scholarly journals Peran biofilm bakteri terhadap derajat keparahan rinosinusitis kronis berdasarkan skor Lund-Mackay

2018 ◽  
Vol 47 (2) ◽  
pp. 113
Author(s):  
Y Yolazenia ◽  
Bestari Jaka Budiman ◽  
Effy Huriyati ◽  
Aziz Djamal ◽  
Rizanda Machmud ◽  
...  
Keyword(s):  
Ct Scan ◽  
Chronic Rhinosinusitis ◽  
Paranasal Sinuses ◽  
Cross Sectional Study ◽  
Bacterial Biofilm ◽  
Bacterial Biofilms ◽  
Cross Sectional ◽  
Exact Test ◽  
Significant Difference ◽  
Scan Data

Latar belakang: Rinosinusitis kronis (RSK) adalah penyakit inflamasi mukosa hidung dan sinus paranasal yang berlangsung lebih dari 12 minggu. Berbagai kondisi telah dikaitkan dengan patogenesis penyakit ini, seperti infeksi bakteri, jamur, superantigen, dan biofilm. Banyak penelitian telah menunjukkan terdapatnya biofilm bakteri pada pasien dengan RSK. Biofilm bakteri dapat memfasilitasi terjadinya resistensi pada antibiotik. CT Scan sinus paranasal (SPN) merupakan pemeriksaan penunjang pilihan untuk diagnosis radiologik RSK. Lund dan Mackay telah mengembangkan suatu sistem berdasarkan skor dari CT Scan SPN untuk menilai kuantifikasi proses peradangan pada sinus paranasal. Beberapa penelitian menunjukkan bahwa pasien dengan biofilm bakteri memiliki skor Lund-Mackay CT Scan SPN yang lebih tinggi pada saat pra operatif. Tujuan: Penelitian ini bertujuan untuk mengetahui peran biofilm bakteri terhadap derajat keparahan RSK berdasarkan skor Lund-Mackay. Metode: Penelitian ini adalah penelitian cross-sectional dengan jumlah total sampel adalah 48 orang pasien RSK. Sekret hidung diambil menggunakan kapas lidi steril dengan swab pada meatus medius lalu dilakukan identifikasi bakteri dan pemeriksaan biofilm dengan tube method. Skor Lund-Mackay dihitung dari CT Scan SPN potongan koronal. Data dianalisis dengan uji Fisher. Hasil: Proporsi pasien RSK dengan skor Lund-Mackay yang tinggi lebih banyak pada pasien dengan biofilm (46,2%), dibandingkan tanpa biofilm (44,4%). Secara statistik tidak terdapat perbedaan bermakna pada skor Lund-Mackay antara pasien dengan biofilm dan tanpa biofilm (p=1,000). Kesimpulan: Tidak terdapat hubungan antara biofilm bakteri dengan derajat keparahan RSK berdasarkan skor Lund-Mackay. Kata Kunci: Rinosinusitis kronis, biofilm bakteri, tube method, skor Lund-Mackay ABSTRACT Background: Chronic rhinosinusitis (CRS) is inflammation of the nose and paranasal sinuses with the symptoms duration more than 12 weeks. Many conditions have been linked to its pathogenesis such as bacterial and fungal infection, superantigens and biofilm. Many studies showed the presence of bacterial biofilms in patients with CRS. Bacterial biofilms can facilitate the resistance to antibiotics. Paranasal sinuses (PNS) CT scan is the method of choice for radiological diagnosis of CRS. Lund and Mackay has developed a scoring system based on the CT finding to assess the quantification of inflammatory process in PNS. Some research suggested that patients with bacterial biofilms have higher Lund-Mackay score pre-operatively. Purpose: To determine the role of bacterial biofilms to the severity of CRS according to Lund-Mackay score. Methods: This was a cross-sectional study with 48 CRS patient’s sample. Nasal discharges were taken by swab in middle meatal using sterile cotton buds, followed by identification of bacteria and detection of bacterial biofilms using tube method. Lund-Mackay score was counted from coronal section of PNS CT Scan. Data was analyzed by Fisher’s exact test. Results: Proportion of patients CRS with high Lund-Mackay score was more common in patient with biofilm (46.2%) compared to patients without biofilm (44.4%). Statistically, there was no significant difference of Lund-Mackay score between patient with biofilm and without biofilm (p=1.00). Conclusion: There was no relationship between the bacterial biofilm with the severity of CRS according to Lund-Mackay score. Keywords: Chronic rhinosinusitis, bacterial biofilm, tube method, Lund-Mackay scores

The influence of varying maxillary central incisor vertical dimension on perceived smile aesthetics

