Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

10.3791/60052 ◽  
2019 ◽  
Author(s):  
Oscar W.H. Wong ◽  
Gabriel P.C. Fung ◽  
Sandra Chan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Eye Tracking ◽  
Eye Movement ◽  
Cognitive Functions ◽  
Movement Parameters ◽  
The Relationship

Eye movement parameters and cognitive functions in Parkinson's disease patients without dementia

2018 ◽  
Vol 52 ◽  
pp. 43-48 ◽  
Author(s):  
Oscar WH Wong ◽  
Anne YY Chan ◽  
Adrian Wong ◽  
Claire KY Lau ◽  
Jonas HM Yeung ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Eye Movement ◽  
Cognitive Functions ◽  
Movement Parameters

scholarly journals Ocular fixations and presaccadic potentials to explain pareidolias in Parkinson’s disease

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Gajanan S Revankar ◽  
Noriaki Hattori ◽  
Yuta Kajiyama ◽  
Tomohito Nakano ◽  
Masahito Mihara ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Eye Tracking ◽  
Eye Movement ◽  
Visual Processing ◽  
Top Down ◽  
Scalp Eeg ◽  
Wide Range ◽  
Saccade Size ◽  
Global And Local

Abstract In Parkinson’s disease, a precursor phenomenon to visual hallucinations presents as ‘pareidolias’ which make ambiguous forms appear meaningful. To evoke and detect pareidolias in patients, a noise pareidolia test was recently developed, although its task-dependent mechanisms are yet to be revealed. When subjected to this test, we hypothesized that patients exhibiting pareidolias would show altered top-down influence of visual processing allowing us to demonstrate the influence of pareidolic illusionary behaviour in Parkinson’s disease patients. To that end, we evaluated eye-movement strategies and fixation-related presaccadic activity on scalp EEG when participants performed the test. Twelve healthy controls and 21 Parkinson’s disease patients, evaluated for cognitive, visuo-spatial and executive functions, took a modified computer-based version of the noise pareidolia test in a free-viewing EEG eye-tracking experiment. Eye-tracking metrics (fixation-related durations and counts) documented the eye movement behaviour employed in correct responses (face/noise) and misperceptions (pareidolia/missed) during early and late visual search conditions. Simultaneously, EEG recorded the presaccadic activity in frontal and parietal areas of the brain. Based on the noise pareidolia test scores, we found certain Parkinson’s disease patients exhibited pareidolias whereas others did not. ANOVA on eye-tracking data showed that patients dwelled significantly longer to detect faces and pareidolias which affected both global and local search dynamics depending on their visuo-perceptual status. Presaccadic activity in parietal electrodes for the groups was positive for faces and pareidolias, and negative for noise, though these results depended mainly on saccade size. However, patients sensitive to pareidolias showed a significantly higher presaccadic potential on frontal electrodes independent of saccade sizes, suggesting a stronger frontal activation for pareidolic stimuli. We concluded with the following interpretations (i) the noise pareidolia test specifically characterizes visuo-perceptual inadequacies in patients despite their wide range of cognitive scores, (ii) Parkinson’s disease patients dwell longer to converge attention to pareidolic stimuli due to abnormal saccade generation proportional to their visuo-perceptual deficit during early search, and during late search, due to time-independent alteration of visual attentional network and (iii) patients with pareidolias show increased frontal activation reflecting the allocation of attention to irrelevant targets that express the pareidolic phenomenon. While the disease per se alters the visuo-perceptual and oculomotor dynamics, pareidolias occur in Parkinson’s disease due to an abnormal top-down modulation of visual processing that affects visual attention and guidance to ambiguous stimuli.

scholarly journals Impulsiveness and executive functions in Parkinson’s disease

2019 ◽  
Vol 13 (4) ◽  
pp. 410-414 ◽  
Author(s):  
Bruna de Assis Almeida ◽  
Amer Cavalheiro Hamdan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Executive Functions ◽  
Cognitive Functions ◽  
Cognitive Assessment ◽  
Correlation Study ◽  
Frontal Assessment Battery ◽  
A Value ◽  
Demographic Questionnaire ◽  
The Relationship

ABSTRACT Cognitive functions, such as impulsiveness and executive functions, are often impaired in Parkinson’s disease. Objective: to analyze the relationship between impulsiveness and executive functions (EF) in people with Parkinson’s disease (PD). Methods: a correlation study involving a sample of 50 patients with an established diagnosis of PD aged 40 years or older was conducted using the following instruments: Demographic Questionnaire, Montreal Cognitive Assessment Basic (MOCA-B), Barratt’s Impulsiveness Scale (BIS-11) and Frontal Assessment Battery (FAB). Results: Pearson’s correlation analysis indicated low associations (p<0.05) between the MOCA-B and BIS-11, with a value of -0.11, and between the FAB and BIS-11, with a value of -0.16. A significant correlation between the MOCA-B and FAB was found, with a value of 0.73. Conclusion: this study revealed an association between EF and other cognitive functions, but no association between impulsivity and EF in Parkinson’s disease.

