scholarly journals Epidemiological profile of salivary gland lesions diagnosed in a higher education institution: an observational and retrospective study of 381 cases

2020 ◽  
Vol 42 ◽  
pp. e51032
Author(s):  
Claudio Freire Sesenta Junior ◽  
Camila Camarini ◽  
Isadora Balan ◽  
Lilian Cristina Vessoni Iwaki ◽  
Mariliani Chicarelli da Silva ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Medical Records ◽  
Education Institution ◽  
Malignant Neoplasms ◽  
Anatomical Location ◽  
Benign Neoplasms ◽  
State University ◽  
Neoplastic Lesions ◽  
Epidemiological Profile ◽  
Microscopic Diagnosis

The aim of this retrospective and observational study was to report the prevalence and characteristics of salivary gland lesions (SGL) in patients treated at the State University of Maringa, between 1995 and 2018. Data from medical records of patients with neoplastic and non-neoplastic SGL concerning to age, sex, ethnicity, anatomical location, microscopic diagnosis and treatment were collected. All SGL with diagnosis confirmed by microscopic examination were considered. Of the 3,127 biopsied lesions, 381 (12.1%) SGL were identified. Caucasian (71%) women (51%) aging from 11 to 20 years (33%) were more affected. 88.5% (n= 337) were non-neoplastic lesions, 7% (n= 27) benign neoplasms and 4.5% (n= 17) malignant neoplasms. Mucocele was the most prevalent lesion (n= 269%), followed by pleomorphic adenoma (n= 25%). Recognition and appropriate management of these lesions is essential, especially because malignant neoplastic lesions of the salivary glands can be very aggressive.

The Role of Ancillary Techniques in Salivary Gland Cytopathology Specimens

2019 ◽  
Vol 64 (1-2) ◽  
pp. 92-102 ◽  
Author(s):  
Kimberly Point du Jour ◽  
Christopher C. Griffith
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Molecular Characteristics ◽  
Malignant Neoplasms ◽  
Benign Neoplasms ◽  
Gland Tumor ◽  
Aspiration Cytology ◽  
Preoperative Test ◽  
Neoplastic Lesions

Salivary gland tumor aspiration cytology is a useful preoperative test to guide the most appropriate clinical and surgical management for these patients. Although salivary gland cytology is often useful to distinguish between non-neoplastic lesions, benign neoplasms and malignant neoplasms, there remain many challenges in this area. Specifically, these tumors are uncommon and may have considerable morphologic overlap, especially in the setting of a malignant tumor. This article reviews some of the immunohistochemical and molecular characteristics of more common salivary gland neoplasms that pathologists and cytotechnologists may encounter. When used in combination with morphologic features, such ancillary testing can be useful to further refine the differential diagnosis, more strongly favor a particular entity, or in some instances confidently provide a specific diagnosis.

Έκφραση πρωτεϊνών θερμικού σοκ και νεοαγγειογένεση στα νεοπλάσματα των σιελογόνων αδένων

2013 ◽  
Author(s):  
Βασίλειος Παπανικολάου
Keyword(s):  
Salivary Gland ◽  
Angiogenesis Inhibitor ◽  
Salivary Gland Neoplasms ◽  
Malignant Neoplasms ◽  
Low Grade ◽  
Benign Neoplasms ◽  
Related Molecule ◽  
Collagen Xviii ◽  
Pleomorphic Adenomas ◽  
Endothelial Marker