2019 ◽  
Vol 46 (2) ◽  
pp. 137-142
Author(s):  
Elis Janaina Lira dos Santos ◽  
Alana Moura Xavier Dantas ◽  
Raíssa Marçal Vilela ◽  
Karina Jerônimo Rodrigues Santiago de Lima ◽  
Rejane Targino Soares Beltrão
Keyword(s):  
Age Groups ◽  
Educational Background ◽  
Cross Sectional Study ◽  
Central Incisor ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Maxillary Central Incisor ◽  
Significant Difference ◽  
Chi Square Test

Objective: To evaluate patient perception of the smile focused on analysis of the upper incisors. Design: Cross-sectional study. Setting: Department of Clinical and Social Dentistry at Federal University of Paraíba, João Pessoa, Brazil. Participants: The sample consisted of 135 individuals (73 women and 62 men). Methods: Images with different characteristics associated with the incisal edges were shown at random and analysed using a Likert scale. Data were analysed using the Chi-square test or Fisher’s exact test with a statistically significant difference ( P < 0.05). Results: Smile I (difference of 1.5 mm in relation to the central incisor and lateral) was considered the most aesthetic, while Smile III (no difference in height between the central and lateral incisors) was the least aesthetic. A significant difference was found between perception of smile II (difference of 1 mm in relation to the central incisor and lateral) and age groups ( P < 0.005), with 31% (n = 13) of individuals aged 45–64 years considering smile II as not pleasant, 4.4% (n = 2) aged 15–24 years and 8.3% (n=4) aged 25–44 years and 4.4% (n = 2) aged 15–24 years considering the same. A significant difference was also found in relation to educational background of the assessor and smile perception, with smile III ( P = 0.0441) and smile IV ( P = 0.0053) considered the most aesthetic ( P = 0.0116). Conclusion: The smile considered most attractive among the sample was that with 1.5 mm steepness between the central and lateral incisors, while a flat smile arc was considered least attractive.

scholarly journals Phosphatase Regenerating Liver3 and ECadherin Expression in Epithelial Ovarian Cancer

2017 ◽  
pp. 170-175
Author(s):  
Risma Maharani ◽  
Syahrul Rauf ◽  
Rina Masadah
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Early Stage ◽  
Cross Sectional Study ◽  
Teaching Hospitals ◽  
Advanced Stage ◽  
Cross Sectional ◽  
Exact Test ◽  
Significant Difference ◽  
E Cadherin

Objective: To determine the expression of Phosphatase Regenerating Liver-3 (PRL-3) and E-Cadherin in the epithelial ovarian cancer on various stages and differentiation grades. Method: This was a cross-sectional study design conducted at Obstetrics and Gynecology Department of several teaching hospitals, Faculty of Medicine Universitas Hasanuddin from January to June 2015. The expression of PRL-3 and E-cadherin was assessed immunohistochemically in 40 patients with epithelial ovarian cancer including 15 patients in early stage and 25 patients in advanced stage. We used the Fisher’s exact test with the significance of p0.05). The significant difference was found in the expression of E-cadherin whereas the high expression was shown at early stage than advanced stage (p0.05). This study also pointed out no correlation between the expression of PRL-3 and E-cadherin in epithelial ovarian cancer (p>0.05). Conclusion: PRL-3 overexpression does not decrease E-cadherin expression in epithelial ovarian cancer. Keywords: E-cadherin, epithelial ovarian cancer, PRL-3

scholarly journals Silent brain infarcts in chronic kidney disease patients with nonspecific neurological symptoms

2021 ◽  
Vol 9 (4) ◽  
pp. 274-279
Author(s):  
P Sasanka ◽  
◽  
Dr. T. Jaya Chandra ◽  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Exact Test ◽  
Brain Infarcts ◽  
Significant Difference

Introduction: Silent brain infarcts (SBI) are parenchymal lesions of previous infarcts, classified astype III cerebrovascular disorder. A study was undertaken to find the relation between SBIs andnonspecific neurological complaints, an association of high sensitivity C-reactive protein (hsCRP)with silent brain infarcts. Methodology: It was a cross-sectional study conducted in the departmentof Nephrology, GSL Medical College, from January to December 2020. Individuals aged > 18 yearswith nonspecific neurological complaints were included. MRI brain, hsCRP and electrocardiogramwere also carried as per the standard protocol. Fischer exact test was used to find the statisticalsignificance; P < 0.05 was considered statistically significant. Results: A total of 51 members haveincluded the male-female ratio was 1.04. SBI was presented in 27.4% (14). Age-wise, among thecortical SBI patients, maximum (75%) were in the> 61 years group. High density lipoprotein levelswere > 40 mg/dL in 39.2%, normal triglycerides (TGL) were observed in 71% and raised hsCRP in62.7% (32). Statistically, there was no significant difference in TGL levels. hsCRP levels were raisedin 3 (75%) members with cortical SBI; statistically, there was no significant difference. Conclusion:The traditional risk factors associated with stroke were present in the patients with SBI. hsCRP wasraised in chronic kidney disease patients having NSCL and having SBI.

