Manufacturing Quality Control Method Based on Bayesian Network Model

2010 ◽  
Vol 450 ◽  
pp. 292-295
Author(s):  
Ye Hong Dong ◽  
Dong Xiang ◽  
Guang Hong Duan
Keyword(s):  
Quality Control ◽  
Bayesian Network ◽  
Model Building ◽  
Control Method ◽  
Drilling Process ◽  
Quality Prediction ◽  
Shewhart Control ◽  
Drilling Quality ◽  
Micro Drilling ◽  
Manufacturing Mode

In order to address the problem of quality control faced in multi-type and small-batch manufacturing mode, the method based on Bayesian Network (BN) is proposed. The building, learning and evolving method as well as the quality prediction and diagnosis method of BN model are described in this paper. The combination of BN model and Shewhart control chart is also mentioned. The model building and evolving method was conducted in PCB micro-drilling process as example, verifying that the prediction accuracy increases with the evolved model. The drilling quality prediction was compared with that obtained through regression analysis and artificial neural network. The advantage of BN model in advanced manufacturing is proved.

Effect of Rapid-Feed Step-Drilling Cycle and Super-High-Speed Spindle for High-Speed Micro Drilling in Printed Wiring Boards

2010 ◽  
Vol 447-448 ◽  
pp. 836-840 ◽  
Author(s):  
Eiichi Aoyama ◽  
Toshiki Hirogaki ◽  
Keiji Ogawa ◽  
Satoshi Nojiri ◽  
Yutaka Takeda
Keyword(s):  
High Speed ◽  
Drilling Process ◽  
Printed Wiring Boards ◽  
Step Method ◽  
Processing Efficiency ◽  
High Productivity ◽  
Micro Holes ◽  
Drilling Quality ◽  
Micro Drilling ◽  
Drilling Conditions

A drilling technique using micro-drills of 0.2 mm or less in diameter and a super-high-speed spindle of 160000 rpm or more has been developed for drilling ultra-micro holes in printed wiring boards (PWBs). The drilling process requires higher reliability and quality to maintain the reliability of the electrical connection between circuit layers. On the other hand, higher processing efficiency is also required in PWBs manufacturing. To maintain high productivity, drilling is normally performed using a non-step method, but heat damage called B-RING occurs around the drilled holes with this method. To solve these problems without the loss of processing efficiency, we applied the rapid-feed step-drilling cycle method. We investigated the B-RING for drilling quality and evaluated the drilling time for processing efficiency under various drilling conditions. We found that using a rapid-feed step-drilling cycle with an appropriate number of steps and feed rates ensures a higher level of hole quality and processing efficiency compared with the conventional non-step drilling.

scholarly journals Bayesian Network for quality control in the drilling process

2010 ◽  
Vol 43 (4) ◽  
pp. 264-269 ◽  
Author(s):  
Susana Ferreiro ◽  
Basilio Sierra ◽  
Eneko Gorritxategi ◽  
Itziar Irigoien
Keyword(s):  
Quality Control ◽  
Bayesian Network ◽  
Drilling Process

scholarly journals Drilling Vibration in a Micro-Drilling Process Using a Gas Bearing Spindle

2020 ◽  
Vol 12 (10) ◽  
pp. 168781402096900
Author(s):  
Bo-Wun Huang ◽  
Jung-Ge Tseng
Keyword(s):  
Printed Circuit Boards ◽  
Engineering Application ◽  
Drilling Process ◽  
High Rotational Speed ◽  
Spindle System ◽  
Drilling Quality ◽  
Micro Drilling ◽  
Spinning Speed ◽  
Gas Bearing ◽  
Micro Drill

In industry, high-density packaging technology is an unavoidable requirement. Therefore, the drilling hole of printed circuit boards, PCB, requires being much smaller, even down to 0.1 mm or less. Drill fractures are frequently found in the micro drilling process due to the micro scale, hole-location errors, reaming. In all micro drilling failure cases, there existed a large vibration or instability is frequently found because of the insufficient rigidity of supports for a system with a super-high spinning speed. To improve the drilling quality and avoid drill breakage, the effects of support stiffness and high rotational speed of the vibration in the micro drilling process must be studied. Most investigations on the vibration of micro drilling are focused on only drill self-structure. However, in an actual engineering application, the micro drill must be attached in a bearing spindle system. This study considers the vibration of a micro drill with a gas bearing spindle. Hence, it includes the effects of the rotation speed, air pressure, and clearance of gas bearing on the vibration in a micro drilling process. After constructing the governing equations of the system, the numerical analysis by the Fortran programming is performed to solve for the frequency and amplitude response of the spindle system over time. The results indicated that the spindle with the gas bearings effect increased the vibration in the micro-drilling process.

