scholarly journals The Need for SPACE to Plan the Future for Spondyloarthritis

2021 ◽  
pp. jrheum.211212
Author(s):  
Mark Hwang ◽  
Michael H. Weisman
Keyword(s):  
Alcohol Consumption ◽  
Natural History ◽  
Disease Activity ◽  
Axial Spondyloarthritis ◽  
Lifestyle Factors ◽  
Recent Onset ◽  
The Future ◽  
History Of ◽  
Over Time

"Lifestyle Factors and Disease Activity Over Time in Early Axial Spondyloarthritis: The SPondyloArthritis Caught Early (SPACE) Cohort" by Exarchou et al aimed at looking at the importance of baseline lifestyle factors of BMI, smoking, and alcohol consumption (AC) on disease activity in recent-onset axial spondyloarthritis (axSpA).1 Does this study add to our knowledge of the natural history of axSpA?

scholarly journals Natural history of glucose tolerance, beta-cell function and peripheral insulin sensitivity in cystic fibrosis patients with fasting euglycemia

2003 ◽  
Vol 149 (1) ◽  
pp. 53-59 ◽  
Author(s):  
F Lombardo ◽  
F De Luca ◽  
M Rosano ◽  
C Sferlazzas ◽  
C Lucanto ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Insulin Sensitivity ◽  
Natural History ◽  
Glucose Tolerance ◽  
Pancreatic Beta Cells ◽  
Cell Function ◽  
Glucose Levels ◽  
Peripheral Insulin Resistance ◽  
History Of ◽  
Over Time

OBJECTIVE: The loss of pancreatic beta-cells is thought to be one of the principal causes of diabetes mellitus (DM) in cystic fibrosis (CF), but the role of peripheral insulin resistance (IR) in the pathogenesis of DM in CF remains unclear. The aim of this study was to evaluate whether eventual changes of glucose tolerance (GT) over time were associated with modifications of insulin secretion or sensitivity. METHODS: Plasma glucose and insulin responses to an oral GT test (OGTT) were investigated and reinvestigated 13 Years later in 14 CF patients with initial and persistent fasting euglycemia and no history of insulin treatment. Insulin sensitivity (IS) at both tests was assessed on the basis of insulin and glucose levels both in the fasting state and during OGTTs. RESULTS: From the 1st to the 2nd OGTT: (a) the prevalence of DM responses significantly increased; (b) the areas beneath the respective glucose and insulin curves significantly increased and decreased respectively; (c) IR and IS indices decreased and increased respectively, even in the patients who developed DM; (d) pulmonary function significantly worsened in the entire series, especially in the patients who developed DM. CONCLUSIONS: (i) the natural history of glyco-metabolic status in CF is characterized by deteriorating GT over time; (ii) insulinopenia plays a prominent role in the pathogenesis of GT worsening; (iii) IR does not play any significant part in the pathogenesis of DM development; (iv) deterioration of lung function tests is more severe in the subjects who develop DM over time.

Dante's New Life of the Book

2021 ◽  
Author(s):  
Martin Eisner
Keyword(s):  
Literary History ◽  
Poetic Form ◽  
Archival Research ◽  
Distinctive Features ◽  
Printed Books ◽  
The World ◽  
The Future ◽  
History Of ◽  
The Relationship ◽  
Over Time

This study uses the material transmission history of Dante’s innovative first book, the Vita nuova (New Life), to intervene in recent debates about literary history, reconceiving the relationship between the work and its reception, and investigating how different material manifestations and transformations in manuscripts, printed books, translations, and adaptations participate in the work. Just as Dante frames his collection of thirty-one poems surrounded by prose narrative and commentary as an attempt to understand his own experiences through the experimental form of the book, so later scribes, editors, and translators use different material forms to embody their own interpretations of it. Traveling from Boccaccio’s Florence to contemporary Hollywood with stops in Emerson’s Cambridge, Rossetti’s London, Nerval’s Paris, Mandelstam’s Russia, De Campos’s Brazil, and Pamuk’s Istanbul, this study builds on extensive archival research to show how Dante’s strange poetic forms continue to challenge readers. In contrast to a conventional reception history’s chronological march, each chapter analyzes how one of these distinctive features has been treated over time, offering new perspectives on topics such as Dante’s love of Beatrice, his relationship with Guido Cavalcanti, and his attraction to another woman, while highlighting Dante’s concern with the future, as he experiments with new ways to keep Beatrice alive for later readers. Deploying numerous illustrations to show the entanglement of the work’s poetic form and its material survival, Dante’s New Life of the Book offers a fresh reading of Dante’s innovations, demonstrating the value of this philological analysis of the work’s survival in the world.

