scholarly journals Determination of Serum C-reactive Protein Levels in Breast Cancer by Enzyme Linked Immunoassay Technique

2021 ◽  
Author(s):  
Mehreen Lateef
Keyword(s):  
Breast Cancer ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Immunoassay Technique

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scholarly journals Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study

2016 ◽  
Vol 34 (7) ◽  
pp. 669-676 ◽  
Author(s):  
Maura Harrigan ◽  
Brenda Cartmel ◽  
Erikka Loftfield ◽  
Tara Sanft ◽  
Anees B. Chagpar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Weight Loss ◽  
Body Composition ◽  
Telephone Counseling ◽  
Serum Biomarkers ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
The Mean

Purpose Obesity is associated with a higher risk of breast cancer mortality. The gold standard approach to weight loss is in-person counseling, but telephone counseling may be more feasible. We examined the effect of in-person versus telephone weight loss counseling versus usual care on 6-month changes in body composition, physical activity, diet, and serum biomarkers. Methods One hundred breast cancer survivors with a body mass index ≥ 25 kg/m2 were randomly assigned to in-person counseling (n = 33), telephone counseling (n = 34), or usual care (UC) (n = 33). In-person and telephone counseling included 11 30-minute counseling sessions over 6 months. These focused on reducing caloric intake, increasing physical activity, and behavioral therapy. Body composition, physical activity, diet, and serum biomarkers were measured at baseline and 6 months. Results The mean age of participants was 59 ± 7.5 years old, with a mean BMI of 33.1 ± 6.6 kg/m2, and the mean time from diagnosis was 2.9 ± 2.1 years. Fifty-one percent of the participants had stage I breast cancer. Average 6-month weight loss was 6.4%, 5.4%, and 2.0% for in-person, telephone, and UC groups, respectively (P = .004, P = .009, and P = .46 comparing in-person with UC, telephone with UC, and in-person with telephone, respectively). A significant 30% decrease in C-reactive protein levels was observed among women randomly assigned to the combined weight loss intervention groups compared with a 1% decrease among women randomly assigned to UC (P = .05). Conclusion Both in-person and telephone counseling were effective weight loss strategies, with favorable effects on C-reactive protein levels. Our findings may help guide the incorporation of weight loss counseling into breast cancer treatment and care.

Preoperative Serum C-Reactive Protein Levels and Early Breast Cancer by BMI and Menopausal Status

2013 ◽  
Vol 31 (4) ◽  
pp. 279-285 ◽  
Author(s):  
Tingting Hong ◽  
Aining Liu ◽  
Dongyan Cai ◽  
Ying Zhang ◽  
Dong Hua ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Menopausal Status ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Preoperative Serum

Rapid determination of C-reactive protein levels: Semiquantitative versus quantitative

1987 ◽  
Vol 110 (2) ◽  
pp. 263-265 ◽  
Author(s):  
Alistair G.S. Philip ◽  
Patricia A. Andrews
Keyword(s):  
Rapid Determination ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Pronounced Diurnal Pattern of Salivary C-Reactive Protein (CRP) With Modest Associations to Circulating CRP Levels

2021 ◽  
Vol 11 ◽  
Author(s):  
Jonas Wetterö ◽  
Sarah von Löhneysen ◽  
Flordelyn Cobar ◽  
Margareta Kristenson ◽  
Peter Garvin ◽  
...  
Keyword(s):  
Total Protein ◽  
Smoking Status ◽  
Age Groups ◽  
Correlation Coefficients ◽  
Sampling Procedure ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Serum Crp

C-reactive protein (CRP), a humoral component of the innate immune system with important functions in host-defense, is extensively used as a sensitive biomarker of systemic inflammation. During inflammation, hepatocyte-derived CRP rises dramatically in the blood due to increased interleukin-6 (IL-6) levels. Reliable detection of CRP in saliva, instead of blood, would offer advantages regarding sampling procedure and availability but using saliva as a diagnostic body fluid comes with challenges. The aims of this study were to evaluate associations between salivary CRP, total protein levels in saliva and serum CRP. Furthermore, we examined associations with plasma IL-6, body mass index (BMI), tobacco smoking and age. Salivary CRP was investigated by ELISA in 107 middle-aged participants from the general population. We employed spectrophotometric determination of total protein levels. Correlation analyses were used for associations of salivary CRP with serum CRP (turbidimetry), plasma IL-6 (Luminex®), BMI and smoking habits. Salivary median CRP was 68% higher (p=0.009), and total protein levels were 167% higher (p<0.0001), in morning compared to evening saliva. The correlation coefficients between serum and salivary CRP were low to moderate, but stronger for evening than morning saliva. Plasma IL-6 correlated significantly with serum CRP (rs=0.41, p<0.01), but not with morning or evening salivary CRP. Non-smokers showed 103% higher salivary CRP levels (p=0.015), whereas serum CRP was independent of smoking status. As opposed to CRP in serum, salivary CRP was not associated with BMI. Salivary CRP was 90% higher among the age interval 60–69 years compared to subjects aged 45–59 (p=0.02) while serum CRP levels did not differ between the age groups. In conclusion, CRP in saliva did not straightforwardly reflect serum concentrations. This raises questions regarding adequate reflection of biological events. The pronounced diurnal salivary CRP pattern accentuates the importance of standardizing the time-point of sampling.

Assessment of cardiovascular disease risk using immunosensors for determination of C-reactive protein levels in serum and saliva: a pilot study

Bioanalysis ◽  
2014 ◽  
Vol 6 (11) ◽  
pp. 1459-1470 ◽  
Author(s):  
Celine IL Justino ◽  
Kátia Duarte ◽  
Susana Lucas ◽  
Paulo Chaves ◽  
Paulo Bettencourt ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Pilot Study ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

C-reactive Protein Levels and Radiation-Induced Skin Reaction in Breast Cancer

2011 ◽  
Vol 81 (2) ◽  
pp. S758
Author(s):  
J.L. Rodriguez-Gil ◽  
V. Thomas ◽  
G. Allen ◽  
M. Poitevien ◽  
C. Takita ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Skin Reaction ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Radiation Induced

Evaluation of c-reactive protein in breast cancer by enzyme linked immunoassay technique

2020 ◽  
pp. 1-13
Author(s):  
Ambreen Usmani ◽  
Mehreen Lateef
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Ribonucleic Acid ◽  
Enzyme Linked Immunosorbent Assay ◽  
Breast Cancer Patients ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Group A ◽  
Group B

Abstract Objective: To explore the serum levels of C-reactive protein in breast cancer patients, and to investigate the relationship between  inflammation and progression of breast cancer. Methods: The  case-control study  was conducted at Bahria University Medical and Dental College, Karachi, from September 2015 to December 2018, and comprised breast cancer patients in group A and and an equal number of age-matched healthy women in control group B. C-reactive protein levels were evaluated in serum samples using enzyme-linked immunosorbent assay in both the groups and micro ribonucleic acid levels in serum were quantified using real time polymerase chain reaction. Data was analysed using SPSS 16. Results: Of the 170 subjects, 85(50%) were in each of the two groups. C-reactive protein and micro ribonucleic acid expression were significantly different in group A (p<0.001). There was no correlation (r = 0.162, p>0.01) between the tumour  markers in  group B (p>0.05). Conclusion: Significantly raised C-reactive protein levels showed there was a link between inflammation and breast cancer. Key Words: Breast cancer, C-reactive protein, MicroRNA 16. Continuous....

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