scholarly journals A Novel Methodology to Assess the Relaxation Rate of the Intervertebral Disc by Increments on Intradiscal Pressure

2014 ◽  
Vol 664 ◽  
pp. 379-383 ◽  
Author(s):  
Ângelo R. Araújo ◽  
Nuno Peixinho ◽  
A.C. Marques Pinho ◽  
J.C.P. Claro
Keyword(s):  
Intervertebral Disc ◽  
Relaxation Rate ◽  
Intradiscal Pressure ◽  
Daily Routine ◽  
Nuclear Region ◽  
Severe Damage ◽  
New Approach ◽  
Physiological Load ◽  
Hydrostatic System ◽  
Cartilaginous Endplate

The Intervertebral Disc (IVD) is subjected to several types of loading during daily routine events. However, the overloading on this structure induces higher Intradiscal Pressure (IDP), which could cause severe damage on its structure. This study describes a new approach to that allows monitorize and pressurize nuclear region of the IVD, with a cartilaginous endplate access, by the insertion of an external fluid, while a Motion Segment (MS-assembly composed by vertebra-disc-vertebra) is compressed at a physiological load. This methodology includes the use of a pneumatic structure that applies a certain pressure on the hydrostatic system, forcing a fluid to enter into the MS through a screw, with a drilled hollow along its entire length. Preliminary results indicated that this methodology presents high potential to efficiently pressurize the IVD, providing a useful tool to better understand the response of this structure under pressure.

scholarly journals Exclusion Spirometry: An Initiative to Increase Lung Function Assessment in Primary Care

2004 ◽  
Vol 11 (3) ◽  
pp. 195-196 ◽  
Author(s):  
José Almirall ◽  
Paul Bégin
Keyword(s):  
Primary Care ◽  
General Practice ◽  
Lung Function ◽  
Primary Care Physicians ◽  
Quality Standards ◽  
Daily Routine ◽  
Respiratory Impairment ◽  
New Approach ◽  
Normal Limits ◽  
Function Assessment

Ongoing spirometry quality standards are difficult to bring into the daily routine of general practice. As a result, spirometry is rarely performed by primary care physicians. A new approach is proposed: exclusion spirometry. Acceptable and reproducible results are sought. However, the goal of the test is to try to reach values within normal limits, even if results do not reach quality standards. Normal results would be sufficient to exclude respiratory impairment, except in asthma. Abnormal results would require further testing in a diagnostic spirometry laboratory. The aim of the initiative is to enhance the compliance of general practitioners in using spirometers for screening.

Intradiscal Pressure, Shear Strain, and Fiber Strain in the Intervertebral Disc Under Combined Loading

Spine ◽  
2007 ◽  
Vol 32 (7) ◽  
pp. 748-755 ◽  
Author(s):  
Hendrik Schmidt ◽  
Annette Kettler ◽  
Frank Heuer ◽  
Ulrich Simon ◽  
Lutz Claes ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Shear Strain ◽  
Intradiscal Pressure ◽  
Combined Loading

Role of load history in intervertebral disc mechanics and intradiscal pressure generation

2011 ◽  
Vol 11 (1-2) ◽  
pp. 95-106 ◽  
Author(s):  
David Hwang ◽  
Adam S. Gabai ◽  
Miao Yu ◽  
Alvin G. Yew ◽  
Adam H. Hsieh
Keyword(s):  
Intervertebral Disc ◽  
Intradiscal Pressure ◽  
Load History

scholarly journals Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

Bone Research ◽  
2022 ◽  
Vol 10 (1) ◽  
Author(s):  
Zuqiang Wang ◽  
Hangang Chen ◽  
Qiaoyan Tan ◽  
Junlan Huang ◽  
Siru Zhou ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Genetic Ablation ◽  
Adult Mice ◽  
Conditional Deletion ◽  
Current Therapies ◽  
Cartilaginous Endplate ◽  
Ivd Degeneration ◽  
Deficient Mice

AbstractThe intervertebral disc (IVD) is the largest avascular tissue. Hypoxia-inducible factors (HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease (DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate (EP) and annulus fibrosus (AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligase Vhl in EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of the Hif1α gene delayed DDD pathogenesis in Vhl-deficient mice. Administration of 2-methoxyestradiol (2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD.

