scholarly journals On the use of the dietary inflammatory index in relation to low-grade inflammation and markers of glucose metabolism in the Cohort study on Diabetes and Atherosclerosis Maastricht (CODAM) and the Hoorn study

2014 ◽  
Vol 99 (6) ◽  
pp. 1520-1520 ◽  
Author(s):  
James R Hébert ◽  
Nitin Shivappa ◽  
Fred K Tabung ◽  
Susan E Steck ◽  
Michael D Wirth ◽  
...  
Keyword(s):  
Cohort Study ◽  
Glucose Metabolism ◽  
Low Grade ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Low Grade Inflammation

scholarly journals Increased Dietary Inflammatory Index Is Associated with Schizophrenia: Results of a Case–Control Study from Bahrain

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1867 ◽  
Author(s):  
Haitham Jahrami ◽  
Mo’ez Al-Islam Faris ◽  
Hadeel Ali Ghazzawi ◽  
Zahra Saif ◽  
Layla Habib ◽  
...  
Keyword(s):  
Middle Eastern ◽  
Caloric Intake ◽  
Continuous Variable ◽  
Low Grade ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Increased Risk ◽  
Unit Increase ◽  
Middle Eastern Population ◽  
Low Grade Inflammation

Background: Several studies have indicated that chronic low-grade inflammation is associated with the development of schizophrenia. Given the role of diet in modulating inflammatory markers, excessive caloric intake and increased consumption of pro-inflammatory components such as calorie-dense, nutrient-sparse foods may contribute toward increased rates of schizophrenia. This study aimed to examine the association between dietary inflammation, as measured by the dietary inflammatory index (DII®), and schizophrenia. Methods: A total of 120 cases attending the out-patient department in the Psychiatric Hospital/Bahrain were recruited, along with 120 healthy controls matched on age and sex. The energy-adjusted DII (E-DII) was computed based on dietary intake assessed using a comprehensive food frequency questionnaire (FFQ). Logistic regression was used to estimate odds ratios and 95% confidence intervals, adjusting for potential confounders including age, sex, body mass index, education, employment, diabetes, hypertension, and cardiovascular disease with E-DII expressed both as a continuous variable and categorized as quartiles. Results: The mean E-DII score for the entire sample was 1.79 ± 1.52, indicating a generally pro-inflammatory diet. The cases with schizophrenia appeared to have a higher E-DII score compared to controls: 1.99 ± 1.39 vs. 1.60 ± 1.38, respectively (p = 0.009). For every one unit increase in the E-DII score, the odds of having schizophrenia increased by 62% (OR 1.62; 95% CI 1.17–2.26). Similarly, increased risk was observed when the E-DII was used as quartiles, with participants in most pro-inflammatory quartile 4 being nearly 6 times more likely to be schizophrenic than participants in the most anti-inflammatory group quartile 1 (OR 5.96; 1.74–20.38; p-trend = 0.01). Conclusions: The data suggest that a pro-inflammatory diet, as indicated by increasing E-DII score, is associated with schizophrenia. This is the first study to examine the association between the DII and schizophrenia in a Middle Eastern population. Although these results are consistent with findings from research conducted in depression, additional studies are required before generalizing the findings to other populations.

scholarly journals Positive Association between Dietary Inflammatory Index and the Risk of Osteoporosis: Results from the KoGES_Health Examinee (HEXA) Cohort Study

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1999 ◽  
Author(s):  
Hye Sun Kim ◽  
Cheongmin Sohn ◽  
Minji Kwon ◽  
Woori Na ◽  
Nitin Shivappa ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Large Scale ◽  
Similar Magnitude ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Menopausal Women ◽  
Osteoporosis Risk

Previous studies have found that diet’s inflammatory potential is related to various diseases. However, little is known about its relationship with osteoporosis. The aim of this study was to investigate the association between the dietary inflammatory index (DII®) and osteoporosis risk in a large-scale prospective cohort study in Korea. This prospective cohort study included 159,846 participants (men 57,740; women 102,106) from South Korea with a mean follow-up of 7.9 years. The DII was calculated through a validated semi-quantitative FFQ (SQFFQ), and information on osteoporosis was self-reported by the participants. Analyses were performed by using a multivariable Cox proportional hazard model. Higher DII scores were associated with higher osteoporosis risk (HR 1.33; 95% CI 1.12–1.58). In women, a higher DII score indicated a higher risk of osteoporosis (HR 1.33; 95% CI 1.11–1.59). However, a hazards ratio of similar magnitude in men was not significant (HR 1.32; 95% CI 0.64–2.71). Post-menopausal women had higher risks of osteoporosis for higher DII scores (HR 1.33; 95% CI 1.09–1.63), whereas among pre-menopausal women, the relationship was not statistically significant (HR 1.39; 95% CI 0.87–2.21). Also, there was an increase in osteoporosis risk when the DII increased among women participants with irregular physical activity (HR 1.53; 95% CI 1.17–2.01); however, there was no statistically significant increase in osteoporosis risk among women participants with regular physical activity (HR 1.19; 95% CI 0.93–1.52). A more pro-inflammatory diet was significantly associated with higher osteoporosis risk in women. Given the similar magnitude of the hazards ratio, studies with sufficient numbers of men are warranted.