scholarly journals Placement of Posterior Composite Restorations: A Cross-Sectional Study of Dental Practitioners in Al-Kharj, Saudi Arabia

2021 ◽  
Vol 18 (23) ◽  
pp. 12408
Author(s):  
Mohamed Awad ◽  
Mansour Alradan ◽  
Nawaf Alshalan ◽  
Ali Alqahtani ◽  
Feras Alhalabi ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Private Sector ◽  
Cross Sectional Study ◽  
Operative Field ◽  
Related Factors ◽  
Cross Sectional ◽  
Exact Test ◽  
Composite Restorations ◽  
Dental Practitioners ◽  
Significant Difference

Dental practitioner-related factors can affect the quality of composite restorations. This study aimed to investigate the clinical techniques used by dental practitioners (DPs) while placing direct posterior composite restorations. Methods: A questionnaire survey that sought information related to the placement of posterior composite restorations was delivered to 161 DPs working in the Al-Kharj area, Saudi Arabia. The collected data were statistically analyzed using Pearson’s Chi-square test and Fisher’s exact test considering the DP’s working sector and the answered questions. Results: A total of 123 DPs completed the survey (76.4% response rate). There was a statistically significant difference between DPs working in the private sector and those working in the governmental sector in 7 out of 17 questionnaire items namely: preparing a minimum depth of 2 mm, (p = 0.001); mechanical means of retention, (p = 0.003); operative field isolation, (p = 0.004); adhesive strategy, (p < 0.001); light-curing unit used, (p = 0.013); the use of radiometer, (p = 0.023), and dental matrix selection, (p < 0.001). Conclusion: The clinical techniques applied by DPs working in the private sector in Al-Kharj, Saudi Arabia when placing posterior composite restorations, including the specifications of cavity preparation, operative field isolation, and selection of the dental matrix system, may be substandard compared to those applied by DPs working in the governmental sector.

scholarly journals Oral-dental hygiene and oral microorganisms in children with and without congenital heart disease

2016 ◽  
Vol 45 (3) ◽  
pp. 127
Author(s):  
Erniwaty P Panggabean ◽  
Lily Irsa ◽  
Rosihan Anwar ◽  
Munar Lubis ◽  
Rusdidjas Rusdidjas ◽  
...  
Keyword(s):  
Oral Hygiene ◽  
Congenital Heart ◽  
Dental Hygiene ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Decayed Tooth ◽  
Significant Difference ◽  
Oral Microorganisms

Objective This study was done to compare the dental and oralhygiene status of children with and without congenital heart dis-ease (CHD) by investigating oral microorganisms and dental andoral hygiene indices.Methods A cross-sectional study was done on children aged 2 to15 years from April 2002 to December 2003 at the Department ofChild Health, Haji Adam Malik Hospital, Medan. There were twosubject groups, the first consisting of children with CHD and thesecond of those without. The dental and oral hygiene status wasdetermined by determining caries index and oral hygiene index.Swabs from the subjects’ upper first molars were taken and cul-tured to determine the types of microorganisms present. Data wereanalyzed using the chi-square test, Fisher’s exact test, and t-test.Results There was a significant difference in mean oral hygieneindex between children with (mean 2.75; SD 1.85) and without(mean 1.45; SD 0.78) CHD (P<0.001). Positive bacterial cultureswere more frequent in children with CHD than in those without.The proportion of normal anaerobes was significantly higher in chil-dren with CHD (P=0.038). Such a significant difference was notfound for normal aerobes, pathogenic aerobes, and pathogenicanaerobes. In children with CHD, there was no significant asso-ciation between mean caries index and oral hygiene index withculture results. In those without CHD, a significant association wasfound between the caries index components of decayed tooth in-dex (P=0.003) and DMF-T (P=0.022) with culture results.Conclusions Oral-dental hygiene in children with CHD is poorrelative to that in children without CHD. Microorganism growth ap-pears more likely in children with CHD than in those without

scholarly journals Adherence to antiretrovirals in people coinfected with the human immunodeficiency virus and tuberculosis

