High-risk human papillomavirus infection and associated factors in the anal canal of HIV-positive patients in Medellín, 2017–2018

OBJECTIVE: To estimate the prevalence of high-risk human papillomavirus (HR-HPV) anal infection and associated factors in human immunodeficiency virus (HIV) positive patients in Medellín. METHODS: Descriptive cross-sectional study in 300 HIV-positive patients, adults, with history of anal intercourse, treated in two health care services of Medellín 2017–2018. We conducted a structured survey on sociodemographics, sexual behavior and medical history. HPV was detected in anal swabs tested by the COBAS 4800 system. Exploratory data analysis of risk factors associated with HR-HPV was conducted by chi-square test of independence and both raw and adjusted prevalence ratios used the Poisson regression model, at a 95% confidence interval. RESULTS: The high-risk HPV had a prevalence of 82.7%; HPV16 had a prevalence of 32.7%, HPV18 a prevalence of 21.7% and other HPV types scored 78.3%. The high-risk HPV prevalence in women was of 68.2% and 83.8% in men. The risk factors associated with high-risk HPV after adjustment were age under 30 years, elementary education, casual sex partners, and first sexual activity before 18 years old. CONCLUSIONS: The high incidence of high-risk HPV, along with the occurrence of coinfections by multiple types in the study population shows their susceptibility to develop some type of anal intra-epithelial neoplasia. It is important to establish sexual health programs focused on primary health care.

Download Full-text

Incidence of persistent and high-risk human papillomavirus infection and associated factors among HIV-positive women in China, 2015–2016

Gynecology and Obstetrics Clinical Medicine ◽

10.1016/j.gocm.2021.07.006 ◽

2021 ◽

Author(s):

Yaping Qiao ◽

Ailing Wang ◽

Liwen Fang ◽

Linhong Wang

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Associated Factors ◽

Hiv Positive ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

Hiv Positive Women

Download Full-text

Differences in Factors Associated With High- and Low-Risk Oral Human Papillomavirus Genotypes in Men

The Journal of Infectious Diseases ◽

10.1093/infdis/jiaa693 ◽

2020 ◽

Author(s):

Deepti Bettampadi ◽

Brittney Dickey ◽

Martha Abrahamsen ◽

Bradley Sirak ◽

Maria Luiza Baggio ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Sexual Behaviors ◽

Hpv Infection ◽

Low Risk ◽

Factors Associated ◽

Hpv Prevalence ◽

Oral Hpv ◽

Multivariable Models ◽

High Risk Hpv

Abstract Background Human papillomavirus (HPV) causes oral warts and oropharyngeal cancer (OPC). Human papillomavirus-attributable OPC incidence among men is significantly increasing worldwide, yet few studies have reported oral HPV across multiple countries or examined factors associated with low- and high-risk HPV separately. Methods Oral gargles from 3095 men in the multinational HPV Infection in Men (HIM) Study were HPV genotyped. Multivariable models assessed factors independently associated with high-risk and low-risk HPV prevalence. Results The prevalence of high-risk and low-risk HPV was 6.0% and 2.8%, respectively. Greater number of sexual partners was only associated with high-risk HPV (1.88; 95% confidence interval [CI], 1.22–2.90) prevalence. In multivariable models, residing in Mexico (1.66; 95% CI, 1.15–2.40) and smoking (1.66; 95% CI, 1.13–2.44) were significantly associated with high-risk HPV, and history of consistent gum bleeding (2.16; 95% CI, 1.35–3.45) was significantly associated with low-risk HPV. Gender of the sexual partner did not alter the results for either high- or low-risk HPV endpoints. Conclusions Different factors were independently associated with high- and low-risk oral HPV. Oral sexual behaviors were associated with high-risk HPV, and oral health was associated with low-risk HPV. High-risk HPV prevalence differed by country of residence, highlighting the need for additional studies in multiple countries.

Download Full-text

Prevalence and Risk Factors for Anal Human Papillomavirus Infection in Human Immunodeficiency Virus (HIV)–Positive and High‐Risk HIV‐Negative Women

The Journal of Infectious Diseases ◽

10.1086/318071 ◽

2001 ◽

Vol 183 (3) ◽

pp. 383-391 ◽

Cited By ~ 215

Author(s):

Joel M. Palefsky ◽

Elizabeth A. Holly ◽

Mary L. Ralston ◽

Maria Da Costa ◽

Ruth M. Greenblatt

Keyword(s):

Risk Factors ◽

Human Immunodeficiency Virus ◽

Human Papillomavirus ◽

High Risk ◽

Hiv Positive ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

Immunodeficiency Virus ◽

Hiv Negative

Download Full-text

Advancements and Future Predictions on Diagnostic Approaches towards Cervical Cancer through Nanotechnology-Based Sensors for the Detection of Human Papillomavirus

Clinical Oncology and Research ◽

10.31487/j.cor.2021.06.02 ◽

2021 ◽

pp. 1-7

Author(s):

Nidhi Chauhan ◽

Sakshi Pareek ◽

Utkarsh Jain ◽

Mayukh Tikadar ◽

Prabhanshu Kumar ◽

...

