scholarly journals Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia

2016 ◽  
Vol 10 (06) ◽  
pp. 619-625 ◽  
Author(s):  
Hatem H AlMutairi ◽  
Mohammad M AlAhmari ◽  
Badr H Al-Zahran ◽  
Ibrahim S Abbas ◽  
Juma`an S Al Ghamdi ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Nucleic Acid ◽  
Blood Donors ◽  
Viral Infections ◽  
Serological Markers ◽  
Viral Nucleic Acid ◽  
Cross Sectional ◽  
Hbv Markers ◽  
Donated Blood ◽  
Anti Hiv

Introduction: Data on blood-borne viral infections in some regions in Saudi Arabia remain scarce. This study investigates the prevalence of serological markers and nucleic acid for blood-borne viruses among blood donors in Al-Baha, Kingdom of Saudi Arabia. Methodology: In this cross-sectional study, 2,807 donors who donated blood between January 2009 and November 2011 were investigated for blood-borne viral serological markers including HBsAg, anti-HBc, anti-HBs, anti-HCV, anti-HIV, and anti-HTLVI/III in addition to viral nucleic acid. Results: All donors were males between 16 to 66 years of age (mean: 31.5 ± 9.3 years). Viral nucleic acid and/or serological markers were detected in a total of 36 (1.3%) donors; of them, 26 (72.2%) had nucleic acid concomitant with serological markers, 6 (16.7%) had only viral nucleic acid, while 4 (11.1%) had only serological markers. Of all donors, 22 (0.8%) had HBsAg, 227 (8.0%) had anti-HBc, 157 (5.0%) had anti-HBs, 2,577 (91.8%) had no HBV markers, 2 (0.07%) had anti-HIV, 1 (0.04%) had anti-HCV, and 1 (0.04%) had anti-HTLVI/II. The donors who were born during HBV vaccination era showed no HBsAg (0.0%; p = 0.052), lower rates of anti-HBc (1.5%; p < 0.001) and anti-HBs (0.7%; p < 0.001), while the majority had no HBV markers (98.5%; p < 0.001). Conclusions: Combined viral nucleic acid and serological testing of donated blood enhances blood safety. The absence of HBV markers among donors suggests susceptibility or declined anti-HBs levels. Thus, HBV revaccination or a vaccine boost among adolescents and adults might be indispensable.

The diagnosis of hepatitis C viral infection

2014 ◽  
Vol 155 (26) ◽  
pp. 1019-1023
Author(s):  
Judit Gervain
Keyword(s):  
Hepatitis C ◽  
Nucleic Acid ◽  
Viral Infection ◽  
Structural Changes ◽  
Viral Infections ◽  
Transient Elastography ◽  
Viral Nucleic Acid ◽  
Length Of Treatment ◽  
Subtype B

The successful therapy of hepatitis C viral infection requires that the illness is diagnosed before the development of structural changes of the liver. Testing is stepwise consisting of screening, diagnosis, and anti-viral therapy follow-up. For these steps there are different biochemical, serological, histological and molecular biological methods available. For screening, alanine aminotransferase and anti-HCV tests are used. The diagnosis of infection is confirmed using real-time polymerase chain reaction of the viral nucleic acid. Before initiation of the therapy liver biopsy is recommended to determine the level of structural changes in the liver. Alternatively, transient elastography or blood biomarkers may be also used for this purpose. Differential diagnosis should exclude the co-existence of other viral infections and chronic hepatitis due to other origin, with special attention to the presence of autoantibodies. The outcome of the antiviral therapy and the length of treatment are mainly determined by the viral genotype. In Hungary, most patients are infected with genotype 1, subtype b. The polymorphism type that occurs in the single nucleotide located next to the interleukin 28B region in chromosome 19 and the viral polymorphism type Q80K for infection with HCV 1a serve as predictive therapeutic markers. The follow-up of therapy is based on the quantitative determination of viral nucleic acid according to national and international protocols and should use the same method and laboratory throughout the treatment of an individual patient. Orv. Hetil., 2014, 155(26), 1019–1023.

scholarly journals The prevalence of transfusion-transmitted infections and nucleic acid testing among blood donors in Majmaah, Saudi Arabia

2018 ◽  
Vol 11 (5) ◽  
pp. 702-706 ◽  
Author(s):  
Mohammed Alaidarous ◽  
Ranjay K. Choudhary ◽  
Mohamed I. Waly ◽  
Shabir Mir ◽  
Abdulaziz Bin Dukhyil ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Nucleic Acid ◽  
Blood Donors ◽  
Nucleic Acid Testing

scholarly journals Seroprevalence of the Serological Markers of Transfusion-Transmissible Infections among Volunteer Blood Donors of Kosti Obstetrics and Gynecology Hospital

