Assessment of Cognitive-Communicative Functions in Persons With Mild Cognitive Impairment and Dementia of Alzheimer's Type

2021 ◽  
pp. 210-223
Author(s):  
Reuben Thomas Varghese ◽  
S. P. Goswami
Keyword(s):  
Differential Diagnosis ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
World Population ◽  
Older Individuals ◽  
Communicative Functions ◽  
Improved Outcomes ◽  
Dementia Of Alzheimer’S Type ◽  
Common Problems ◽  
Clinical Description

According to world population prospects data report, older individuals, especially those aged 60 years and above, have increased substantially over the recent year, which is going to accelerate in the coming decades. The most common problems the aging population faces are dementia of the Alzheimer's type (DAT) and mild cognitive impairment (MCI). Assessment of cognitive-communicative markers is essential for persons with MCI and DAT. Furthermore, it can help in the differential diagnosis of DAT and MCI. Proper assessment by speech-language pathologists is warranted in this area as it will throw light on the differential diagnosis of MCI and DAT, the clinical description of the characteristics between the two clinical groups, the prognosis for improved outcomes, recommendations for intervention and support, and referral for other professionals for assessments or services.

Assessment of Cognitive-Communicative Functions in Persons With Mild Cognitive Impairment and Dementia of Alzheimer's Type

2018 ◽  
pp. 269-282
Author(s):  
Reuben Thomas Varghese ◽  
S. P. Goswami
Keyword(s):  
Differential Diagnosis ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
World Population ◽  
Older Individuals ◽  
Communicative Functions ◽  
Improved Outcomes ◽  
Dementia Of Alzheimer’S Type ◽  
Common Problems ◽  
Clinical Description

According to world population prospects data report, older individuals, especially those aged 60 years and above, have increased substantially over the recent year, which is going to accelerate in the coming decades. The most common problems the aging population faces are dementia of the Alzheimer's type (DAT) and mild cognitive impairment (MCI). Assessment of cognitive-communicative markers is essential for persons with MCI and DAT. Furthermore, it can help in the differential diagnosis of DAT and MCI. Proper assessment by speech-language pathologists is warranted in this area as it will throw light on the differential diagnosis of MCI and DAT, the clinical description of the characteristics between the two clinical groups, the prognosis for improved outcomes, recommendations for intervention and support, and referral for other professionals for assessments or services.

scholarly journals Reliability and validity of a Mediterranean diet and culinary index (MediCul) tool in an older population with mild cognitive impairment

2018 ◽  
Vol 120 (10) ◽  
pp. 1189-1200 ◽  
Author(s):  
Sue Radd-Vagenas ◽  
Maria A. Fiatarone Singh ◽  
Michael Inskip ◽  
Yorgi Mavros ◽  
Nicola Gates ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mediterranean Diet ◽  
Reliability And Validity ◽  
Community Dwelling ◽  
Systematic Bias ◽  
Older Individuals ◽  
Retest Reliability ◽  
The Mean ◽  
Test Retest Reliability

AbstractDementia is a leading cause of morbidity and mortality without pharmacologic prevention or cure. Mounting evidence suggests that adherence to a Mediterranean dietary pattern may slow cognitive decline, and is important to characterise in at-risk cohorts. Thus, we determined the reliability and validity of the Mediterranean Diet and Culinary Index (MediCul), a new tool, among community-dwelling individuals with mild cognitive impairment (MCI). A total of sixty-eight participants (66 % female) aged 75·9 (sd 6·6) years, from the Study of Mental and Resistance Training study MCI cohort, completed the fifty-item MediCul at two time points, followed by a 3-d food record (FR). MediCul test–retest reliability was assessed using intra-class correlation coefficients (ICC), Bland–Altman plots and κ agreement within seventeen dietary element categories. Validity was assessed against the FR using the Bland–Altman method and nutrient trends across MediCul score tertiles. The mean MediCul score was 54·6/100·0, with few participants reaching thresholds for key Mediterranean foods. MediCul had very good test–retest reliability (ICC=0·93, 95 % CI 0·884, 0·954, P<0·0001) with fair-to-almost-perfect agreement for classifying elements within the same category. Validity was moderate with no systematic bias between methods of measurement, according to the regression coefficient (y=−2·30+0·17x) (95 % CI −0·027, 0·358; P=0·091). MediCul over-estimated the mean FR score by 6 %, with limits of agreement being under- and over-estimated by 11 and 23 %, respectively. Nutrient trends were significantly associated with increased MediCul scoring, consistent with a Mediterranean pattern. MediCul provides reliable and moderately valid information about Mediterranean diet adherence among older individuals with MCI, with potential application in future studies assessing relationships between diet and cognitive function.

scholarly journals Memory-Related Frontal Brainwaves Predict Transition to Mild Cognitive Impairment in Healthy Older Individuals Five Years Before Diagnosis

2020 ◽  
pp. 1-11
Author(s):  
Yang Jiang ◽  
Juan Li ◽  
Frederick A. Schmitt ◽  
Gregory A. Jicha ◽  
Nancy B. Munro ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Performance ◽  
Memory Task ◽  
Cognitive Status ◽  
Older Individuals ◽  
Increased Risk ◽  
Differentiation Pattern