Perencanaan Pengendalian Kualitas Produk Pakaian Bayi dengan Metode Six Sigma Pada CV. AGP

JEMAP ◽  
2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Albertus Reynaldo Kurniawan ◽  
Bayu Prestianto
Keyword(s):  
Quality Control ◽  
Continuous Improvement ◽  
Six Sigma ◽  
Screen Printing ◽  
Control Method ◽  
Operational Performance ◽  
Machine Maintenance ◽  
Quality Product ◽  
Break Time ◽  
And Control

Quality control becomes an important key for companies in suppressing the number of defective produced products. Six Sigma is a quality control method that aims to minimize defective products to the lowest point or achieve operational performance with a sigma value of 6 with only yielding 3.4 defective products of 1 million product. Stages of Six Sigma method starts from the DMAIC (Define, Measure, Analyze, Improve and Control) stages that help the company in improving quality and continuous improvement. Based on the results of research on baby clothes products, data in March 2018 the percentage of defective products produced reached 1.4% exceeding 1% tolerance limit, with a Sigma value of 4.14 meaning a possible defect product of 4033.39 opportunities per million products. In the pareto diagram there were 5 types of CTQ (Critical to Quality) such as oblique obras, blobor screen printing, there is a fabric / head cloth code on the final product, hollow fabric / thin fabric fiber, and dirty cloth. The factors caused quality problems such as Manpower, Materials, Environtment, and Machine. Suggestion for consideration of company improvement was continuous improvement on every existing quality problem like in Manpower factor namely improving comprehension, awareness of employees in producing quality product and improve employee's accuracy, Strength Quality Control and give break time. Materials by making the method of cutting the fabric head, the Machine by scheduling machine maintenance and the provision of needle containers at each employees desk sewing and better environtment by installing exhaust fan and renovating the production room.

Chemical Fingerprint Analysis and Simultaneous Determination of Nucleosides and Amino Acids in Kang Fu Xin Liquid by High Performance Liquid Chromatography with Diode Array Detector

2020 ◽  
Vol 16 (7) ◽  
pp. 831-843
Author(s):  
Yuwen Wang ◽  
Shuping Li ◽  
Liuhong Zhang ◽  
Shenglan Qi ◽  
Huida Guan ◽  
...  
Keyword(s):  
Amino Acids ◽  
Quality Control ◽  
Uric Acid ◽  
Control Method ◽  
Principal Component ◽  
Gradient Elution ◽  
Hplc Method ◽  
Array Detector ◽  
Fingerprint Analysis ◽  
Wavelength Switching

Background and Objective: Kang Fu Xin liquid (KFX) is an official preparation made from the ethanol extract product from P. Americana. The present quality control method cannot control the quality of the preparation well. The aim of the present study is to establish a convenient HPLC method for multicomponents determination combined with fingerprint analysis for quality control of KFX. Methods: An HPLC-DAD method with gradient elution and detective wavelength switching program was developed to establish HPLC fingerprints of KFX, and 38 batches of KFX were compared and evaluated by similarity analysis (SA), hierarchical clustering analysis (HCA), and principal component analysis (PCA). Meanwhile, six nucleosides and three amino acids, including uracil, hypoxanthine, uric acid, adenosine, xanthine, inosine, tyrosine, phenylalanine and tryptophan in KFX were determined based on the HPLC fingerprints. Results: An HPLC method assisted with gradient elution and wavelength switching program was established and validated for multicomponents determination combined with fingerprint analysis of KFX. The results demonstrated that the similarity values of the KFX samples were more than 0.845. PCA indicated that peaks 4 (hypoxanthine), 7 (xanthine), 9 (tyrosine), 11, 13 and 17 might be the characteristic contributed components. The nine constituents in KFX, uracil, hypoxanthine, uric acid, adenosine, xanthine, inosine, tyrosine, phenylalanine and tryptophan, showed good regression (R2 > 0.9997) within test ranges and the recoveries of the method for all analytes were in the range from 96.74 to 104.24%. The limits of detections and quantifications for nine constituents in DAD were less than 0.22 and 0.43 μg•mL-1, respectively. Conclusion: The qualitative analysis of chemical fingerprints and the quantitative analysis of multiple indicators provide a powerful and rational way to control the KFX quality for pharmaceutical companies.