Medicines ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 64
Author(s):  
Babiker Saad Almugadam ◽  
Omer Mohammed Ali Ibrahim ◽  
Yousif Mousa Alobaid Ahmed
Keyword(s):  
Urban Areas ◽  
Blood Donors ◽  
Blood Groups ◽  
Obstetrics And Gynecology ◽  
Serological Markers ◽  
Education Programs ◽  
Cross Sectional ◽  
Seropositivity Rate ◽  
Multiple Markers ◽  
Comprehensive Surveillance

Background: Transfusion-transmissible infections are well-known global health challenges. The present study is proposed to investigate the seropositivity of anti-HIV1/2, anti-HCV, HBsAg, and anti-T.pallidum among volunteer blood donors of Kosti Obstetrics and Gynecology Hospital. Methods: Our study was conducted in a cross-sectional retrospective manner. The data of donors who attended Kosti Obstetrics and Gynecology Hospital throughout 2016 to 2018 were reviewed and retrieved manually from blood bank records. Results: Out of 8139 donors, 22.52% were seropositive for serological markers of TTIs and 1.67% were seropositive for at least two serological markers of TTIs. The overall seropositivity rate of anti-HIV1/2, HBsAg, anti-HCV, and anti-T.pallidum was 1.77%, 6.07%, 1.14%, and 11.87%, respectively (p < 0.000). Anti-T.pallidum was the most frequently detected (p < 0.000) marker across all study variables. TTIs seroprevalence was significantly (p < 0.000) varied according to the age, residence, occupations, and blood groups. Notably, there was a rising trend in the rate of anti-HIV1/2 and seropositivity for more than one marker with age (p < 0.000). Regionally, rural area residents had a higher rate of anti-HIV1/2 (2.20%), HBsAg (6.31%), anti-HCV (1.42%), anti-T.pallidum (18.38%), and multiple markers seropositivity (2.28%) compared to urban areas. Between occupations, the highest rate of anti-HIV1/2 (p = 0.497), HBsAg (p = 0.003), anti-HCV (p = 0.385), anti-T.pallidum (p < 0.000), and multiple markers seropositivity (p < 0.000) were detected in farmers. Regarding the screening, we also found that the frequency of anti-T.pallidum was significantly (p = 0.004) higher in donors that carry the AB+ve blood group, whereas anti-HCV (1.83%) was more frequent in O−ve blood groups (p = 0.004). Anti-T.pallidum+HBsAg was the most frequently (1.22%) co-occurring marker. In contrast, anti-T.pallidum+anti-HIV1/2+HBsAg was the lowest frequency marker (p < 0.000). Conclusions: The study showed an alarming rate of TTIs, which suggests the requirement for comprehensive surveillance and health education programs.

scholarly journals Determinants of Antibiotics Misuse by the Parents in Children: A Survey From Northern Region of Saudi Arabia

2017 ◽  
Vol 40 (2) ◽  
pp. 64-71 ◽  
Author(s):  
Mohammad Asif Aleem ◽  
Md Mizanur Rahman ◽  
Mateen Ishfaq ◽  
Kashif Mehmood ◽  
Sayed Shabbir Ahmed
Keyword(s):  
Saudi Arabia ◽  
Family Member ◽  
Low Income ◽  
Viral Infections ◽  
Cross Sectional Study ◽  
Northern Region ◽  
The Other ◽  
Cross Sectional ◽  
Beliefs And Practices ◽  
The Past

Objectives: To investigate knowledge, beliefs and practices associated with parental antibiotic misuse.Methods: This cross sectional study was conducted among the parents visited 4 major shopping malls (selling medicines) of Tabuk, Saudi Arabia from June to December 2015. Self-prescription of antibiotics for a child in the past year was defined as antibiotic misuse was noted.Results: From 610 parents (60.5% mothers and 39.5% fathers) 11.6% reported selfprescription. Responded parents differed by age, education, number of children and profession. Parents responded that antibiotics should be used for runny nose, sore throat, cough and fever (50%); to reduce symptom severity and duration (57.7%), should be stopped on clinical improvement (28.7%), are effective in viral infections (68.6%) and if used by the other family members should be given to the children (20.1%). Determinants of misuse in a multivariable model, were income, number of kid, type of infection treated last year, knowledge of diseases requiring antibiotics, or being unsure, using same antibiotics used by the other family person, unsure of such use and adjusting for the type of responding parent. Logistic regression model shows that those who incorrectly had knowledge that any type of infection with fever needs to be treated by antibiotics had twice the odds of misusing antibiotic (AOR: 2.17, 95%CL: 1.19-3.96), Parents who believed that it was acceptable to administer the same antibiotics to their children that were used for a similar illness by any other family member in the past; had thrice the Odds of using non-prescribed antibiotics (AOR=3.01, 95% CI=1.77-5.37). Similarly, those who were not sure about the use of prior antibiotics by any other family member were also three times more likely to misuse antibiotics (AOR:3.00,95%CI/ :1.00-9.01). Parents reporting monthly income of less than SAR 5000 had twice the Odds of misusing anti biotics (OR:2.00,95% CI:1.05-3.83).Conclusion: Parents having low income, more than two kids below 12 years age, low education level, inappropriate beliefs and practices are vulnerable for misusing antibiotics in their children.Bangladesh J Child Health 2016; VOL 40 (2) :64-71

