Human Papillomavirus Type Distribution in Anal Condylomata Acuminata (2nd Report) -High Prevalence Rate of High-risk HPV in HIV Positive Cases

OBJECTIVE: To estimate the prevalence of high-risk human papillomavirus (HR-HPV) anal infection and associated factors in human immunodeficiency virus (HIV) positive patients in Medellín. METHODS: Descriptive cross-sectional study in 300 HIV-positive patients, adults, with history of anal intercourse, treated in two health care services of Medellín 2017–2018. We conducted a structured survey on sociodemographics, sexual behavior and medical history. HPV was detected in anal swabs tested by the COBAS 4800 system. Exploratory data analysis of risk factors associated with HR-HPV was conducted by chi-square test of independence and both raw and adjusted prevalence ratios used the Poisson regression model, at a 95% confidence interval. RESULTS: The high-risk HPV had a prevalence of 82.7%; HPV16 had a prevalence of 32.7%, HPV18 a prevalence of 21.7% and other HPV types scored 78.3%. The high-risk HPV prevalence in women was of 68.2% and 83.8% in men. The risk factors associated with high-risk HPV after adjustment were age under 30 years, elementary education, casual sex partners, and first sexual activity before 18 years old. CONCLUSIONS: The high incidence of high-risk HPV, along with the occurrence of coinfections by multiple types in the study population shows their susceptibility to develop some type of anal intra-epithelial neoplasia. It is important to establish sexual health programs focused on primary health care.

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Prevalence and Distribution of High-Risk Human Papillomavirus Genotypes in Invasive Carcinoma of the Uterine Cervix in Uruguay

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e318285e753 ◽

2013 ◽

Vol 23 (3) ◽

pp. 527-532 ◽

Cited By ~ 9

Author(s):

Nora Berois ◽

Patricia De Cremoux ◽

Daniel Mazal ◽

Adela Sica ◽

Mabel Cedeira ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Dna Sequences ◽

Invasive Cervical Cancer ◽

Human Papillomaviruses ◽

Geographical Differences ◽

Hpv Dna ◽

High Prevalence ◽

Hpv Types ◽

High Risk Hpv

ObjectivesPersistent infection with specific genotypes of human papillomaviruses (HPVs) is the main cause of invasive cervical cancer (ICC). Only a few of the various HPV types account for most of the cases worldwide, and geographical differences in their distribution are evident. Data from locally prevalent genotypes are essential in view of introduction of HPV type-specific prophylactic vaccines.MethodsIn this work, we have investigated HPV type distribution in samples of ICC cases that occurred in Uruguayan women. DNA extracted from ICC treated in Centro Hospitalario Pereira Rossell of Montevideo between 1999 and 2007 were analyzed. Search and typing were performed by polymerase chain reaction using generic GP5+/GP6+ primers and specific primers for HPV types 16, 18, 33, and 45. Positive GP5+/GP6+ samples, which were negative for all 4 high-risk HPV-specific types screened were further analyzed by sequencing.ResultsHuman papillomavirus DNA sequences were found in 163 (92.6%) of 176 cases. The most prevalent genotypes were HPV16 (67.6%) and HPV18 (8.5%) followed by HPV45 (6.8%) and HPV33 (3.4%), as single or mixed infection. Other less frequent genotypes were HPV31, HPV35, HPV39, HPV51, HPV52, HPV58, HPV66, and HPV73. The viral type could not be determined (HPV X) in 1 case (0.6%) of the HPV DNA–positive cervical cancers and double infections were found in 1.7% of the cases. The higher percentage of most aggressive HPV (16/18/45) genotypes was detected in cases diagnosed at younger than 60 years old, whereas these genotypes were less frequent in older patients.ConclusionWe conclude that HPV types 16, 18, and 45 have a very high prevalence in ICC of Uruguayan women. Results provide evidence that 16 of 18 infections are more aggressive, but most cancers could be vaccine preventable.

