scholarly journals Streptococcus agalactiae causing pyometra in an elderly female with cervical cancer

2012 ◽  
Vol 6 (12) ◽  
pp. 891-894 ◽  
Author(s):  
Ruchi Gupta ◽  
Anupam Das ◽  
Prakash S Krishna
Keyword(s):  
Cervical Cancer ◽  
Streptococcus Agalactiae ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Uterine Cavity ◽  
Elderly Female ◽  
Ascending Infection ◽  
Invasive Infections ◽  
Female Genital

Streptococcus agalactiae is an important cause of invasive infections in neonates and is emerging as an important pathogen in elderly females. S. agalactiae is a commensal organism of the female genital tract; however, isolation from the uterine cavity suggests ascending infection of this organism caused by occlusion of the uterine cavity. We report a case of S. agalactiae causing pyometra in an elderly female with cervical cancer.

scholarly journals Vaginal, Cervical and Uterine pH in Women with Normal and Abnormal Vaginal Microbiota

Pathogens ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 90
Author(s):  
Malene Risager Lykke ◽  
Naja Becher ◽  
Thor Haahr ◽  
Ebbe Boedtkjer ◽  
Jørgen Skov Jensen ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Genital Tract ◽  
Quantitative Polymerase Chain Reaction ◽  
Female Genital Tract ◽  
Uterine Cavity ◽  
Vaginal Microbiota ◽  
Reproductive Age ◽  
Ph Gradient ◽  
Increased Risk ◽  
Female Genital

Introduction: Healthy women of reproductive age have a vaginal pH around 4.5, whereas little is known about pH in the upper genital tract. A shift in the vaginal microbiota may result in an elevated pH in the upper genital tract. This might contribute to decreased fertility and increased risk of preterm birth. Therefore, we aimed to measure pH in different compartments of the female genital tract in both nonpregnant and pregnant women, stratifying into a normal and abnormal vaginal microbiota. Material and methods: In this descriptive study, we included 6 nonpregnant, 12 early-pregnant, and 8 term-pregnant women. A pH gradient was recorded with a flexible pH probe. An abnormal vaginal microbiota was diagnosed by a quantitative polymerase chain reaction technique for Atopobium vaginae; Sneathia sanguinegens; Leptotrichia amnionii; bacterial vaginosis-associated bacterium 1, 2, 3, and TM7; and Prevotella spp. among others. Results: In all participants we found the pH gradient in the lower reproductive canal to be most acidic in the lower vagina and most alkaline in the upper uterine cavity. Women with an abnormal vaginal microbiota had an increased pH in the lower vagina compared to the other groups. Conclusions: There is a pronounced pH gradient within the female genital tract. This gradient is not disrupted in women with an abnormal vaginal microbiota.

scholarly journals Microbiome and Cervical Cancer

Pathobiology ◽  
2020 ◽  
pp. 1-11
Author(s):  
Cristina Paula Castanheira ◽  
Mayara Luciana Sallas ◽  
Rafaella Almeida Lima Nunes ◽  
Noely Paula Cristina Lorenzi ◽  
Lara Termini
Keyword(s):  
Cervical Cancer ◽  
Genital Tract ◽  
Current Knowledge ◽  
Disease Onset ◽  
Female Genital Tract ◽  
Hpv Infection ◽  
Vaginal Microbiome ◽  
Associated Lesions ◽  
Cervical Disease ◽  
Female Genital