A NEW APPROACH FOR NEUROLYTIC SUPERIOR HYPO-GASTRIC PLEXUS BLOCK THE MEDIAN (TRANSTHECAL TRANS-INTERVERTEBRAL DISC, L4-5 OR L5-S1) APPROACH

1998 ◽  
Vol 86 (Supplement) ◽  
pp. 304S ◽  
Author(s):  
Y Ohfusa ◽  
H Ina ◽  
T Kitoh ◽  
M Kobayashi ◽  
T Otagiri ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
New Approach ◽  
Plexus Block

New Approach for B-Mode Ultrasound (US) Evaluation of the Plantar Aponeurosis (PA) Thickness in Healthy Subjects

2018 ◽  
Vol 191 (04) ◽  
pp. 333-339 ◽  
Author(s):  
Mohamed Abd Ellah ◽  
Christian Kremser ◽  
Sylvia Strobl ◽  
Stefan Rauch ◽  
Christian Deml ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Interobserver Agreement ◽  
Age Groups ◽  
Daily Routine ◽  
New Approach ◽  
Plantar Aponeurosis ◽  
Younger Age ◽  
Key Points ◽  
Significant Difference ◽  
Males And Females

Purpose To compare ultrasound (US) measurements in the sagittal and axial plane of the plantar aponeurosis (PA) in healthy subjects. Materials and Methods PA thickness was measured in 40 healthy subjects (mean age: 34 years) by two radiologists using US in sagittal, axial medial and axial lateral planes. Subjects were classified according to gender (female and male) and age (18 – 35 versus 50 – 75 years). All measurements were compared and the interobserver agreement was calculated. Results The PA was medially significantly thicker than laterally (mean ± std 3.1 ± 0.7 mm versus 2.5 ± 0.5 mm respectively, P< 0.001). A significant difference was found between males and females (3.3 ± 0.7 mm versus 2.9 ± 0.6 mm medially and 2.7 ± 0.6 mm versus 2.3 ± 0.4 mm laterally, p < 0.05) and between the older and younger age groups (3.8 ± 0.6 mm versus 2.8 ± 0.4 mm medially and 3.1 ± 0.4 mm versus 2.3 ± 0.4 mm laterally, p < 0.001). Good interobserver agreement was detected (0.74). Conclusion Measurement of central and lateral fascicles of the plantar aponeurosis in both planes (sagittal and axial) is recommended in the daily routine. Key points  Citation Format

scholarly journals The microstratigraphy of middens: capturing daily routine in rubbish at Neolithic Çatalhöyük, Turkey

Antiquity ◽  
2011 ◽  
Vol 85 (329) ◽  
pp. 1024-1038 ◽  
Author(s):  
Lisa-Marie Shillito ◽  
Wendy Matthews ◽  
Matthew J. Almond ◽  
Ian D. Bull
Keyword(s):  
Daily Activities ◽  
Daily Routine ◽  
Major Advance ◽  
New Approach ◽  
Archaeological Investigation ◽  
Biological Signals

Microstratigraphy — the sequencing of detailed biological signals on site — is an important new approach being developed in the Çatalhöyük project. Here the authors show how microscopic recording of the strata and content of widespread middens on the tell are revealing daily activities and the selective employment of plants in houses and as fuel. Here we continue to witness a major advance in the practice of archaeological investigation.

scholarly journals Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Ke Chen ◽  
Xiaohua Lv ◽  
Wei Li ◽  
Fei Yu ◽  
Jianjing Lin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Flow Cytometry ◽  
Intervertebral Disc ◽  
Western Blot ◽  
Lumbar Disc ◽  
The Elderly ◽  
Western Blot Assay ◽  
Cartilaginous Endplate ◽  
Autophagy Activity ◽  
New Strategies

Low back pain (LBP) is the leading cause of disability in the elderly. Intervertebral disc degeneration (IDD) was considered as the main cause for LBP. Degeneration of cartilaginous endplate was a crucial harmful factor during the initiation and development of IDD. Oxidative stress was implicated in IDD. However, the underlying molecular mechanism for the degeneration of cartilaginous endplate remains elusive. Herein, we found that oxidative stress could induce apoptosis and autophagy in endplate chondrocytes evidenced by western blot analysis, flow cytometry, immunofluorescence staining, GFP-LC3B transfection, and MDC staining. In addition, we also found that the apoptosis of endplate chondrocytes was significantly increased after the inhibition of autophagy by bafilomycin A1 shown by flow cytometry. Furthermore, mTOR pathway upstream autophagy was greatly suppressed suggested by western blot assay. In conclusion, our study strongly revealed that oxidative stress could increase autophagy and apoptosis of endplate chondrocytes in intervertebral disc. The increase of autophagy activity could prevent endplate chondrocytes from apoptosis. The autophagy in endplate chondrocytes induced by oxidative stress was mTOR dependent. These findings might shed some new lights on the mechanism for IDD and provide new strategies for the treatments of IDD.

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