scholarly journals Development and Validation of a GMP-Compliant High-Pressure Liquid Chromatography Method for the Determination of the Chemical and Radiochemical Purity of [18F]PSMA-1007, a PET Tracer for the Imaging of Prostate Cancer

2021 ◽  
Vol 14 (3) ◽  
pp. 188
Author(s):  
Ines Katzschmann ◽  
Heike Marx ◽  
Klaus Kopka ◽  
Ute Hennrich
Keyword(s):  
Prostate Cancer ◽  
Quality Control ◽  
Radiochemical Purity ◽  
Control Method ◽  
Solid Phase ◽  
Hplc Method ◽  
Attractive Alternative ◽  
Chromatography Method ◽  
Pet Tracer

For the PET imaging of prostate cancer, radiotracers targeting the prostate-specific membrane antigen (PSMA) are nowadays used in clinical practice. [18F]PSMA-1007, a radiopharmaceutical labeled with fluorine-18, has excellent properties for the detection of prostate cancer. Essential for the human use of a radiotracer is its production and quality control under GMP-compliance. For this purpose, all analytical methods have to be validated. [18F]PSMA-1007 is easily radiosynthesized in a one-step procedure and isolated using solid phase extraction (SPE) cartridges followed by formulation of a buffered injection solution and for the determination of its chemical and radiochemical purity a robust, fast and reliable quality control method using radio-HPLC is necessary. After development and optimizations overcoming problems in reproducibility, the here described radio-HPLC method fulfills all acceptance criteria—for e.g., specificity, linearity, and accuracy—and is therefore well suited for the routine quality control of [18F]PSMA-1007 before release of the radiopharmaceutical. Recently a European Pharmacopeia monograph for [18F]PSMA-1007 was published suggesting a different radio-HPLC method for the determination of its chemical and radiochemical purity. Since the here described method has certain advantages, not least of all easier technical implementation, it can be an attractive alternative to the monograph method. The here described method was successfully validated on several radio-HPLC systems in our lab and used for the analysis of more than 60 batches of [18F]PSMA-1007. Using this method, the chemical and radiochemical purity of [18F]PSMA-1007 can routinely be evaluated assuring patient safety.

scholarly journals A Reliable, Label Free Quality Control Method for the Production of DNA Microarrays with Clinical Applications

Polymers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 340
Author(s):  
Elisa Chiodi ◽  
Francesco Damin ◽  
Laura Sola ◽  
Lucia Ferraro ◽  
Dario Brambilla ◽  
...  
Keyword(s):  
Quality Control ◽  
Dna Microarrays ◽  
Control Method ◽  
False Negative ◽  
Label Free ◽  
Negative Results ◽  
System A ◽  
Quality Control Method ◽  
False Negative Results ◽  
Imaging Sensor

The manufacture of a very high-quality microarray support is essential for the adoption of this assay format in clinical routine. In fact, poorly surface-bound probes can affect the diagnostic sensitivity or, in worst cases, lead to false negative results. Here we report on a reliable and easy quality control method for the evaluation of spotted probe properties in a microarray test, based on the Interferometric Reflectance Imaging Sensor (IRIS) system, a high-resolution label free technique able to evaluate the variation of the mass bound to a surface. In particular, we demonstrated that the IRIS analysis of microarray chips immediately after probe immobilization can detect the absence of probes, which recognizably causes a lack of signal when performing a test, with clinical relevance, using fluorescence detection. Moreover, the use of the IRIS technique allowed also to determine the optimal concentration of the probe, that has to be immobilized on the surface, to maximize the target recognition, thus the signal, but to avoid crowding effects. Finally, through this preliminary quality inspection it is possible to highlight differences in the immobilization chemistries. In particular, we have compared NHS ester versus click chemistry reactions using two different surface coatings, demonstrating that, in the diagnostic case used as an example (colorectal cancer) a higher probe density does not reflect a higher binding signal, probably because of a crowding effect.

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