scholarly journals Neonatal vitamin D status from archived dried blood spots and future risk of fractures in childhood: results from the D-tect study, a population-based case-cohort study

2017 ◽  
Vol 106 (1) ◽  
pp. 155-161 ◽  
Author(s):  
Mina Nicole Händel ◽  
Peder Frederiksen ◽  
Arieh Cohen ◽  
Cyrus Cooper ◽  
Berit Lilienthal Heitmann ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Dried Blood Spots ◽  
Population Based ◽  
Vitamin D Status ◽  
Blood Spots ◽  
Future Risk ◽  
Fractures In Childhood

Vitamin D concentrations from neonatal dried blood spots and the risk of early-onset type 2 diabetes in the Danish D-tect case-cohort study

Diabetologia ◽  
2021 ◽  
Author(s):  
Amélie Keller ◽  
Fanney Thorsteinsdottir ◽  
Maria Stougaard ◽  
Isabel Cardoso ◽  
Peder Frederiksen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Cohort Study ◽  
Early Onset ◽  
Dried Blood Spots ◽  
Onset Type ◽  
Blood Spots

scholarly journals Late Pregnancy Vitamin D Deficiency is Associated with Doubled Odds of Birth Asphyxia and Emergency Caesarean Section: A Prospective Cohort Study

2020 ◽  
Vol 24 (11) ◽  
pp. 1412-1418
Author(s):  
Hanna Augustin ◽  
Sinead Mulcahy ◽  
Inez Schoenmakers ◽  
Maria Bullarbo ◽  
Anna Glantz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Caesarean Section ◽  
Vitamin D Deficiency ◽  
Epidural Anaesthesia ◽  
Birth Asphyxia ◽  
Late Pregnancy ◽  
Population Based ◽  
Emergency Caesarean Section ◽  
Vitamin D Status

Abstract Objectives The aim of this prospective cohort study was to investigate the associations between maternal vitamin D status in late pregnancy and emergency caesarean section (EMCS) and birth asphyxia, in a population based sample of women in Sweden. Methods Pregnant women were recruited at the antenatal care in Sweden and 1832 women were included after exclusion of miscarriages, terminated pregnancies and missing data on vitamin D status. Mode of delivery was retrieved from medical records. EMCS was defined as caesarean section after onset of labour. Birth asphyxia was defined as either 5 min Apgar score < 7 or arterial umbilical cord pH < 7.1. Serum was sampled in the third trimester of pregnancy (T3) and 25-hydroxyvitamin D (25OHD) was analysed by liquid chromatography tandem mass spectrometry. Vitamin D deficiency was defined as 25OHD < 30 nmol/L, and associations were studied using logistic regression analysis and expressed as adjusted odds ratios (AOR). Results In total, 141 (7.7%) women had an EMCS and 58 (3.2%) children were born with birth asphyxia. Vitamin D deficiency was only associated with higher odds of EMCS in women without epidural anaesthesia (AOR = 2.01, p = 0.044). Vitamin D deficiency was also associated with higher odds of birth asphyxia (AOR = 2.22, p = 0.044). Conclusions for Practice In this Swedish prospective population-based cohort study, vitamin D deficiency in late pregnancy was associated with doubled odds of birth asphyxia and with EMCS in deliveries not aided by epidural anaesthesia. Prevention of vitamin D deficiency among pregnant women may reduce the incidence of EMCS and birth asphyxia. The mechanism behind the findings require further investigation.

The utility of neonatal dried blood spots for the assessment of neonatal vitamin D status

2010 ◽  
Vol 24 (3) ◽  
pp. 303-308 ◽  
Author(s):  
Darryl W. Eyles ◽  
Ruth Morley ◽  
Cameron Anderson ◽  
Pauline Ko ◽  
Thomas Burne ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dried Blood Spots ◽  
Vitamin D Status ◽  
Blood Spots

scholarly journals Blood pressure in 3-year-old girls associates inversely with umbilical cord serum 25-hydroxyvitamin D: an Odense Child Cohort study

2018 ◽  
Vol 7 (12) ◽  
pp. 1236-1244 ◽  
Author(s):  
Søs Dragsbæk Larsen ◽  
Christine Dalgård ◽  
Mathilde Egelund Christensen ◽  
Sine Lykkedegn ◽  
Louise Bjørkholt Andersen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Cohort Study ◽  
A Priori ◽  
Later Life ◽  
Population Based ◽  
Vitamin D Status ◽  
Young Girls ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Background Low foetal vitamin D status may be associated with higher blood pressure (BP) in later life. Objective To examine whether serum 25-hydroxyvitamin D2+3 (s-25OHD) in cord and pregnancy associates with systolic and diastolic BP (SBP; DBP) in children up to 3 years of age. Design Prospective, population-based cohort study. Methods We included 1594 singletons from the Odense Child Cohort with available cord s-25OHD and BP data at median age 3.7 months (48% girls), 18.9 months (44% girls) or 3 years (48% girls). Maternal s-25OHD was also assessed at gestational ages 12 and 29 weeks. Multiple regression models were stratified by sex a priori and adjusted for maternal educational level, season of birth and child height, weight and age. Results In 3-year-old girls, SBP decreased with −0.7 mmHg (95% CI −1.1; −0.3, P = 0.001) and DBP with −0.4 mmHg (95% CI −0.7; −0.1, P = 0.016) for every 10 nmol/L increase in cord s-25OHD in adjusted analyses. Moreover, the adjusted odds of having SBP >90th percentile were reduced by 30% for every 10 nmol/L increase in cord s-25OHD (P = 0.004) and by 64% for cord s-25OHD above the median 45.1 nmol/L (P = 0.02). Similar findings were observed between pregnancy s-25OHD and 3-year SBP, cord s-25OHD and SBP at 18.9 months, and cord s-25OHD and DBP at 3 years. No consistent associations were observed between s-25OHD and BP in boys. Conclusion Cord s-25OHD was inversely associated with SBP and DBP in young girls, but not in boys. Higher vitamin D status in foetal life may modulate BP in young girls. The sex difference remains unexplained.

