A Low Temperature Co-Fired Ceramic Microfluidic Cell Counter

2014 ◽  
Vol 592-594 ◽  
pp. 2261-2266
Author(s):  
A. Priya Rathi ◽  
A. Vimala Juliet
Keyword(s):  
Low Temperature ◽  
Saline Solution ◽  
Three Dimensional ◽  
Comsol Multiphysics ◽  
Mixing Efficiency ◽  
Electrode Pair ◽  
Two Fluids ◽  
Microfluidic Biosensor ◽  
A Cell ◽  
Cell Counter

A three-dimensional microfluidic biosensor has been successfully designed using a low temperature co-fired ceramic (LTCC) technology. This microfluidic sensor consists of mixing, focusing and measuring region. The mixing region is a rectangular shaped channel, to enable the complete mixing of sample and buffered saline solution. An electrode pair in the focusing region uses negative dielectrophoretic forces to direct the cells from all directions of the channel towards the center. The measuring region consists of eleven pairs of gold plated electrodes to measure the change in impedance whenever a cell passes through it. The layout of the design is made using AUTOCAD tool and simulated using COMSOL Multiphysics. The results demonstrate the mixing efficiency of two fluids for different velocities.

A Study on Mixing Efficiency in a Two-Channel Circular Micromixer

2006 ◽  
Vol 22 (4) ◽  
pp. 331-338
Author(s):  
M. Chang ◽  
Y.-H. Hu ◽  
S.-W. Chau ◽  
K.-H. Lin
Keyword(s):  
Three Dimensional ◽  
Numerical Prediction ◽  
Mixing Efficiency ◽  
Experimental Measurements ◽  
Inspection Method ◽  
Flow Rates ◽  
Two Fluids ◽  
Finite Volume Discretization ◽  
Mixing Chamber ◽  
Image Inspection

AbstractThe mixing behavior of a two-channel micromixer with a circular mixing chamber at four different chamber depths and six different flow rates had been investigated. Experiments were implemented with the mixings of two fluids. An image inspection method using the variance of the image gray level contrast as the measurement parameter to determine the mixing efficiency distribution in these mixers. The steady, three-dimensional and laminar flow fields inside the micromixers were also simulated numerically with a finite volume discretization. Through the numerical integration over the chamber depth, the three-dimensional numerical prediction could be compressed into a two-dimensional result, which could be directly used to compare with the experimental measurements. Experimental results show that the measured mixing efficiency is raised with the increase of chamber depth. The numerical prediction of mixing efficiency agreed qualitatively with those obtained from the experimental measurements, while the ratio of the depth to diameter of the mixing chamber is big enough to eliminate the viscosity effect.

scholarly journals Rapid Growth of TiO2 Nanoflowers via Low-Temperature Solution Process: Photovoltaic and Sensing Applications

Materials ◽  
2019 ◽  
Vol 12 (4) ◽  
pp. 566 ◽  
Author(s):  
M. Akhtar ◽  
Ahmad Umar ◽  
Swati Sood ◽  
InSung Jung ◽  
H. Hegazy ◽  
...  
Keyword(s):  
Low Temperature ◽  
Anatase Phase ◽  
Three Dimensional ◽  
Solution Process ◽  
Dye Sensitized Solar Cell ◽  
Sensor Applications ◽  
Dye Sensitized ◽  
Sensing Applications ◽  
Density Growth ◽  
Temperature Solution

This paper reports the rapid synthesis, characterization, and photovoltaic and sensing applications of TiO2 nanoflowers prepared by a facile low-temperature solution process. The morphological characterizations clearly reveal the high-density growth of a three-dimensional flower-shaped structure composed of small petal-like rods. The detailed properties confirmed that the synthesized nanoflowers exhibited high crystallinity with anatase phase and possessed an energy bandgap of 3.2 eV. The synthesized TiO2 nanoflowers were utilized as photo-anode and electron-mediating materials to fabricate dye-sensitized solar cell (DSSC) and liquid nitroaniline sensor applications. The fabricated DSSC demonstrated a moderate conversion efficiency of ~3.64% with a maximum incident photon to current efficiency (IPCE) of ~41% at 540 nm. The fabricated liquid nitroaniline sensor demonstrated a good sensitivity of ~268.9 μA mM−1 cm−2 with a low detection limit of 1.05 mM in a short response time of 10 s.

scholarly journals A Numerical Study of Sub-Millisecond Integrated Mix-and-Inject Microfluidic Devices for Sample Delivery at Synchrotron and XFELs

2021 ◽  
Vol 11 (8) ◽  
pp. 3404
Author(s):  
Majid Hejazian ◽  
Eugeniu Balaur ◽  
Brian Abbey
Keyword(s):  
Molecular Dynamics ◽  
Flow Rate ◽  
Numerical Study ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Liquid Jets ◽  
Mixing Efficiency ◽  
X Ray Diffraction ◽  
Cross Sectional ◽  
Time Required

Microfluidic devices which integrate both rapid mixing and liquid jetting for sample delivery are an emerging solution for studying molecular dynamics via X-ray diffraction. Here we use finite element modelling to investigate the efficiency and time-resolution achievable using microfluidic mixers within the parameter range required for producing stable liquid jets. Three-dimensional simulations, validated by experimental data, are used to determine the velocity and concentration distribution within these devices. The results show that by adopting a serpentine geometry, it is possible to induce chaotic mixing, which effectively reduces the time required to achieve a homogeneous mixture for sample delivery. Further, we investigate the effect of flow rate and the mixer microchannel size on the mixing efficiency and minimum time required for complete mixing of the two solutions whilst maintaining a stable jet. In general, we find that the smaller the cross-sectional area of the mixer microchannel, the shorter the time needed to achieve homogeneous mixing for a given flow rate. The results of these simulations will form the basis for optimised designs enabling the study of molecular dynamics occurring on millisecond timescales using integrated mix-and-inject microfluidic devices.

