Copper Doping TiO2 Nanotube Arrays Loaded with Hydrophilic and Hydrophobic Drugs and its Release

2017 ◽  
Vol 872 ◽  
pp. 178-182
Author(s):  
Feng Fen Zhang ◽  
Chun Lin Xie ◽  
Xiao Juan Yang ◽  
Xiu Feng Xiao
Keyword(s):  
Hydrothermal Treatment ◽  
Biomedical Applications ◽  
Drug Loading ◽  
Phosphate Buffer Solution ◽  
Nanotube Arrays ◽  
X Ray Diffraction ◽  
Buffer Solution ◽  
Treatment Conditions ◽  
Titania Nanotube Arrays ◽  
Vertically Aligned

In this work, vertically aligned titania nanotube arrays (TNTs) were fabricated on Ti surface in fluoride-containing electrolytes by anodization. TNTs were treated by hydrothermal treatment in the saturated solution of [Cu(NH3)4 (H2O)2]2+. Different hydrothermal treatment conditions were studied to obtain the best modification effect in the experiment. The TNTs were loaded with alendronate and ibuprofen via vacuum drying method and the release properties from the nanotubes were detected in phosphate buffer solution (PBS). The samples were characterized by field emission scanning electron microscopy, X-ray diffraction, and UV-Vis spectrophotometer. The data show that copper is successfully doped to the nanotube surface by hydrothermal treatment, and the optimum hydrothermal treatment conditions are 200°C, 0.5h. The drug loading capacity of the modified sample increased obviously, whether it was hydrophilic or hydrophobic. Meanwhile, the modified nanotubes release more slowly in the later stage. This approach provides an alternative to tailor the surface of TNTs and offer considerable propects for diverse biomedical applications.

The Study of Using TiO2 Nanotube Arrays as a Drug Delivery for Alendronate

2011 ◽  
Vol 335-336 ◽  
pp. 1469-1472 ◽  
Author(s):  
Chun Yan Wang ◽  
Xiu Feng Xiao ◽  
Dan Mao ◽  
Hai Zhen Tang ◽  
Rong Fang Liu
Keyword(s):  
Sustained Release ◽  
Phosphate Buffer Solution ◽  
Hollow Structure ◽  
Titanium Substrate ◽  
Nanotube Arrays ◽  
Burst Release ◽  
X Ray Diffraction ◽  
Buffer Solution ◽  
Vertically Aligned ◽  
Two Stages

TiO2 nanotube arrays possess regular hollow structure, large specific surface area and good biocompatibility, which are good for filling with drugs. In this paper, a vertically aligned nanotube arrays of titanium oxide was fabricated on the surface of titanium substrate in fluoride-containing electrolytes by anodization. The TiO2 nanotube arrays were loaded with alendronate via vacuum drying method and the release of alendronate from the nanotubes were detected in phosphate buffer solution(PBS). The samples were characterized by scanning electronic microscope(SEM), X-ray diffraction(XRD), Fourier transform infrared(FTIR), Thermogravimetric analysis (TG) and visible ultraviolet spectrophotometer(UV-vis). The data showed that the release of alendronate from the nanotubes includes two stages: burst release and sustained release, the result indicated that the drug loaded in the TiO2 nanotubes has a certain amounts of sustained-release effect.

Preparation and Antibacterial Bioactivity of Ti-Base Titania Nanotube Arrays

2014 ◽  
Vol 609-610 ◽  
pp. 435-441
Author(s):  
Tian Tian
Keyword(s):  
Staphylococcus Aureus ◽  
Silver Particle ◽  
Titanium Substrate ◽  
Titanium Implant ◽  
Nanotube Arrays ◽  
Titania Nanotube Arrays ◽  
Titania Nanotube ◽  
Vertically Aligned ◽  
Tube Structure

A vertically aligned bioactivity titania nanotube arrays was fabricated on the surface of titanium substrate by anodization. The nanotubes were then treated with optical deposition of silver to make them antibacterial, and to inhibition growth of bacterial in the antibacterial test in vitro. It is shown that the present of silver particle inhibition the growth staphylococcus aureus. Such bioactivity titania nanotube arrays and associated hollow tube structure can be useful as a well-adhered antibacterial bioactive surface layer on titanium implant metals for orthopaedic and dental implants.

