Development of Gelatin Films with Designed Antimicrobial Peptide and Silver Nanoparticles

2011 ◽  
Vol 1 (2) ◽  
pp. 13-29
Author(s):  
Mohamed A. Abdalla ◽  
Hannah G. Harding ◽  
Temesgen Samuel ◽  
Jesse Jayne ◽  
Heshmat A. Aglan
Keyword(s):  
Silver Nanoparticles ◽  
Antimicrobial Peptide ◽  
Gelatin Films

Development of Gelatin Films with Designed Antimicrobial Peptide and Silver Nanoparticles

2011 ◽  
Vol 1 (2) ◽  
pp. 13-29
Author(s):  
Mohamed A. Abdalla ◽  
Hannah G. Harding ◽  
Temesgen Samuel ◽  
Jesse Jayne ◽  
Heshmat A. Aglan
Keyword(s):  
Silver Nanoparticles ◽  
Antimicrobial Peptide ◽  
Biomedical Applications ◽  
Cold Water ◽  
Surrounding Medium ◽  
Antibacterial Activities ◽  
Superficial Infection ◽  
Contamination Control ◽  
Gelatin Films ◽  
Lytic Peptides

Gelatin films from cold water fish skin filled with designed antimicrobial peptide or silver nanoparticles were formulated for biomedical applications. Antibacterial activities of gelatin films containing silver nanoparticles and lytic peptides were evaluated to study the growth of a Staphylococcus species. The results suggest that inclusion of silver nanoparticles and lytic peptides into the composition of biocompatible films is feasible, with significant retention of the antimicrobial activity for both agents. The results presented here give evidence that both the silver nanoparticles and lytic peptides retain their antibacterial activity in such film matrices and the surrounding medium. Therefore, such biocompatible films may have potential use in biomedical applications such as wound dressing, superficial infection and contamination control. Evaluation of the mechanical properties for silver nanoparticles gelatin films revealed that the tensile strength appeared to be optimal at 0.3% silver nanoparticles loading. However, the strain-to-failure decreased with respect to the neat film.

Silver Nanoparticles Synthesized Using Mint Extract and their Application in Chitosan/Gelatin Composite Packaging Film

2017 ◽  
Vol 16 (01) ◽  
pp. 1650022 ◽  
Author(s):  
Shraddha A. Bhoir ◽  
S. P. Chawla
Keyword(s):  
Silver Nanoparticles ◽  
Food Packaging ◽  
Uv Light ◽  
Transmission Rate ◽  
Light Transmittance ◽  
Synthesis Of Nanoparticles ◽  
Gelatin Films ◽  
Food Borne ◽  
Measuring Surface ◽  
Test Organisms

The present study reports synthesis of silver nanoparticles (AgNPs) using mint extract (ME) in the presence of polyvinyl alcohol (PVA) as capping material. PVA, ME and silver nitrate at concentration of 1%, 0.01% and 0.02%, respectively were found to be optimum for the synthesis of nanoparticles. The formation of AgNPs was confirmed by measuring surface plasmon resonance (SPR) peak. The intensity of SPR peak remained unaltered thus suggesting stability of colloid without aggregation during storage. The nanoparticles inhibited the growth of food borne bacteria namely Escherichia coli, Pseudomonas aeruginosa and Bacillus cereus. The incorporation of these nanoparticles in chitosan and gelatin blend resulted in homogenous films. Mechanical properties and water vapor transmission rate of chitosan-gelatin films improved due to addition of AgNPs, whereas optical (opacity and UV light transmittance) and oxygen permeability properties remained unchanged. These films had the ability to inhibit growth of 5 log CFU of the above test organisms. These findings suggest that the AgNPs obtained by reduction of silver by ME can be effectively utilized to prepare antibacterial eco-friendly food packaging material.

scholarly journals Antibacterial Efficacy of Gold and Silver Nanoparticles Functionalized with the Ubiquicidin (29–41) Antimicrobial Peptide

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Enrique Morales-Avila ◽  
Guillermina Ferro-Flores ◽  
Blanca E. Ocampo-García ◽  
Gustavo López-Téllez ◽  
Johnny López-Ortega ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antimicrobial Peptide ◽  
Metallic Nanoparticles ◽  
Bacterial Infections ◽  
Alternative Therapy ◽  
Antibacterial Efficacy ◽  
Nanoparticle Concentration ◽  
Gold And Silver Nanoparticles ◽  
Cationic Antimicrobial Peptide ◽  
High Affinity