Background: Early prognosis of high-risk older adults for amnestic mild cognitive impairment (aMCI), using noninvasive and sensitive neuromarkers, is key for early prevention of Alzheimer’s disease. We have developed individualized measures in electrophysiological brain signals during working memory that distinguish patients with aMCI from age-matched cognitively intact older individuals. Objective: Here we test longitudinally the prognosis of the baseline neuromarkers for aMCI risk. We hypothesized that the older individuals diagnosed with incident aMCI already have aMCI-like brain signatures years before diagnosis. Methods: Electroencephalogram (EEG) and memory performance were recorded during a working memory task at baseline. The individualized baseline neuromarkers, annual cognitive status, and longitudinal changes in memory recall scores up to 10 years were analyzed. Results: Seven of the 19 cognitively normal older adults were diagnosed with incident aMCI for a median 5.2 years later. The seven converters’ frontal brainwaves were statistically identical to those patients with diagnosed aMCI (n = 14) at baseline. Importantly, the converters’ baseline memory-related brainwaves (reduced mean frontal responses to memory targets) were significantly different from those who remained normal. Furthermore, differentiation pattern of left frontal memory-related responses (targets versus nontargets) was associated with an increased risk hazard of aMCI (HR = 1.47, 95% CI 1.03, 2.08). Conclusion: The memory-related neuromarkers detect MCI-like brain signatures about five years before diagnosis. The individualized frontal neuromarkers index increased MCI risk at baseline. These noninvasive neuromarkers during our Bluegrass memory task have great potential to be used repeatedly for individualized prognosis of MCI risk and progression before clinical diagnosis.

scholarly journals Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer’s disease

2020 ◽  
Author(s):  
Xiong Jiang ◽  
James H. Howard ◽  
G. Wiliam Rebeck ◽  
R. Scott Turner
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Medial Temporal Lobe ◽  
Inhibition Of Return ◽  
Memory Performance ◽  
Brain Regions ◽  
List Type ◽  
Older Individuals

ABSTRACTSpatial inhibition of return (IOR) refers to the phenomenon by which individuals are slower to respond to stimuli appearing at a previously cued location compared to un-cued locations. Here we provide evidence supporting that spatial IOR is mildly impaired in individuals with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD), and the impairment is readily detectable using a novel double cue paradigm. Furthermore, reduced spatial IOR in high-risk healthy older individuals is associated with reduced memory and other neurocognitive task performance, suggesting that the novel double cue spatial IOR paradigm may be useful in detecting MCI and early AD.SIGNIFICANCE STATEMENTNovel double cue spatial inhibition of return (IOR) paradigm revealed a robust effect IOR deficits in individuals with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD)Spatial IOR effect correlates with memory performance in healthy older adults at a elevated risk of Alzheimer’s disease (with a family history or APOE e4 allele)The data suggests that double cue spatial IOR may be sensitive to detect early AD pathological changes, which may be linked to disease progress at the posterior brain regions (rather than the medial temporal lobe)

scholarly journals Biogeographical factors affecting people with dementia of Alzheimer’s type and mild cognitive impairment

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Pooja Rai ◽  
Tara Singh ◽  
Indramani L. Singh ◽  
Trayambak Tiwari ◽  
Deepika Joshi
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Factors Affecting ◽  
People With Dementia ◽  
Dementia Of Alzheimer’S Type

scholarly journals Serum Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Levels in Older Subjects with Dementia and Mild Cognitive Impairment

2016 ◽  
Vol 41 (5-6) ◽  
pp. 273-280 ◽  
Author(s):  
Veronica Tisato ◽  
Erika Rimondi ◽  
Gloria Brombo ◽  
Stefano Volpato ◽  
Amedeo Zurlo ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Late Onset ◽  
Univariate Analysis ◽  
Multiple Linear Regression Model ◽  
Older Individuals ◽  
The Central Nervous System ◽  
Necrosis Factor

Background: The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been involved in both physiological and pathological conditions, including vascular pathologies and pathologies of the central nervous system. Nonetheless, the knowledge about the role of systemic TRAIL in patients affected by different types of dementia and mild cognitive impairment (MCI) is still limited. Objective: We assessed serum TRAIL levels in a large cohort of older individuals (n = 644) including patients with late-onset Alzheimer's disease (LOAD), vascular dementia (VAD), ‘mixed' dementia (MIX), MCI, and healthy controls. Methods: Circulating TRAIL was measured by ELISA. Results: At univariate analysis, TRAIL levels were higher in VAD, MIX, and MCI patients compared with LOAD patients and controls. Using the multiple linear regression model, we found that TRAIL levels were associated with VAD and MCI, but not MIX, independent of potential confounding factors. Conclusion: The finding of high levels of circulating TRAIL in VAD and MCI seems to suggest that both of these conditions are characterized by a significant vascular damage with respect to LOAD.

Subjective Memory Complaints and Mild Cognitive Impairment

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
M. Simoes ◽  
L.C. Castro ◽  
O. Ribeiro ◽  
T. Salgado ◽  
C. Paz
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
The Elderly ◽  
Future Research ◽  
Older Individuals ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Cross Sectional ◽  
Memory Complaints ◽  
Increased Risk

Background:Subjective Memory Complaints (SMC) are common in clinical practice. the clinical significance of these subjective complaints among older individuals is not well understood.Aim:To study and discuss the association between SMC and MCI, underlining the importance of an adequate clinical assessment of SMC in the elderly.Methods:Review of the literature.Results:There is no consistent definition of SMC in the literature. Some prospective studies showed an association with objective memory impairments, conceptualizing SMC as a Pre-Mild Cognitive Impairment. SMC are also currently considered to be a core feature of Mild Cognitive Impairment (MCI). Cross-sectional studies and longitudinal studies showed conflicting results concerning the association between SMC and MCI.Discussion:The understanding of the predictive value of SMC in cognitive decline is still poorly understood. It is important to define criteria aimed to increase specificity of memory complaints, allowing an earlier identification of populations with higher risk of MCI. Future research on this complex association is important to identify SMC individuals at increased risk of conversion to MCI and dementia.

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