Self Hardening Macroporous Biphasic Calcium Phosphate Bone Void Filler for Bone Reconstruction; Animal Study and Human Data

2011 ◽  
Vol 493-494 ◽  
pp. 709-713 ◽  
Author(s):  
G. Daculsi ◽  
Marlene Durand ◽  
O. Hauger ◽  
Seris Elodie ◽  
Pascal Borget ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Vertebral Body ◽  
Biphasic Calcium Phosphate ◽  
Bone Ingrowth ◽  
Preclinical Study ◽  
Bone Reconstruction ◽  
Bone Void Filler ◽  
The Matrix ◽  
Bone Trabeculae ◽  
Bone Void

Due to the lack of macroporosity in current available Calcium Phosphate cement used in osteoarticular surgery, Micro and Macroporous Biphasic CaP Cement (MCPC™) was developed. The MCPC™ concept was the association of a settable and a fast resorbable matrix and a sieved fraction of microporous biphasic calcium phosphate (BCP) granules, recognized for the high osteoconductive and osteogenic properties. During the resorption of the matrix, a porous structure is created and the osteoconductive effect of the granules promotes the bone ingrowth. A goat preclinical study was realized to evaluate the efficacy of MCPC™ for C3 and C4 vertebral body filling defects during 6 months. Bone remodelling was evidenced demonstrating bone ingrowth at the expense of the cement and surrounding the residual BCP granules. Bone trabeculae were observed coming from the spongious bone to the implant site. Human vertebral body filling cases demonstrated the biocompatibility and the safety of MCPC™ for bone reconstruction. Results of this study demonstrated the importance of special combination of calcium phosphate granules in the MCPC™ to provide macroporosity and scaffolding for newly formed bone.

Macro/Microporous Biphasic Calcium Phosphate Cylinders and Resorbable Collagen Membranes for Guided Bone Growth

2007 ◽  
Vol 361-363 ◽  
pp. 439-442
Author(s):  
Borhane H. Fellah ◽  
Said Kimakhe ◽  
G. Daculsi ◽  
Pierre Layrolle
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Growth ◽  
Bone Ingrowth ◽  
Collagen Membrane ◽  
Calcium Phosphate Ceramic ◽  
Collagen Membranes ◽  
Large Bone ◽  
Empty Control ◽  
Large Bone Defects

This study aims at evaluating bone growth in critical-sized femoral defects of rats filled with macro micro porous biphasic calcium phosphate ceramic (MBCP) cylinders surrounded or not by a resorbable collagen membrane. Femoral defects left empty (control) exhibited partial bone ingrowths after 3 and 6 weeks and were completely healed at 12 weeks. The defects filled with the collagen membranes appeared partially healed suggesting that the membranes constraint bone ingrowth. Bone formation occurred around the collagen membrane which partially degraded over time. In the MBCP/membrane group, bone has grown inside the macro pores of the MBCP cylinders. Bone ingrowth was more rapid and abundant in the defects filled with MBCP alone. The combination MBCP/collagen membrane may be beneficial for the reconstruction of large bone defects without using repetitive surgeries and autologous bone grafting.

Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth

Biomaterials ◽  
1998 ◽  
Vol 19 (1-3) ◽  
pp. 133-139 ◽  
Author(s):  
Olivier Gauthier ◽  
Jean-Michel Bouler ◽  
Eric Aguado ◽  
Paul Pilet ◽  
Guy Daculsi
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Ingrowth ◽  
Calcium Phosphate Ceramics

scholarly journals Biphasic Calcium Phosphate Bioceramics for Orthopaedic Reconstructions: Clinical Outcomes

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Carlos A. Garrido ◽  
Sonja E. Lobo ◽  
Flávio M. Turíbio ◽  
Racquel Z. LeGeros
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Clinical Outcomes ◽  
Biphasic Calcium Phosphate ◽  
Excellent Result ◽  
Bone Substitutes ◽  
Bone Defects ◽  
Clinical Parameters ◽  
Bone Reconstruction

