High prevalence of human papillomavirus and European variants of HPV 16 infecting concomitantly to cervix and oral cavity in HIV positive women

There are limited data on human papillomavirus (HPV) type-specific cervical cancer risk among human immunodeficiency virus (HIV)-positive women. Previous studies have suggested that HPV 16 would be relatively less important as a causative agent among HIV-positive compared with HIV-negative women. This study investigates HPV type-specific cervical cancer risk in a population in which HIV is endemic. At the Central Hospital, Maputo, Mozambique, 221 cervical cancer cases and 203 hospital-based controls were consecutively enrolled. HPV typing from cervical samples, HIV testing and recording of socio-demographic factors were performed. Logistic regression modelling was used to assess HPV type-specific risk and effect modification between HIV and HPV infection. Infection with HPV 16, 18 and ‘high-risk non-HPV 16/18 types’ (HPV 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59) was associated with cervical cancer in both crude and adjusted analyses. HPV 16 and 18 were the most common types detected in cancer biopsies among both HIV-negative and HIV-positive women. There was no significant evidence of effect modification between any HPV type and HIV infection, and there were no significant differences in the HPV type-specific prevalence when cervical cancers among HIV-positive and HIV-negative women were compared. Within the limitations of the study, the relative importance of different HPV types in cervical carcinogenesis appears not to be modified greatly by HIV infection, suggesting that HPV vaccines might not need to be type-specifically modified to be suitable for populations where HIV is endemic.

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The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

The Journal of Infection in Developing Countries ◽

10.3855/jidc.9711 ◽

2018 ◽

Vol 12 (06) ◽

pp. 477-484 ◽

Cited By ~ 2

Author(s):

Ahd Ouladlahsen ◽

Naouar Fayssel ◽

Rajaa Bensghir ◽

Hanâ Baba ◽

Hassan Lamdini ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Papillomavirus ◽

High Risk ◽

Hpv Infection ◽

Hiv Positive ◽

Cell Counts ◽

Hiv Positive Women ◽

Immunodeficiency Virus ◽

High Prevalence ◽

Hpv Types

Introduction: Women infected with human immunodeficiency virus (HIV) have a higher risk of contracting human papillomavirus (HPV) infections and are more prone to develop cervical cancer. The objective of this study was to determine the prevalence of HPV and its association with risk factors among Moroccan women living with HIV/AIDS. Methodology: We enrolled 251 HIV-infected non-pregnant women in Morocco from February 2013 to September 2016. Sociodemographic, lifestyles, behavioral and clinical data were collected. Polymerase chain reaction followed by sequencing were performed for molecular detection and HPV genotyping in cervical samples, respectively. Results: Abnormal cervical smears were found in 34/246 patients (13.82%). The overall prevalence of HPV was 74.50%. HPV 58 was the most prevalent (39.29%) followed by HPV 18 (10.71%), HPV 70 (8.93%), HPV 33 (7.14%), HPV 6 (6.25%) and other genotypes (< 3%). Overall, high-risk HPV (HR-HPV) types were present in 75% (84/112) of patients and the prevalence of HR-HPV types in samples with abnormal Pap was higher than in normal Pap (55/83, 66.27% vs. 28/83, 33.33%, p < 0.0001). Univariate analyses showed that none of the socio-demographic and behaviors factors was associated with HPV infection. Moreover, Pap results were not affected by HPV status (p = 0.532). Whereas, CD4 T-cell counts above 200/mm3 at enrolment were apparently not protective to HPV infection. We found a high prevalence of HPV infection and HR-HPV types among HIV-positive women that significantly associated with abnormal Pap. Conclusion: Our findings suggest a high prevalence of HPV infection with high-risk types was observed among HIV-positive women warrant to implement a regular screening by Pap smear.

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Serological Detection of Human Papillomavirus Type 16 Infection in Human Immunodeficiency Virus (HIV)-Positive and High-Risk HIV-Negative Women

Clinical and Vaccine Immunology ◽

10.1128/cvi.13.4.511-519.2006 ◽

2006 ◽

Vol 13 (4) ◽

pp. 511-519 ◽

Cited By ~ 15

Author(s):

Michael J. Silverberg ◽

Michael F. Schneider ◽

Barbara Silver ◽

Kathryn M. Anastos ◽

Robert D. Burk ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Papillomavirus ◽