IntroductionSalivary gland neoplasms comprise a wide group of tumors with diverse histology and broad biologic behavior, often presenting difficulties in their definitive diagnosis and treatment. In the last decades, the prominent role of angiogenesis in the neoplastic process has been recognized, and alterations of its promoters and inhibitors have been investigated in most human tumors. However, angiogenesis in salivary gland neoplasms has not been thoroughly studied.Material and MethodsWe evaluated the immunohistochemical expression of various angiogenesis-related molecules and the vascularity of 61 malignant (16 adenoid cystic carcinomas, 12 mucoepidermoid carcinomas, 11 polymorphous low grade adenocarcinomas, 9 adenocarcinomas NOS, 6 salivary duct carcinomas, 3 carcinomas ex-pleomorphic adenomas, 2 lymphoepithelial carcinomas, 1 myoepithelial carninoma, 1 clear cell carinoma NOS) and 18 benign salivary gland neoplasms (13 pleomorphic adenomas, 5 Warthin tumours).The evaluated molecules were: angiogenesis-promoter vascular endothelial growth factor (VEGF). angiogenesis-inhibitor Endostatin. angiogenesis related molecule collagen angiogenesis related molecule HSP47. endothelial marker FVIIIR:Ag. Vascularity was assessed by calculation of MicroVessel Density (MVD) and by FVIIIR:Ag immunostaining intensity.ResultsVEGF was expressed in 83.6% of malignant and 94.44% of benign neoplasms. Endostatin was expressed in 91.8% and 100% of malignant and benign cases respectively. Collagen XVIII was expressed in 100% of both benign and malignant neoplasms. HSP47 was expressed in 78.68% of malignant and 100% of benign neoplasms.All markers predominantly showed a diffuse pattern of immunostaining (more than 50% positive cells). VEGF immunostaining intensity varied widely among cases, ranging from weak to strong for both malignant and benign cases. Endostatin, Collagen XVIII and HSP47 presented varying immunointensity for malignant cases, whereas benign cases mainly presented strong immunostaining.Statistical analysis correlated VEGF expression in malignant neoplasms with TNM stage and extraparenchymal infiltration (p=0,0005 and 0,00063 respectively). The total score of immunoreactivity for Endostatin, Collagen XVIII and HSP47 was significantly higher in benign compared to malignant cases (p=0.01, p=0.02, and p=0,00996 respectively). Furthermore, HSP47 positivity and intensity was statistically higher in benign neoplasms, compared to malignant (p=0,0067 and p=0.0249 respectively). Additionally Endostatin immunoexpression correlated with Collagen XVIII expression in benign cases (p<0.001). No association was found regarding tumor MVD. However, immunostaining intensity of the endothelial marker FVIIIR:Ag was higher in malignant tumours (p=0,013).ConclusionsOur results show that benign compared to malignant salivary gland neoplasms express higher levels of Endostatin, Collagen XVIII and HSP47. Ιn malignant neoplasms an increase in the ratio of angiogenic to angiostatic elements is observed. It suggested that enhanced angiogenesis may contribute to salivary gland carcinogenesis.

scholarly journals Epidemiological profile of canine neoplasms in São Luís/MA: a retrospective study (2008-2015)

2020 ◽  
Vol 9 (12) ◽  
pp. e8291210496
Author(s):  
Tatiane Avelar Ribeiro ◽  
Valéria Raiana Fonseca Ferreira ◽  
Renata Mondêgo-Oliveira ◽  
Fábio Henrique Evangelista Andrade ◽  
Ana Lúcia Abreu-Silva ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mammary Gland ◽  
Medical Records ◽  
Cell Tumor ◽  
State University ◽  
Round Cell ◽  
Mast Cell Tumor ◽  
Epidemiological Profile ◽  
Veterinary Hospital ◽  
Round Cell Tumors

The diversity of neoplasms observed in dogs can vary geographically depending on individual susceptibility, the habitat of the animals, and environmental characteristics. The aim of this study was to evaluate the epidemiological aspects of neoplasms in dogs treated at the Veterinary Hospital of the State University of Maranhão from 2008 to 2015. We studied the medical records of 1089 dogs affected by neoplasms and treated at a hospital during the period of study, relating to the casuistry with their breed, age, sex and origin. The present study included 764 cases that were confirmed through cytopathology. The most prevalent tumors were transmissible venereal tumors (TVT) (20.17%), adenocarcinoma of the mammary gland (19.53%), mixed malignant tumor of the mammary gland (18.63%), mast cell tumor (11.31%), and mammary carcinoma (6.42%). Females with a mean age of 9.2 years were the most affected, as were SRDs, Poodles, American Pitbulls, and Dobermann Pinschers. According to the cytomorphogenetic classification, the round cell tumors were the most prevalent, with values close to those of epithelial, followed by mixed and mesenchymal cells.