scholarly journals Dietary inflammatory index and the aging kidney in older women: a 10-year prospective cohort study

2019 ◽  
Vol 59 (7) ◽  
pp. 3201-3211 ◽  
Author(s):  
Nicola P. Bondonno ◽  
Lauren C. Blekkenhorst ◽  
Anna L. Bird ◽  
Joshua R. Lewis ◽  
Jonathan M. Hodgson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Older Women ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Aging Kidney

scholarly journals The Dietary Inflammatory Index and All-Cause, Cardiovascular Disease, and Cancer Mortality in the Multiethnic Cohort Study

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1844 ◽  
Author(s):  
Song-Yi Park ◽  
Minji Kang ◽  
Lynne Wilkens ◽  
Yurii Shvetsov ◽  
Brook Harmon ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Study ◽  
Cancer Mortality ◽  
Native Hawaiians ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Multiethnic Cohort ◽  
Increased Risk ◽  
Race Ethnicity ◽  
Racial Ethnic

Diet quality based on inflammatory potential, assessed by the Dietary Inflammatory Index (DII®), has been related to mortality, but studies from racially/ethnically diverse populations are scarce. Using data from the Multiethnic Cohort Study in Hawaii and California, we investigated the association of the DII with all-cause, cardiovascular disease (CVD) and cancer mortality, both overall and by race/ethnicity. The analysis included 150,405 African Americans, Native Hawaiians, Japanese Americans, Latinos, and Whites aged 45–75 years, with 47,436 deaths during an average follow-up of 18.2 ± 4.9 years. In multivariable-adjusted Cox models, the hazard ratios (95% confidence intervals) for the highest vs. lowest quintile of the DII in men and women were 1.15 (1.09–1.21) and 1.22 (1.14–1.28) for all-cause, 1.13 (1.03–1.23) and 1.29 (1.17–1.42) for CVD, and 1.10 (1.00–1.21) and 1.13 (1.02–1.26) for cancer mortality. In men, an increased risk of all-cause mortality with higher DII scores was found in all racial/ethnic groups except for Native Hawaiians (P for heterogeneity < 0.001). Similarly, in women, an increased risk of CVD mortality was found in the four racial/ethnic groups, but not in Native Hawaiians. These findings support the association of a pro-inflammatory diet with a higher risk of mortality and suggest the association may vary by race/ethnicity.

Association Between Diabetic Retinopathy, Dietary Inflammatory Index and Metabolic Syndrome in Azar Cohort Study

2020 ◽  
Author(s):  
Mohammad hossein Somi ◽  
Zeinab Nikniaz ◽  
Mohammad Asghari Jafarabadi ◽  
Amir Taher Eftekharsadat ◽  
Mohammad Mirzaei ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Diabetic Retinopathy ◽  
Cohort Study ◽  
Proliferative Diabetic Retinopathy ◽  
Diabetic Patients ◽  
Dietary Inflammatory Index ◽  
Cross Sectional ◽  
Inflammatory Index

Abstract Background : The aim of present study was to evaluate the association between diabetic retinopathy (DR), dietary inflammatory index (DII), and metabolic syndrome (MetS) in patients with type 2 diabetes in a cohort study in Iran. Methods: This cross-sectional study was a part of the large Azar eye cohort study that included 1378 patients with type 2 diabetes. To diagnose DR, two mydriatric fundus photographs were captured using a digital fundus camera. The DR severity was classified as non-proliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR). MetS was determined on the basis of the ATPIII criteria. DII was calculated according to Shivappa et al. method. Results: Of 1378 diabetic patients, 185 (13.4%) had NPDR and 142 (10.3%) had PDR. The risk of NPDR and PDR increased by 2.65-fold and 2.01-fold, respectively, in patients having blood glucose levels that fell outside the recommended range. There was no statistically significant relationship between Mets, Mets components, and DII in NPDR and PDR. Conclusion: The results suggest that intensive glycemic control, rather than conventional control, may help reduce the progression of DR. It seems that longitudinal studies and clinical trials for evaluating role of DII in DR are necessary.