Viral Replication ◽

Smoking History ◽

Hiv Positive ◽

Hpv 16 ◽

Serial Measurement ◽

Hiv Positive Women ◽

Immunodeficiency Virus ◽

Hiv Negative

ABSTRACT Serial measurement of antibodies has not been used to provide evidence of active viral replication of human papillomavirus (HPV). Serum specimens from sequential study visits contributed by 642 human immunodeficiency virus (HIV)-positive and 116 HIV-negative participants enrolled in the Women's Interagency HIV Study were used to detect significant rises in HPV type 16 (HPV-16) antibody levels. Factors associated with a significant rise were identified using multivariable logistic regression models with generalized estimating equations. Among HIV-positive women, 8.3% of 1,997 pairs showed antibody rises, compared to 6.1% of 361 pairs among HIV-negative women (P = 0.191). For HIV-positive women, rises were associated with current (odds ratio [OR], 23.4; P < 0.001) or past (OR, 8.9; P < 0.001) HPV-16 infection relative to never being HPV-16 infected and with CD4+ cell counts (OR per 100-cell increase, 0.8; P < 0.001) but not with sexual behavior. For HIV-negative women, rises were associated with past (OR, 10.9; P = 0.033) HPV-16 infection relative to no HPV-16, current cigarette smoking (OR, 5.0; P = 0.029) relative to no smoking history, and having 6 to 10 lifetime sexual partners compared to 0 to 5 partners (OR, 9.9; P = 0.036). Serial measurement of HPV-16 serum antibodies is a useful tool for identifying active HPV-16 viral replication. Rises among HIV-positive women may more often result from reactivation of a latent HPV infection in the context of HIV-induced immunosuppression, while rises among HIV-negative women may more often result from reinfection with HPV.

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Faculty Opinions recommendation of Carcinogenicity of Human Papillomavirus (HPV) Types in HIV-Positive Women: A Meta-Analysis From HPV Infection to Cervical Cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727565191.793546767 ◽

2018 ◽

Author(s):

Santosh Kumar

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Meta Analysis ◽

Hpv Infection ◽

Hiv Positive ◽

Hiv Positive Women ◽

Hpv Types

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Gender-Based Violence Among HIV-Positive Women in Kazakhstan: Prevalence, Types, and Associated Risk and Protective Factors

Violence Against Women ◽

10.1177/1077801217741218 ◽

2017 ◽

Vol 24 (13) ◽

pp. 1570-1590 ◽

Cited By ~ 2

Author(s):

Tina Jiwatram-Negrón ◽

Nabila El-Bassel ◽

Sholpan Primbetova ◽

Assel Terlikbayeva

Keyword(s):

Protective Factors ◽

Partner Violence ◽

Risk And Protective Factors ◽

Future Research ◽

Hiv Positive ◽

Gender Based Violence ◽

Hiv Positive Women ◽

High Prevalence ◽

Gender Based ◽

Partner Gender

This article examines the prevalence and associated multilevel risk and protective factors of intimate and nonintimate partner violence among a sample of 249 HIV-positive women in Kazakhstan. We found high prevalence of both lifetime intimate partner violence (52%) and nonintimate partner violence (30%). Together, nearly 60% experienced at least one incident of violence by either an intimate or nonintimate partner (gender-based violence [GBV]). In the multivariate analyses, we found associations between several individual, interpersonal, and socio-structural risk factors and GBV. Findings provide direction for practice, policy, and future research to address the intersection of GBV and HIV in Kazakhstan.

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Identification of Genetic Variants of Human Papillomavirus in a Group of Mexican HIV/AIDS Patients and Their Possible Association with Cervical Cancer

Polish Journal of Microbiology ◽

10.33073/pjm-2021-047 ◽

2021 ◽

Vol 70 (4) ◽

pp. 501-509

Author(s):

FELIPE ORTIZ-GUTIÉRREZ ◽

LILIA SÁNCHEZ-MINUTTI ◽

JOSÉ F. MARTÍNEZ-HERRERA ◽

INDIANA D. TORRES-ESCOBAR ◽

ELIAS B. PEZZAT-SAID ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Genetic Variants ◽