Growth and Characterisation of Ag2S Films on ZnS/Indium-Tin-Oxide Coated Glass

2013 ◽  
Vol 721 ◽  
pp. 33-36 ◽  
Author(s):  
Hong Cheng Pan ◽  
Xue Peng Li ◽  
Wei Hong Liu ◽  
Yan Bin Ren
Keyword(s):  
Tin Oxide ◽  
Indium Tin Oxide ◽  
Phosphate Buffer Solution ◽  
Deposition Method ◽  
X Ray Diffraction ◽  
Buffer Solution ◽  
Solution Ph ◽  
X Ray ◽  
Coated Glass ◽  
Glass Substrates

ZnS thin films were deposited on indium–tin-oxide (ITO) coated glass substrates by a chemical bath deposition method. Then the ZnS/ITO slides were immersed in the solution containing 6 mM phosphate buffer solution (pH 7.4), sodium polyacrylate (0.01% w/w), and 0.24 mM AgNO3 at 37°C for 3 h to growth Ag2S films on the surface of ZnS/ITO slides. The absorption band of Ag2S/ZnS/ITO slide displays a considerably blue-shifted. The X-ray diffraction analysis demonstrated the presence of acanthite Ag2S on the surface of ZnS/ITO slides, which is consistent with the cyclic voltammetic data.

In Vivo Biological Behavior of Calcium Phosphate Cements with Different Ca/P Ratio

2008 ◽  
Vol 396-398 ◽  
pp. 237-240
Author(s):  
Sybele Saska ◽  
N.S. Nunes ◽  
Emelly Aveiro ◽  
Cristina A.C. Pavan ◽  
S.H. Santagneli ◽  
...  
Keyword(s):  
Thermogravimetric Analysis ◽  
31P Nmr ◽  
Phosphate Buffer Solution ◽  
Biological Behavior ◽  
X Ray Diffraction ◽  
Buffer Solution ◽  
X Ray ◽  
Calcium Phosphate Cements ◽  
Subcutaneous Tissues

Bioceramics with different Ca/P ratio were prepared from a mechanical mixture of NaPO3, CaCO3, Ca(OH)2 and phosphate buffer solution and implanted in rats subcutaneous tissues. The cements were characterized by Thermogravimetric analysis (TG-TDA), X-ray diffraction and 31P-NMR. The implant sites were excised after 1, 4 and 16 weeks, fixed, dehydrated, included in paraffin wax for serial cutting and examined under the light transmitted microscope. They were biocompatible and biodegradable when implanted in rat subcutaneous. None of the materials induced ectopic osteogenesis. According to the results, the studied materials seem to be able for manufacturing reabsorbable bone implants.

Synthesis, Characterization and In Vitro Drug Release of Melphalan Magnetic Microspheres

2013 ◽  
Vol 22 ◽  
pp. 31-40
Author(s):  
Jin Qiao Xu ◽  
Hai Xing Xu ◽  
Zubad Newaz ◽  
Ran Li ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Drug Release ◽  
Drug Loading ◽  
Phosphate Buffer Solution ◽  
Magnetic Microspheres ◽  
Targeted Chemotherapy ◽  
Buffer Solution ◽  
Magnetization Measurements ◽  
Co Precipitation

A new method of reversible association of melphalan (MEL) to magnetic Fe3O4 nanoparticles preparing MEL magnetic microspheres was developed for magnetically targeted chemotherapy. The efficacy of this approach was evaluated in terms of encapsulation efficiency (EE), drug loading content (DLC), delivery properties and cytotoxicity in vitro. Magnetic Fe3O4 nanoparticles were synthesized by co-precipitation methods and characterized by X-ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and magnetization measurements. The MEL magnetic microspheres were obtained through emulsion cross-linking method and characterized by FTIR, magnetization measurements and scan electron microscopy (SEM). The EE and DLC were determined using a Spectro Vision DB-18805 spectrophotometer. The MEL magnetic microspheres showed good EE values, between 60.6% and 75.6%, as well as good DLC values, between 16.7% and 32.2%, and the magnetic properties were not significantly affected by incorporation of the drug. The in vitro drug release study was carried out in phosphate buffer solution (PBS), simulating physiologic body fluid conditions at 37o C with pH = 7.4. The release profiles showed an initial fast release rate, which decreased as time progressed; about 60% of the drug was released in the first 4 h, and about 78.23 % had been released after 24 h. The results indicated that the prepared magnetic microspheres may be useful for potential applications of MEL for magnetically targeted chemotherapy.

scholarly journals Solubility Enhancement of Clozapine Through Co-Crystal Formation with Isonicotinamide

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Fikri Alatas ◽  
Hestiary Ratih ◽  
Hesti Kurnia ◽  
Sundani Nurono Soewandhi
Keyword(s):  
Dissolution Rate ◽  
Phosphate Buffer Solution ◽  
Crystal Formation ◽  
X Ray Diffraction ◽  
High Permeability ◽  
Buffer Solution ◽  
Pxrd Pattern ◽  
Low Solubility ◽  
Biopharmaceutical Classification System

