scholarly journals Evaluation of Neonatal Hemolytic Jaundice: Clinical and Laboratory Parameters

2015 ◽  
Vol 3 (4) ◽  
pp. 694-698 ◽  
Author(s):  
Anet Papazovska Cherepnalkovski ◽  
Vjekoslav Krzelj ◽  
Beti Zafirovska-Ivanovska ◽  
Todor Gruev ◽  
Josko Markic ◽  
...  
Keyword(s):  
Hematological Parameters ◽  
Significant Risk ◽  
Neonatal Hyperbilirubinemia ◽  
Diagnostic Methods ◽  
Mean Values ◽  
Laboratory Parameters ◽  
Abo Incompatibility ◽  
Rh Incompatibility ◽  
Severe Hyperbilirubinemia ◽  
Blood Grouping

BACKGROUND: Neonatal jaundice that occurs in ABO or Rhesus issoimunisation has been recognized as one of the major risk factors for development of severe hyperbilirubinemia and bilirubin neurotoxicity.AIM: Aim of our study was to investigate clinical and laboratory parameters associated with hemolytic jaundice due to Rh and ABO incompatibility and compare results with the group of unspecific jaundice.MATERIAL AND METHODS: One hundred sixty seven (167) neonatal hyperbilirubinemia cases were included in the study, 24.6% of which presented with ABO/Rhesus type hemolytic jaundice, and the rest with unspecific jaundice. Evaluation included: blood count, reticulocites, serum bilirubin, aminotransferases, blood grouping, and Coombs test, also the day of bilirubin peak, duration of the hyperbilirubinemia, and additional bilirubin measurements.RESULTS: We showed significantly lower mean values of hemoglobin, erythrocytes and hematocrit and significantly higher values of reticulocytes in the group of ABO/Rh incompatibility compared to the group of jaundice of unspecific etiology; also an earlier presentation and a higher-grade jaundice in this group.CONCLUSIONS: The laboratory profile in ABO/Rh isoimmunisation cases depicts hemolytic mechanism of jaundice. These cases carry a significant risk for early and severe hyperbilirubinemia and are eligible for neurodevelopmental follow-up. Hematological parameters and blood grouping are simple diagnostic methods that assist the etiological diagnosis of neonatal hyperbilirubinemia.

scholarly journals Neonatal Hyperbilirubinemia treatment by Locally Made Low-Cost Phototherapy Units

2021 ◽  
Vol 31 (1) ◽  
Author(s):  
Netsanet Workneh Gidi ◽  
Matthias Siebeck
Keyword(s):  
Bilirubin Level ◽  
Medical Center ◽  
Low Cost ◽  
Retrospective Chart Review ◽  
Maximum Level ◽  
Neonatal Hyperbilirubinemia ◽  
Common Finding ◽  
Abo Incompatibility ◽  
Rh Incompatibility ◽  
Severe Hyperbilirubinemia

BACKGROUND፡ Hyperbilirubinemia is a very common finding in neonates and may occasionally cause severe morbidity and even mortality. Severe hyperbilirubinemia is typically treated, either with phototherapy or exchange transfusions. This study assessed the effectiveness of a locally manufactured phototherapy device for reducing serum bilirubin in neonates with severe hyperbilirubinemia.METHODS: Retrospective chart review was carried out to assess the outcome of 32 infants who were treated for neonatal hyperbilirubinemia at Jimma Medical Center (JMC) from May, 2017 to April, 2018. RESULTS: Out of 75 charts reviewed, only 32 had subsequent bilirubin level determination, 18(56.3%) of them were males. The age at which jaundice was noticed and confirmed with plasma bilirubin level was 4 + 2.7 days (mean+SD). Sepsis was thought to be the cause of hyperbilirubinemia in 13(40.5%) of the cases, while hemolysis from ABO incompatibility or RH incompatibility contributed in 5(15.6%) and 3(9.4) of the infants respectively. The mean (minimum, maximum) level of baseline TSB was 21.4(14, 55) mg/dL. Five infants (15.6%) had exchange transfusions because of extreme hyperbilirubinemia. The duration of phototherapy and decline in TSB were 5.34 +2.8 days and 2.2+1.5mg/dl/day (mean+SD) respectively. The levels of TSB before and at the end of phototherapy were significantly different (p<0.001).CONCLUSION: Acceptable reduction of TSB was achieved by using locally manufactured PT devices. Benefits included better accessibility and lower price and maintenance costs. High mean baseline TSB was observed, and duration of phototherapy is prolonged which could indicate late diagnosis compared to similar studies.