BCP are considered the most promising biomaterials for bone reconstruction. This study aims at analyzing the outcomes of patients who received BCP as bone substitutes in orthopaedic surgeries. Sixty-six patients were categorized according to the etiology and morphology of the bone defects and received scores after clinical and radiographic evaluations. The final results corresponded to the combination of both parameters and varied from 5 (excellent result) to 2 or lower (poor result). Most of the patients who presented cavitary defects or bone losses due to prosthesis placement or revision, osteotomies, or arthrodesis showed good results, and some of them excellent results. However, patients with segmental defects equal or larger than 3 cm in length were classified as moderate results. This study established clinical parameters where the BCP alone can successfully support the osteogenic process and where the association with other tissue engineering strategies may be considered.

Calcium Phosphate Ceramic Blasting on Titanium Surface Improve Bone Ingrowth

2007 ◽  
Vol 361-363 ◽  
pp. 1351-1354 ◽  
Author(s):  
Eric Goyenvalle ◽  
Eric Aguado ◽  
Ronan Cognet ◽  
Xavier Bourges ◽  
G. Daculsi
Keyword(s):  
Surface Roughness ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Titanium Surface ◽  
Bone Ingrowth ◽  
High Surface ◽  
Titanium Implants ◽  
Calcium Phosphate Ceramic ◽  
Abrasive Particles ◽  
Roughened Surface

Surface roughness modulates the osseointegration of orthopaedic and dental titanium implants. High surface roughness is currently obtained by blasting of titanium implants with silica or aluminium abrasive particles. This process includes into the surface abrasive particles and may cause the release of cytotoxic silica or aluminium ions in the peri implant tissue. To overcome this drawback, we currently develop an innovative gridblasting process using Biphasic Calcium Phosphate (BCP) particles (RBBM Resorbable and Biocompatible Blast Media) to generate biocompatible roughened titanium surface. This work present the technique of blasting using RBBM particles to provide a roughened surface which does not release cytotoxic elements and (ii) to assess the effects of such a roughened surface for bone osteointegration in critical size rabbit defect. Our results demonstrate that resorbable biphasic calcium phosphate abrasive particles can be used to create titanium surface roughness. This grid blasting process increases surface roughness of titanium implants and offers a non cytotoxic surface for rapid and efficient osteointegration.

Bone Marrow Autograft Associated to Macroporous Biphasic Calcium Phosphate for Bone Substitution in an Animal Model of Sequels of Radiotherapy

2005 ◽  
Vol 284-286 ◽  
pp. 285-288
Author(s):  
Oliver Malard ◽  
Jean Michel Bouler ◽  
Jerome Guicheux ◽  
Olivier Gauthier ◽  
E. Lerouxel ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Calcium Phosphate ◽  
Bone Formation ◽  
Biphasic Calcium Phosphate ◽  
Bone Repair ◽  
Major Surgery ◽  
Graft Versus Host Reaction ◽  
Bone Reconstruction ◽  
New Bone Formation ◽  
Study Results

Bone invasion is common in case of Squamous Cell Carcinomas (SCC) of the upper aero-digestive tract. Radiotherapy is required in addition to large surgical tumor removal. This treatment usually generates irreversible injuries on the reparation properties of the tissues, especially on bone. The quality of life of patients undergoing major surgery and radiotherapy in maxillary and mandible areas is reduced, but could be improved by bone reconstruction. The aim of this study was to evaluate the bone reconstruction possibilities by Macroporous Biphasic Calcium-Phosphate (MBCPÔ). The MBCP substitute was evaluated as granules and associated to autologous bone marrow (BM) graft in irradiated areas, in an inbreeding rodent model. Radiation sequels were created on inferior members of half of the rats. 3 weeks later, 3-mm osseous defects were created on each animal. The inbreeding model allows BM to be grafted without graft-versus-host reaction. Defects were filled either with MBCP alone, BM alone or a mixture of MBCP and BM. Six weeks after implantation, animals were sacrificed: bone repair and ceramic degradation were evaluated by qualitative and quantitative study. Results showed that bioceramics were well osteointegrated. Filling the defects with BM alone showed a significant increased of newly-formed bone formation but only after irradiation, whereas filling defects with MBCP alone increased new-bone formation only without previous irradiation. Associating MBCP to BM provided the best new-bone formation rates after irradiation. Degradation of the ceramic was the most important in case of BM grafting. This study demonstrated that BM added to MBCP constitute an appropriate material to be considered in case of bone defect occurring in irradiated tissue, and could be foreseen for use after bone removal for oncologic obligations.