scholarly journals The Epidemiology of Salivary Glands Pathologies in Adult Population over 10 Years in Poland—Cohort Study

2021 ◽  
Vol 19 (1) ◽  
pp. 179
Author(s):  
Michał Żurek ◽  
Anna Rzepakowska ◽  
Kamil Jasak ◽  
Kazimierz Niemczyk
Keyword(s):  
Salivary Gland ◽  
Adult Population ◽  
Incidence Rates ◽  
Medical Services ◽  
Malignant Neoplasms ◽  
Neoplastic Lesions ◽  
Icd 10 ◽  
Hospital Stays ◽  
Malignant Lesions ◽  
The Mean

Background: The aim of this study was a comprehensive analysis of the incidence of different salivary gland pathologies in the adult population of Poland. Methods: A retrospective analysis of salivary gland pathologies diagnosed in Poland in 2010–2019 based on the National Health Fund (NHF) database was performed. Non-neoplastic diseases, and benign and malignant lesions were identified using ICD-10 codes. Demographic characteristics, incidence rates, and the number of inpatient and outpatient medical services were analyzed. Results: Salivary gland pathologies were diagnosed in 230,589 patients over 10 years (85.5% were non-neoplastic lesions, 11.53% benign and 2.93% malignant neoplasms). Incidence rate for all pathologies was 59.94/100,000. The mean incidence for malignant neoplasms was 1.78, and decreasing trend was observed over the analyzed period. Contrarily, for benign neoplasms (mean incidence—6.91), an increase in numbers was noted annually. The incidence for non-malignant lesions was quite stable (mean: 51.25) over the time. The highest number of medical services per patient concerned malignant neoplasms (on average, two hospital stays, and eleven outpatient consultations). Conclusions: An increase of benign salivary gland tumors, and a decrease of malignant neoplasms was observed during the studied period. The number of medical services related to salivary gland pathologies increased during the period under study.

scholarly journals Correlation of FNAC and histopathology in diagnosis of salivary gland lesions

2014 ◽  
Vol 4 (8) ◽  
pp. 654-657 ◽  
Author(s):  
S Koirala ◽  
G Sayami ◽  
AD Pant
Keyword(s):  
Salivary Gland ◽  
Preoperative Diagnosis ◽  
Needle Aspiration ◽  
University Teaching ◽  
Malignant Neoplasms ◽  
Histopathological Diagnosis ◽  
Institute Of Medicine ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity ◽  
Diagnostic Pitfalls

Background: Value of fine needle aspiration cytology in preoperative diagnosis of salivary gland lumps has been established in various studies. This study aims to calculate sensitivity, specificity accuracy of FNAC, correlate FNAC findings with histopathology and find out reasons for common diagnostic pitfalls in FNAC.Materials and methods: This study was performed in 67 patients that presented with salivary gland lumps at Department of pathology, Tribhuvan University Teaching Hospital, Institute of medicine, Kathmandu, Nepal from January 2009 to June 2010. FNAC was performed and was correlated with histopathological diagnosis to judge the sensitivity, specificity and accuracy of FNAC.Results: Out of 36 cases there was cyto-histological correlation in 28 cases. Pleomorphic adenoma was the most frequent lesion in this study. Parotid gland was the most common site affected by salivary gland lesions. The sensitivity, specificity and accuracy for non-neoplastic lesions was 100%, 89.28%, 91.67%, for benign neoplasms was 100%, 86.95%, 91.67% and for malignant neoplasms was 57.14%, 100%, 83.33% respectively.Conclusion: FNAC is a useful tool in preoperative diagnosis of salivary gland lesions and can be crucial for the management of the patient. Aspiration and reporting of salivary gland lesions demands a competent pathologist who considers all the possible diagnostic pitfalls in mind.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11593 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 654-657

scholarly journals An intrasellar germinoma with normal tumor marker concentrations mimicking primary lymphocytic hypophysitis

