Apatite-Forming Ability of Pectin Gels in Simulated Body Environment

2007 ◽  
Vol 330-332 ◽  
pp. 675-678
Author(s):  
Takashi Ichibouji ◽  
Toshiki Miyazaki ◽  
Eiichi Ishida ◽  
Masahiro Ashizuka ◽  
Atsushi Sugino ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Aqueous Solutions ◽  
Body Fluid ◽  
Bone Substitutes ◽  
Pectic Acid ◽  
Natural Bone ◽  
Apatite Deposition ◽  
Cacl2 Treatment ◽  
Mechanical Performances ◽  
Pectin Gels

Apatite-polymer hybrids are expected as novel bone substitutes exhibiting bone-bonding ability and mechanical performances analogous to those of natural bone. In this study, we attempted preparation of organic-inorganic hybrids from different pectins such as pectic acid, apple-derived pectin and citrus-derived pectin through apatite deposition in simulated body fluid (SBF). Pectin gels were prepared by CaCl2 treatment of aqueous solutions of pectin. Apatite-forming ability of the gels was examined in SBF. The citrus-derived pectin showed tendency to form the largest amount of the apatite in SBF.

Improvement of Apatite-Forming Ability of Tantalum Metal by CaCl2 Treatment

2007 ◽  
Vol 361-363 ◽  
pp. 681-684
Author(s):  
Deepak K. Pattanayak ◽  
Tomiharu Matsushita ◽  
Hiroaki Takadama ◽  
Tadashi Kokubo ◽  
Takashi Nakamura
Keyword(s):  
Heat Treatment ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Edx Analysis ◽  
Na Ions ◽  
Naoh Treatment ◽  
Tantalum Metal ◽  
Cacl2 Treatment ◽  
Xrd Patterns

Tantalum metal was soaked in NaOH and CaCl2 solutions, and then subjected to heat treatment at 500°C. EDX analysis showed that about 6.5 at. % of Na was incorporated into the surface of the tantalum metal by the first NaOH treatment. These Na+ ions were replaced by Ca2+ ions by the subsequent CaCl2 treatment. According to TF-XRD patterns, an amorphous sodium tantalate was seemed to be formed on the tantalum metal by the NaOH treatment and transformed into amorphous calcium tantalate by the CaCl2 treatment. This phase was crystallized into Ca2Ta2O7 by heat treatment. Critical detaching load of the surface of the CaCl2-treated tantalum metal was as low as 5mN, while as high as 42mN after the heat treatment. Apatite-forming ability of the NaOH-treated tantalum metal in a simulated body fluid (SBF) was appreciably increased by the CaCl2 treatment and maintained even after the heat treatment.

Processing Technology and Characteristic Evaluation of Polylactic Acid/316L Stainless Steel Composite Braids with Hydroxylapatite Deposition

2011 ◽  
Vol 332-334 ◽  
pp. 1951-1954 ◽  
Author(s):  
Jia Horng Lin ◽  
Wen Cheng Chen ◽  
Jin Jia Hu ◽  
Yueh Sheng Chen ◽  
Shih Peng Wen ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Simulated Body Fluid ◽  
Polylactic Acid ◽  
Biodegradable Polymer ◽  
Body Fluid ◽  
316L Stainless Steel ◽  
Artificial Bone ◽  
Surgical Suture ◽  
Steel Composite ◽  
Apatite Deposition

Biodegradable polymer has been widely used in surgical suture, dressing, artificial bone and other bone-related applications. Studies have demonstrated that metals, such as titanium, titanium alloys or 316L stainless steel, can be widely used in dental and maxillofacial surgeries. The present study aimed to fabricate a scaffold with a blend of multilayer polylactic acid (PLA) ply yarns with 316L stainless steel (SS) braids, which was then immersed in simulated body fluid (SBF), forming the PLA/SS composite braid with hydroxylapatite deposition. After being immersed in SBF for 14 days, the PLA/SS composite braid was covered with precipitate which was confirmed to be apatite deposition according to surface observation and EDS evaluation.

