scholarly journals Effects of Ethanolic Extracts of Phoenix dactylifera Fruit, Cyperus esculentus Nut and Cocos nucifera Nut on Selected Indices of Kidney Function in Male Albino Rats

2018 ◽  
Vol 18 (3) ◽  
pp. 116-121 ◽  
Author(s):  
Chinedu Imo ◽  
Chukwumaobim Daniel Uzochukwuw ◽  
Emmanuel Mamma ◽  
Mida Habila Mayel ◽  
Ayobami Jahdahunsi Kukoyi ◽  
...  
Keyword(s):  
Kidney Function ◽  
Cocos Nucifera ◽  
Phoenix Dactylifera ◽  
Albino Rats ◽  
Cyperus Esculentus ◽  
Ethanolic Extracts

Phoenix dactylifera, Cyperus esculentus, and Cocos nucifera Pooled Extracts Ameliorate Pesticides-induced Hormonal Toxicity and Maintains Testicular Histology in Rats

2020 ◽  
Vol 15 (2) ◽  
pp. 43-51
Author(s):  
B.E. Ogeyemhe ◽  
P.U. Achukwu ◽  
E.B. Odigie
Keyword(s):  
Oral Treatment ◽  
Cocos Nucifera ◽  
Phoenix Dactylifera ◽  
Equal Proportion ◽  
Cyperus Esculentus ◽  
Testicular Weight ◽  
Before And After ◽  
Male Wistar Rats ◽  
Group B ◽  
Testicular Histology

Male infertility is increasingly worrisome and has been linked to increase rate of hormonal toxicity and imbalance. Sufferers now result to using medicinal plants due to its availability and cost effectiveness. This study was to assess ameliorating effects of Phoenix dactylifera (date), Cyperus esculentus (tigernut) and Cocos nucifera (coconut)mixture on pesticides-induced hormonal toxicity in male Wistar rats. Aqueous extraction of crops - date (maceration apparatus), tiger nut (rotary evaporator) and coconut (spray drying process) wereconducted after which, 5g of each extract were mixed in equal proportion. Hormonal toxicity was induced in rats using Ochratoxin A and endosulfan before oral treatment of the mix at graded doses (250 to 1000 mg/kg/day) for 28 days. Aseptic bloodsample was obtained before and after treatment for hormonal assay. At termination, animals were euthanized via decapitation; organs were excised, processed histologically, stained with H&E, and testes examined microscopically. Hormonal toxicity in rats was successfully induced, body weight of highly treated rats reduced (P ≤ 0.02) while testicular weight increased insignificantly (P ≥ 0.05). Mixed extract ameliorated the effect of pesticides on testosterone levels in group: B (1.8 ± 0.5ng/dL), C (2.4 ± 0.4ng/dL), D (3.8 ± 0.6 ng/dL) and E (4.1 ± 0.3 ng/dL) including FSH and LH values (P ≤ 0.05). Stained sections of testis were in keeping with normal histology after investigations. High doses of extract mix successfully reversed pesticides-induced hormonal toxicity in rats without harming the testes. Keywords: Cocos nucifera, Coconut, Cyperus esculentus, Date, Hormonal imbalance, Pesticide, Phoenix dactylifera, and Tiger nut

scholarly journals Biochemical and histological effects of ethanolic extracts of fruits of Xylopia aethiopica and seeds and leaves of Piper guineense on liver and kidney function in male albino rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Chinedu Imo ◽  
Kayode Adebisi Arowora ◽  
Chukwuma Stephen Ezeonu ◽  
Joseph Ikwebe ◽  
Ojochenemi Ejeh Yakubu ◽  
...  
Keyword(s):  
Kidney Function ◽  
Albino Rats ◽  
Piper Guineense ◽  
Group 4 ◽  
Ethanolic Extracts ◽  
Liver And Kidney ◽  
Group 3 ◽  
Group 2 ◽  
Xylopia Aethiopica ◽  
Group 1