Clozapine (CLO) is an effective atypical antipsychotic to control the symptoms of psychosis and schizophrenia. Clozapine has low solubility and high permeability, so it is classified as a class II in the biopharmaceutical classification system. The aim of this study was to improve the solubility and dissolution rate of clozapine by clozapine-isonicotinamide (CLO-INA) co-crystal formation. CLO-INA co-crystal was prepared by solvent-drop grinding (SDG) method using water as a solvent. Characterization of SDG result was conducted by powder X-ray diffraction (PXRD) and Fourier transform infrared (FTIR).  Solubility test was performed in water at room temperature. The dissolution test was performed in 900 mL of pH 6.8 phosphate buffer solution, 50 rotation per minute of paddle rotation, and at 37±0.5 °C. The PXRD pattern of  SDG result of CLO-INA has many different peaks from its parent components, and this may indicate the co-crystal formation. The solubility of the co-crystal clozapine was fifteen folds higher than pure clozapine. The dissolution rate of CLO-INA co-crystal increased in the first 10 minutes compared to pure clozapine. Percentage of clozapine dissolved after 10 minutes from CLO-INA co-crystal and pure CLO were 10.2 and 2.4%, respectively. CLO and INA can form co-crystal by SDG method that can improve the solubility and dissolution rate of clozapine.Keywords: Clozapine, Isonicotinamide, Co-crystal, Solubility, Dissolution

Enhanced Photoelectrocatalytic Degradation of Azo-Dye Pollutants Using Transparent Titania Nanotube Arrays Glass Electrode

2011 ◽  
Vol 311-313 ◽  
pp. 2089-2092 ◽  
Author(s):  
Jing Bai ◽  
Bao Xue Zhou ◽  
Jin Hua Li ◽  
Wei Min Cai
Keyword(s):  
Removal Rate ◽  
Metal Electrode ◽  
Glass Electrode ◽  
Nanotube Arrays ◽  
Acid Orange 7 ◽  
Dye Pollutants ◽  
Conductive Glass ◽  
Treatment Conditions ◽  
Titania Nanotube Arrays ◽  
Titania Nanotube

Transparent and highly ordered titania nanotube arrays (TNAs) film electrode was synthesized by anodization from the sputtered titanium (Ti) film on a conductive glass and then applied in the degradation of Acid-orange 7 (AO7) model wastewater. The resulting nanotubes have a length of ~900nm and a pore diameter of ~80nm, resting upon a thin barrier layer. Using 20mg L-1 AO7 solutions as a model system, the removal rate of AO7 by the TNAs glass electrode reaches 95.9% within 180min for the fixed bias potential, higher than 86.2% removal by the TNAs metal electrode under the same treatment conditions.

Hydroxyapatite Formation and Protein Absorption on Triethyl Phosphate Modified Titanium Surface

2007 ◽  
Vol 26-28 ◽  
pp. 797-800
Author(s):  
N. Wu ◽  
Jie Weng ◽  
Shu Xin Qu ◽  
Jian Xin Wang ◽  
Xiong Lu ◽  
...  
Keyword(s):  
Titanium Surface ◽  
Phosphate Buffer Solution ◽  
Attenuated Total Reflection ◽  
Triethyl Phosphate ◽  
X Ray Diffraction ◽  
Buffer Solution ◽  
Visible Absorption ◽  
Phosphate Ions ◽  
Ha Coating ◽  
Hydroxyapatite Formation

In this work, triethyl phosphate (TEP) was used to bioactivating titanium. Titanium plates grafted with TEP were immersed in a two times concentrated simulated body fluid (2SBF) to investigate deposition of hydoxyapatite (HA) on the surface. A phosphate buffer solution (PBS) with bovine serum albumin (BSA) was used to evaluate adsorption of protein on the grafted titanium surface. The morphology, component and structure of samples were examined by scanning electronic microscopy, attenuated total reflection Fourier transform infrared spectroscopy and X-ray diffraction respectively. The concentration change of BSA in adsorption test was examined with the ultraviolet-visible absorption spectra (UV). The analyses showed that TEP grafted onto the titanium surface. In 2SBF, calcium and phosphate ions deposited spontaneously onto the grafted titanium surface and formed a HA coating with a network-like microporous structure after being immersed for 3 days. The coating consisted of HA particles with 180-265nm in thickness and 72-85nm in width. The diameter of the micropores was about 200nm. The HA coating appeared better uniformity than that on the modified titanium using phosphoric acid. BSA rapidly adsorbed onto the grafted titanium surface at first half an hour and then the adsorption quantity almost kept constant. These results indicate that TEP grafting is an effective approach to modify bioactivity of titanium.