Direct Relationship ◽

Low Risk ◽

Hiv Positive ◽

Hiv Positive Women ◽

Immunodeficiency Virus ◽

Regional Population ◽

Polymerase Chain

Infections caused by the human immunodeficiency virus (HIV) and human papillomavirus (HPV) cause thousands of deaths worldwide each year. So far, there has been no consensus on whether there is a direct relationship between the incidence of neoplasms and the immunosuppression caused by HIV that could help understand if coinfection increases the likelihood of cervical cancer. The objective of the study was to identify the presence of genetic variants of HPV in a group of HIV-positive women and their possible association with cervical cancer. Cervical samples were taken from HIV-positive patients for cytological analysis to identify the HPV genotype by polymerase chain reaction (PCR) and sequencing. The most preva¬lent L1 capsid protein mutations in the HPV genotype were ana¬lyzed in silico. Various types of HPV were identified, both high-risk (HR) and low-risk (LR). The most prevalent genotype was HPV51. Analysis of the L1 gene sequences of HPV51 isolates showed nucleo¬tide variations. Of the samples analyzed in Puebla, Mexico, HPV51 had the highest incidence (17.5%, 7/40). Different mutations, which could be used as population markers, were detected in this area, and they have not been reported in the L1 databases for HPV51 in Mexico. Genotypes 6, 14, 86, 87, 89, and 91, not detected or reported in samples from patients with HPV in Mexico, were also identified. Data from the population analyzed suggest no direct relationship between HIV immunosuppression and cervical cancer, regardless of the high- or low-risk HPV genotype. Furthermore, it is possible to develop regional population markers for the detection of HPV based on the mutations that occur in the sequence of nucleotides analyzed.

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Persistent Low-Risk and High-Risk Human Papillomavirus Infections of the Uterine Cervix in HIV-Negative and HIV-Positive Women

Frontiers in Public Health ◽

10.3389/fpubh.2017.00178 ◽

2017 ◽

Vol 5 ◽

Cited By ~ 12

Author(s):

Sally N. Adebamowo ◽

Oluwatoyosi Olawande ◽

Ayotunde Famooto ◽

Eileen O. Dareng ◽

Richard Offiong ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Uterine Cervix ◽

Low Risk ◽

Hiv Positive ◽

Papillomavirus Infections ◽

Hiv Positive Women ◽

Hiv Negative

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High prevalent human papillomavirus infections of the oral cavity of asymptomatic HIV-positive men

BMC Infectious Diseases ◽

10.1186/s12879-019-4677-9 ◽

2020 ◽

Vol 20 (1) ◽

Cited By ~ 1

Author(s):

Rocío Méndez-Martínez ◽

Silvia Maldonado-Frías ◽

Salvador Vázquez-Vega ◽

Yanink Caro-Vega ◽

José Guadalupe Rendón-Maldonado ◽

...

Keyword(s):

Human Papillomavirus ◽

Oral Cavity ◽

Anal Canal ◽

Cross Sectional Study ◽

Cross Sectional ◽

Oral Infections ◽

Immunodeficiency Virus ◽

High Prevalence ◽

Sex With Men ◽

High Risk Hpv

Abstract Background Incidence of anal and oral infections with Human Papillomavirus (HPV) is increasing, particularly among Human Immunodeficiency Virus-positive (HIV+) men. HPV type 16 has exhibited the highest incidence and only limited data is available on other prevalent types, variants of HPV16, as well as associated factors. We were interested in identifying prevalent HPV types, variants of type 16, as well as factors associated with HPV16 infections in the oral cavity of HIV+ men who have sex with men (MSM). Methods A cross-sectional study of oral cavity samples from HIV+ MSM, that in a previous study were identified as positive for HPV16 in the anal canal. Cells from the oral cavity (102 samples, paired with 102 from the anal canal of same patient) were used to extract DNA and detect HPV infections using INNO-LiPA HPV Genotyping Extra II, and PCR. From these, 80 samples (paired, 40 anal and 40 oral) were used to identify variants of type 16 by sequencing. Statistical differences were estimated by the X2 test, and p values equal to or less than 0.05 were considered significant. SPSS ver. Twenty-four statistical software (IBM Corp) was used. Results We found a high prevalence of High-Risk HPV (HR-HPV) and Low-Risk HPV (LR-HPV). Patients were positive in the oral cavity for HR types; 16, 39 and 18 (80.4, 61.8 and 52.9% respectively) and LR types 11 and 6 (53.9 and 34.3% respectively). Surprisingly, only European variants of type 16 were found in the oral cavity, although American Asian (22.5%) and African (2.5%) variants were identified in the anal canal. The analysis showed that CD4 counts could be the most important risk factor associated with HR-HPV infections in the oral cavity, anal canal or both anatomical regions. The risk of infection of the oral cavity with type 18 increased in men diagnosed with HIV for more than 6 years. Conclusions Prevalence of both HR and LR HPV’s in the oral cavity of Mexican HIV+ MSM is very high. The fact that only European variants of HPV16 were found in the oral cavity suggest a possible tropism not previously described.

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