Persistent infection with some types of mucosal human papillomavirus (HPV) is the etiological factor for the development of cervical cancer and its precursor lesions. Besides, several cofactors are known to play a role in cervical disease onset and progression either by favoring or by preventing HPV infection and persistence. The microbiome of a healthy female genital tract is characterized by the presence of 1 or few varieties of lactobacilli. However, high-throughput studies addressing the bacterial diversity and abundance in the female genital tract have shown that several factors, including hormonal levels, hygiene habits, and sexually transmitted diseases may disrupt the natural balance, favoring the outgrowth of some groups of bacteria, which in turn may favor some pathological states. Recently, the vaginal microbiome has emerged as a new variable that could greatly influence the natural history of HPV infections and their clinical impact. In this context, changes in the vaginal microbiome have been detected in women infected with HPV and women with HPV-associated lesions and cancer. However, the role of specific bacteria groups in the development/progression or prevention/regression of HPV-associated pathologies is not well understood. In this review we summarize the current knowledge concerning changes in vaginal microbiome and cervical disease. We discuss the potential functional interplay between specific bacterial groups and HPV infection outcomes.

scholarly journals Malignant Tumors of the Female Genital Tract – a Hospital Based Analysis

2016 ◽  
Vol 10 (2) ◽  
pp. 24-28
Author(s):  
R Joshi ◽  
G Baral ◽  
K Malla
Keyword(s):  
Ovarian Cancer ◽  
Cervical Cancer ◽  
Endometrial Cancer ◽  
Genital Tract ◽  
Malignant Tumors ◽  
Female Genital Tract ◽  
Limited Data ◽  
Corpus Uteri ◽  
Female Genital

Aims: The incidence of cancer and the cancer related deaths are increasing worldwide. There is limited data regarding  gynecological cancers in Nepal. This study is conducted to analyze the trends of female genital tract malignancies in Paropakar Maternity and Women’s Hospital (PMWH) and compare it with the national/international data.Methods: This was a retrospective study conducted in Department of Obstetrics/Gynecology and Pathology in PMWH.  All female diagnosed with the genital tract malignancies from July 2013 to July 2015 were included in the study.Results: Among 62 cases, cervical cancer was the commonest (71%) followed by ovarian cancer (14%), endometrial cancer (8%) and choriocarcinoma (3%). Majority of women belonged to 50-59 years for each type of tumors. Four-fifth of endometrial, half of the cervical and one-third of ovarian cancers were among grand-multipara. Sixty nine percent of women received treatment with 22 (9 cervical, 9 ovarian, 3 endometrial and one of corpus uteri)  surgical and 21 primary chemo/radiotherapy but 19 (31%) were lost for follow-up. Squamous type of cervical cancer was the commonest (93%).Conclusions: Cervical cancer was the commonest genital tract malignancy followed by ovarian cancer, endometrial cancer and choriocarcinoma. For each type of tumors, 50-59 years was the common age group and grand multiparity was seen in half of the women with the cervical cancer. Squamous type of cervical cancer was the commonest variety.  

scholarly journals The Endometrial Microbiome and Its Impact on Human Conception

2022 ◽  
Vol 23 (1) ◽  
pp. 485
Author(s):  
Bruno Toson ◽  
Carlos Simon ◽  
Inmaculada Moreno
Keyword(s):  
Experimental Design ◽  
Bacterial Communities ◽  
Genital Tract ◽  
Current Knowledge ◽  
Female Genital Tract ◽  
Uterine Cavity ◽  
Human Reproduction ◽  
Fertility Treatment ◽  
Review Current ◽  
Female Genital

Changes in the female genital tract microbiome are consistently correlated to gynecological and obstetrical pathologies, and tract dysbiosis can impact reproductive outcomes during fertility treatment. Nonetheless, a consensus regarding the physiological microbiome core inside the uterine cavity has not been reached due to a myriad of study limitations, such as sample size and experimental design variations, and the influence of endometrial bacterial communities on human reproduction remains debated. Understanding the healthy endometrial microbiota and how changes in its composition affect fertility would potentially allow personalized treatment through microbiome management during assisted reproductive therapies, ultimately leading to improvement of clinical outcomes. Here, we review current knowledge regarding the uterine microbiota and how it relates to human conception.

scholarly journals A Case of Maternal Sepsis and Fetal Demise Associated with Streptococcus pseudoporcinus