Pretreatment with Huperzine A-Loaded Poly(lactide-co-glycolide) Nanoparticles Protects against Lethal Effects of Soman-Induced in Mice

2015 ◽  
Vol 645-646 ◽  
pp. 1374-1382 ◽  
Author(s):  
Rui Hua Zhang ◽  
Li Qin Li ◽  
Chen Wang ◽  
Xiao Jing Lu ◽  
Tong Shi ◽  
...  
Keyword(s):  
Whole Blood ◽  
Protective Efficacy ◽  
Drug Loading ◽  
Phosphate Buffer Solution ◽  
Huperzine A ◽  
Reversible Inhibitor ◽  
Burst Release ◽  
Ache Inhibition ◽  
Buffer Solution

Huperzine A (HupA), an alkaloid isolated from theChinese club moss, is a reversible inhibitor of cholinesterases which cross the blood-brain barrier and show high specificity for acetylcholinesterase (AChE). However, HupA induces unwanted side effects in an effective dose against nerve agent poisoning. In the present study, HupA–loaded poly (lactide-co-glycolide) nanoparticles (HupA-PLGA-NP) were prepared using the O/W emulsion solvent evaporation method. The results of SEM demonstrated that HupA-PLGA-NP had an spherical shape and a smooth surface without pores. It’s mean diameter and PDI were 208.5±3.6nm and 0.09±0.01 respectively. The Zeta potential was-35.3±1.8mV and the drug loading was 2.86±0.6%.In vitrodrug release studies showed that HupA-PLGA-NP had a sustained-release behavior in phosphate buffer solution, The accumulated amount of HupA was about 72.1% at 48h with a low burst release within 30min. The LD50values of HupA and HupA-PLGA-NP were 1.40 and 4.85mg/kg respectively, showing that the toxicity of HupA was reduced by 3.5 times. We evaluated the protective efficacy for different doses of HupA or HupA-PLGA-NP against 1.0×LD95(143.0μg/kg) soman toxicity. The results confirmed that HupA (0.3~0.5mg/kg) or HupA-PLGA-NP (0.5~1.5mg/kg) could ensure animals survive. However, about 10% of the animals injected with HupA (0.8mg/kg) died, while no animals died when injected with HupA-PLGA-NP (1.5mg/kg). Aim to 100% survival rate, the effective protective time (12h) of HupA-PLGA-NP (0.5mg/kg,iv) against 1.0×LD95soman toxicity in mice was significantly prolonged compared with that of HupA (4h). The study of AChE activity showed that whole-blood and supernatant of brain diluted by 80-fold and 10-fold respectively were optimum in this study. AChE inhibition after administration of HupA and HupA-PLGA-NP (0.5mg/kg,iv) was recorded and analyzed, The peak values of AChE inhibition in whole-blood and brain by HupA-PLGA-NP (17.6% and 21.8%) were lower than those by HupA (33.7% and 31.9%) and AChE inhibition time by HupA-PLGA-NP was longer than that by HupA. These data confirmed that HupA-PLGA-NP had less toxic and more longer time than HupA against 1.0×LD95soman poisoning and warrant further development as a potent medical countermeasure against chemical warfare nerve agents (CWNAs) poisoning.

scholarly journals Olanzapine Loaded Nanostructured Lipid Carriers via High Shear Homogenization and Ultrasonication

2021 ◽  
Vol 89 (2) ◽  
pp. 25
Author(s):  
Adejumoke Lara Ajiboye ◽  
Uttom Nandi ◽  
Martin Galli ◽  
Vivek Trivedi
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Drug Loading ◽  
Particle Diameter ◽  
Phosphate Buffer Solution ◽  
Nanostructured Lipid Carriers ◽  
High Shear ◽  
Buffer Solution ◽  
High Shear Homogenization

The aim of this study was to understand the effect of high shear homogenization (HSH) and ultrasonication (US) on the physicochemical properties of blank and olanzapine loaded nanostructured lipid carriers (NLCs) along with their drug loading potential and drug release profiles from formulated particles. NLCs were prepared with different ratios of Compritol and Miglyol as the solid and liquid lipids, respectively, under changing HSH and US times between 0 to 15 minutes. The surfactants (Poloxamer 188 (P188) and tween 80) and the drug content was kept constant in all formulations. The prepared NLCs were evaluated for particle size, polydispersity index, zeta potential, drug crystallinity and chemical interactions between lipids and OLZ. The in-vitro drug release was performed using dialysis tube method in phosphate buffer solution (PBS) at pH 7.4. The formulated NLCs were negatively charged, spherically shaped and monodisperse, with particle sizes ranging from 112 to 191 nm. There was a significant influence of US time on the preparation of NLCs in comparison to HSH, where a significant reduction in the mean particle diameter was seen after 5 min of sonication. An increase of Miglyol content in NLCs led to an increase in particle size. In general, application of US led to decrease in particle size after HSH but an increase in particle diameter of low Miglyol containing preparation was also observed with longer sonication time. OLZ was successfully encapsulated in the NLCs and a total release of 89% was achieved in 24 hours in PBS at pH 7.4.

Sign in / Sign up

Export Citation Format

Share Document