4. Religion

2021 ◽  
pp. 81-103
Author(s):  
James A. Harris
Keyword(s):  
Natural History ◽  
Human Nature ◽  
Human Beings ◽  
History Of Religion ◽  
Natural Religion ◽  
Treatise Of Human Nature ◽  
The Future ◽  
History Of

‘Religion' discusses Hume’s various treatments of religion, particularly in the essay ‘Of Miracles’, Dialogues concerning Natural Religion, and ‘The Natural History of Religion’. Hume's earlier writings show some interesting implications for religion, including A Treatise of Human Nature and the essay ‘Of National Characters’. Looking at ‘Of Miracles’ shows that Hume’s theme was not the possibility of miracles as such, but rather the rational grounds of belief in reports of miracles. Considering the Dialogues emphasizes the distinction between scepticism and atheism. Meanwhile, ‘Natural History’ emphasizes Hume’s interest in the dangerous moral consequences of monotheism. What is the future for religion? Perhaps Hume was unlikely to have supposed that his writings would do anything to reduce religion’s hold on the vast majority of human beings.

Chapter XXXVI Seeds of the Future (second Sowing)

Man and Wife ◽  
2008 ◽  
Author(s):  
Wilkie Collins
Keyword(s):  
Natural History ◽  
Aquatic Birds ◽  
The Future ◽  
History Of

And what did the visitors say of the Swans? They said, ‘Oh, what a number of them!’—which was all that was to be said, by persons ignorant of the natural history of aquatic birds. And what did the visitors say of the lake? Some of...

Bonnet, Charles (1720–93)

2018 ◽  
Author(s):  
F.C.T. Moore
Keyword(s):  
Natural History ◽  
Empirical Work ◽  
Later Life ◽  
Mental States ◽  
History Of ◽  
History Of Theology ◽  
Formed Part ◽  
The Moment ◽  
The Universe ◽  
Over Time

In his youth, Bonnet made a meticulous and creative study of insects, which won him international fame for his discoveries, as well as his methods. He turned to psychology and offered a detailed, but speculative, account of the physiology of mental states. His empirical work was overtaken by speculative ambition. In later life, he developed (from elements already present in his early studies) a comprehensive view of the universe, of its history and its natural history, of theology and of moral philosophy. Christianity was proved, the great chain of being was mapped over time towards an ultimate perfection, and human morality, based on self-love, formed part of the Creator’s scheme. The Creator, at the moment of creation, brought into being all the elements from which this vast unfolding would occur, without further intervention.

scholarly journals Spontaneous dyskinesia and parkinsonism in never-medicated, chronically ill patients with schizophrenia: 18-month follow-up

2002 ◽  
Vol 181 (2) ◽  
pp. 135-137 ◽  
Author(s):  
R. G. McCreadie ◽  
R. Padmavati ◽  
R. Thara ◽  
T. N. Srinivasan
Keyword(s):  
Natural History ◽  
Disease Process ◽  
Chronically Ill ◽  
Abnormal Involuntary Movements ◽  
Syndrome Scale ◽  
History Of ◽  
Chronically Ill Patients ◽  
Negative Syndrome ◽  
Over Time

BackgroundSpontaneous dyskinesia and parkinsonism have been reported in never-medicated patients with schizophrenia but there has been no previous study of the natural history of these conditions.AimsTo determine the prevalence of spontaneous dyskinesia and parkinsonism in a group of never-medicated, chronically ill patients with schizophrenia on two occasions separated by an 18-month interval.MethodDyskinesia was assessed by the Abnormal Involuntary Movements Scale using Schooler and Kane criteria for its presence; parkinsonism by the Simpson and Angus scale; and mental state by the Positive and Negative Syndrome Scale for schizophrenia.ResultsThirty-seven patients were examined on two occasions. Nine (24%) had dyskinesia on both occasions, 12 (33%) on one occasion and 16 (43%) on neither occasion. Twenty-one (57%) had dyskinesia on at least one occasion. Thirteen patients (35%) had parkinsonism on at least one occasion.ConclusionsSpontaneous dyskinesia and parkinsonism fluctuate over time. The former was found on at least one occasion in the majority of patients. It is an integral part ofthe schizophrenic disease process.

Do Illness Perceptions and Coping Strategies Change Over Time in Patients Recently Diagnosed With Axial Spondyloarthritis?