Incidence of Cochlear Involvement in Hyperbilirubinemic Deafness

2002 ◽  
Vol 111 (11) ◽  
pp. 1021-1025 ◽  
Author(s):  
Cagatay Oysu ◽  
Arif Ulubil ◽  
Ismet Aslan ◽  
Nermin Baserer
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Significant Risk ◽  
Neonatal Hyperbilirubinemia ◽  
Neural Pathways ◽  
Auditory Brain Stem Response ◽  
Childhood Deafness ◽  
Identifiable Risk Factor ◽  
Auditory Brain Stem ◽  
Severe Hyperbilirubinemia

Neonatal hyperbilirubinemia remains an important cause of childhood deafness, especially in developing countries. After neonatal hyperbilirubinemia, the auditory neural pathways, cochlea, or both may be affected. In this study, we aimed to determine the incidence of cochlear impairment and the appropriate means of hearing screening in hyperbilirubinemic neonates. A retrospective review of 1,032 pediatric patients with hearing loss revealed 67 cases (6.5%) of severe hyperbilirubinemia in the neonatal period. Thirty of these patients had neonatal hyperbilirubinemia as the single identifiable risk factor for hearing loss. In 26 of 30 cases (87%), otoacoustic emissions (OAEs) were absent, whereas in the remaining 4 cases (13%), robust emissions were detected despite an absent auditory brain stem response (ABR). Auditory screening of newborns with jaundice by OAEs possesses a significant risk of undiagnosed deafness. On the other hand, if the ABR is used as the single means of screening, auditory neuropathic conditions will probably be underlooked. Therefore, we recommend dual screening of hearing by ABR and OAEs in hyperbilirubinemic newborns.

scholarly journals Clinical profile and aetiological factors of neonatal jaundice from a rural area of Kutch, Gujarat, India

2020 ◽  
Vol 8 (1) ◽  
pp. 143
Author(s):  
Avinash Patel ◽  
Karan Saradava ◽  
Hasmukh Chauhan
Keyword(s):  
Birth Weight ◽  
Neonatal Intensive Care ◽  
Neonatal Jaundice ◽  
Prospective Observational Study ◽  
Medical Science ◽  
Clinical Profile ◽  
Rural Setting ◽  
Abo Incompatibility ◽  
Rh Incompatibility ◽  
Blood Grouping

Background: Etiology of hyperbilirubinemia is not only crucial for optimal management of the patient but also it may have implications for subsequent pregnancies. The objective of this study was to study the clinical profile and the underlying aetiological factors leading to neonatal jaundice in this rural setting of Kutch District, Gujarat, India.Methods: This prospective observational study was conducted in the neonatal intensive care unit (NICU) and Post Natal ward Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat. Total of 150 cases were enrolled for the study. Blood grouping and Rh typing of baby and mother were done. Cord blood bilirubin and haemoglobin, direct coomb's test (DCT) and bilirubin monitoring were done whenever there was a setting for Rh incompatibility.Results: Among 150 neonates studied, majority had birth weight between 2501g and 3000g. Only 21 babies had birth weight <2.5kg (14%) (Table 2). Of the 150 neonates 85 were males and 65 were females.Conclusions: This study concludes that physiological jaundice is the most common cause of neonatal jaundice in our hospital. This is followed by ABO incompatibility, sepsis, Rh incompatibility and idiopathic cases.

scholarly journals Effectiveness of conventional phototherapy, intensive phototherapy and exchange transfusion in treating neonatal jaundice at Fatima Al-Zahra Hospital for maternity and children in Baghdad

2020 ◽  
Vol 16 (2) ◽  
pp. 25-29
Author(s):  
Ahmed Salih Marzoog ◽  
Hussein Naeem Mohammed ◽  
Kholod Dhaher Habib
Keyword(s):  
Exchange Transfusion ◽  
Neonatal Jaundice ◽  
Neonatal Care ◽  
Neonatal Hyperbilirubinemia ◽  
Total Serum ◽  
Common Disease ◽  
Female Ratio ◽  
Abo Incompatibility ◽  
Rh Incompatibility ◽  
Neonatal Care Unit