scholarly journals Seroprevalence of Hepatitis B and Hepatitis C among Blood Donors at Dharan, Sunsari, Nepal

2016 ◽  
Vol 2 (1) ◽  
pp. 13-16
Author(s):  
Sabina Rai ◽  
Pranita Dongol ◽  
Hemanta Khanal
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Technical College ◽  
Blood Donors ◽  
Cross Sectional Study ◽  
P Value ◽  
Age Group ◽  
Cross Sectional ◽  
Blood Samples ◽  
Donated Blood

Hepatitis B and Hepatitis C are the chronic viral infection that might be transmitted by blood transfusion. Nepal is known to have lowest seroprevalence in Asia. The main objective of the present study is to find out the prevalence of hepatitis B and Hepatitis C and their co-infection among blood donors during study period from March to August 2014. This was a cross sectional study among volunteer blood donors in Dharan who had donated the Blood. A total of 4930 donated blood samples were collected and screened for hepatitis B and hepatitis C by using a rapid enzyme immunoassay (EIA) technique. Among 4930 blood samples under study, the overall seroprevalence of hepatitis B were 0.22% (11 out of 4930) and hepatitis C were 0.39% (19 out of 4930) (P value = 0.01) and the prevalence being lower in females than males for both cases. Hepatitis B were more in age group of 21 -30 (0.4%) but hepatitis C in age group of 31-40 (0.5%). Hepatitis B and C are potential threats to be transmitted from unscreened blood.Sunsari Technical College Journal 2015, 2(1):13-16

scholarly journals SYPHILIS;

2019 ◽  
Vol 26 (04) ◽  
Author(s):  
Ahsan Ashfaq ◽  
KAUSAR ABBAS SALDERA ◽  
AYESHA EJAZ ◽  
NOOR-UN NISA MEMON ◽  
HINA RASHID ◽  
...  
Keyword(s):  
Blood Donors ◽  
Viral Infections ◽  
Local Population ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Serum Neopterin ◽  
Neopterin Level

Objectives: To assess serum Neopterin levels in blood donors of local population and to study its relationship with transfusion transmitted infections (TTIs) including syphilis. Study Design: Descriptive cross-sectional study. Place and Duration of Study: This study was carried out in the Department of Physiology LNMC in collaboration with Basic Medical Sciences Institute, (BMSI), and Jinnah Post Graduate Medical Centre (J.P.M.C.) Karachi, from Jan to July 2015.”Methods: Total 174 blood donors were included in the study through random sampling technique. They were screen through the standard procedures used for screening at the JPMC blood bank for WHO recommended diseases. Neopterin was estimated using ELISA. Data analysis was performed using SPSS version 21. Chi square and ANOVA were applied at a confidence level of 95%.”Results: Neopterin level in the sera of syphilis positive blood donors was 5.86 ± 0.78 nmol/l which was within normal range below the cutoff value of 10 nmol/l. Neopterin content in the serum of blood donors who were negative for transfusion transmitted infections was 6.23± 2.19 nmol/l as compared to blood donors testing positive for transfusion transmitted viral infections showing high Neopterin level of 15.10 ± 4.93 nmol/l. (P value 0.001).”Conclusion: Neopterin levels were found to be within normal limits in blood donors testing positive for syphilis However in  blood donors with transfusion transmitted viral infections  serum neopterin levels were elevated.

scholarly journals Epidemiological Profiles of Foreign-Born and US-Born Hispanic Blood Donors in a Major Metropolitan Area in the United States

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Adelbert B. James ◽  
Cassandra D. Josephson ◽  
Marta I. Castillejo ◽  
George B. Schreiber ◽  
John D. Roback
Keyword(s):  
Blood Donors ◽  
Blood Donation ◽  
The United States ◽  
Cross Sectional Study ◽  
Foreign Born ◽  
Rates Of Return ◽  
Cross Sectional ◽  
Major Metropolitan Area ◽  
The Us ◽  
Donated Blood

