Chemotherapy and vitamin D supplement use are determinants of serum 25-hydroxyvitamin D levels during the first six months after colorectal cancer diagnosis

The aim of the present study was to describe vitamin D status and seasonal variation in the general Danish population. In this study, 3092 persons aged 2 to 69 years (2565 adults, 527 children) had blood drawn twice (spring and autumn) between 2012 and 2014. A sub-sample of participants had blood samples taken monthly over a year. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured by liquid chromatography mass spectrometry, and information on supplement use was assessed from questionnaires. Seasonal variations in 25(OH)D concentrations were evaluated graphically and descriptively, and status according to age, sex, and supplement use was described. It was found that 86% of both adults and children were vitamin D-sufficient in either spring and or/autumn; however, many had a spring concentration below 50 nmol/L. A wide range of 25(OH)D concentrations were found in spring and autumn, with very low and very high values in both seasons. Among adults, women in general had higher median 25(OH)D concentrations than men. Furthermore, vitamin D supplement use was substantial and affected the median concentrations markedly, more so during spring than autumn. Seasonal variation was thus found to be substantial, and bi-seasonal measurements are vital in order to capture the sizable fluctuations in vitamin D status in this Nordic population.

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The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study

Nutrients ◽

10.3390/nu12092742 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2742 ◽

Cited By ~ 1

Author(s):

Sarah Hakeem ◽

Nuno Mendonca ◽

Terry Aspray ◽

Andrew Kingston ◽

Carmen Ruiz-Martin ◽

...

Keyword(s):

Vitamin D ◽

Cognitive Status ◽

Vitamin D Status ◽

Very Old ◽

Old Adults ◽

Hydroxyvitamin D ◽

Supplement Use ◽

Major Predictor ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement

Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate’ 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25–50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.

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Vitamin D deficiency prevalence and risk factors among pregnant Chinese women

Public Health Nutrition ◽

10.1017/s1368980015002980 ◽

2015 ◽

Vol 20 (10) ◽

pp. 1746-1754 ◽

Cited By ~ 18

Author(s):

Chunfeng Yun ◽

Jing Chen ◽

Yuna He ◽

Deqian Mao ◽

Rui Wang ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Chinese Women ◽

Sun Exposure ◽

Regression Analyses ◽

Hydroxyvitamin D ◽

Supplement Use ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement

AbstractObjectiveTo evaluate vitamin D deficiency prevalence and risk factors among pregnant Chinese women.DesignA descriptive cross-sectional analysis.SettingChina National Nutrition and Health Survey (CNNHS) 2010–2013.SubjectsA total of 1985 healthy pregnant women participated. Possible predictors of vitamin D deficiency were evaluated via multiple logistic regression analyses.ResultsThe median serum 25-hydroxyvitamin D level was 15·5 (interquartile range 11·9–20·0, range 3·0–51·5) ng/ml, with 74·9 (95 % CI 73·0, 76·7) % of participants being vitamin D deficient (25-hydroxyvitamin D <20 ng/ml). According to the multivariate logistic regression analyses, vitamin D deficiency was positively correlated with Hui ethnicity (P=0·016), lack of vitamin D supplement use (P=0·021) and low ambient UVB level (P<0·001). In the autumn months, vitamin D deficiency was related to Hui ethnicity (P=0·012) and low ambient UVB level (P<0·001). In the winter months, vitamin D deficiency was correlated with younger age (P=0·050), later gestational age (P=0·035), higher pre-pregnancy BMI (P=0·019), low ambient UVB level (P<0·001) and lack of vitamin D supplement use (P=0·007).ConclusionsVitamin D deficiency is prevalent among pregnant Chinese women. Residing in areas with low ambient UVB levels increases the risk of vitamin D deficiency, especially for women experiencing advanced stages of gestation, for younger pregnant women and for women of Hui ethnicity; therefore, vitamin D supplementation and sensible sun exposure should be encouraged, especially in the winter months. Further studies must determine optimal vitamin D intake and sun exposure levels for maintaining sufficient vitamin D levels in pregnant Chinese women.

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Changes in Vitamin D Supplement Use and Baseline Plasma 25-Hydroxyvitamin D Concentration Predict 5-y Change in Concentration in Postmenopausal Women

Journal of Nutrition ◽

10.3945/jn.112.159988 ◽

2012 ◽

Vol 142 (9) ◽

pp. 1705-1712 ◽

Cited By ~ 8

Author(s):

Melissa A. Kluczynski ◽

Jean Wactawski-Wende ◽

Mary E. Platek ◽

Carol A. DeNysschen ◽

Kathleen M. Hovey ◽

...

