Novel Organic-Inorganic Hybrid Nanoparticles as Non-Viral Gene Vector
2008 ◽
Vol 47-50
◽
pp. 1319-1322
Keyword(s):
Sol Gel
◽
Novel hybrid biomaterial of gelatin-siloxane nanoparticles (GS NPs), with positive surface potential and lower cytotoxicity, was synthesized through a 2-step sol-gel process. The pDNA-GS NPs complex was formulated with high encapsulation efficiency, and exhibited and efficient transfection in vitro. We thus envision that the GS NPs material could serve as non-viral gene vectors for gene therapy.