Background. The explosive growth of Hispanics in the US makes this population a significant and untapped source for blood donation. Methods. A cross-sectional study was performed to evaluate blood donation behaviors and demographics of foreign-born and US-born Hispanic donors between 2006 and 2009 in metropolitan Atlanta, GA, USA. Bivariate analyses and multivariate logistic regression were used to assess factors associated with foreign-born donors. Results. 5,119 foreign-born and 11,841 US-born Hispanics donated blood. Foreign-born Hispanic donors were more likely than US-born donors to be blood group O (57.6% versus 52.0%; P<.001) and more frequent donors (2.2 versus 2.0; P<.001). Cuban-born donors had the highest rates of return donation (63.2%). In contrast, Mexicans, the most prevalent subpopulation among foreign-born Hispanic donors (31.8%), had the lowest rates of return donation (42.0%). Conclusions. The heterogeneity found among Hispanic donors in this study is valuable for the design of recruitment strategies to increase blood donations.

scholarly journals Cross-Sectional Survey among General Population Regarding Knowledge and Attitude toward Antibiotic Usage in Western Saudi Arabia

Pharmacy ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 98
Author(s):  
Syed Faisal Zaidi ◽  
Muhannad Wael Baroom ◽  
Adil Ibrahim Hanbashi ◽  
Abdulrahman Abdulaziz Alkhaibari ◽  
Ahmed Omar Yahya ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
General Population ◽  
Viral Infections ◽  
Personal Characteristics ◽  
Antibiotic Usage ◽  
Age Group ◽  
Monthly Income ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Validated Questionnaire

Background: Antibiotic resistance is a threatening issue to human wellbeing and an obstacle in the treatment process of many life-threating illnesses. This study aims to assess the knowledge and attitudes toward antibiotic usage among the general population in Jeddah, Saudi Arabia. Methods: A self-administered cross-sectional survey of 460 participants was distributed among the general population in Jeddah in the form of a validated questionnaire. Sample size was calculated to be 460 adults of either gender. Descriptive and inferential statistical analyses were performed using the Statistical Package for Social Sciences. Results: the age of more than half of participants (55.6%) was 18–30 years old, followed by the age group 31–40 years old (26.6%), with the smallest age group >60 years old (1.9%). More than two thirds of participants were male (69.5%), while 131 were female, accounting for 30.5%. Almost one third of participants had poor knowledge about antibiotics (30.5%), 51.0% had used antibiotics without any prescriptions, 54.6% of participants thought antibiotics could be used to treat viral infections, and 55.1% thought it was acceptable to stop taking antibiotics if symptoms start to improve. In addition, 49% believed that taking antibiotics would help them get better more rapidly when suffering from the common cold. Some personal characteristics were significantly associated with the public’s knowledge (e.g., age, education, and monthly income) and their attitudes (e.g., monthly income). Conclusion: Findings revealed a low level of knowledge on the use of antibiotics among the general public in Jeddah. This study signifies the need for improvement in the public’s knowledge and enhancement of their attitudes toward proper utilization of antibiotics.

scholarly journals Prevalence of hepatitis B and hepatitis C viral infections and impact of control program among blood donors in Al-Baha region, Saudi Arabia

2020 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
TalalA. Sallam ◽  
HaithamMohamed El-Bingawi ◽  
KhalidIbrahim Alzahrani ◽  
BaderHassan Alzahrani ◽  
AtyahAli Alzahrani
Keyword(s):  
Saudi Arabia ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Blood Donors ◽  
Viral Infections ◽  
Control Program

scholarly journals Knowledge, Attitudes, Practices, and Factors Associated with Voluntary Blood Donation among University Students in Kilimanjaro, Tanzania

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Elionora Elias ◽  
Wilhellmuss Mauka ◽  
Rune N. Philemon ◽  
Damian J. Damian ◽  
Michael J. Mahande ◽  
...  
Keyword(s):  
Young People ◽  
Blood Donors ◽  
Blood Donation ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Attitudes And Practices ◽  
Positive Attitudes ◽  
Willingness To Donate ◽  
The Future ◽  
Donated Blood

Background. Understanding the knowledge and awareness of blood donation among potential blood donors in the population, like young people, and the associated attitudes and practices is important. Methodology. This was a cross-sectional study whereby a self-administered questionnaire was used to collect information from the consenting participants. Results. A total of 422 participants were enrolled. Their mean age was 24.2 (SD 3.6) years. Of the 422, 30% have ever donated blood. 55% of those who had ever donated were repeated blood donors. Majority of the participants (93%) had positive attitudes towards blood donation and 88% were willing to donate in the future. Factors that were significantly associated with ever donating blood were male gender, knowing a person who has donated blood, knowledge of the amount of blood donated, willingness to donate in the future, and not expecting any postdonation reward. Discussion. High awareness, positive attitude, and high intention to donate in the future should be used to underscore the need to educate the young people on the value of blood donation in saving lives and to give them correct information on overall requirements for blood donation.

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