A Three-Dimensional Viscous Transonic Inverse Design Method

2000 ◽  
Author(s):  
W. T. Tiow ◽  
M. Zangeneh
Keyword(s):  
Design Method ◽  
Flow Analysis ◽  
Three Dimensional ◽  
Viscous Effects ◽  
Flow Equations ◽  
Flow Solution ◽  
Turbomachinery Blades ◽  
A Cell ◽  
Inverse Design Method ◽  
Euler Solver

The development and application of a three-dimensional inverse methodology is presented for the design of turbomachinery blades. The method is based on the mass-averaged swirl, rV~θ distribution and computes the necessary blade changes directly from the discrepancies between the target and initial distributions. The flow solution and blade modification converge simultaneously giving the final blade geometry and the corresponding steady state flow solution. The flow analysis is performed using a cell-vertex finite volume time-marching algorithm employing the multistage Runge-Kutta integrator in conjunction with accelerating techniques (local time stepping and grid sequencing). To account for viscous effects, dissipative forces are included in the Euler solver using the log-law and mixing length models. The design method can be used with any existing solver solving the same flow equations without any modifications to the blade surface wall boundary condition. Validation of the method has been carried out using a transonic annular turbine nozzle and NASA rotor 67. Finally, the method is demonstrated on the re-design of the blades.

Studies on three-dimensional moulding, bonding and assembling of low-temperature-cofired ceramics for MEMS and MST applications

2005 ◽  
Vol 89 (1) ◽  
pp. 72-79 ◽  
Author(s):  
P.K. Khanna ◽  
B. Hornbostel ◽  
M. Burgard ◽  
W. Schäfer ◽  
J. Dorner
Keyword(s):  
Low Temperature ◽  
Three Dimensional ◽  
Cofired Ceramics

LOW TEMPERATURE MODELS OF METAL OXIDE SEMICONDUCTOR FIELD-EFFECT TRANSISTORS

1995 ◽  
Vol 06 (02) ◽  
pp. 317-373 ◽  
Author(s):  
G. GILDENBLAT ◽  
D. FOTY
Keyword(s):  
Low Temperature ◽  
Field Effect Transistors ◽  
Numerical Models ◽  
Three Dimensional ◽  
Oxide Semiconductor ◽  
Characteristic Time Scale ◽  
Mos Transistors ◽  
Short Channel ◽  
Temperature Range ◽  
Dimensional Models

We review the modeling of silicon MOS devices in the 10–300 K temperature range with an emphasis on the specifics of low-temperature operation. Recently developed one-dimensional models of long-channel transistors are discussed in connection with experimental determination and verification of the effective channel mobility in a wide temperature range. We also present analytical pseudo-two-dimensional models of short-channel devices which have been proposed for potential use in circuit simulators. Several one-, two-, and three-dimensional numerical models are discussed in order to gain insight into the more subtle details of the low-temperature device physics of MOS transistors and capacitors. Particular attention is paid to freezeout effects which, depending on the device design and the ambient temperature range, may or may not be important for actual device operation. The numerical models are applied to study the characteristic time scale of freezeout transients in the space-charge regions of silicon devices, to the analysis and suppression of delayed turn-off in MOS transistors with compensated channel, and to the temperature dependence of three-dimensional effects in short-channel, narrow-channel MOSFETs.

scholarly journals Numerical simulation of Faraday waves

2009 ◽  
Vol 635 ◽  
pp. 1-26 ◽  
Author(s):  
NICOLAS PÉRINET ◽  
DAMIR JURIC ◽  
LAURETTE S. TUCKERMAN
Keyword(s):  
Stokes Equations ◽  
Three Dimensional ◽  
Oscillation Period ◽  
Finite Amplitude ◽  
Three Dimensions ◽  
Navier Stokes ◽  
Faraday Waves ◽  
Temporal Behaviour ◽  
Two Fluids ◽  
Front Tracking Method

We simulate numerically the full dynamics of Faraday waves in three dimensions for two incompressible and immiscible viscous fluids. The Navier–Stokes equations are solved using a finite-difference projection method coupled with a front-tracking method for the interface between the two fluids. The critical accelerations and wavenumbers, as well as the temporal behaviour at onset are compared with the results of the linear Floquet analysis of Kumar & Tuckerman (J. Fluid Mech., vol. 279, 1994, p. 49). The finite-amplitude results are compared with the experiments of Kityk et al (Phys. Rev. E, vol. 72, 2005, p. 036209). In particular, we reproduce the detailed spatio-temporal spectrum of both square and hexagonal patterns within experimental uncertainty. We present the first calculations of a three-dimensional velocity field arising from the Faraday instability for a hexagonal pattern as it varies over its oscillation period.

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