Enhancing Effect of Autoclaving on Bioactivity of ß-Titanium Alloy Coated with Calcium Phosphate Glass-Ceramic

2005 ◽  
Vol 284-286 ◽  
pp. 243-246 ◽  
Author(s):  
Toshihiro Kasuga ◽  
Masayuki Nogami ◽  
Mitsuo Niinomi ◽  
Tomokazu Hattori ◽  
Larry L. Hench
Keyword(s):  
Titanium Alloy ◽  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Glass Ceramic ◽  
Body Fluid ◽  
Strong Bond ◽  
Enhancing Effect ◽  
Natural Bone ◽  
In Vivo Tests

60CaO-30P2O5-7Na2O-3TiO2 (mol%) glass-ceramic can be strongly joined with a new β-type Ti-29Nb-13Ta-4.6Zr alloy. In the present work apatite-forming ability in simulated body fluid of the glass-ceramic-coated titanium alloy was enhanced by autoclaving in water at 120°C for 1 h; surface of the autoclaved coating was completely covered with apatite after 10 days of soaking. In vivo tests showed that the glass-ceramic-coated titanium alloy after autoclaving in water makes a strong bond to natural bone.

Apatite Deposition on Polypeptides Derived from Plants in a Solution Mimicking Body Fluid

2006 ◽  
Vol 309-311 ◽  
pp. 671-674
Author(s):  
Toshiki Miyazaki ◽  
Chikara Ohtsuki ◽  
Shinichi Ogata ◽  
Masahiro Ashizuka
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Mechanical Performance ◽  
Extracellular Fluid ◽  
Organic Polymer ◽  
Carboxyl Groups ◽  
Organic Substrates ◽  
Ion Concentrations ◽  
Inorganic Ion ◽  
Apatite Deposition

Organic-inorganic hybrids composed of organic polymer and apatite is quite attractive as novel bone-repairing materials since it has mechanical performance analogous to those of natural bone as well as bone-bonding ability, i.e. bioactivity. To fabricate such an apatite-polymer hybrid, biomimetic process has been recently paid much attention. In this process, bone-like apatite is deposited on the surfaces of organic substrates in simulated body fluid (SBF, Kokubo solution) having ion concentrations analogous to those of human extracellular fluid or more concentrated solutions. Previous studies showed that the apatite deposition is triggered by a catalytic effect of carboxyl groups (COOH) on the surfaces of the organic substrates. In this study, we examined apatite deposition on natural polypeptides derived from crops in a biomimetic solution. We selected gluten derived from wheat and zein derived from corn. Both of gluten and zein formed bone-like apatite on their surfaces in a solution that has inorganic ion concentrations 1.5 times those of simulated body fluid, when they were treated with 1 mol/L calcium chloride solution. High content of acidic amino acids such as glutamic acid and aspartic acid in gluten and zein would give large amount of carboxyl groups effective for the apatite nucleation.

Simple surface modification of poly(ε-caprolactone) for apatite deposition from simulated body fluid

Biomaterials ◽  
2005 ◽  
Vol 26 (15) ◽  
pp. 2407-2413 ◽  
Author(s):  
Ayako Oyane ◽  
Masaki Uchida ◽  
Cleo Choong ◽  
James Triffitt ◽  
John Jones ◽  
...  
Keyword(s):  
Surface Modification ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Apatite Deposition ◽  
Simple Surface

Influence of Cross-Linking Agents on Apatite-forming Ability of Pectin Gels

2007 ◽  
Vol 361-363 ◽  
pp. 559-562
Author(s):  
Takashi Ichibouji ◽  
Toshiki Miyazaki ◽  
Eiichi Ishida ◽  
Masahiro Ashizuka ◽  
Atsushi Sugino ◽  
...  
Keyword(s):  
Calcium Ions ◽  
Body Fluid ◽  
Bone Structure ◽  
High Fracture Toughness ◽  
Cross Linking ◽  
High Fracture ◽  
Natural Bone ◽  
Bone Repairing ◽  
High Flexibility ◽  
Pectin Gels

Natural bone is a kind of organic-inorganic hybrid composed of collagen and apatite crystals with a structure that provides specific mechanical properties such as high fracture toughness and flexibility. Materials exhibiting both high flexibility and bioactivity similar to natural bone are required for novel bone-repairing materials in medical fields. We expect that we can design such materials by mimicking the bone structure. Biomimetic process has been paid much attention where bone-like apatite is deposited on organic polymers in simulated body fluid (SBF). In this study, we investigated influence of cross-linking agents on apatite-forming ability of pectin gels. Pectin is a polysaccharide abundant in carboxyl group. Pectin gels were prepared by cross-linking of pectin aqueous solutions with calcium ions or divinylsulfone (DVS). Apatite-forming ability of the gels was examined in SBF. The citrus-derived pectin showed tendency to form the largest amount of the apatite independent on a kind of cross-linking agents in SBF.