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High Prevalence Rate of Human Papillomavirus Infection and Association With Abnormal Papanicolaou Smears in Sexually Active Adolescents

Archives of Pediatrics and Adolescent Medicine ◽

10.1001/archpedi.1989.02150240065018 ◽

1989 ◽

Vol 143 (12) ◽

pp. 1443 ◽

Cited By ~ 4

Author(s):

Walter D. Rosenfeld

Keyword(s):

Human Papillomavirus ◽

Prevalence Rate ◽

Sexually Active ◽

High Prevalence Rate ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

High Prevalence ◽

Papanicolaou Smears

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Condylomata acuminata of HIV-positive men may harbour focal areas of dysplasia: relevant implications for the management of human papillomavirus-induced disease in high-risk patients

British Journal of Dermatology ◽

10.1111/bjd.14855 ◽

2016 ◽

Vol 175 (4) ◽

pp. 672-673 ◽

Cited By ~ 1

Author(s):

A. Kreuter ◽

U. Wieland

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Condylomata Acuminata ◽

Hiv Positive ◽

High Risk Patients ◽

Risk Patients ◽

Hiv Positive Men

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The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

The Journal of Infection in Developing Countries ◽

10.3855/jidc.9711 ◽

2018 ◽

Vol 12 (06) ◽

pp. 477-484 ◽

Cited By ~ 2

Author(s):

Ahd Ouladlahsen ◽

Naouar Fayssel ◽

Rajaa Bensghir ◽

Hanâ Baba ◽

Hassan Lamdini ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Papillomavirus ◽

High Risk ◽

Hpv Infection ◽

Hiv Positive ◽

Cell Counts ◽

Hiv Positive Women ◽

Immunodeficiency Virus ◽

High Prevalence ◽

Hpv Types

Introduction: Women infected with human immunodeficiency virus (HIV) have a higher risk of contracting human papillomavirus (HPV) infections and are more prone to develop cervical cancer. The objective of this study was to determine the prevalence of HPV and its association with risk factors among Moroccan women living with HIV/AIDS. Methodology: We enrolled 251 HIV-infected non-pregnant women in Morocco from February 2013 to September 2016. Sociodemographic, lifestyles, behavioral and clinical data were collected. Polymerase chain reaction followed by sequencing were performed for molecular detection and HPV genotyping in cervical samples, respectively. Results: Abnormal cervical smears were found in 34/246 patients (13.82%). The overall prevalence of HPV was 74.50%. HPV 58 was the most prevalent (39.29%) followed by HPV 18 (10.71%), HPV 70 (8.93%), HPV 33 (7.14%), HPV 6 (6.25%) and other genotypes (< 3%). Overall, high-risk HPV (HR-HPV) types were present in 75% (84/112) of patients and the prevalence of HR-HPV types in samples with abnormal Pap was higher than in normal Pap (55/83, 66.27% vs. 28/83, 33.33%, p < 0.0001). Univariate analyses showed that none of the socio-demographic and behaviors factors was associated with HPV infection. Moreover, Pap results were not affected by HPV status (p = 0.532). Whereas, CD4 T-cell counts above 200/mm3 at enrolment were apparently not protective to HPV infection. We found a high prevalence of HPV infection and HR-HPV types among HIV-positive women that significantly associated with abnormal Pap. Conclusion: Our findings suggest a high prevalence of HPV infection with high-risk types was observed among HIV-positive women warrant to implement a regular screening by Pap smear.

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Molecular Characterization of High-Risk Human Papillomavirus in Women in Bobo-Dioulasso, Burkina Faso

BioMed Research International ◽

10.1155/2016/7092583 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 5

Author(s):

Ina Marie Angèle Traore ◽

Théodora Mahoukèdè Zohoncon ◽

Adama Dembele ◽

Florencia W. Djigma ◽

Dorcas Obiri-Yeboah ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

University Hospital ◽

Cervical Cancers ◽

High Prevalence ◽

Bobo Dioulasso ◽

Hpv Types ◽

High Risk Hpv ◽

Hpv 18

High-risk human papillomavirus (HPV) is found in over 99% of cervical cancers. The aim of this study was to determine the prevalence of HPV in a population of women in Bobo-Dioulasso and to identify the high-risk types present in these women. From May to June, 2015, 181 women who came for consultation at the Souro Sanou University Hospital of Bobo-Dioulasso have been included in this study. Uterine endocervical swabs have been taken in these women. DNA obtained by extraction from the samples thus collected was used to determine the prevalence of high-risk human papillomavirus genotypes through real-time PCR. The age of the women ranged from 20 to 56 years with a mean of35.3±8.1years. The prevalence of infection by high-risk HPV types was 25.4% (46/181). The most common high-risk HPV genotypes were HPV 39 (18.5%), HPV 52 (16.7%), HPV 18 (14.8%), and HPV 35 (13.0%). HPV 16 which is included in the HPV vaccines was not found in the population studied. This type of study which is the first one in Bobo-Dioulasso has showed a high prevalence of genotypes HPV 39, HPV 52, and HPV 35 which are not yet covered by a vaccine.