Keyword(s):

Vitamin D ◽

Postmenopausal Women ◽

Hydroxyvitamin D ◽

Supplement Use ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement

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Circulating vitamin D binding protein, total, free and bioavailable 25-hydroxyvitamin D and risk of colorectal cancer

Scientific Reports ◽

10.1038/srep07956 ◽

2015 ◽

Vol 5 (1) ◽

Cited By ~ 30

Author(s):

Hou-Qun Ying ◽

Hui-Ling Sun ◽

Bang-Shun He ◽

Yu-Qin Pan ◽

Feng Wang ◽

...

Keyword(s):

Colorectal Cancer ◽

Vitamin D ◽

Binding Protein ◽

Vitamin D Binding Protein ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Development and validation of an interview-administered FFQ for assessment of vitamin D and calcium intakes in Finnish women

British Journal Of Nutrition ◽

10.1017/s0007114515005474 ◽

2016 ◽

Vol 115 (6) ◽

pp. 1100-1107 ◽

Cited By ~ 8

Author(s):

Suvi T. Itkonen ◽

Maijaliisa Erkkola ◽

Essi Skaffari ◽

Pilvi Saaristo ◽

Elisa M. Saarnio ◽

...

Keyword(s):

Vitamin D ◽

Food Groups ◽

Hydroxyvitamin D ◽

Supplement Use ◽

Food Records ◽

Supplemental Vitamin ◽

25 Hydroxyvitamin D ◽

Mean Differences ◽

Development And Validation ◽

Supplement Intake

AbstractIncreased vitamin D fortification of dairy products has increased the supply of vitamin D-containing products with different vitamin D contents on the market in Finland. The authors developed a ninety-eight-item FFQ with eight food groups and with a question on supplementation to assess dietary and supplemental vitamin D and Ca intakes in Finnish women (60ºN). The FFQ was validated in subgroups with different habitual vitamin D supplement use (0–57·5 µg/d) against the biomarker serum 25-hydroxyvitamin D (S-25(OH)D) and against 3-d food records (FR) (n29–67). Median total vitamin D intake among participants was 9·4 (range 1·6–30·5) µg/d. Spearman’s correlations for vitamin D and Ca ranged from 0·28 (P0·146, FFQv. S-25(OH)D, persons not using supplements) to 0·75 (P<0·001, FFQv. FR, supplement use included). The correlations between the FFQ and S-25(OH)D concentrations improved within increasing supplement intake. The Bland–Altman analysis showed wide limits of agreement between FFQ and FR: for vitamin D between −7·8 and 8·8 µg/d and for Ca between −938 and 934 mg/d, with mean differences being 0·5 µg/d and 2 mg/d, respectively. The triads method was used to calculate the validity coefficients of the FFQ for vitamin D, resulting in a mean of 1·00 (95 % CI 0·59, 1·00) and a range from 0·33 to 1·00. The perceived variation in the estimates could have been avoided with a longer FR period and larger number of participants. The results are comparable with earlier studies, and the FFQ provides a reasonable estimation of vitamin D and Ca intakes.

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Typical Prenatal Vitamin D Supplement Intake Does Not Prevent Decrease of Plasma 25-Hydroxyvitamin D at Birth

Journal of the American College of Nutrition ◽

10.1080/07315724.2013.879843 ◽

2014 ◽

Vol 33 (5) ◽

pp. 394-399 ◽

Cited By ~ 5

Author(s):

Marlies K. Ozias ◽

Elizabeth H. Kerling ◽

Danielle N. Christifano ◽

Susan A. Scholtz ◽

John Colombo ◽

...

Keyword(s):

Vitamin D ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement ◽

Supplement Intake

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Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model

Medicina ◽

10.3390/medicina55060265 ◽

2019 ◽

Vol 55 (6) ◽

pp. 265 ◽

Cited By ~ 1

Author(s):

Egidijus Šimoliūnas ◽

Ieva Rinkūnaitė ◽

Živilė Bukelskienė ◽

Virginija Bukelskienė

Keyword(s):

Vitamin D ◽

Vitamin D3 ◽

Delivery Systems ◽

Oral Vitamin ◽

Medical Testing ◽

Laboratory Rats ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Oral Supplements ◽

Vitamin D Supplement

Background and Objectives: The major cause of vitamin D deficiency is inadequate exposure to sunlight. It is difficult to supplement it with food because sufficient concentrations of vitamin D naturally occur only in a handful of food products. Thereby, deficiency of this vitamin is commonly corrected with oral supplements. Different supplement delivery systems for improved vitamin D stability and bioavailability are proposed. In this study, we compared efficiency of three vitamin D delivery systems: microencapsulated, micellized, and oil-based. Materials and Methods: As a model in this medical testing, laboratory rats were used for the evaluation of bioavailability of different vitamin D vehicles. Animals were divided into three groups: the first one was given microencapsulated vitamin D3, the second—oil-based vitamin D3, and the third—micellized vitamin D3. Test substances were given per os to each animal for 7 days, and vitamin D concentration in a form of 25-hydroxyvitamin D (25(OH)D) in the blood was checked both during the vitamin delivery period and later, up to the 24th day. Results: Comparison of all three tested products showed that the microencapsulated and oil-based vitamin D3 vehicles were the most bioavailable in comparison to micellized vitamin D3. Even more, the effect of the microencapsulated form of vitamin D3 remained constant for the longest period (up to 14 days). Conclusions: The results of this study suggest that the oral vitamin D supplement vehicle has an impact on its bioavailability, thus it is important to take into account how much of the suppled vitamin D will be absorbed. To maximize the full exploit of supplement, the best delivery strategy should be employed. In our study, the microencapsulated form of vitamin D was the most bioavailable.