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Stephanie L. Pierce ◽  
Dena R. Shibib ◽  
Denise Robison ◽  
Rodney K. Edwards
Keyword(s):  
Abdominal Pain ◽  
Blood Culture ◽  
Streptococcus Agalactiae ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Morbidity And Mortality ◽  
Genitourinary Tract ◽  
Fetal Demise ◽  
Maternal Sepsis ◽  
Female Genital

Streptococcus pseudoporcinus has recently been described in relation to its colonization of the female genitourinary tract. Since prior reports have linked S. pseudoporcinus only with minor morbidities, the organism previously has not been considered to be a cause of serious puerperal infections. A 41-year-old gravida 2, para 1-0-0-1 presented with abdominal pain and intrauterine fetal demise. A beta hemolytic Streptococcus was isolated from her placenta, endometrium, urine, and two blood culture sets. The isolate was a Streptococcus pseudoporcinus, which colonizes the female genital tract and can resemble Streptococcus agalactiae. This case demonstrates that S. pseudoporcinus is a potential cause of severe maternal and fetal morbidity and mortality.

scholarly journals Hysterosalpingography (HSG), hysteroscopy and laparoscopic evaluation of female genital tract of patient attending tertiary infertility centre and correlation of various modalities

2018 ◽  
Vol 7 (4) ◽  
pp. 1597
Author(s):  
G. D. Maiti ◽  
Prasad Lele
Keyword(s):  
Genital Tract ◽  
False Negative ◽  
Female Genital Tract ◽  
Neonatal Resuscitation ◽  
Uterine Cavity ◽  
Infertile Couple ◽  
Specificity And Sensitivity ◽  
Tubal Factor ◽  
Diagnostic Hysteroscopy ◽  
Female Genital

Background: Hysterosalpingogarphy (HSG) has traditionally been the first line of investigation anatomy and contour of uterine cavity along with fallopian tube and its patency. Because of limitations of HSG, video endoscopic evaluation of endometrial and peritoneal cavity by diagnostic hysteroscopy and laparoscopy can diagnose many subtle and obvious pathologies in evaluation of infertile couple. To know this difference author studied the efficacy of HSG along with diagnostic laparohysteroscopy.Methods: HSG, Diagnostic Hysteroscopy and Laparoscopy were performed on a group of 50 Patient of primary and secondary infertility. Findings of HSG, Hysteroscopy and Laparoscopy were computed, analyzed and corelated.Results: HSG showed a false positive rate of 25% for tubal factor and false negative 12% for uterine factors when compared with hysteroscopic and laparoscopic findings. The sensitivity of HSG was 75% and specificity was 88 % when compared with Hysteroscopic and Laparoscopic findings. Among various abnormality detected during the present study were, congenital anomaly 7(14%), Asherman syndrome 5 (10%), Tubal factor defect 6(12%), fibroid 3(6%) and Pelvi-inflammatory disease in 7(14%) of cases.Conclusions: This study showed UA-S/D ratio and UA-RI >2SD are significant predictors of perinatal deaths and immediate neonatal resuscitation in preeclampsia. Acute fetal distress in labour or neonatal nursery admission could not be predicted. Though HSG is a simple procedure for detecting abnormality of female genital tract, due to its low specificity and sensitivity hysterolaparoscopy should be complemented during infertility work up in all patient.

Staphylococcus sciuri: an unusual cause of pelvic inflammatory disease

2005 ◽  
Vol 16 (6) ◽  
pp. 452-453 ◽  
Author(s):  
S Stepanović ◽  
P Ježek ◽  
I Dakić ◽  
D Vuković ◽  
L Seifert
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Streptococcus Agalactiae ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Lower Genital Tract ◽  
One Year ◽  
The One ◽  
Low Rate ◽  
Female Genital