2016 ◽  
Vol 24 (0) ◽  
Author(s):  
Larissa de Araújo Lemos ◽  
Maria Luciana Teles Fiuza ◽  
Renata Karina Reis ◽  
André Carvalho Ferrer ◽  
Elucir Gir ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Low Income ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Number Of Children ◽  
Significant Difference ◽  
Adherence Assessment

Objective: assess the adherence levels to antiretroviral therapy in people coinfected with HIV/tuberculosis and correlate these levels with the sociodemographic and clinical variables of the study population. Method: cross-sectional study involving 74 male and female adults coinfected with HIV/tuberculosis. For the data collection, a sociodemographic and clinical assessment form and the Antiretroviral Treatment Adherence Assessment Questionnaire were used. For the data analysis, the software STATA version 11 was used, through descriptive statistics, Fisher's chi-square exact test and the probability test. Results: men were predominant (79.7%), between 30 and 39 years of age (35.1%), low income (75.7%) and pulmonary tuberculosis (71.6%). Adherence to antiretroviral therapy was inappropriate in 78.1% of the men; 61.0% of single people; 47.0% unemployed and 76.5% among people gaining less than one minimum wage. A significant difference was observed between compliance and length of use of antiretrovirals (p=0.018), sexual orientation (p=0.024) and number of children (p=0.029). Conclusion: the coinfected patients presented inappropriate adherence to the antiretrovirals, a fact that negatively affects the health conditions of the people living with HIV/tuberculosis coinfection. A statistically significant correlation was found between the levels of adherence and some sociodemographic and clinical characteristics.

scholarly journals Signs and symptoms related to inhalation of surgical smoke in the nursing team

2019 ◽  
Vol 23 (3) ◽  
Author(s):  
Ana Claudia Saito ◽  
Amanda Salles Margatho ◽  
Aryane Apolinario Bieniek ◽  
Nathanye Crystal Stanganelli ◽  
Renata Perfeito Ribeiro
Keyword(s):  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Surgical Smoke ◽  
Exact Test ◽  
Significant Difference ◽  
Surgical Technologists ◽  
Nursing Professionals ◽  
Electrocautery Smoke

ABSTRACT Objective: To compare the prevalence of signs and symptoms related to inhalation of surgical smoke among surgical technologists and non-surgical technologists nursing professionals. Method: A cross-sectional study with 46 professionals from a university hospital. To evaluate the prevalence, an instrument with signs/symptoms related to the inhalation of electrocautery smoke was used. To verify the comparison between the prevalence of signs/symptoms, the Fisher’s exact test was performed. Results: Higher prevalence of all signs/symptoms among surgical technologists, with a statistically significant difference between the act of instrumenting with the presence of at least one signs/symptoms related to inhalation of surgical smoke (p=0.01); eye irritation (p=0.02); irritation of nasal mucosa and oral cavity (p=0.03); headache (p=0.04). Conclusion: The presence of problems related to surgical smoke in nursing workers elicits more attention. Implications for practice: Health units must be aware of the risk of such exposure and take measures to preventing it.

scholarly journals Prevalence of sinonasal anatomical variations and their effect on chronic rhinosinusitis in Al-Ramadi teaching hospital, Ramadi city, Iraq

2021 ◽  
Vol 8 (1) ◽  
pp. 35-39
Author(s):  
Raid M. Al-Ani, ◽  
Ghassan M. Khalaf
Keyword(s):  
Chronic Rhinosinusitis ◽  
Teaching Hospital ◽  
Anatomical Variations ◽  
Cross Sectional Study ◽  
Ct Scans ◽  
P Value ◽  
Deviated Nasal Septum ◽  
Cross Sectional ◽  
Radiological Features ◽  
Significant Difference

Anatomical variations (AVs) of the nose and paranasal sinuses (NPS) are quite common findings on CT scans. However, their effect on chronic rhinosinusitis (CRS) is still controversial. The objectives of this study is to estimate the prevalence of AVs of the NPS on CT scans and to assess the association between multiple versus single variant and CRS. A cross-sectional study was conducted in the Al-Ramadi Teaching Hospital during the period from January 1, 2018, to March 31, 2019. We reviewed the CT scans of the patients with suggestive symptoms and signs of CRS. Out of 203 CT scans, there were 153 (75.4%) scans associated with AVs of the NPS (group A). Seventy-eight with and 75 without radiological features of sinusitis. While group B (n=50 24.6%) were not detected any variants, 24 with and 26 without features of sinusitis. There was no statistically significant difference between the two groups (p-value>0.05). There were 11 AVs detected. The septal deviation of 63% was the commonest one. Most of the AVs of the NPS were multiple (2 or more) 99 (64.7%). Forty-nine (49.5%) of them were associated with features of sinusitis. There was a statistically significant difference (p-value <0.05) between those with multiple and those with single AVS concerning the radiological features of sinusitis. In conclusion; AVs of the sinonasal region were common findings on CT scans. A deviated nasal septum is the commonest AVs. Most of our patients contain more than 2 AVs, and they were more vulnerable to sinusitis.

