RNA Interference Therapeutics and Human Diseases

2018 ◽  
pp. 477-490
Author(s):  
Dolly Sharma ◽  
Shailendra Singh ◽  
Trilok Chand
Keyword(s):  
Gene Expression ◽  
Protein Synthesis ◽  
Rna Interference ◽  
The State ◽  
Human Diseases ◽  
Future Prospects ◽  
The Future ◽  
Rnai Therapeutics ◽  
State Of Art ◽  
Interference Rna

Defective protein synthesis leads to diseases. If protein synthesis can be controlled, disease causing molecules can be tailored in some way. This is the perception behind RNA interference. RNA interference (RNAi) Therapeutics is branch of medicine which deals with the treatment of diseases while controlling the gene expression at RNA level. The motive of this chapter is to discover the state- of-art of RNAi Therapeutics, to explore various techniques used by RNAi Therapeutics to fight from diseases and discuss the future prospects of it.

RNA Interference Therapeutics and Human Diseases

2019 ◽  
pp. 69-83
Author(s):  
Dolly Sharma ◽  
Shailendra Singh ◽  
Trilok Chand
Keyword(s):  
Gene Expression ◽  
Protein Synthesis ◽  
Rna Interference ◽  
State Of The Art ◽  
The State ◽  
Human Diseases ◽  
Future Prospects ◽  
The Future ◽  
Rnai Therapeutics ◽  
Interference Rna

Defective protein synthesis leads to diseases. If protein synthesis can be controlled, disease causing molecules can be tailored in some way. This is the perception behind RNA interference. RNA interference (RNAi) therapeutics is branch of medicine which deals with the treatment of diseases while controlling the gene expression at RNA level. The motive of this chapter is to discover the state-of-the-art of RNAi therapeutics, to explore various techniques used by RNAi therapeutics to fight from diseases, and discuss the future prospects of it.

scholarly journals The State of the Art and the Future Prospects on Long-Span Concrete Arch Bridges

2001 ◽  
Vol 39 (3) ◽  
pp. 12-20 ◽  
Author(s):  
T. Mori ◽  
T. Yamamoto ◽  
N. Tamehiro ◽  
J. Niwa
Keyword(s):  
State Of The Art ◽  
The State ◽  
Future Prospects ◽  
Long Span ◽  
The Future ◽  
Arch Bridges

Mobility Challenges and Management in the Future Wireless Heterogeneous Networks

2011 ◽  
pp. 18-51
Author(s):  
Jianfeng Guan ◽  
Changqiao Xu ◽  
Hongke Zhang ◽  
Huachun Zhou
Keyword(s):  
Heterogeneous Networks ◽  
Mobility Management ◽  
The State ◽  
Heterogeneous Environments ◽  
Advantages And Disadvantages ◽  
Wireless Heterogeneous Networks ◽  
The Future ◽  
State Of Art

The organization of this chapter is as follows: It begins by analyzing the mobility challenges under the multi-accessing wireless heterogeneous environments. Next the chapter gives a brief introduction of the mobility management. Afterwards it introduces the state-of-art of the mobility management solutions and describes the respective approaches and compares their advantages and disadvantages. The last section concludes this chapter.

3. RNA

2016 ◽  
Author(s):  
Aysha Divan ◽  
Janice A. Royds
Keyword(s):  
Gene Expression ◽  
Protein Synthesis ◽  
Rna Interference ◽  
Ribosomal Rna ◽  
Gene Function ◽  
Transfer Rna ◽  
Vast Number ◽  
Rna Molecules ◽  
Catalytic Rnas ◽  
Non Coding Rnas

The first RNA molecules to be discovered were those involved in protein synthesis, mRNA, transfer RNA (tRNA), and ribosomal RNA (rRNA). In recent years, a vast number of additional RNA molecules have been identified. ‘RNA’ explains that these are non-coding RNAs that are not involved in protein synthesis, but influence many normal cellular and disease processes by regulating gene expression. RNA interference (RNAi) as one of the main ways in which gene expression is regulated is described with applications to therapy. Classes of RNA, including long non-coding RNAs and catalytic RNAs, are explained along with RNA techniques used to study RNA molecule and gene function.

scholarly journals Dendrochronological Dating in Egypt: Work Accomplished and Future Prospects

Radiocarbon ◽  
2014 ◽  
Vol 56 (04) ◽  
pp. S93-S102
Author(s):  
Peter Ian Kuniholm ◽  
Maryanne Newton ◽  
Hend Sherbiny ◽  
Hussein Bassir
Keyword(s):  
Tree Ring ◽  
The State ◽  
Future Prospects ◽  
The Future

We assess the state of and potential for expansion of dendroarchaeological research in Egypt. We also report previously unpublished findings, which we hope will assist with the new effort in constructing tree-ring chronologies in Egypt. In doing so, we explain briefly some of the problems and potential of the future enterprise.

scholarly journals JMJD3 in the regulation of human diseases

2019 ◽  
Vol 10 (12) ◽  
pp. 864-882 ◽  
Author(s):  
Xiangxian Zhang ◽  
Li Liu ◽  
Xia Yuan ◽  
Yuquan Wei ◽  
Xiawei Wei
Keyword(s):  
Gene Expression ◽  
Infectious Diseases ◽  
Histone Methylation ◽  
Histone H3 ◽  
Human Diseases ◽  
Recent Advances ◽  
The Future ◽  
Silent State

ABSTRACT In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review.

scholarly journals Dendrochronological Dating in Egypt: Work Accomplished and Future Prospects

Radiocarbon ◽  
2014 ◽  
Vol 56 (4) ◽  
pp. S93-S102 ◽  
Author(s):  
Peter Ian Kuniholm ◽  
Maryanne Newton ◽  
Hend Sherbiny ◽  
Hussein Bassir
Keyword(s):  
Tree Ring ◽  
The State ◽  
Future Prospects ◽  
The Future

We assess the state of and potential for expansion of dendroarchaeological research in Egypt. We also report previously unpublished findings, which we hope will assist with the new effort in constructing tree-ring chronologies in Egypt. In doing so, we explain briefly some of the problems and potential of the future enterprise.

Three major handbooks in three years: Stylistics as a mature discipline

2016 ◽  
Vol 25 (3) ◽  
pp. 286-301 ◽  
Author(s):  
Sandrine Sorlin
Keyword(s):  
Theoretical Models ◽  
Review Article ◽  
The State ◽  
Primary Concern ◽  
Specific Character ◽  
Future Prospects ◽  
The Past ◽  
The Future ◽  
Publishing Houses ◽  
Do So

This review article brings to the fore what the publication of three handbooks in major publishing houses in the past three years ( The Routledge Handbook of Stylistics, The Cambridge Handbook of Stylistics and The Bloomsbury Companion to Stylistics) can reveal about the state of stylistics in 2016. After depicting the specific character of each volume, the article highlights the way old theoretical models in stylistics are re-exploited in innovative ways and gives prominence to new theories and perspectives that have developed rigorous methodologies and proper purposes. It also makes apparent how the volumes both explicitly and implicitly perceive the field of stylistics as regards its scope and frontiers, the extent of its corpora and its relation with other close disciplines. If it inherently welcomes interdisciplinary collaborations, it yet seems to do so without adulterating its primary concern for language. The three handbooks show that stylistics has entered its prime as a discipline. Yet although it has become a self-assured field, it remains uncompromisingly open to criticism and debate as reflected in some chapters. The last sub-section is devoted to the future prospects of stylistics in terms of the promising research paths the discipline is currently taking.

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