Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles

2007 ◽  
Vol 336-338 ◽  
pp. 1534-1537 ◽  
Author(s):  
Hua De Zheng ◽  
Ying Jun Wang ◽  
Chun Rong Yang ◽  
Xiao Feng Chen ◽  
Na Ru Zhao
Keyword(s):  
Body Fluid ◽  
Structural Characteristics ◽  
Nano Particles ◽  
Carbonate Apatite ◽  
Nano Materials ◽  
Porous Composite ◽  
Bioactive Glasses ◽  
Inorganic Particles ◽  
Tissue Reconstruction ◽  
Micro Emulsion

The spherical nano-sized bioactive particles in the system of CaO-P2O5-SiO2 were bio-mimetically synthesized using micro-emulsion method. The microstructures and properties of the bio- mimetic nano-materials were characterized using XRD, FTIR, SEM/EDAX and TEM techniques. It was indicated that the nano-particles possessed glassy structural characteristics. The porous composite for bone tissue reconstruction was prepared by compounding poly (hydroxybutyrate-2-co-2-hydroxyvalerate) (PHBV) and the nano-particles of bio-mimetic bioactive glasses (BMBG). Bone-like hydroxyl- carbonate-apatite (HCA) could formed on the surface of porous composite by immersing the composite in simulated body fluid (SBF) at 37°C for 8 hours. With increase of immersion time, the morphology of HCA changed from spherical into flake-like crystals. The study on cells attachment of the porous PHBV/BMBG composite proved that the material possessed satisfactory bioactivity, bio-mineralization function and cells biocompatibility.

scholarly journals Contrasting In Vitro Apatite Growth from Bioactive Glass Surfaces with that of Spontaneous Precipitation

Materials ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 1690 ◽  
Author(s):  
Yang Yu ◽  
Zoltán Bacsik ◽  
Mattias Edén
Keyword(s):  
Body Fluid ◽  
Carbonate Apatite ◽  
X Ray Diffraction ◽  
Bioactive Glasses ◽  
Direct Precipitation ◽  
Living Tissues ◽  
Glass Surfaces ◽  
Supersaturated Solutions ◽  
Hydroxy Carbonate

Body-fluid-exposed bioactive glasses (BGs) integrate with living tissues due to the formation of a biomimetic surface layer of calcium hydroxy-carbonate apatite (HCA) with a close composition to bone mineral. Vast efforts have been spent to understand the mechanisms underlying in vitro apatite mineralization, as either formed by direct precipitation from supersaturated solutions, or from BG substrates in a simulated body fluid (SBF). Formally, these two scenarios are distinct and have hitherto been discussed as such. Herein, we contrast them and identify several shared features. We monitored the formation of amorphous calcium phosphate (ACP) and its crystallization into HCA from a Na 2 O–CaO–SiO 2 –P 2 O 5 glass exposed to SBF for variable periods out to 28 days. The HCA growth was assessed semi-quantitatively by Fourier transform infrared spectroscopy and powder X-ray diffraction, with the evolution of the relative apatite content for increasing SBF-exposure periods evaluated against trends in Ca and P concentrations in the accompanying solutions. This revealed a sigmoidal apatite growth behavior, well-known to apply to spontaneously precipitated apatite. The results are discussed in relation to the prevailing mechanism proposed for in vitro HCA formation from silicate-based BGs, where we highlight largely simultaneous growth processes of ACP and HCA.

Development of Novel Mesoporous Silica-Based Bioactive Glass Scaffolds with Drug Delivery Capabilities

2014 ◽  
Vol 96 ◽  
pp. 54-60 ◽  
Author(s):  
Anahí Philippart ◽  
Elena Boccardi ◽  
Lucia Pontiroli ◽  
Ana Maria Beltrán ◽  
Alexandra Inayat ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Simulated Body Fluid ◽  
Mesoporous Silica ◽  
Body Fluid ◽  
Glass Composition ◽  
Glass Structure ◽  
Sol Gel ◽  
Bioactive Glasses

Novel silica-based bioactive glasses were successfully prepared by the sol-gel method. The optimized glass composition for fabrication of the scaffolds was (in mol.%) 60% SiO2 – 30% CaO - 5% Na2O - 5% P2O5 (60S30C5N5P). This composition was confirmed to develop a thick hydroxycarbonate apatite (HCA) layer in Simulated Body Fluid (SBF) after 7 days, as revealed by Fourier Transform Infrared Spectroscopy (FTIR), indicating the bioactive character of the scaffolds. The mesoporous nature of the glass structure allows the load of tetracycline and a sustained release of the drug in PBS during 7 days was measured.