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Association Between Vitamin D and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies

Journal of Clinical Oncology ◽

10.1200/jco.2011.35.7566 ◽

2011 ◽

Vol 29 (28) ◽

pp. 3775-3782 ◽

Cited By ~ 239

Author(s):

Yanlei Ma ◽

Peng Zhang ◽

Feng Wang ◽

Jianjun Yang ◽

Zhihua Liu ◽

...

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Rectal Cancer ◽

Vitamin D ◽

Prospective Studies ◽

Meta Analysis ◽

Blood Levels ◽

Hydroxyvitamin D ◽

Vitamin D Intake ◽

25 Hydroxyvitamin D

Purpose To conduct a systematic review of prospective studies assessing the association of vitamin D intake or blood levels of 25-hydroxyvitamin D [25(OH)D] with the risk of colorectal cancer using meta-analysis. Methods Relevant studies were identified by a search of MEDLINE and EMBASE databases before October 2010 with no restrictions. We included prospective studies that reported relative risk (RR) estimates with 95% CIs for the association between vitamin D intake or blood 25(OH)D levels and the risk of colorectal, colon, or rectal cancer. Approximately 1,000,000 participants from several countries were included in this analysis. Results Nine studies on vitamin D intake and nine studies on blood 25(OH)D levels were included in the meta-analysis. The pooled RRs of colorectal cancer for the highest versus lowest categories of vitamin D intake and blood 25(OH)D levels were 0.88 (95% CI, 0.80 to 0.96) and 0.67 (95% CI, 0.54 to 0.80), respectively. There was no heterogeneity among studies of vitamin D intake (P = .19) or among studies of blood 25(OH)D levels (P = .96). A 10 ng/mL increment in blood 25(OH)D level conferred an RR of 0.74 (95% CI, 0.63 to 0.89). Conclusion Vitamin D intake and blood 25(OH)D levels were inversely associated with the risk of colorectal cancer in this meta-analysis.

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Vitamin D in pregnancy at high latitude in Scotland

British Journal Of Nutrition ◽

10.1017/s0007114512002255 ◽

2012 ◽

Vol 109 (5) ◽

pp. 898-905 ◽

Cited By ~ 27

Author(s):

Paul Haggarty ◽

Doris M. Campbell ◽

Susan Knox ◽

Graham W. Horgan ◽

Gwen Hoad ◽

...

Keyword(s):

Vitamin D ◽

Dietary Intake ◽

High Latitude ◽

Maternity Hospital ◽

Hydroxyvitamin D ◽

Supplement Use ◽

The North ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplements ◽

In Pregnancy

The aims of the present study were to determine compliance with current advice on vitamin D and to assess the influence of season, dietary intake, supplement use and deprivation on vitamin D status in pregnant mothers and newborns in the north of Scotland where sunlight exposure is low. Pregnant women (n 1205) and their singleton newborns were studied in the Aberdeen Maternity Hospital (latitude 57°N) between 2000 and 2006. Plasma 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 were measured at 19 weeks of gestation in mothers and at delivery in newborns. During pregnancy, 21·0 (95 % CI 18·5, 23·5) % of women took vitamin D supplements. The median intake was 5 μg/d and only 0·6 (95 % CI 0·1, 1·0) % took the recommended 10 μg/d. Supplement use, adjusted for season, dietary intake and deprivation, significantly increased maternal 25-hydroxyvitamin D (25(OH)D) by 10·5 (95 % CI 5·7, 15·2) nmol/l (P< 0·001); however, there was no significant effect on cord 25(OH)D (1·4 (95 % CI − 1·8, 4·5) nmol/l). The biggest influence on both maternal and cord 25(OH)D was season of birth (P< 0·001). Compared with the least deprived women (top three deciles), the most deprived pregnancies (bottom three deciles) were characterised by a significantly lower seasonally adjusted 25(OH)D ( − 11·6 (95 % CI − 7·5, − 15·7) nmol/l in the mother and − 5·8 (95 % CI − 2·3, − 9·4) nmol/l in the cord), and a lower level of supplement use (10 (95 % CI 4, 17) v. 23 (95 % CI 20, 26) %). More should be done to promote vitamin D supplement use in pregnancy but the critical importance of endogenous vitamin D synthesis, and known adaptations of fat metabolism specific to pregnancy, suggest that safe sun advice may be a useful additional strategy, even at high latitude.

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