Immune-Targeted Nanomedicine

2021 ◽  
pp. 294-305
Author(s):  
Andrew Pradeep ◽  
R. Sethu Nagarajan ◽  
H. Fazil
Keyword(s):  
Drug Delivery ◽  
Immune Response ◽  
Solid Tumor ◽  
Surface Antigens ◽  
Pharmacokinetic Property ◽  
Cell Mediated Immunity ◽  
Tumor Mass ◽  
Enhanced Permeability And Retention ◽  
Targeted Drug ◽  
Antigen Presenting

Immunotherapy has become a preferable candidate for many diseases in recent days. The infusion or administration of immune complexes or components to elicit the own immune response against a particular disease by attracting the antigen presenting cells against the disease causing organism and eliciting the T-cell mediated killing and further activating cell mediated immunity based on the processed surface antigens underlies the basic concept behind the immunotherapy. Immunotherapy can be applied for all course of diseases even in the treatment of cancer. The limitation in using immunotherapy is that it needs a proper delivery vehicle to reach the diseased spot to shows its pharmacokinetic property. In case of cancer, the immune components administered itself are not able to pertain and penetrate the solid tumor mass. Nanoparticles are small-sized particles which are generally specific in action used in the field of medicine. Nanoparticles aid in targeted drug delivery to the specific spots and immune targeting of nanoparticles is due to its enhanced permeability and retention (EPR).

scholarly journals Targeted drug delivery using iRGD peptide for solid cancer treatment

2017 ◽  
Vol 2 (4) ◽  
pp. 370-379 ◽  
Author(s):  
Xiangsheng Liu ◽  
Jinhong Jiang ◽  
Ying Ji ◽  
Jianqin Lu ◽  
Ryan Chan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Solid Tumor ◽  
Targeted Drug Delivery ◽  
Solid Cancer ◽  
Targeted Drug

iRGD-mediated nanoparticle transcytosis in a solid tumor.

Advanced drug-delivery systems: mechanoresponsive nanoplatforms applicable in atherosclerosis management

Nanomedicine ◽  
2019 ◽  
Vol 14 (23) ◽  
pp. 3105-3122 ◽  
Author(s):  
Deti Nurhidayah ◽  
Ali Maruf ◽  
Xiaojuan Zhang ◽  
Xiaoling Liao ◽  
Wei Wu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Molecular Level ◽  
Mechanical Stimuli ◽  
Delivery Performance ◽  
On Demand ◽  
Enhanced Permeability And Retention ◽  
Targeted Drug

Nanoplatforms have been used extensively as advanced carriers to enhance the effectiveness of drug delivery, mostly through passive aggregation provided by the enhanced permeability and retention effect. Mechanical stimuli provide a robust strategy to bolster drug delivery performance by increasing the accumulation of nanoplatforms at the lesion sites, facilitating on-demand cargo release and providing theranostic aims. In this review, we focus on recent advances of mechanoresponsive nanoplatforms that can accomplish targeted drug delivery, and subsequent drug release, under specific stimuli, either endogenous (shear stress) or exogenous (magnetic field and ultrasound), to synergistically combat atherosclerosis at the molecular level.

scholarly journals Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery

Nanoscale ◽  
2016 ◽  
Vol 8 (2) ◽  
pp. 938-948 ◽  
Author(s):  
Simon Heidegger ◽  
Dorothée Gößl ◽  
Alexandra Schmidt ◽  
Stefan Niedermayer ◽  
Christian Argyo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Immune Response ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Immune Cells ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Vehicle ◽  
Functionalized Mesoporous Silica ◽  
Targeted Drug

Mesoporous silica nanoparticles represent an efficient drug delivery vehicle to primary immune cells that is both non-toxic and non-inflammagenic.

scholarly journals Immunomodulatory Lectin-like Peptides for Fish Erythrocytes-Targeting as Potential Antiviral Drug Delivery Platforms

2021 ◽  
Vol 22 (21) ◽  
pp. 11821
Author(s):  
Maria Salvador-Mira ◽  
Veronica Chico ◽  
Monica Arostica ◽  
Fanny Guzmán ◽  
Nerea Roher ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Immune Response ◽  
Plasmodium Falciparum ◽  
Rainbow Trout ◽  
Disease Prevention ◽  
Blood Cells ◽  
Antiviral Drug ◽  
The Body ◽  
Antigen Presenting ◽  
Cell Carriers

One of the challenges of science in disease prevention is optimizing drug and vaccine delivery. Until now, many strategies have been employed in this sector, but most are quite complex and labile. To overcome these limitations, great efforts are directed to coupling drugs to carriers, either of natural or synthetic origin. Among the most studied cell carriers are antigen-presenting cells (APCs), however, red blood cells (RBCs) are positioned as attractive carriers in drug delivery due to their abundance and availability in the body. Furthermore, fish RBCs have a nucleus and have been shown to have a strong involvement in modulating the immune response. In this study, we evaluated the binding of three peptides to rainbow trout RBCs, two lectin-like peptides and another derived from Plasmodium falciparum membrane protein, in order to take advantage of this peptide-RBCs binding to generate tools to improve the specificity, efficacy, immunostimulatory effect, and safety of the antiviral therapeutic or prophylactic administration systems currently used.

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