Keyword(s):

Risk Factors ◽

Health Care ◽

Cervical Cancer ◽

Human Papillomavirus ◽

High Risk ◽

Mortality Rate ◽

Diagnostic Methods ◽

Health Care Practitioners ◽

Incidence And Mortality ◽

Diagnostic Approaches

Cervical cancer has the highest mortality rate worldwide. In the quest for reducing such a high mortality rate, advancements in diagnosis as well as treatment are being undertaken at various scales across the globe. With the recent advancements in the applications of nanotechnology, simple, rapid and inexpensive diagnostic methods for cervical cancer, i.e., human papillomavirus (HPV), especially high-risk oncogenic subtypes 16 and 18 have started to gain attention of health care practitioners. This review outlines the current applications of biosensors for the diagnosis of HPV, as compared to the conventional techniques for measuring HPV that have some limitations. The traditional methods used for cervix cancer are less sensitive, whereas nanotechnology has greatly improved the sensitivity. Due to cancer incidence and mortality growing rapidly worldwide, the prevalence and risk factors are also discussed in this review.

Download Full-text

Heterogeneity in the prevalence of high-risk human papillomavirus infection in HIV-negative and HIV-positive men who have sex with men in West Africa

Clinical Infectious Diseases ◽

10.1093/cid/ciab157 ◽

2021 ◽

Author(s):

Issifou Yaya ◽

Véronique Boyer ◽

Phyllis Amivi Ehlan ◽

Alou Coulibaly ◽

Mawuényégan Kouamivi Agboyibor ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

West Africa ◽

Associated Factors ◽

Hpv Infection ◽

Hiv Positive ◽

Hpv Prevalence ◽

Study Country ◽

Sex With Men ◽

Hiv Negative

Abstract Background Men who have sex with men (MSM) are at high risk of human papillomavirus (HPV) infection. We assessed (i) the prevalence of high-risk HPV (HR-HPV) infection and associated factors, and (ii) the prevalence of vaccine-preventable HPV infections in MSM in Burkina Faso, Côte d’Ivoire, Mali, and Togo. Methods A cross-sectional study was conducted in 2017-2018 among MSM ≥18 years old followed in community-based clinics. HPV infection was investigated in oral and anal samples using the e-BRID system. Factors associated with HR-HPV infection were identified using multivariate logistic regressions. Results Among 631 participants, 425 were HIV-negative and 206 HIV-positive. HR-HPV prevalence ranged from 9.2 to 34.8% in the former, and 33.3 to 71.0% in the latter according to the study country. In multivariate analysis, HIV infection (adjusted odds ratio 3.61, 95% confidence interval 2.48–5.27) and study country (4.73, 2.66–8.43 for Mali; 3.12, 1.68–5.80 for Burkina Faso; 3.51, 1.92–6.42 for Togo) were associated with HR-HPV infection. Other associated factors were low educational level, self-defined homosexual identity and condomless anal sex. The prevalence of infections which can be prevented with bivalent, quadrivalent and nonavalent vaccines was 5.9, 27.1, and 34.6% in HIV-negative participants, and 18.9, 43.7, and 54.9% in HIV-positive participants, respectively. Conclusion HR-HPV prevalence was very heterogeneous between the study countries in both HIV-negative and HIV-positive MSM. Vaccine-preventable HPV infections predominated. Vaccination should be proposed to young MSM to reduce the burden of HPV infection in this vulnerable population and their female partners in West Africa.

Download Full-text

HPV types, cervical high-grade lesions and risk factors for oncogenic human papillomavirus infection among 3416 Tanzanian women

Sexually Transmitted Infections ◽

10.1136/sextrans-2019-054263 ◽

2020 ◽

pp. sextrans-2019-054263 ◽

Cited By ~ 2

Author(s):

Bariki Lawrence Mchome ◽

Susanne Krüger Kjaer ◽

Rachel Manongi ◽

Patricia Swai ◽

Marianne Waldstroem ◽

...

Keyword(s):