Background: Neonatal hyperbilirubinemia is a common disease in neonates especially in early days of birth that requires a good and successful treatment for reducing the severity and its complications that can produce important and irreversible effects. Objectives: To evaluate the effectiveness of conventional phototherapy, intensive phototherapy and exchange transfusion on outcomes of neonatal jaundice at Fatima Al-Zahra Hospital for maternity and child care in Baghdad. Patients & Methods: A retrospective study was carried out using medical records of neonates with diagnosis of unconjugated jaundice, admitted in the septic neonatal care unit of Fatima Al-Zahra hospital over 6 months period between 1st May till 31st October 2018. The total serum bilirubin, fractionations and blood group were done in all cases. They treated with conventional phototherapy, intensive phototherapy and exchange transfusion according to the severity of jaundice. Results: Total neonates admitted from 1st may to 31st October 2018 in septic neonatal care unit were 1254, among them 432 (35%) were diagnosed as unconjugated neonatal jaundice “indirect hyperbilirubinemia”. Male: Female ratio (1.4:1), males 256(59.3%), females 176(40.7%). Physiological jaundice was the most common cause 129(29.9%) cases. Prematurity in 104(24.1%) and ABO incompatibility 59(13.7%) while Rh incompatibility 14(3.2%), sepsis 8(1.9%) and unknown causes of jaundice were 118(27.3%) because lack of lab facilities. Conventional phototherapy was the most common kind of treatment in 237(55%) while intensive phototherapy used in 175(40.3%) cases with successful reduction in T.S.B level and the rate of improvement without need for exchange transfusion (92%) (161/175).Only 20(4.5%) cases were treated with exchange transfusion especially for ABO incompatibility 8 (42.1%) cases and Rh incompatibility 4 (21.1%) cases. Most of neonates 429 (99.3%) discharged with complete improvement and only 2 (0.5%) neonates suffered from kernicterus and one death (0.2%). Conclusion: Conventional phototherapy is still the standard treatment of mild to moderate indirect hyperbilirubinemia. Use of intensive phototherapy in the treatment of unconjugated neonatal hyperbilirubinemia is effective in reducing T.S.B level, need for exchange transfusion and hospital staying. Recommendations: provide aseptic neonatal care unit in the hospital with further number of intensive phototherapy devices as it is so effective in treating unconjugated neonatal jaundice and reduces need for exchange transfusion as it is proven in the study.

scholarly journals Risk Factors and Causes of Neonatal Hyperbilirubinemia: A Systematic Review Study

2020 ◽  
Vol 8 (4) ◽  
pp. 211-222
Author(s):  
Hassan Boskabadi ◽  
◽  
Forough Rakhshanizadeh ◽  
Ali Moradi ◽  
Maryam Zakerihamidi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Birth Weight ◽  
G6pd Deficiency ◽  
Neonatal Jaundice ◽  
Diabetic Mother ◽  
Neonatal Hyperbilirubinemia ◽  
Abo Incompatibility ◽  
Rh Incompatibility ◽  
Review Study

Context: Jaundice is a common problem and the most common risk factor for hospitalization during the neonatal period.      Objective: The prevention of neonatal hyperbilirubinemia would not be possible without identifying its predisposing risk factors. The present systematic review study aims to determine the risk factors of neonatal jaundice. Data Sources: Databases including Science Direct, Cochrane Library, Web of Science (ISI), PubMed, and Google Scholar were searched to identify all eligible papers concerning the risk factors of neonatal hyperbilirubinemia.  Study Selection: This systematic review was performed to review the causes and risk factors of neonatal hyperbilirubinemia. Finally, 18 articles were defined as eligible for further review. Data Extraction: The keywords included neonates, jaundice, hyperbilirubinemia, and risk factors. The inclusion criteria were studies determining jaundice risk factors, while papers with only published abstracts were excluded. Results: A total of 18 eligible articles (3 retrospective, 4 prospective, 10 cross-sectional, and 1 historical cohort) out of 421 retrieved articles were included in this review. The etiologic causes for neonatal jaundice were ABO incompatibility (24.6%), infection (including UTI and sepsis) (13.7%), G6PD deficiency (9.4%), Rh incompatibility (7%), and cephalohematoma (2.9%), while, known predisposing factors for neonatal jaundice included unknown (33.2%), low birth weight (30.9%), hyperbilirubinemia in siblings (22.7%), prematurity (20.1%), and infant of diabetic mother (6.7%). Conclusion: According to our review with considering the studies, the etiologic causes for neonatal jaundice are ABO incompatibility, infection (including UTI and sepsis), G6PD deficiency, Rh incompatibility, and cephalohematoma. While, known predisposing factors for neonatal jaundice include low birth weight, hyperbilirubinemia in siblings, prematurity, and infant of diabetic mother.

Assessment of some hematological indicators of breeding falls of the zabaikalsky breed

2021 ◽  
Vol 1 (2) ◽  
pp. 36-42
Author(s):  
B. Z. Bazaron ◽  
◽  
T. N. Khamiruev ◽  
S. M. Dashinimaev ◽  
G. M. Shkuratova ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Steppe Zone ◽  
Diagnostic Methods ◽  
Clinical State ◽  
Forest Steppe ◽  
Research Material ◽  
Hematological Indicators ◽  
Young Horses

The results of studying the morphological and biochemical parameters of the blood of young horses of the Trans-Baikal breed, depending on the zone of their breeding and age, are presented. The study of hematological parameters is one of the most important diagnostic methods for assessing the physiological and clinical state of animals. The research material was stallions at the age of 12, 18, 24 and 36 months. It was found that hematological parameters were within physiological norms, while in stallions of the forest-steppe zone they were higher in comparison with analogs of the steppe zone. With age, there is a decrease in the estimated hematological parameters in the experimental stallions.