2013 ◽  
Vol 57 (7) ◽  
pp. 566-570 ◽  
Author(s):  
Mariana F. Guzzo ◽  
Cristina B. Formiga Bueno ◽  
Thiago T. Amancio ◽  
Sergio Rosemberg ◽  
Cleonice Bueno ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Correct Diagnosis ◽  
Careful Analysis ◽  
Malignant Neoplasms ◽  
Pituitary Hormone ◽  
Appropriate Treatment ◽  
Suprasellar Region ◽  
Neoplastic Lesions ◽  
Posterior Pituitary Hormone ◽  
Pituitary Stalk Thickening

Intracranial germinomas (GE) are malignant neoplasms most commonly found in the suprasellar region, which may cause anterior and particularly posterior pituitary hormone deficits with central diabetes insipidus (DI). Differential diagnosis of pituitary stalk thickening includes granulomatous, inflammatory, infectious, and neoplastic lesions. Although careful analysis of clinical, laboratory, and imaging findings may facilitate the diagnosis, transsphenoidal biopsy is indicated to confirm the disease, as the correct diagnosis directs the appropriate treatment.

Clinicopathological Spectrum of Mediastinal Mass Lesions - A Cross-Sectional Study of 58 Cases in Kolkata, West Bengal

2021 ◽  
Vol 8 (25) ◽  
pp. 2180-2186
Author(s):  
Debarati Pathak ◽  
Abhijit Banerjee ◽  
Soma Ghosh ◽  
Arghya Bandyopadhyay ◽  
Tushar Kanti Das
Keyword(s):  
Germ Cell ◽  
Superior Vena ◽  
Vena Cava ◽  
Histopathological Study ◽  
Anatomical Location ◽  
Germ Cell Tumours ◽  
Surgical Biopsy ◽  
Ct Guided ◽  
Mediastinal Masses ◽  
Neoplastic Lesions

BACKGROUND Mediastinal masses, an enigma to surgical pathologist are among the most complicated lesions explored and relatively inaccessible. They often connote a process with mass effect presenting with superior mediastinal syndrome. This is a challenging area faced by surgical pathologist as varied lesions are found here and often biopsies obtained are tiny and crushed. Appropriate therapy of various mediastinal tumours differs considerably and may significantly impact survival. We wanted to evaluate the various lesions in different compartments of mediastinum and categorise them according to anatomical location, and histopathology. METHODS Patients with mediastinal masses attending outpatient department were selected, history taken and relevant investigations done with radiological evaluation for proper anatomical location of lesion. Histopathological study done on tissues obtained by ultrasound / CT guided biopsy, open surgical biopsy were categorized according to histologic types. Immunohistochemistry was done wherever applicable. RESULTS A total of 58 cases of mediastinal lesions were studied where males predominated and age of patients ranged from 11 months to 68 yrs. All patients were symptomatic. Shortness of breath, superior vena cava syndrome was dominant in anterior and superior mediastinal lesions, middle and posterior mediastinal masses presented with chest pain. Most lesions were neoplastic. Germ cell tumours were found in (24.14 %) followed by lymphoma in (20.69 %) and thymic lesions in (18.97 %) of patients. Neurogenic tumours found in (13.79 %) were located in posterior mediastinum whereas, germ cell tumours and lymphomas were located in anterior mediastinum. Non neoplastic lesions included tuberculosis, sarcoidosis. Unsuspected lesion was metastatic deposit of adenoid cystic carcinoma. CONCLUSIONS A wide variety of non-neoplastic and neoplastic lesions can be found in different compartments of mediastinum and accurate diagnosis is considered necessary to formulate management strategies. KEYWORDS Mediastinum, Biopsy, Radiology, Histopathology

scholarly journals PROFILE OF PATIENTS RECEIVING TOTAL KNEE ARTHROPLASTY: A CROSS-SECTIONAL STUDY