Risk Factors ◽

Human Papillomavirus ◽

Quadrivalent Vaccine ◽

Hiv Positive ◽

High Grade ◽

Factors Associated ◽

Hpv Prevalence ◽

Hiv Positive Women ◽

Increased Risk ◽

Hiv Negative

ObjectiveThe objective of the present study was to assess the prevalence and type-specific distribution of cervical high-risk (HR) human papillomavirus (HPV) among women with normal and abnormal cytology, and to describe risk factors for HR HPV among HIV-positive and HIV-negative women in Tanzania.MethodologyA cross-sectional study was conducted in existing cervical cancer screening clinics in Kilimanjaro and Dar es Salaam. Cervical specimens were obtained from women aged 25–60 years. Samples were shipped to Denmark for cytological examination, and to Germany for HR HPV testing (using Hybrid Capture 2) and genotyping (using LiPaExtra). Risk factors associated with HPV were assessed by multivariable logistic regression analysis.ResultAltogether, 4080 women were recruited with 3416 women contributing data for the present paper, including 609 HIV-positive women and 2807 HIV-negative women. The overall HR HPV prevalence was 18.9%, whereas the HR HPV prevalence in women with high-grade squamous intraepithelial lesions (HSILs) was 92.7%. Among HPV-positive women with HSIL, HPV16 (32.5%) and HPV58 (19.3%) were the the most common types followed by HPV18 (16.7%) and HPV52 (16.7%). Factors associated with HR HPV included younger age, increasing number of partners and early age at first intercourse. Similar risk factors were found among HIV-positive and HIV-negative women. In addition, among HIV-positive women, those with CD4 counts <200 cells/mm3 had an increased risk of HR HPV (OR 2.2; 95% CI 1.2 to 4.8) compared with individuals with CD4 count ≥500 cells/mm3.ConclusionGiven the HPV distribution among Tanzanian women, the current HPV vaccination in Tanzania using quadrivalent vaccine may be considered replaced by the nonavalent vaccine in the future. In addition, appropriate antiretroviral treatment management including monitoring of viremia may decrease the burden of HR HPV in HIV-positive women.

Download Full-text

Human Papillomavirus Type Distribution in Anal Condylomata Acuminata (2nd Report) -High Prevalence Rate of High-risk HPV in HIV Positive Cases

Nippon Daicho Komonbyo Gakkai Zasshi ◽

10.3862/jcoloproctology.64.11 ◽

2011 ◽

Vol 64 (1) ◽

pp. 11-16 ◽

Cited By ~ 1

Author(s):

Hiroshi Sashiyama ◽

Yasunobu Tsujinaka ◽

Yukihiro Hamahata ◽

Osamu Tsutsumi ◽

Kazunari Akagi ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Prevalence Rate ◽

Condylomata Acuminata ◽

Hiv Positive ◽

Type Distribution ◽

High Prevalence Rate ◽

High Prevalence ◽

High Risk Hpv

Download Full-text

Risk Factors for High-Risk Human Papillomavirus Detection Among HIV-Negative and HIV-Positive Women From Tanzania

Sexually Transmitted Diseases ◽

10.1097/olq.0000000000000005 ◽

2013 ◽

Vol 40 (9) ◽

pp. 737-743 ◽

Cited By ~ 14

Author(s):

Myassa Dartell ◽

Vibeke Rasch ◽

Christian Munk ◽

Crispin Kahesa ◽

Julius Mwaiselage ◽

...

Keyword(s):

Risk Factors ◽

Human Papillomavirus ◽

High Risk ◽

Hiv Positive ◽

Hiv Positive Women ◽

Hiv Negative

Download Full-text

Epidemiological Risk Factors for Acquiring Severe COVID-19: Prospective Cohort Study

Oman Medical Journal ◽

10.5001/omj.2021.127 ◽

2021 ◽

Vol 36 (5) ◽

pp. e301-e301

Author(s):

Salah T. Al Awaidy ◽

Faryal Khamis ◽

Ozayr Mahomed ◽

Ronald Wesonga ◽

Muna Al Shuabi ◽

...

Keyword(s):

Risk Factors ◽

Health Care ◽

Cohort Study ◽

High Risk ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Care Facility ◽

Health Care Facility ◽

Factors Associated ◽

Epidemiological Risk

Objectives: We aimed to determine epidemiological risk factors associated with acquiring severe coronavirus disease 2019 (COVID-19) in patients requiring hospitalization. Methods: A prospective cohort study was conducted using a questionnaire comprised of six closed-ended questions to identify potential risk factors for severe COVID-19. Using COVID-19 associated illnesses and complications (pneumonia, acute respiratory distress syndrome, need for mechanical ventilation, acute kidney failure, cardiac failure, and thromboembolic events), we derived an index variable to measure the severity of COVID-19 in patients. Results: We included 143 adult patients with confirmed COVID-19 of whom 62.2% (n = 89) were male and 37.8% (n = 54) were female. The average age of the cohort was 50.6±16.5 years. Our study found that being a female, working at the health care facility, being a healthcare worker, attending a mass gathering within the last 14 days, attending a gathering with 10 persons or less, and being admitted to a hospital were associated with increased risk of developing severe COVID-19. The only risk factor associated with severe COVID-19 was working at a health care facility (odds ratio = 33.42, p =0.029). Conclusions: Intervention directed to control risk factors associated with acquiring severe COVID-19 should be a core priority for all countries, especially among high-risk occupations and workplaces, including working at a health care facility. A risk-based approach to prioritize vaccination among these high-risk individuals should be supported to strengthen the implementation of non-pharmaceutical interventions.

Download Full-text