scholarly journals The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations

2017 ◽  
Vol 4 (5) ◽  
pp. 698-709 ◽  
Author(s):  
Sang Soo Cho ◽  
Antonio P. Strafella ◽  
Sarah Duff-Canning ◽  
Mateusz Zurowski ◽  
Anne-Catherine Vijverman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Functions ◽  
Visual Hallucinations ◽  
Serotonin 2A Receptor ◽  
The Relationship ◽  
Serotonin 2A

scholarly journals Fixation Duration and Pupil Size as Diagnostic Tools in Parkinson’s Disease

2021 ◽  
pp. 1-11
Author(s):  
Panagiota Tsitsi ◽  
Mattias Nilsson Benfatto ◽  
Gustaf Öqvist Seimyr ◽  
Olof Larsson ◽  
Prof Per Svenningsson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Eye Movements ◽  
Eye Tracking ◽  
Eye Movement ◽  
Pupil Size ◽  
Clinical Investigation ◽  
Sampling Rate ◽  
Diagnostic Tools ◽  
Eye Tracker

Background: Visual and oculomotor problems are very common in Parkinson’s disease (PD) and by using eye-tracking such problems could be characterized in more detail. However, eye-tracking is not part of the routine clinical investigation of parkinsonism. Objective: To evaluate gaze stability and pupil size in stable light conditions, as well as eye movements during sustained fixation in a population of PD patients and healthy controls (HC). Methods: In total, 50 PD patients (66% males) with unilateral to mild-to-moderate disease (Hoehn & Yahr 1– 3, Schwab and England 70– 90% ) and 43 HC (37% males) were included in the study. Eye movements were recorded with Tobii Pro Spectrum, a screen-based eye tracker with a sampling rate of 1200 Hz. Logistic regression analysis was applied to investigate the strength of association of eye-movement measures with diagnosis. Results: Median pupil size (OR 0.811; 95% CI 0.666– 0.987; p = 0.037) and longest fixation period (OR 0.798; 95% CI 0.691-0.921; p = 0.002), were the eye-movement parameters that were independently associated with diagnosis, after adjustment for sex (OR 4.35; 95% CI 1.516– 12.483; p = 0.006) and visuospatial/executive score in Montreal Cognitive Assessment (OR 0.422; 95% CI 0.233– 0.764; p = 0.004). The area under the ROC curve was determined to 0.817; 95% (CI) 0.732– 0.901. Conclusion: Eye-tracking based measurements of gaze fixation and pupil reaction may be useful biomarkers of PD diagnosis. However, larger studies of eye-tracking parameters integrated into the screening of patients with suspected PD are necessary, to further investigate and confirm their diagnostic value.

scholarly journals The Relationship of Rapid Eye Movement Sleep Behavior Disorder and Freezing of Gait in Parkinson’s Disease

Cureus ◽  
2020 ◽  
Author(s):  
Chelsea Mae N Nobleza ◽  
Mariah Siddiqui ◽  
Parth V Shah ◽  
Prachi Balani ◽  
Angel R Lopez ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Eye Movement ◽  
Freezing Of Gait ◽  
Behavior Disorder ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Sleep Behavior ◽  
Relationship Of ◽  
The Relationship

Appendectomy Does Not Increase the Risk of Future Emergence of Parkinson’s Disease: A Meta-analysis

2021 ◽  
pp. 000313482198903
Author(s):  
Mitsuru Ishizuka ◽  
Norisuke Shibuya ◽  
Kazutoshi Takagi ◽  
Hiroyuki Hachiya ◽  
Kazuma Tago ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Random Effects Models ◽  
Significant Difference ◽  
The Cochrane Library ◽  
The Impact ◽  
The Relationship ◽  
Observation Period

Objective To explore the impact of appendectomy history on emergence of Parkinson’s disease (PD). Background Although there are several studies to investigate the relationship between appendectomy history and emergence of PD, the results are still controversial. Methods We performed a comprehensive electronic search of the literature (the Cochrane Library, PubMed, and the Web of Science) up to April 2020 to identify studies that had employed databases allowing comparison of emergence of PD between patients with and those without appendectomy history. To integrate the impact of appendectomy history on emergence of PD, a meta-analysis was performed using random-effects models to calculate the risk ratio (RR) and 95% confidence interval (CI) for the selected studies, and heterogeneity was analyzed using I2 statistics. Results Four studies involving a total of 6 080 710 patients were included in this meta-analysis. Among 1 470 613 patients with appendectomy history, 1845 (.13%) had emergences of PD during the observation period, whereas among 4 610 097 patients without appendectomy history, 6743 (.15%) had emergences of PD during the observation period. These results revealed that patients with appendectomy history and without appendectomy had almost the same emergence of PD (RR, 1.02; 95% CI, .87-1.20; P = .83; I2 = 87%). Conclusion This meta-analysis has demonstrated that there was no significant difference in emergence of PD between patients with and those without appendectomy history.

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