yi Wu ◽  
Ping-Jen Chen ◽  
Tzu-Lin Ho ◽  
Wen-Yuan Lin ◽  
Shao-Yi Cheng
Keyword(s):  
Cancer Patients ◽  
Proportional Hazards Model ◽  
Clinical Symptoms ◽  
Terminally Ill ◽  
Good Death ◽  
Artificial Nutrition ◽  
Symptom Improvement ◽  
Terminally Ill Cancer Patients ◽  
Quality Of Dying

Abstract Background Artificial nutrition and hydration do not prolong survival or improve clinical symptoms of terminally ill cancer patients. Nonetheless, little is known about the effect of artificial hydration (AH) alone on patients’ survival, symptoms or quality of dying. This study explored the relationship between AH and survival, symptoms and quality of dying among terminally ill cancer patients. Methods A pilot prospective, observational study was conducted in the palliative care units of three tertiary hospitals in Taiwan between October 2016 and December 2017. A total of 100 patients were included and classified into the hydration and non-hydration group using 400 mL of fluid per day as the cut-off point. The quality of dying was measured by the Good Death Scale (GDS). Multivariate analyses using Cox’s proportional hazards model were used to assess the survival status of patients, the Wilcoxon rank-sum test for within-group analyses and the Mann-Whitney U test for between-groups analyses to evaluate changes in symptoms between day 0 and 7 in both groups. Logistic regression analysis was used to assess the predictors of a good death. Results There were no differences in survival (p = 0.337) or symptom improvement between the hydration and non-hydration group, however, patients with AH had higher GDS scores. Conclusions AH did not prolong survival nor significantly improve dehydration symptoms of terminally ill cancer patients but it may influence the quality of dying. Communication with patients and their families on the effect of AH may help them better prepared for the end-of-life experience.

Sign in / Sign up

Export Citation Format

Share Document