scholarly journals Review of Machine Learning Technologies and Neural Networks in Drug Synergy Combination pharmacological research

2020 ◽  
Vol 6 (3) ◽  
pp. 27-32
Author(s):  
Artur S. Ter-Levonian ◽  
Konstantin A. Koshechkin

Introduction: Nowadays an increase in the amount of information creates the need to replace and update data processing technologies. One of the tasks of clinical pharmacology is to create the right combination of drugs for the treatment of a particular disease. It takes months and even years to create a treatment regimen. Using machine learning (in silico) allows predicting how to get the right combination of drugs and skip the experimental steps in a study that take a lot of time and financial expenses. Gradual preparation is needed for the Deep Learning of Drug Synergy, starting from creating a base of drugs, their characteristics and ways of interacting. Aim: Our review aims to draw attention to the prospect of the introduction of Deep Learning technology to predict possible combinations of drugs for the treatment of various diseases. Materials and methods: Literary review of articles based on the PUBMED project and related bibliographic resources over the past 5 years (2015–2019). Results and discussion: In the analyzed articles, Machine or Deep Learning completed the assigned tasks. It was able to determine the most appropriate combinations for the treatment of certain diseases, select the necessary regimen and doses. In addition, using this technology, new combinations have been identified that may be further involved in preclinical studies. Conclusions: From the analysis of the articles, we obtained evidence of the positive effects of Deep Learning to select “key” combinations for further stages of preclinical research.

2020 ◽  
Vol 114 ◽  
pp. 242-245
Author(s):  
Jootaek Lee

The term, Artificial Intelligence (AI), has changed since it was first coined by John MacCarthy in 1956. AI, believed to have been created with Kurt Gödel's unprovable computational statements in 1931, is now called deep learning or machine learning. AI is defined as a computer machine with the ability to make predictions about the future and solve complex tasks, using algorithms. The AI algorithms are enhanced and become effective with big data capturing the present and the past while still necessarily reflecting human biases into models and equations. AI is also capable of making choices like humans, mirroring human reasoning. AI can help robots to efficiently repeat the same labor intensive procedures in factories and can analyze historic and present data efficiently through deep learning, natural language processing, and anomaly detection. Thus, AI covers a spectrum of augmented intelligence relating to prediction, autonomous intelligence relating to decision making, automated intelligence for labor robots, and assisted intelligence for data analysis.


Symmetry ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1116
Author(s):  
Zeba Mahmood ◽  
Vacius Jusas

This paper introduces a blockchain-based federated learning (FL) framework with incentives for participating nodes to enhance the accuracy of classification problems. Machine learning technology has been rapidly developed and changed from a global perspective for the past few years. The FL framework is based on the Ethereum blockchain and creates an autonomous ecosystem, where nodes compete to improve the accuracy of classification problems. With privacy being one of the biggest concerns, FL makes use of the blockchain-based approach to ensure privacy and security. Another important technology that underlies the FL framework is zero-knowledge proofs (ZKPs), which ensure that data uploaded to the network are accurate and private. Basically, ZKPs allow nodes to compete fairly by only submitting accurate models to the parameter server and get rewarded for that. We have conducted an analysis and found that ZKPs can help improve the accuracy of models submitted to the parameter server and facilitate the honest participation of all nodes in FL.


2021 ◽  
Vol 10 (3) ◽  
pp. 137
Author(s):  
Youngok Kang ◽  
Nahye Cho ◽  
Jiyoung Yoon ◽  
Soyeon Park ◽  
Jiyeon Kim

Recently, as computer vision and image processing technologies have rapidly advanced in the artificial intelligence (AI) field, deep learning technologies have been applied in the field of urban and regional study through transfer learning. In the tourism field, studies are emerging to analyze the tourists’ urban image by identifying the visual content of photos. However, previous studies have limitations in properly reflecting unique landscape, cultural characteristics, and traditional elements of the region that are prominent in tourism. With the purpose of going beyond these limitations of previous studies, we crawled 168,216 Flickr photos, created 75 scenes and 13 categories as a tourist’ photo classification by analyzing the characteristics of photos posted by tourists and developed a deep learning model by continuously re-training the Inception-v3 model. The final model shows high accuracy of 85.77% for the Top 1 and 95.69% for the Top 5. The final model was applied to the entire dataset to analyze the regions of attraction and the tourists’ urban image in Seoul. We found that tourists feel attracted to Seoul where the modern features such as skyscrapers and uniquely designed architectures and traditional features such as palaces and cultural elements are mixed together in the city. This work demonstrates a tourist photo classification suitable for local characteristics and the process of re-training a deep learning model to effectively classify a large volume of tourists’ photos.