Abstract Background The fruits of Xylopia aethiopica and seeds and leaves of Piper guineense are commonly used as spices. Due to their wide use in nutrition and traditional medicine, there is need to examine the biochemical and histological effects of ethanolic extracts of fruits of Xylopia aethiopica and seeds and leaves of Piper guineense on liver and kidney function in male albino rats. The test animals (groups 2, 3 and 4) received 100 mg/kg each of the corresponding extract for 21 days. Group 1 served as normal control and received a placebo of normal saline. The animals were later fasted overnight, sacrificed and their blood collected through cardiac puncture for biochemical indices. Results AST activity decreased significantly (p < 0.05) in rats of group 2 compared to the normal control; ALP decreased significantly (p < 0.05) in animals of group 3; while ALT increased significantly (p < 0.05) in group 4. The concentrations of urea and potassium showed significant decrease (p < 0.05) in animals of group 3. Creatinine increased significantly (p < 0.05) in group 2. Concentrations of total protein, albumin, globulin, sodium and chlorides in the test animals did not show any significant alteration. WBC count increased significantly (p < 0.05) in rats of group 3 and non-significantly (p > 0.05) in groups 2 and 4. PCV increased significantly in rats of group 4 and non-significantly in groups 2 and 3. RBC count and Hb levels increased non-significantly (p > 0.05) in all the test groups compared to group 1. The histoarchitectural states of the liver and kidneys showed no apparent alteration by the different extracts. Conclusion The extracts have no apparent toxic effect on the liver and kidneys of the experimental rats, although fruits’ extract of Xylopia aethiopica showed possibility of exhibiting mild liver toxicity.

scholarly journals Effects of ethanolic extracts of leaf, seed and fruit of Datura metel L. on kidney function of male albino rats

2019 ◽  
Vol 9 (4) ◽  
pp. 271-277 ◽  
Author(s):  
Chinedu Imo ◽  
Kayode A. Arowora ◽  
Chukwuma S. Ezeonu ◽  
Ojochenemi E. Yakubu ◽  
Chukwumaobim D. Nwokwu ◽  
...  
Keyword(s):  
Kidney Function ◽  
Albino Rats ◽  
Datura Metel ◽  
Ethanolic Extracts

scholarly journals Comparative evaluation of anti-diabetic action and pancreatic histopathology of rats treated with two alkaloidal plant extracts

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1841-1846
Author(s):  
Bonagiri Sreedevi ◽  
Vijaya Kuchana ◽  
Shobharani S
Keyword(s):  
Blood Glucose ◽  
Ethanolic Extract ◽  
Bark Extract ◽  
Albino Rats ◽  
Histopathological Study ◽  
Standard Group ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Soxhlet Apparatus ◽  
Ethanolic Extracts

This study aimed to understand Strychnosnuxvomica and Holarrhena pubescens Stem bark extract action towards M3 receptor in controlling blood glucose levels. Strychnos nux vomica  and Holarrhena pubescens are both alkaloidal drugs can help in controlling Hyperglycemic level. This will be useful in the formulation of a new herbal drug molecule for treating diabetes. Chloroform and ethanolic extracts of selected alkaloidal plants were extracted using the soxhlet apparatus and obtained quotes were tested for acute toxicity studies and carried out anti-diabetic action on Wister albino rats for 21 days. Results obtained from Blood glucose levels and histopathological study of test groups are compared with blood glucose levels of standard group, and highly significant action was identified by the chloroform extract of Strychnos nux vomica and Holarrhena pubescens group. Moderate anti-diabetic action was observed remaining two groups of ethanolic extracts. Strychnos nux vomica and Holarrhena pubescens ethanolic extract groups are acting on M3 receptors and controlling Hyperglycemic levels.