Preparation of Hydroxyapatite / Titania Double Layer Coating on Poly-I-lactide due to Hydrolysis of Titanium Tetrachloride

2007 ◽  
Vol 330-332 ◽  
pp. 687-690
Author(s):  
Jin Fang Liu ◽  
Satoshi Hayakawa ◽  
Kanji Tsuru ◽  
Jian Zhong Jiang ◽  
Akiyoshi Osaka
Keyword(s):  
Aqueous Solution ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Titanium Tetrachloride ◽  
In Vitro Bioactivity ◽  
Biodegradable Scaffolds ◽  
Apatite Deposition ◽  
Hydrolysis Of ◽  
Layer Coating

Rutile films were deposited on poly-l-lactide (PLLA) substrates using 0.5 M titanium tetrachloride aqueous solution at 40 °C for 72 h. The rutile films exhibited excellent in vitro bioactivity as they induced apatite deposition in a simulated body fluid (SBF) within 3 days. This simple treatment provided an effective route to synthesize bioactive and biodegradable scaffolds.

Bonelike Apatite Formation on Synthetic Organic Polymers and Fiber Coated with Titania

2007 ◽  
Vol 330-332 ◽  
pp. 679-682
Author(s):  
Jin Fang Liu ◽  
Satoshi Hayakawa ◽  
Kanji Tsuru ◽  
Jian Zhong Jiang ◽  
Akiyoshi Osaka
Keyword(s):  
Aqueous Solution ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Apatite Formation ◽  
Organic Polymers ◽  
In Vitro Bioactivity ◽  
Nylon Fiber ◽  
Apatite Deposition ◽  
Bonelike Apatite

Rutile films were deposited on polyethylene terephatalate (PET), polytetrafluoroethylene (PTFE), Silicone, poly6-caprolactam (Nylon6), polyhexamethylene adipamide (Nylon6,6) and Nylon fiber substrates using 0.03 M TiOSO4 and 0.03 M H2O2 aqueous solution at 80°C for 24 h. The rutile films exhibited excellent in vitro bioactivity as they induced apatite deposition in a simulated body fluid (SBF).

Apatite deposition on thermally and anodically oxidized titanium surfaces in a simulated body fluid

Biomaterials ◽  
2003 ◽  
Vol 24 (25) ◽  
pp. 4631-4637 ◽  
Author(s):  
Xiao-Xiang Wang ◽  
Wei Yan ◽  
Satoshi Hayakawa ◽  
Kanji Tsuru ◽  
Akiyoshi Osaka
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Titanium Surfaces ◽  
Apatite Deposition

Bioactive PMMA-Based Cement Incorporated with Nano-Sized Rutile Particles

2006 ◽  
Vol 309-311 ◽  
pp. 797-800 ◽  
Author(s):  
Masami Hashimoto ◽  
Hiroaki Takadama ◽  
Mineo Mizuno ◽  
Tadashi Kokubo ◽  
Koji Goto ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Compressive Strength ◽  
Simulated Body Fluid ◽  
Mechanical Strength ◽  
Bone Cement ◽  
Body Fluid ◽  
Bone Substitutes ◽  
Hardened Cement ◽  
Pmma Bone Cement

Bioactive bone cement with mechanical properties higher than that of commercial polymethylmethacrylate (PMMA) bone cement are strongly desired to be developed. In the present study, PMMA-based cement incorporated with nano-sized rutile particles was prepared. The PMMA-based cement (rutile content was 50 wt%) shows the compressive strength (136 MPa) higher than that of commercial PMMA bone cement (88 MPa). The hardened cement formed apatite on the surface in a simulated body fluid within 3 days. Therefore, this PMMA-based cement incorporated with rutile particles might be useful as cement for fixation of prostheses as well as self-setting bone substitutes, because of its high apatite forming ability and mechanical strength.

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