Calcium Phosphate Bone Void Filler Increases Threaded Suture Anchor Pullout Strength: A Biomechanical Study

2020 ◽  
Vol 36 (4) ◽  
pp. 1000-1008 ◽  
Author(s):  
Miguel A. Diaz ◽  
Eric A. Branch ◽  
Luis A. Paredes ◽  
Emily Oakley ◽  
Christopher E. Baker
Keyword(s):  
Calcium Phosphate ◽  
Suture Anchor ◽  
Biomechanical Study ◽  
Pullout Strength ◽  
Bone Void Filler ◽  
Bone Void

Five Years Clinical Follow Up Bone Regeneration with CaP Bioceramics

2007 ◽  
Vol 361-363 ◽  
pp. 1339-1342 ◽  
Author(s):  
Clemencia Rodríguez ◽  
Alain Jean ◽  
Sylvia Mitja ◽  
G. Daculsi
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Bone Ingrowth ◽  
X Ray ◽  
Dental Implantation ◽  
Preventive Method

To overcome autograft use for dental implantation, it is important to prevent bone loss after tooth extraction or to restore alveolar bone level after pathological diseases. Biphasic calcium phosphate (BCP), mixture of HA and ß-TCP, have proven its performance in orthopaedic, while few studies have been reported in dentistry. We reported 5 years clinical follow up on bone regeneration after immediate dental root filling. MBCP 60/40 and MBCP 20/80 are biphasic CaP intimate mixture of HA/TCP 60/40 and 20/80; with interconnected macroporosity and microporosity. Forty cases have been distributed in two groups for alveolar pocket filling. Seven cases without filling are used as control. X-Ray at 0, 3, 6, 12 months and 5 years follow up for some patients were performed. In all the 40 cases, radio-opacity of the implantation area decreases on time, indicating resorption and bone ingrowths at the expense of the two bioceramics. No difference in the resorption kinetics appeared on X-Ray. After 1 year, the implantation area looks as physiological bone and is maintained on time. The newly formed bone is preserved after 5 years contrarily to the controls cases (without filling)where we observed decrease of 2 to 5 mm. This study demonstrated that immediate filling of alveolar pocket after tooth extraction is a preventive method of the jaw bone resorption. After long term (other one year) resorption and bone ingrowth were demonstrated for both micro and macroporous biphasic calcium phosphate with two different HA/TCP ratio.

Microstructural Evolution on Dissolution of Commercial Calcium Phosphate Ceramics

2004 ◽  
Vol 449-452 ◽  
pp. 1177-1180
Author(s):  
Dong Seok Seo ◽  
Hwan Kim ◽  
Jong Kook Lee
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Distilled Water ◽  
High Porosity ◽  
Primary Defect ◽  
Calcium Phosphate Ceramics ◽  
Defect Site ◽  
Soluble Compound ◽  
The Matrix ◽  
Moisture Protection

Three types of calcium phosphate ceramics, i.e. tricalcium phosphate, biphasic calcium phosphate and near stoichiometric hydroxyapatite, were prepared by sintering at 1200oC for 2 h in air with moisture protection. Their dissolution processes were investigated by taking microstructural observations after immersion in distilled water for 3 or 7 days. It was found that the surface dissolution of the ceramics was initiated at grain boundaries and generated many separated grains. In case of the materials with high porosity, the residual pores on the surface appeared to be a primary defect site where the dissolution starts although the soluble compound was existed on the matrix.

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