Inhibitory effects of brusatol delivered using glycosaminoglycan‑placental chondroitin sulfate A‑modified nanoparticles on the proliferation, migration and invasion of cancer cells

Chondrosarcoma is a primary malignant bone cancer, with a potent capacity to invade locally and cause distant metastasis, especially to the lungs. Patients diagnosed with chondrosarcoma have poor prognosis. Berberine, an active component of the Ranunculaceae and Papaveraceae families of plant, has been proven to induce tumor apoptosis and to prevent the metastasis of cancer cells. However, the effects of berberine in human chondrosarcoma are largely unknown. In this study, we found that berberine did not induce cell apoptosis in human primary chondrocytes and chondrosarcoma cells. However, at noncytotoxic concentrations, berberine reduced the migration and invasion of chondrosarcoma cancer cells. Integrins are the major adhesive molecules in mammalian cells and have been associated with the metastasis of cancer cells. We also found that incubation of chondrosarcoma cells with berberine reduced mRNA transcription for, and cell surface expression of, theαvβ3 integrin, with additional inhibitory effects on PKCδ, c-Src, and NF-κB activation. Thus, berberine may be a novel antimetastasis agent for the treatment of metastatic chondrosarcoma.

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Hedyotis Diffusa Willd. Extracts Inhibit the Proliferation and Migration of Ovarian Cancer Cells by Modulating the AKT/ERK Signaling Pathway

Current Topics in Nutraceutical Research ◽

10.37290/ctnr2641-452x.17:451-456 ◽

2019 ◽

Vol 17 (4) ◽

pp. 451-456

Author(s):

Xu Liwei ◽

Guo Liang ◽

Li Hong ◽

Bian Xiyun

Keyword(s):

Ovarian Cancer ◽

Cancer Cells ◽

Migration And Invasion ◽

Ovarian Cancer Cells ◽

Control Group ◽

Inhibitory Effects ◽

Hedyotis Diffusa ◽

And Migration ◽

Proliferation And Migration ◽

Promising Therapeutic Agent

Hedyotis diffusa Willd. (HDW) is a traditional Chinese medicine used for the treatment of colorectal cancer. The aim of this study was to investigate the molecular mechanism of inhibitory effects of HDW on the growth of ovarian cancer cells. Treatment of ovarian cancer cells with increasing doses of HDW for 48 or 72 h resulted in a significant reduction in the viability and colony formation of cancer cells. In HDW-treated cancer cells, the cell cycle was blocked at the G0/G1 phase and cell apoptosis was 4- to 5-fold higher than that of control group. HDW treatment also markedly inhibited the migration and invasion of ovarian cancer cells. Mechanistically, the phosphorylation levels of AKT and ERK were down-regulated in HDW-treated ovarian cancer cells. Therefore, HDW is likely to become a promising therapeutic agent for ovarian cancer treatment.

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723: Chemokine Receptor CXCR4 Mediates Migration and Invasion of Bladder Cancer Cells

The Journal of Urology ◽

10.1016/s0022-5347(18)37972-2 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 192-192 ◽

Cited By ~ 2

Author(s):

Margitta Retz ◽

Sukhvinder S. Sidhu ◽

Gregory M. Dolganov ◽

Jan Lehmann ◽

Peter R. Carroll ◽

...

Keyword(s):

Bladder Cancer ◽

Cancer Cells ◽

Chemokine Receptor ◽

Migration And Invasion ◽

Chemokine Receptor Cxcr4 ◽

Bladder Cancer Cells

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Inhibitory effects of Actinidia Chinensis planch root extracts (acRoots) on human lung cancer cells through retinoic acid receptor beta

Molecular and Cellular Therapies ◽

10.26781/2052-8426-2017-02 ◽

2017 ◽

Vol 5 (1) ◽

Cited By ~ 1

Author(s):

Lingyan Wang ◽

Jiayun Hou ◽

Minghuan Zheng ◽

Lin Shi

Keyword(s):

Lung Cancer ◽

Cancer Cells ◽

Human Lung ◽

Retinoic Acid Receptor ◽

Lung Cancer Cells ◽

Human Lung Cancer ◽

Inhibitory Effects ◽

The Core ◽

Human Lung Cancer Cells ◽

Receptor Beta

Actinidia Chinensis Planch roots (acRoots) are used to treat many cancers, although the anti-tumor mechanism by which acRoots inhibit cancer cell growth remains unclear. The present study aims at investigating inhibitory effects of acRoots on human lung cancer cells and potential mechanisms. Our data demonstrate that the inhibitory effects of acRoots on lung cancer cells depend on genetic backgrounds and phenotypes of cells. We furthermore found the expression of metabolism-associated gene profiles varied between acRoots-hypersensitive (H460) or hyposensitive lung cancer cells (H1299) after screening lung cancer cells with different genetic backgrounds. We selected retinoic acid receptor beta (RARB) as the core target within metabolism-associated core gene networks and evaluated RARB changes and roles in cells treated with acRoots at different concentrations and timeframes. Hypersensitive cancer cells with the deletion of RARB expression did not response to the treatment with acRoots, while RARB deletion did not change effects of acRoots on hyposensitive cells. Thus, it seems that RARB as the core target within metabolism-associated networks plays important roles in the regulation of lung cancer cell sensitivity to acRoots.

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