scholarly journals Bonding between Bioactive Glasses, Glass-Ceramics or Ceramics in a Simulated Body Fluid

1987 ◽  
Vol 95 (1104) ◽  
pp. 785-791 ◽  
Author(s):  
Takashi KOKUBO ◽  
Tetsuya HAYASHI ◽  
Sumio SAKKA ◽  
Toshiaki KITSUGI ◽  
Takashi YAMAMURO
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Glass Ceramics ◽  
Bioactive Glasses

scholarly journals Epoxy resin filled with primary and secondary raw material – useable in agriculture

2014 ◽  
Vol 60 (No. 4) ◽  
pp. 165-171 ◽  
Author(s):  
P. Valášek ◽  
J. Kejval ◽  
M. Müller
Keyword(s):  
Mechanical Properties ◽  
Wear Resistance ◽  
Epoxy Resin ◽  
Filler Particle ◽  
Polymeric Materials ◽  
Raw Material ◽  
Nano Particles ◽  
Inorganic Particles ◽  
Increase Wear Resistance ◽  
Secondary Raw Material

Hard inorganic particles in the interaction with polymeric materials increase wear resistance. Also reactoplastics are suitable for filling with micro- and nano-particles for a purpose of some mechanical properties optimization. The paper compares chosen mechanical properties – hardness, wear resistance and tensile characteristics of epoxy resin filled with artificial corundum with various middle particles sizes and their ratio combination. Mentioned systems can be used in a sphere of the agricultural production at renovation of machine parts, they can serve for creating resistant layers on machines, floors and grillages at the same time. The aim of the carried out experiment is to compare the properties of reactoplastics filled with a primary and secondary raw material and to define an optimum ratio of the filler particle size relating to a given mechanical quality. The artificial corundum was chosen as the primary material, the waste corundum from the process of material mechanical treatment was chosen as the secondary one.    

scholarly journals A thermodynamic discourse on the dissolution behavior of bioactive glasses

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Barbara Pföss ◽  
Reinhard Conradt
Keyword(s):  
Bioactive Glass ◽  
Body Fluid ◽  
Solid Material ◽  
Aqueous System ◽  
Dissolution Behavior ◽  
Glassy Material ◽  
Bioactive Glasses ◽  
Gibbs Energies ◽  
The Impact ◽  
Glass Compositions

AbstractThe interaction between bioactive glass and body fluid is crucial for the special properties of this material, therefore a large number of experimental data is available in literature. However, a frame for systematic interpretation of these results in terms of understanding the mechanisms at the interface between glass and body medium and the relation between glass composition and dissolution behavior is still missing. For two multicomponent bioactive glasses, 45S5 and 13-93, the Gibbs energies of the glassy material on one side and their aqueous system on the other side were calculated individually. The difference between solid material and aqueous system further constitutes the pH dependent Gibbs energy of hydration, ∆Ghydr. The impact of glass compositions and glassy or crystalline state on ∆Ghydr is demonstrated referring to chemical durability. Along considerations regarding the aqueous system, the thermodynamic calculations proof the precipitation of hydroxyapatite inwater and simulated body fluid for a systemcontaining P2O5 and Ca2+. In the course of deriving the Gibbs energies for bioactive glass compositions via constitutional compounds, bioactive behavior is discussed from the point of coexisting equilibrium phases in the system of Na2O-CaO-SiO2.

scholarly journals Hierarchical Structures and Shaped Particles of Bioactive Glass and ItsIn VitroBioactivity

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
U. Boonyang ◽  
F. Li ◽  
A. Stein
Keyword(s):  
Body Temperature ◽  
Simulated Body Fluid ◽  
Bioactive Glass ◽  
Body Fluid ◽  
Colloidal Crystals ◽  
Hierarchical Structures ◽  
The Other ◽  
Bioactive Glasses ◽  
Ordered Macroporous

In this study, bioactive glass particles with controllable structure and porosity were prepared using dual-templating methods. Block copolymers used as one template component produced mesopores in the calcined samples. Polymer colloidal crystals as the other template component yielded either three-dimensionally ordered macroporous (3DOM) products or shaped bioactive glass nanoparticles. Thein vitrobioactivity of these bioactive glasses was studied by soaking the samples in simulated body fluid (SBF) at body temperature (37°C) for varying lengths of time and monitoring the formation of bone-like apatite on the surface of the bioactive glass. A considerable bioactivity was found that all of bioactive glass samples have the ability to induce the formation of an apatite layer on its surface when in contact with SBF. The development of bone-like apatite is faster for 3DOM bioactive glasses than for nanoparticles.