scholarly journals THE ASSOCIATION BETWEEN THE USE OF ALCOHOL, MARIJUANA AND COCAINE AND THE SOCIODEMOGRAPHIC CHARACTERISTICS OF UNIVERSITY STUDENTS OF RIBEIRÃO PRETO, BRAZIL

2019 ◽  
Vol 28 (spe) ◽  
Author(s):  
Ana Carolina Guidorizzi Zanetti ◽  
Francisco Cumsille ◽  
Robert Mann
Keyword(s):  
University Students ◽  
Sociodemographic Factors ◽  
Cross Sectional Study ◽  
Psychoactive Substances ◽  
Chi Square ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Exact Test ◽  
Significant Difference ◽  
Chi Square Test

ABSTRACT Objective: to determine the prevalence of use in life and in the last three months of alcohol, marijuana and cocaine among university students from the social and health Sciences areas of Ribeirão Preto, Brazil and to evaluate the association between use in life and in the last three months of alcohol, marijuana and cocaine and the variables gender, area of the course, with whom the student lives, importance of religion, age and year of study. Method: a cross-sectional study, carried out with a convenience sample of 275 students from a public university in Ribeirão Preto-SP. For data collection, two instruments were used, containing sociodemographic, training and psychoactive substances. For the analysis, the following tests were used: Fisher's exact test, Chi-square test of Person and Mann-Whitney test. Results: As for sociodemographic factors, there was a significant association between the gender of the participants among the use of marijuana and cocaine in life (p=0.024 and p=0.005, respectively) and the last three months (p=0.013 and p=0.009, respectively), among the importance of religion and the lifetime use of alcohol, marijuana and cocaine (p <0.001, p <0.001 and p = 0.024, respectively) and the use of only marijuana in the last three months (p <0.001) and among the use of marijuana in the last three months and the year of graduation (p=0.003). Regarding age, the results showed a significant difference only between the groups that reported not to use alcohol in life (p=0.037). Conclusion: the investigated university students presented a prevalence of use in their lifetime and in the last three months of marijuana and cocaine greater among men, but not for alcohol. The importance of religion was negatively associated with the use of investigated drugs. The results can provide important subsidies for the structuring of preventive measures for abuse of psychoactive substances between university students and the need for new investigations that cover the subject.

scholarly journals The Method and Results of a Treatment Targeting SARS-CoV-2-Activated Inflammasomes

2021 ◽  
Author(s):  
Badar Kanwar ◽  
Asif Khattak ◽  
Chul Joong Lee ◽  
Jenny Balentine ◽  
R. E. Kast ◽  
...  
Keyword(s):  
Case Series ◽  
Cross Sectional Study ◽  
Control Group ◽  
P Value ◽  
Test Statistic ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Pyrin Domain ◽  
Significant Difference

Abstract Background Clinicians in critical care medicine considered dapsone administration to treat SARS-CoV-2 inflammasome. Dapsone is useful in the molecular regulation of Nod-like receptor family pyrin domain-containing 3 (NLRP3). Objective To study the targeting of NLRP3 itself or up-/downstream factors of the NLRP3 inflammasome by dapsone must be responsible for its observed preventive effects, functioning as a competitor. Methods This is case series with or without intervention; a cross-sectional study. We set out to use objective criteria of improvement, such as A. a reduction in the FIO2 requirement and B. a decrease in the progression of hypoxia. We treated the patients with standard COVID-19 ARDS treatment with dapsone 100 mg to target NLRP3 inflammasomes. Results The 22 cases were treated with standard COVID-19 therapy with dapsone (trial group), and the 22 cases were the control group. The comparison was made assuming that only decreased FIO2 was influential in the trial and control groups, which applied to only the ARDS onset stage. The chi-square statistic is 5.1836. The p-value is .02280. Fisher’s exact test statistic value is 0.0433. (The result is significant at p < .05) Furthermore, the ARDS-onset mortality rates were 0% (with dapsone) and 40% (without dapsone). Conclusion There was a significant difference in dapsone treatment results in the ARDS-onset group. We confirmed that dapsone clinically treated the onset of ARDS by targeting SARS-CoV-2-activated inflammasomes. Like chemically reacting substances, inflammasome and dapsone are competing, proving that it is only effective in treating early ARDS.

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