scholarly journals Dietary inflammatory index in relation to sub-clinical atherosclerosis and atherosclerotic vascular disease mortality in older women

2017 ◽  
Vol 117 (11) ◽  
pp. 1577-1586 ◽  
Author(s):  
Nicola P. Bondonno ◽  
Joshua R. Lewis ◽  
Lauren C. Blekkenhorst ◽  
Nitin Shivappa ◽  
Richard J. Woodman ◽  
...  
Keyword(s):  
Vascular Disease ◽  
Systemic Inflammation ◽  
Clinical Importance ◽  
Primary Objective ◽  
Wall Thickening ◽  
Low Grade ◽  
Dietary Inflammatory Index ◽  
Atherosclerotic Vascular Disease ◽  
Inflammatory Index ◽  
Related Mortality

AbstractArterial wall thickening, stimulated by low-grade systemic inflammation, underlies many cardiovascular events. As diet is a significant moderator of systemic inflammation, the dietary inflammatory index (DIITM) has recently been devised to assess the overall inflammatory potential of an individual’s diet. The primary objective of this study was to assess the association of the DII with common carotid artery–intima-media thickness (CCA–IMT) and carotid plaques. To substantiate the clinical importance of these findings we assessed the relationship of DII score with atherosclerotic vascular disease (ASVD)-related mortality, ischaemic cerebrovascular disease (CVA)-related mortality and ischaemic heart disease (IHD)-related mortality more. The study was conducted in Western Australian women aged over 70 years (n 1304). Dietary data derived from a validated FFQ (completed at baseline) were used to calculate a DII score for each individual. In multivariable-adjusted models, DII scores were associated with sub-clinical atherosclerosis: a 1 sd (2·13 units) higher DII score was associated with a 0·013-mm higher mean CCA–IMT (P=0·016) and a 0·016-mm higher maximum CCA–IMT (P=0·008), measured at 36 months. No relationship was seen between DII score and carotid plaque severity. There were 269 deaths during follow-up. High DII scores were positively associated with ASVD-related death (per sd, hazard ratio (HR): 1·36; 95 % CI 1·15, 1·60), CVA-related death (per sd, HR: 1·30; 95 % CI 1·00, 1·69) and IHD-related death (per sd, HR: 1·40; 95 % CI 1·13, 1·75). These results support the hypothesis that a pro-inflammatory diet increases systemic inflammation leading to development and progression of atherosclerosis and eventual ASVD-related death.

scholarly journals Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1873 ◽  
Author(s):  
Catherine M. Phillips ◽  
Ling-Wei Chen ◽  
Barbara Heude ◽  
Jonathan Y. Bernard ◽  
Nicholas C. Harvey ◽  
...  
Keyword(s):  
Mental Health ◽  
Health Outcomes ◽  
Disease Risk ◽  
Narrative Review ◽  
Mental Health Outcomes ◽  
Low Grade ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Inflammatory Status ◽  
Wide Range

There are over 1,000,000 publications on diet and health and over 480,000 references on inflammation in the National Library of Medicine database. In addition, there have now been over 30,000 peer-reviewed articles published on the relationship between diet, inflammation, and health outcomes. Based on this voluminous literature, it is now recognized that low-grade, chronic systemic inflammation is associated with most non-communicable diseases (NCDs), including diabetes, obesity, cardiovascular disease, cancers, respiratory and musculoskeletal disorders, as well as impaired neurodevelopment and adverse mental health outcomes. Dietary components modulate inflammatory status. In recent years, the Dietary Inflammatory Index (DII®), a literature-derived dietary index, was developed to characterize the inflammatory potential of habitual diet. Subsequently, a large and rapidly growing body of research investigating associations between dietary inflammatory potential, determined by the DII, and risk of a wide range of NCDs has emerged. In this narrative review, we examine the current state of the science regarding relationships between the DII and cancer, cardiometabolic, respiratory and musculoskeletal diseases, neurodevelopment, and adverse mental health outcomes. We synthesize the findings from recent studies, discuss potential underlying mechanisms, and look to the future regarding novel applications of the adult and children’s DII (C-DII) scores and new avenues of investigation in this field of nutritional research.

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