scholarly journals Structural And Thermal Characteristics of Aluminum Grades 6063 and 7075 with Application of Nano Coatings

2018 ◽  
Vol 7 (2.32) ◽  
pp. 187
Author(s):  
Ch Sridhar Yesaswi ◽  
N Venkata Sai ◽  
K Vivek ◽  
B Raju ◽  
G Venkat
Keyword(s):  
Heat Exchangers ◽  
Power Plants ◽  
Material Selection ◽  
Structural Characteristics ◽  
Thermal Characteristics ◽  
Vital Role ◽  
Nano Particles ◽  
Technology Advancement ◽  
Nano Coating ◽  
Metal Pipes

To fabricate any product, material selection is one of the major constraints for many engineers even on today. An intensive research is being done by scientists and engineers over the properties and characteristics of the materials. Due to the technology advancement, applications of various new products are entering into market with different materials. From the past few decades composites and alloy materials are playing a vital role because of their unique nature. In the present work heat exchangers are taken into application. In nuclear and power plants heat exchangers plays a crucial role in cooling the reactors. When these are made to cool with water by sending through metal pipes over a period of time, metal pipes get easily corroded because of water and thermal conductivity of the metal. When base metals are coated with Nano-particles there is a drastic change in their behavior. In this paper Aluminum grade 6063 and grade 7075 are considered and coated with Al2O3-NaOH Nano fluids. Their thermal and structural characteristics are identified before and after Nano coating.    

Strength and Drying Shrinkage of Pavement Concrete with Nano-Particles

2013 ◽  
Vol 662 ◽  
pp. 182-185
Author(s):  
Mao Hua Zhang ◽  
Hong Guang Wang
Keyword(s):  
Chemical Properties ◽  
Drying Shrinkage ◽  
Nano Particles ◽  
Shrinkage Rate ◽  
Nano Materials ◽  
Nano Tio2 ◽  
Science Field ◽  
Ordinary Concrete ◽  
Nano Sio2 ◽  
Pavement Concrete

With the development of national economy in Mainland China, the heavier vehicles and traffic flow have arisen in highway transportation. Concrete pavement has high strength and good durability, and thus is widely used in high-grade highway. Due to the small dimension, nano- materials have many unique physical and chemical properties, and become the focus of material science field. In this thesis, based on the unique characteristics of nano-materials, the ordinary concrete with nano-SiO2 or nano-TiO2 is prepared to research the drying shrinkage of pavement concrete. The test results indicate that the concrete with nano-SiO2 and nano-TiO2 in the amount of 2.0% and 1.0% by weight of binder have the respectively biggest drying shrinkage rate of the same concrete type, which are significantly increased than the ordinary concrete. After 28 days, the dying shrinkage rate of the concrete with nano-TiO2 is 1.6 times to the ordinary concrete.

In Vitro Study of Microplasma Sprayed Hydroxyapatite Coatings in Simulated Body Fluid

2009 ◽  
Vol 79-82 ◽  
pp. 815-818 ◽  
Author(s):  
Qiu Ying Zhao ◽  
Ding Yong He ◽  
Xiao Yan Li ◽  
Jian Min Jiang
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Carbonate Apatite ◽  
In Vitro Test ◽  
X Ray Diffraction ◽  
X Ray ◽  
Amorphous Phases ◽  
Hydroxyapatite Coatings ◽  
Vitro Test

Hydroxyapatite (HA) coatings were deposited onto Ti6Al4V substrate by microplasma spraying (MPS) in the current research. The morphology, phase compositions, and percentage of crystallinity of the coatings were characterized by means of scanning electron microscopy (SEM) and X-ray diffraction. An in vitro evaluation by soaking the coatings in simulated body fluid (SBF) for up to 14 days was conducted aiming at the evaluation of their bioactivity. Results from the present investigation suggest that microplasma sprayed HA coatings exhibited certain roughness, pores, and microcracks. Thermal decomposition existed in the coatings where HA, α-TCP，β-TCP, amorphous phases, and CaO-exclusive impurities were observed. The in vitro test indicated that HA coatings deposited by MPS possessed better bioactivity and stability. A layer of carbonate-apatite covered most of the coating surface, which did not exhibit significant spalling after incubation in SBF.

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