Analysis of diagnostic criteria for ventilator-associated pneumonia: a cohort study

2021 ◽  
Vol 74 (6) ◽  
Author(s):  
Caroline Gonçalves Pustiglione Campos ◽  
Aline Pacheco ◽  
Maria Dagmar da Rocha Gaspar ◽  
Guilherme Arcaro ◽  
Péricles Martim Reche ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Cohort Study ◽  
Intensive Care ◽  
Diagnostic Criteria ◽  
Statistical Tests ◽  
Significant Risk ◽  
Diagnostic Methods ◽  
Ventilator Associated Pneumonia

ABSTRACT Objectives: to analyze the diagnostic criteria for ventilator-associated pneumonia recommended by the Brazilian Health Regulatory Agency and the National Healthcare Safety Network/Centers for Disease Control and Prevention, as well as its risk factors. Methods: retrospective cohort study carried out in an intensive care unit throughout 12 months, in 2017. Analyses included chi-square, simple linear regression, and Kappa statistical tests and were conducted using Stata 12 software. Results: the sample was 543 patients who were in the intensive care unit and under mechanical ventilation, of whom 330 (60.9%) were men and 213 (39.1%) were women. Variables such as gender, age, time under mechanical ventilation, and oral hygiene proved to be significant risk factors for the development of ventilator-associated pneumonia. Conclusions: patients submitted to mechanical ventilation need to be constantly evaluated so the used diagnostic methods can be accurate and applied in an objective and standardized way in Brazilian hospitals.

scholarly journals Physiological parameters of male goats raised under tropical climate conditions (Brazil)

2020 ◽  
Vol 9 (9) ◽  
pp. e768997698
Author(s):  
Julio Cesar Oliveira Dias ◽  
Cristina Mattos Veloso ◽  
Madriano Christilis da Rocha Santos ◽  
Carlos Thiago Silveira Alvim Mendes de Oliveira ◽  
Camila Oliveira Silveira
Keyword(s):  
Complete Blood Count ◽  
Hematological Parameters ◽  
Experimental Period ◽  
Tropical Climate ◽  
Physiological Parameters ◽  
Climate Conditions ◽  
Mean Values ◽  
Humidity Index ◽  
Globe Temperature ◽  
Hormonal Levels

This study evaluated the adaptive capacity and variations in physiological parameters of four male goats originate from a temperate region (Alpine breed) in a tropical climate over twelve months. The ambient temperature, relative humidity, and temperature via a black globe thermometer were evaluated to calculate the black globe temperature and humidity index; they were collected five times during the day, three times during the week, and during the four annual seasons. Every fortnight throughout the experimental period, respiratory and heart rates as well as rectal and surface temperatures of the animals were measured in the morning, and blood samples were acquired for hormonal levels (cortisol, T3, and T4) and complete blood count. There was a difference between the mean values of surface temperature, respiratory rate, hormones, and some hematological parameters (total protein and monocytes) between the seasons (P<0.05). However, no differences were observed in cases of heat stress, based on the fact that physiological parameters were within normal and expected limits for goats. Thus, it is concluded that the male goats of the Alpine breed, when reared intensively, maintain homeothermia and are greatly adaptable to the conditions of the tropical climate.

The Development of Immunological Factors in Infants with Hyperbilirubinemia

PEDIATRICS ◽  
1970 ◽  
Vol 45 (1) ◽  
pp. 102-104
Author(s):  
Zdenka Nejedlá
Keyword(s):  
Exchange Transfusion ◽  
Causative Factor ◽  
Neonatal Hyperbilirubinemia ◽  
Control Group ◽  
Abo Incompatibility ◽  
Healthy Infants ◽  
Significant Depression ◽  
Immunological Factors ◽  
Antibody Levels

Twelve infants with neonatal hyperbilirubinemia caused by Rh or ABO incompatibility were followed for 1 year after birth. Antibodv determinations for diphtheria, tetanus, pertussis and three strains of E. coil (026, 055, and 079) were done. The results were compared with those from a control group of 25 healthy infants and from 40 infants who had received exchange transfusion after birth. The data suggests that bilirubin is a causative factor in the significant depression of antibody levels against diphtheria, tetanus, and pertussis in infants with hyperbilirubinemia when compared to healthy infants. [see pdf for figures]

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