Author(s):  
Anastasiia Ivanitska ◽  
Dmytro Ivanov ◽  
Ludmila Zubik

The analysis of the available methods and models of formation of recommendations for the potential buyer in network information systems for the purpose of development of effective modules of selection of advertising is executed. The effectiveness of the use of machine learning technologies for the analysis of user preferences based on the processing of data on purchases made by users with a similar profile is substantiated. A model of recommendation formation based on machine learning technology is proposed, its work on test data sets is tested and the adequacy of the RMSE model is assessed. Keywords: behavior prediction; advertising based on similarity; collaborative filtering; matrix factorization; big data; machine learning


Sensors ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 3910 ◽  
Author(s):  
Taeho Hur ◽  
Jaehun Bang ◽  
Thien Huynh-The ◽  
Jongwon Lee ◽  
Jee-In Kim ◽  
...  

The most significant barrier to success in human activity recognition is extracting and selecting the right features. In traditional methods, the features are chosen by humans, which requires the user to have expert knowledge or to do a large amount of empirical study. Newly developed deep learning technology can automatically extract and select features. Among the various deep learning methods, convolutional neural networks (CNNs) have the advantages of local dependency and scale invariance and are suitable for temporal data such as accelerometer (ACC) signals. In this paper, we propose an efficient human activity recognition method, namely Iss2Image (Inertial sensor signal to Image), a novel encoding technique for transforming an inertial sensor signal into an image with minimum distortion and a CNN model for image-based activity classification. Iss2Image converts real number values from the X, Y, and Z axes into three color channels to precisely infer correlations among successive sensor signal values in three different dimensions. We experimentally evaluated our method using several well-known datasets and our own dataset collected from a smartphone and smartwatch. The proposed method shows higher accuracy than other state-of-the-art approaches on the tested datasets.


Deep Learning technology can accurately predict the presence of diseases and pests in the agricultural farms. Upon this Machine learning algorithm, we can even predict accurately the chance of any disease and pest attacks in future For spraying the correct amount of fertilizer/pesticide to elimate host, the normal human monitoring system unable to predict accurately the total amount and ardent of pest and disease attack in farm. At the specified target area the artificial percepton tells the value accurately and give corrective measure and amount of fertilizers/ pesticides to be sprayed.


2022 ◽  
Vol 2 ◽  
Author(s):  
Rasheed Omobolaji Alabi ◽  
Alhadi Almangush ◽  
Mohammed Elmusrati ◽  
Antti A. Mäkitie

Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers worldwide and its incidence is on the rise in many populations. The high incidence rate, late diagnosis, and improper treatment planning still form a significant concern. Diagnosis at an early-stage is important for better prognosis, treatment, and survival. Despite the recent improvement in the understanding of the molecular mechanisms, late diagnosis and approach toward precision medicine for OSCC patients remain a challenge. To enhance precision medicine, deep machine learning technique has been touted to enhance early detection, and consequently to reduce cancer-specific mortality and morbidity. This technique has been reported to have made a significant progress in data extraction and analysis of vital information in medical imaging in recent years. Therefore, it has the potential to assist in the early-stage detection of oral squamous cell carcinoma. Furthermore, automated image analysis can assist pathologists and clinicians to make an informed decision regarding cancer patients. This article discusses the technical knowledge and algorithms of deep learning for OSCC. It examines the application of deep learning technology in cancer detection, image classification, segmentation and synthesis, and treatment planning. Finally, we discuss how this technique can assist in precision medicine and the future perspective of deep learning technology in oral squamous cell carcinoma.


2019 ◽  
Vol 8 (3) ◽  
pp. 8619-8622

People, due to their complexity and volatile actions, are constantly faced with challenges in understanding the situation in the market share and the forecast for the future. For any financial investment, the stock market is a very important aspect. It is necessary to study while understanding the price fluctuations of the stock market. In this paper, the stock market prediction model using the Recurrent Digital natural Network (RDNN) is described. The model is designed using two important machine learning concepts: the recurrent neural network (RNN), multilayer perceptron (MLP) and reinforcement learning (RL). Deep learning is used to automatically extract important functions of the stock market; reinforcement learning of these functions will be useful for future prediction of the stock market, the system uses historical stock market data to understand the dynamic market behavior when you make decisions in an unknown environment. In this paper, the understanding of the dynamic stock market and the deep learning technology for predicting the price of the future stock market are described.


Author(s):  
Stefan Papastefanou

AbstractHaving huge power grids successfully integrate sustainable energy sources requires a smart and flexible power grid management system. Such smart systems have to adapt fast and accurately to a great amount of data input – a task which is made easier by applying modern machine learning technology. Solutions crafted by dynamic and powerful computing algorithms have the potential to surpass human cognitive capabilities. The question arises whether and how intellectual property law can be used to set the right incentives. This paper initially describes the basic functions of smart grids and the corresponding necessity of machine learning. Subsequently, it will analyze the current approaches of the most relevant patent offices in dealing with the challenges of AI-related smart grid inventions. Ultimately, it will be demonstrated that the contemporary discussions fail to focus on practical considerations of market entry possibilities that might be more promising than the approach of creating new exclusionary intellectual property rights.


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