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Prevalence of vaccine and non-vaccine human papillomavirus types among women in Accra and Kumasi, Ghana: a cross-sectional study

BMC Women s Health ◽

10.1186/s12905-021-01511-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Oksana Debrah ◽

Francis Agyemang-Yeboah ◽

Emmanuel Timmy Donkoh ◽

Richard Harry Asmah

Keyword(s):

Risk Factors ◽

Cervical Cancer ◽

Human Papillomavirus ◽

High Risk ◽

Reproductive Health ◽

Hpv Infection ◽

Reproductive Health Services ◽

High Prevalence ◽

Hpv Genotypes ◽

High Risk Hpv

Abstract Background Human Papillomavirus (HPV) infection is the main etiological factor for pre-invasive and invasive cervical cancer. HPV type-specific vaccination is being widely recommended to control the burden of disease, but the genotype-specific distribution of HPV may vary in different countries. The aim of the study was to determine the prevalence and distribution of HPV genotypes among women attending reproductive health services in Ghana, their associated risk factors, and to assess the potential coverage of identified HPV genotypes by three licensed vaccines among these women. Method Women presenting for reproductive health services in two regional hospitals in Accra and Kumasi from October 2014 to March 2015 were conveniently recruited into the study (n = 317). HPV-DNA detection and genotype identification were carried out by a nested multiplex PCR assay that combines degenerate E6/E7 consensus primers and type-specific primers for the detection and typing of eighteen HPV genotypes. Cytology was performed to screen women for cervical cancer lesions. Risk factors for HPV infection were analyzed by logistic regression. Statistical significance was accepted for p < 0.05. Results The age of study participants ranged from 21 to 76 years. Among women positive for HPV, 35.0% were infected with high-risk HPV, 14.5% with probable high-risk HPV, and 17.0% with low-risk HPV. The prevalence of HPV 16/18 was 8.2%, HPV 6/11/16/18 was 9.1% and HPV 6/11/16/18/31/33/45/52/58 was 28.4%. The most prevalent among HR-HPV were types 52 (18.3%) and 58 (8.8%). HPV positivity may be associated with educational background (p < 0.001), age at first pregnancy (p = 0.028), and age at coitarche (p = 0.016). Conclusions Our study revealed a high prevalence of HR-HPV infection among women. The high prevalence of HR HPV indicates that multivalent vaccines will be useful for controlling HPV burden in general population contexts. The distribution of HPVs in this population suggests that of the three currently available vaccines the nonavalent vaccine, which protects against seven HPV types in addition to HPV 16 and 18, has the highest coverage of HPV infections among Ghanaian women. Healthcare officials planning to reduce the transmission of HPV and cervical cancer must consider the coverage of the nonavalent vaccine as an advantage.

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Testicular Tuberculosis in an HIV Positive Patient Co-infection with Pulmonary Tuberculosis Mimicking Malignancy: A Case Report

Jurnal Respirasi ◽

10.20473/jr.v6-i.2.2020.45-48 ◽

2020 ◽

Vol 6 (2) ◽

pp. 45

Author(s):

Wahyu Agung Purnomo ◽

Tutik Kusmiati ◽

Soedarsono Soedarsono

Keyword(s):

Clinical Manifestation ◽

Prevalence Rate ◽

Rare Case ◽

Hiv Positive ◽

Pulmonary Tb ◽

Scrotal Mass ◽

High Prevalence Rate ◽

Microscopic Evaluation ◽

High Prevalence ◽

History Of

Background: Extrapulmonary involvement can be seen in more than 50% of patients with concurrent HIV and tuberculosis (TB). Approximately 7% of those are presented as a rare case, namely testicular TB, with scrotal mass as common clinical manifestation. Testicular TB should be a different diagnosis, especially in areas with a high prevalence rate for TB.Case: A 24-year-old male with HIV positive co-infection with pulmonary TB presented with a progressively increasing painless right testicular swelling of 1-month duration. History of chronic cough was complained, accompanied by loss of appetite and decrease of body weight. There was no history of testicular traumatic accident before. Genital examination was right testicular mass measuring 7cm x 4cm and depletion of right side scrotal skin with pus and necrotic tissue. He had right orchidectomy by an urologist in a private hospital; then an anatomical pathology was examined. The result of the microscopic evaluation showed granuloma inflammation process typical for orchitis tuberculosis. The patient was reactive for HIV and had Mycobacterium tuberculosis (MTB) detected, Rifampicin resistant not recognized as the result of Gene Xpert MTB/RIF assay.Conclusion: Although a rare case, testicular TB should be a different diagnosis when there is a patient with HIV positive concurrent pulmonary TB with scrotal mass as clinical manifestation, especially in areas with a high prevalence rate for TB.

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