Recent studies have demonstrated that drug antimicrobial activity is enhanced when metallic nanoparticles are used as an inorganic support, obtaining synergic effects against microorganisms. The cationic antimicrobial peptide ubiquicidin 29–41 (UBI) has demonstrated high affinity and sensitivity towards fungal and bacterial infections. The aim of this research was to prepare and evaluate the antimicrobial efficacy of engineered multivalent nanoparticle systems based on silver or gold nanoparticles functionalized with UBI. Spectroscopy techniques demonstrated that NPs were functionalized with UBI mainly through interactions with the -NH2 groups. A significant increase in the antibacterial activity against Escherichia coli and Pseudomonas aeruginosa was obtained with the conjugate AgNP-UBI with regard to that of AgNP. No inhibition of bacterial growth was observed with AuNP and AuNP-UBI using a nanoparticle concentration of up to 182 μg mL−1. Nonetheless, silver nanoparticles conjugated to the UBI antimicrobial peptide may provide an alternative therapy for topical infections.

scholarly journals Antimicrobial peptide-modified silver nanoparticles for enhancing the antibacterial efficacy

RSC Advances ◽  
2020 ◽  
Vol 10 (64) ◽  
pp. 38746-38754
Author(s):  
Wenxi Li ◽  
Yongchun Li ◽  
Pengchao Sun ◽  
Nan Zhang ◽  
Yidan Zhao ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Antimicrobial Peptide ◽  
Multidrug Resistant ◽  
Antibacterial Efficacy ◽  
Multifunctional Peptides

Multifunctional peptides (MFP)-coated silver nanoparticles (MFP@AgNPs) enhanced the antibacterial activity of AgNPs against multidrug-resistant A. baumannii (MDB-AB) strains.

Synthesis, performance and growth mechanism of silver nanoparticle coated SERS fiber probe

2019 ◽  
Vol 107 (3) ◽  
pp. 305
Author(s):  
Mengmei Geng ◽  
Yuting Long ◽  
Tongqing Liu ◽  
Zijuan Du ◽  
Hong Li ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Absorption Spectrum ◽  
Reaction Time ◽  
Growth Mechanism ◽  
Fiber Optic ◽  
Fiber Optic Probe ◽  
Visible Absorption ◽  
Fiber Probe ◽  
Surface Enhanced Raman ◽  
Optic Probe

Surface-enhanced Raman Scattering (SERS) fiber probe provides abundant interaction area between light and materials, permits detection within limited space and is especially useful for remote or in situ detection. A silver decorated SERS fiber optic probe was prepared by hydrothermal method. This method manages to accomplish the growth of silver nanoparticles and its adherence on fiber optic tip within one step, simplifying the synthetic procedure. The effects of reaction time on phase composition, surface plasmon resonance property and morphology were investigated by X-ray diffraction analysis (XRD), ultraviolet-visible absorption spectrum (UV-VIS absorption spectrum) and scanning electron microscope (SEM). The results showed that when reaction time is prolonged from 4–8 hours at 180 °C, crystals size and size distribution of silver nanoparticles increase. Furthermore, the morphology, crystal size and distribution density of silver nanoparticles evolve along with reaction time. A growth mechanism based on two factors, equilibrium between nucleation and growth, and the existence of PVP, is hypothesized. The SERS fiber probe can detect rhodamin 6G (R6G) at the concentration of 10−6 M. This SERS fiber probe exhibits promising potential in organic dye and pesticide residue detection.

The Human Endogenous Antimicrobial Peptide Ll-37 Stimulates Airway Epithelial Repair

Pneumologie ◽  
2006 ◽  
Vol 59 (12) ◽  
Author(s):  
R Shaykhiev ◽  
C Beißwenger ◽  
K Kändler ◽  
J Senske ◽  
A Püchner ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Airway Epithelial ◽  
Epithelial Repair

Antimicrobial Peptide Prodrugs and Mimetics

2016 ◽  
Author(s):  
Marc Devocelle ◽  
Éanna Forde ◽  
André Schütte ◽  
Andrea Molero-Bondia ◽  
Emer Reeves ◽  
...  
Keyword(s):  
Antimicrobial Peptide
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