Parity and tanned white skin as novel predictors of vitamin D status in early pregnancy: a population-based cohort study

2013 ◽  
Vol 79 (3) ◽  
pp. 333-341 ◽  
Author(s):  
L. B. Andersen ◽  
B. Abrahamsen ◽  
C. Dalgård ◽  
H. B. Kyhl ◽  
S. S. Beck-Nielsen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Early Pregnancy ◽  
Population Based ◽  
Vitamin D Status ◽  
White Skin

scholarly journals Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project

2015 ◽  
Vol 115 (2) ◽  
pp. 202-211 ◽  
Author(s):  
Ulrich Hoeller ◽  
Manuela Baur ◽  
Franz F. Roos ◽  
Lorraine Brennan ◽  
Hannelore Daniel ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dried Blood Spots ◽  
International Standards ◽  
Nutrition Intervention ◽  
Seasonal Effects ◽  
Vitamin D Status ◽  
Blood Spots ◽  
Nutritional Study ◽  
Study Centre ◽  
25 Hydroxy Vitamin D

AbstractAn efficient and robust method to measure vitamin D (25-hydroxy vitamin D3(25(OH)D3) and 25-hydroxy vitamin D2in dried blood spots (DBS) has been developed and applied in the pan-European multi-centre, internet-based, personalised nutrition intervention study Food4Me. The method includes calibration with blood containing endogenous 25(OH)D3, spotted as DBS and corrected for haematocrit content. The methodology was validated following international standards. The performance characteristics did not reach those of the current gold standard liquid chromatography-MS/MS in plasma for all parameters, but were found to be very suitable for status-level determination under field conditions. DBS sample quality was very high, and 3778 measurements of 25(OH)D3were obtained from 1465 participants. The study centre and the season within the study centre were very good predictors of 25(OH)D3levels (P<0·001 for each case). Seasonal effects were modelled by fitting a sine function with a minimum 25(OH)D3level on 20 January and a maximum on 21 July. The seasonal amplitude varied from centre to centre. The largest difference between winter and summer levels was found in Germany and the smallest in Poland. The model was cross-validated to determine the consistency of the predictions and the performance of the DBS method. The Pearson’s correlation between the measured values and the predicted values wasr0·65, and thesdof their differences was 21·2 nmol/l. This includes the analytical variation and the biological variation within subjects. Overall, DBS obtained by unsupervised sampling of the participants at home was a viable methodology for obtaining vitamin D status information in a large nutritional study.

scholarly journals Comparison between Enzyme Immunoassays Performed on Samples of Dried Blood and Serum for Toxoplasmosis Prenatal Screening: Population-based Study

2021 ◽  
Vol 43 (05) ◽  
pp. 351-356
Author(s):  
Bárbara Araújo Marques ◽  
Ericka Vianna Machado Carellos ◽  
Vânia Maria Novato Silva ◽  
Fernando Henrique Pereira ◽  
Maria Regina Lage Guerra ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Prenatal Screening ◽  
Dried Blood Spots ◽  
Population Based ◽  
Minas Gerais ◽  
Immunoglobulin M ◽  
Screening Tests ◽  
Reference Test ◽  
Screening Programs ◽  
Blood Spots

Abstract Objective Most prenatal screening programs for toxoplasmosis use immunoassays in serum samples of pregnant women. Few studies assess the accuracy of screening tests in dried blood spots, which are of easy collection, storage, and transportation. The goals of the present study are to determine the performance and evaluate the agreement between an immunoassay of dried blood spots and a reference test in the serum of pregnant women from a population-based prenatal screening program for toxoplasmosis in Brazil. Methods A cross-sectional study was performed to compare the immunoassays Imunoscreen Toxoplasmose IgM and Imunoscreen Toxoplasmose IgG (Mbiolog Diagnósticos, Ltda., Contagem, Minas Gerais, Brazil)in dried blood spots with the enzyme-linked fluorescent assay (ELFA, BioMérieux S.A., Lyon, France) reference standard in the serum of pregnant women from Minas Gerais Congenital Toxoplasmosis Control Program. Results The dried blood spot test was able to discriminate positive and negative results of pregnant women when compared with the reference test, with an accuracy of 98.2% for immunoglobulin G (IgG), and of 95.8% for immunoglobulin M (IgM). Conclusion Dried blood samples are easy to collect, store, and transport, and they have a good performance, making this a promising method for prenatal toxoplasmosis screening programs in countries with continental dimensions, limited resources, and a high prevalence of toxoplasmosis, as is the case of Brazil.

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