Emerging Dichlorvos-Based Air Freshener Pertube Kidney Function in Male Albino Rats

2020 ◽  
pp. 363-372
Author(s):  
E. I. O. Ajayi ◽  
J. B. Adetunji ◽  
M. A. Adeleke ◽  
A. O. Onilejin ◽  
M. O. Idrees ◽  
...  
Keyword(s):  
Kidney Function ◽  
Albino Rats

scholarly journals Introduction Pages

2019 ◽  
Vol 11 (1) ◽  
pp. I-VI
Author(s):  
Radu E. SESTRAS
Keyword(s):  
Date Palm ◽  
Disease Status ◽  
Shoot Elongation ◽  
Phoenix Dactylifera ◽  
Effective Control ◽  
Albino Rats ◽  
Normal Male ◽  
Shoot Cultures ◽  
African Mahogany

Notulae Scientia Biologicae (http://www.notulaebiologicae.ro), Issue 1, Volume 11, 2019: The papers published in this issue (http://www.notulaebiologicae.ro/index.php/nsb/issue/current) represent interesting novelties in different topics of life science. Among the exciting researches, we invite readers to find news about: The role of DNA Methylation in perennial plants; Peste des petits ruminants: Aetiology, pathology, immunology, disease status in Africa, diagnosis, control, prevention and treatment; Phytotherapy and polycyclic logging: implication on genetic multiplicity and diversity of African mahogany in tropical rainforest; Insight into re-emergence of cassava brown streak disease: the need to explore diverse approaches for effective control; Microbiological characterization of grilled meat “Tchatchanga” in Cotonou (Southern Benin): Enumeration, isolation and resistance profile of Staphylococcus aureus and Escherichia coli; Development of shoot cultures from leaf explant of Portulaca quadrifida L.; Evaluation of in vitro shoot elongation and rooting of date palm, and determination of physiological characteristics of regenerated plantlets; Maturation and germination of date palm (Phoenix dactylifera L.) somatic embryos; Hypoglycaemic and hypolipidemic effects of black brand of lipton tea (Camellia sinensis) on normal male albino rats.

scholarly journals PREVENTIVE EFFECTS OF PHOENIX DACTYLIFERA POLYPHENOLS AGAINST 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED MAMMARY CANCER

2017 ◽  
Vol 10 (7) ◽  
pp. 172 ◽  
Author(s):  
Rabab Omran ◽  
Zahraam M Al-taee ◽  
Hayder O Hashim ◽  
Mohammed J Al-jassani
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Mammary Cancer ◽  
Cancer Cell Line ◽  
Phoenix Dactylifera ◽  
Albino Rats ◽  
Phenolic Fraction ◽  
Quercetin Derivatives ◽  
Preventive Effects ◽  
Mcf 7

Objectives: Polyphenols are vital micronutrients, in our diet, which have a role in the prevention of progressive cancer and cardiovascular diseases developing. The main objective of this research was to evaluate the hemopreventive effects of some polyphenols of Phoenix dactylifera pits on 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary cancer of female albino rats.Methods: The phenolics of P. dactylifera pits (Zahidi cultivar) were prepared by successive steps; extraction by ethanol:methanol:HCl:H2O, adsorption chromatography using a silica gel column and preparative high performers chromatography. The cytotoxic activity of the phenolics was detected against human breast cancer cell line (MCF-7). The acetone phenolic fraction, 50 female albino rats, and DMBA carcinogen were used to study the preventive effects.Results: The acetone phenolic fraction contained considerable amounts of the total phenolics and having antioxidant activity, which inhibit cancer cell line MCF-7 growth, and the inhibitory concentration 50% of cells (IC50) at 24 hrs was 202 μg/ml for MCF-7 and 480 μg/ml for WRL-68. The purified phenolic compounds may be related to genistein and quercetin derivatives that inhibited MCF-7 cell line growth and IC50 were 1030 and 203.9 μg/ml, respectively, compared with negligible effects on normal cell line. The acetone phenolic fraction prevented mammary cancer formation in the DMBA-induced rat model.Conclusions: The phenolics of date palm had chemopreventive effects against DMBA-induced mammary cancer, and they required further research to clarify the possible mechanisms that might have contributed to the preventive effects against mammary cancer.

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