2020 ◽  
Vol 47 (12) ◽  
pp. 1752-1759
Author(s):  
Miranda van Lunteren ◽  
Robert Landewé ◽  
Camilla Fongen ◽  
Roberta Ramonda ◽  
Désirée van der Heijde ◽  
...  
Keyword(s):  
Back Pain ◽  
Disease Activity ◽  
Coping Strategies ◽  
Illness Perceptions ◽  
Rating Scale ◽  
Axial Spondyloarthritis ◽  
Numeric Rating Scale ◽  
And Coping ◽  
Numeric Rating ◽  
Over Time

ObjectiveIt is unknown if in axial spondyloarthritis (axSpA) patients’ illness perceptions and coping strategies change when disease activity changes.MethodsPatients diagnosed with axSpA and with 1 or more follow-up visits (1 and/or 2 yrs in the SPACE cohort) were included. Mixed linear models were used for illness perceptions (range 1–5), coping (range 1–4), back pain (numeric rating scale range 0–10), health-related quality of life (range 0–100), physical and mental component summary (PCS and MCS; range 0–100), work productivity loss (WPL; range 0–100), and activity impairment (AI; range 0–100%), separately, to test if they changed over time.ResultsAt baseline, 150 axSpA patients (mean age 30.4 yrs, 51% female, 65% HLA-B27+) had a mean (SD) numeric rating scale back pain of 4.0 (2.5), PCS of 28.8 (14.0), MCS of 47.8 (12.4), WPL of 34.1% (29.8), and AI of 38.7% (27.9). Over 2 years, clinically and statistically significant improvements were seen in the proportion of patients with an Ankylosing Spondylitis Disease Activity Score (ASDAS) of low disease activity (from 39% at baseline to 68% at 2 years), back pain (−1.5, SD 2.2), AI (−14.4%, SD 27.2), PCS (11.1, SD 13.3), and WPL (−15.3%, SD 28.7), but MCS did not change (0.7, SD 13.9; P = 0.201). In contrast, illness perceptions and coping strategies did not change over a period of 2 years. For example, at 2 years patients believed that their illness had severe “consequences” (2.8, SD 0.9) and they had negative emotions (e.g., feeling upset or fear) towards their illness [“emotional representation”, 2.5 (0.8)]. Patients most often coped with their pain by putting pain into perspective [“comforting cognitions”, 2.8 (0.6)] and tended to cope with limitations by being optimistic [“optimism”, 2.9 (0.7)].ConclusionWhile back pain, disease activity, and health outcomes clearly improved over 2 years, illness perceptions and coping strategies remained remarkably stable.

scholarly journals The impact of extra-musculoskeletal manifestations on disease activity, functional status, and treatment patterns in patients with axial spondyloarthritis: results from a nationwide population-based study

2020 ◽  
Vol 12 ◽  
pp. 1759720X2097261
Author(s):  
Imke Redeker ◽  
Britta Siegmund ◽  
Kamran Ghoreschi ◽  
Uwe Pleyer ◽  
Johanna Callhoff ◽  
...  
Keyword(s):  
Disease Activity ◽  
Functional Status ◽  
Axial Spondyloarthritis ◽  
Population Based ◽  
Treatment Patterns ◽  
Health Insurance Data ◽  
History Of ◽  
Musculoskeletal Manifestations ◽  
Disease Modifying ◽  
Insurance Data

Objective: The aim of this study was to investigate the association of extra-musculoskeletal manifestations (EMMs) with disease activity, functional status, and treatment patterns in a large population-based cohort of patients with axial spondyloarthritis (axSpA). Methods: A stratified random sample of patients with axSpA, drawn from health insurance data, received a survey on disease-related characteristics including history (ever presence) of the following EMMs: inflammatory bowel disease (IBD), psoriasis (PSO), and anterior uveitis (AU). Survey data were linked to health insurance data, gathering additional information on current occurrence (within one year) of EMMs and drug prescriptions. Separate multivariable linear regression models were calculated to determine the association of EMMs with disease activity (Bath Ankylosing Spondylitis Disease Activity Index), and functional status (Bath Ankylosing Spondylitis Functional Index) after adjustment for relevant parameters, including treatment. Results: A total of 1729 patients with axSpA were included in the analyses (response: 47%; mean age: 56 years; 46% female) of whom 6% (9%) had current (ever) IBD, 10% (15%) had current (ever) PSO, and 9% (27%) had current (ever) AU. Ever presence of IBD and history of PSO were significantly associated with higher level of disease activity. Ever presence of PSO was also associated with higher level of functional impairment, whereas current AU was significantly associated with lower disease activity. Patients with current IBD or PSO received more frequently biological and conventional synthetic disease-modifying anti-rheumatic drugs as well as systemic steroids. AU was associated with a higher use of conventional synthetic disease-modifying anti-rheumatic drugs only. Conclusion: Disease activity is higher in patients with axSpA with history of IBD or history of PSO. Functional impairment is also higher in patients with axSpA with history of PSO. The presence of different EMMs was associated with different treatment patterns in axSpA.

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