2017 ◽  
Vol 25 (5) ◽  
pp. 202-205 ◽  
Author(s):  
MARCELO JOSÉ CORTEZ BEZERRA ◽  
IGOR MAGALHÃES BARBOSA ◽  
THALES GONÇALVES DE SOUSA ◽  
LARISSA MEIRELES FERNANDES ◽  
DIEGO LEONARDO MENEZES MAIA ◽  
...  
Keyword(s):  
Medical Records ◽  
Severe Disease ◽  
Functional Limitation ◽  
Cross Sectional Study ◽  
Level Of Evidence ◽  
Cross Sectional ◽  
Lequesne Index ◽  
Total Knee ◽  
Epidemiological Profile

ABSTRACT Objective: To describe the epidemiological profile, presented deformities, associated comorbidities, and impact on quality of life in patients with knee osteoarthritis. This study was conducted in a philanthropic hospital in Fortaleza from 2014 to 2015. Methods: Data were collected from medical records, epidemiological forms, and by applying the Lequesne index questionnaire, which contains several questions related to pain, discomfort and functional limitation to assess the severity of symptoms. Results: Females were more prevalent (76.7%), as were patients over 65 years of age (61.6%) and non-whites (81.6%). As for comorbidities, 83.3% had hypertension and 31.7% had diabetes. Of the total, 76.5% cases were genu varum, and 23.5% genu valgum. According to the Lequesne index findings, 61.6% cases were “extremely severe,” and women had higher scores. Conclusion: Females were more prevalent and whites were less prevalent. The most frequent comorbidity was hypertension. Female and elderly patients have more severe disease according to Lequesne index score, and these findings were statistically significant. Level of Evidence II, Prospective Study.

scholarly journals A comparative study of fine-needle aspiration cytology and histopathology in salivary gland lesions

1970 ◽  
Vol 1 (2) ◽  
pp. 108-113 ◽  
Author(s):  
S Vaidya ◽  
A Sinha ◽  
S Narayan ◽  
S Adhikari ◽  
KC Sabira
Keyword(s):  
Salivary Gland ◽  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Neoplastic Lesions ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity

Background: A wide variety of benign and malignant tumours originate in the salivary glands and insufficient tumour cells make their diagnosis difficult in some patients. The aim of this study was to evaluate the efficacy of fine-needle aspiration cytology in the diagnosis of salivary gland lesions and to correlate cytological findings with histopathology. Materials and Methods: This was a prospective study done from September 2002 to May 2004. Fine needle aspiration cytology was performed in 58 patients with clinically significant salivary gland masses. Results: Fine needle aspiration cytology categorized 67.24% of the salivary gland lesions as neoplastic and 32.76% as non-neoplastic lesions. Amongst the neoplastic lesions, 76.9% were benign and 23.1% were malignant cases. Histopathological examination revealed that 81.05% of the cases were benign and 18.95% were malignant. Fine needle aspiration cytology had a sensitivity, specificity and diagnostic accuracy of 81.82%, 100% and 96.55%, respectively. The positive predictive value and negative predictive value was 100% and 95.9%, respectively. Conclusion: Fine needle aspiration of the salivary gland is a safe and reliable technique in the primary diagnosis of salivary gland lesions. Although, limitations are encountered while predicting specific lesions on cytology, especially when dealing with cystic and some malignant lesions, this study has shown that fine needle aspiration cytology has a high sensitivity, specificity and diagnostic accuracy in diagnosing salivary gland lesions. Keywords: Salivary glands; Fine needle aspiration cytology; Histopathology DOI: http://dx.doi.org/10.3126/jpn.v1i2.5403 JPN 2011; 1(2): 108-113

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