We present the case of polymicrobial pelvic inflammatory disease (PID) that involved Staphylococcus sciuri, S. epidermidis, and Streptococcus agalactiae. In order to determine the frequency of S. sciuri isolation from the female lower genital tract, 3415 vaginal samples were analysed during the one-year study period. S. sciuri was isolated from three (0.09%) samples. In all the three cases, S. sciuri was obtained in mixed culture from outpatients without symptoms of infection. While the origin of S. sciuri in the female genital tract remains to be elucidated, the present study showed that this bacterium may colonize vagina and, moreover, may be involved in the pathogenesis of an infection as serious as PID. The low rate of isolation we established, however, indicates infrequent and, most probably, transient colonization of the female genital tract by S. sciuri.

scholarly journals Comprehensive Characterization of Microbial Community in the Female Genital Tract of Reproductive-Aged Women in China

2021 ◽  
Vol 11 ◽  
Author(s):  
Ningxia Sun ◽  
Haixia Ding ◽  
Hongjing Yu ◽  
Yixuan Ji ◽  
Xiuyue Xifang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Genital Tract ◽  
Chinese Women ◽  
Female Genital Tract ◽  
Uterine Cavity ◽  
Functional Roles ◽  
Neurotrophin Signaling ◽  
Reproductive Aged Women ◽  
Infertile Patients ◽  
Female Genital

The microbiota in the human body play critical roles in many physiological and pathological processes. However, the diversity and dynamics of the female genital tract (FGT) microbiota have not been fully unveiled. In this study, we characterized the microbiome variations in reproductive-aged Chinese women, and we revealed that the cervicovaginal microbiota were dominated by Lactobacillus. Overall, the composition of microbiota in the uterine cavity was more diverse than that in the vagina and cervix. A positive correlation between Lactobacillus iners and Lactobacillus crispatus was observed in both the vagina and the cervix, suggesting that these two species might have a symbiotic relationship in the cervicovaginal microbiota. Moreover, we, for the first time, stratified the reproductive-aged Chinese women into subgroups, based on their microbiome profiles. Furthermore, we identified the bacteria whose abundance changed in the uterine cavity of infertile patients when compared with healthy controls, such as L. iners and L. crispatus. Functionally, the metabolism-related pathways, neurotrophin signaling pathway, and adipocytokine signaling pathway were predominantly dysregulated in the uterine cavity of infertile patients. In conclusion, we characterized a comprehensive microbial landscape in FGT, as well as their functional roles in female infertility of the Chinese population.

scholarly journals Clostridium sordellii Infection of Female Genital Tract: A Rare but Fulminating Reaction

2015 ◽  
Vol 7 (3) ◽  
pp. 197-198
Author(s):  
Anu Pathak ◽  
Manisha Pathak
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Gas Production ◽  
Leukemoid Reaction ◽  
Clostridium Sordellii ◽  
Cytopathic Effects ◽  
Decidual Tissue ◽  
Ascending Infection ◽  
Vaginal Tract ◽  
Female Genital

ABSTRACT Clostridium sordellii, an anaerobic pathogen, is ubiquitously distributed in the environment and causes fatal necrotizing infections in approximately 70% of all reported cases. Characteristic clinical features include absence of fever and rash, dramatic leukemoid reaction (LR), capillary leak and fluid sequestration with hemoconcentration, refractory tachycardia and hypotension, and marked edema of infected tissues without gas production or extensive myonecrosis. C. sordellii has rarely been identified in the genital tract, other Clostridium species colonize the vagina in 4 to 18% of healthy women and commonly are associated with postpartum endometritis and septic abortion. Pregnancy, childbirth, or abortion may predispose a some women to acquire C. sordellii in the vaginal tract. Dilatation of the cervix may lead to ascending infection of necrotic decidual tissue. The acidic pH of the vaginal tract may enhance the cytopathic effects of C. sordellii lethal toxin C. sordellii infections pose difficult clinical challenges and are usually fatal. How to cite this article Agrawal PK, Garg R, Singh R, Pathak A, Pathak M. Clostridium sordellii Infection of Female Genital Tract: A Rare but Fulminating Reaction. J South Asian Feder Obst Gynae 2015;7(3):197-198.

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